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Localized delivery of chemotherapy to the cervix for radiosensitization.
Gynecologic oncology 20121001
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Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells.
Pharmaceutical research 20120701
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Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors.
Pharmacogenomics 20120701
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Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine.
Expert opinion on investigational drugs 20120401
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[Population pharmacokinetics of gemcitabine applied to personalize the dosage used in cancer patients].
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20120101
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Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.
Nucleosides, nucleotides & nucleic acids 20111201
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A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
Cancer chemotherapy and pharmacology 20111101
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The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
Drug metabolism and disposition: the biological fate of chemicals 20111101
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Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 20110915
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Difluorodeoxyuridine plasma concentrations after low-dose gemcitabine during chemoradiation in head and neck cancer patients.
Cancer chemotherapy and pharmacology 20110701
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Effect of its deaminated metabolite, 2',2'-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells.
Biochemical pharmacology 20110401
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Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU.
ChemMedChem 20110307
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[Pharmacogenomic research for avoiding adverse reactions by anti-cancer drugs].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110201
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Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites.
Chemosphere 20100901
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Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms.
Clinical pharmacokinetics 20100801
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Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity.
Journal of controlled release : official journal of the Controlled Release Society 20100601
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Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism.
European journal of clinical pharmacology 20100601
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Gemcitabine and epirubicin plasma concentration-related excretion in saliva in patients with non-small cell lung cancer.
Therapeutic drug monitoring 20100601
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Systemic absorption and pharmacokinetics of single-dose intravesical gemcitabine after transurethral resection of the bladder in non-muscle-invasive bladder cancer.
Urology 20091101
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Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 20091001
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Development of a sensitive and selective LC-MS/MS method for simultaneous determination of gemcitabine and 2,2-difluoro-2-deoxyuridine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715
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Mass flows of X-ray contrast media and cytostatics in hospital wastewater.
Environmental science & technology 20090701
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Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method.
Journal of chromatography. A 20090410
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Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry.
Journal of chromatography. A 20090213
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A phase I pharmacokinetic study of hypoxic abdominal stop-flow perfusion with gemcitabine in patients with advanced pancreatic cancer and refractory malignant ascites.
Cancer chemotherapy and pharmacology 20090101
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Pharmacokinetics of gemcitabine at fixed-dose rate infusion in patients with normal and impaired hepatic function.
Clinical pharmacokinetics 20090101
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Does saturable formation of gemcitabine triphosphate occur in patients?
Cancer chemotherapy and pharmacology 20081201
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Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice.
Drug metabolism and disposition: the biological fate of chemicals 20080801
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New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.
Molecular cancer therapeutics 20080801
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Phase I clinical trial of intrathecal gemcitabine in patients with neoplastic meningitis.
Cancer chemotherapy and pharmacology 20080701
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A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 20080701
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Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.
Clinical cancer research : an official journal of the American Association for Cancer Research 20080601
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Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer.
Japanese journal of clinical oncology 20080301
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Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy.
The oncologist 20080301
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Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry.
Journal of mass spectrometry : JMS 20080201
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Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas.
Cancer chemotherapy and pharmacology 20070201
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Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070101
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Pharmacokinetics and toxicity of an early single intravesical instillation of gemcitabine after endoscopic resection of superficial bladder cancer.
Anticancer research 20070101
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Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 20070101
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Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Journal of mass spectrometry : JMS 20061201
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The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro.
Cancer chemotherapy and pharmacology 20060801
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Phase I/II trial of doxorubicin and fixed dose-rate infusion gemcitabine in advanced soft tissue sarcomas: a GEIS study.
British journal of cancer 20060619
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High-performance liquid chromatographic method for the determination of gemcitabine and 2',2'-difluorodeoxyuridine in plasma and tissue culture media.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501
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Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous bolus dosing and its in vitro pharmacodynamics.
Journal of veterinary pharmacology and therapeutics 20060401
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Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous infusion.
Journal of veterinary pharmacology and therapeutics 20060401
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Gemcitabine and atrial fibrillation: a rare manifestation of chemotherapy toxicity.
Anti-cancer drugs 20060301
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Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits.
Nucleosides, nucleotides & nucleic acids 20060101
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Characterization of lipophilic gemcitabine prodrug-liposomal membrane interaction by differential scanning calorimetry.
Molecular pharmaceutics 20060101
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Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.
Anti-cancer drugs 20051001
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Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050401
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Intravesical gemcitabine in superficial bladder cancer: a phase II safety, efficacy and pharmacokinetic study.
Anticancer research 20050101
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Comparative pharmacokinetics and metabolic pathway of gemcitabine during intravenous and intra-arterial delivery in unresectable pancreatic cancer patients.
Clinical pharmacokinetics 20050101
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Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs.
Journal of controlled release : official journal of the Controlled Release Society 20041210
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Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromatography coupled with a diode array detector.
Acta pharmacologica Sinica 20041201
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Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation.
Cancer 20041115
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Investigation of the pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in human plasma by liquid chromatography.
Analytical biochemistry 20040915
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Phase I trial and pharmacokinetics of gemcitabine in children with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040615
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Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation.
BJU international 20040301
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Validated procedure for simultaneous trace level determination of the anti-cancer agent gemcitabine and its metabolite in human urine by high-performance liquid chromatography with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 20040101
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An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.
Therapeutic drug monitoring 20031001
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Pharmacokinetics of gemcitabine in a patient with end-stage renal disease: effective clearance of its main metabolite by standard hemodialysis treatment.
Cancer chemotherapy and pharmacology 20030301
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Measurement of the anti-cancer agent gemcitabine in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030225
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Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: a phase I and pharmacokinetic study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030215
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In vitro studies on the immunosuppressive effect of 2',2'-difluorodeoxycytidine (dFdC) and its metabolite 2',2'-difluorodeoxyuridine (dFdU).
Immunobiology 20030101
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Phase I-II and pharmacokinetic study of gemcitabine combined with oxaliplatin in patients with advanced non-small-cell lung cancer and ovarian carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology 20020901
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Pharmacokinetics of intrathecal gemcitabine in nonhuman primates.
Clinical cancer research : an official journal of the American Association for Cancer Research 20020701
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Gemcitabine, epirubicin and paclitaxel: pharmacokinetic and pharmacodynamic interactions in advanced breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology 20020601
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Drug distribution and pharmacokinetic/pharmacodynamic relationship of paclitaxel and gemcitabine in patients with non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology 20011101
