114432-13-2 | FANTOFARONE

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$57.00	$40.00
5mg	98%	in stock	$236.00	$165.00
10mg	98%	in stock	$413.00	$289.00
25mg	98%	in stock	$958.00	$671.00

Description

• Catalog Number: AE18357
• Chemical Name: FANTOFARONE
• CAS Number: 114432-13-2
• Molecular Formula: C31H38N2O5S
• Molecular Weight: 550.7088
• MDL Number: MFCD00867144
• SMILES: COc1cc(CCN(CCCOc2ccc(cc2)S(=O)(=O)c2c(cn3c2cccc3)C(C)C)C)ccc1OC

Computed Properties

• Complexity: 825
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 13
• XLogP3: 6.7

Literature

• (7R,8S,8aS)-8-Hydr-oxy-7-phenyl-perhydro-indolizin-3-one.

  Acta crystallographica. Section E, Structure reports online 20090601

• Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis.

  Apoptosis : an international journal on programmed cell death 20070901

• De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis.

  Journal of leukocyte biology 20070601

• Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.

  The FEBS journal 20070601

• SR33805, a Ca2+ antagonist with length-dependent Ca2+ -sensitizing properties in cardiac myocytes.

  British journal of pharmacology 20030501

• Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells.

  Experimental cell research 20020215

• SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.

  The Journal of pharmacology and experimental therapeutics 19901101