1150114-53-6 | 5-(t-Butyldimethylsilyloxy)-2-fluorophenylboronic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$249.00	$175.00
5g	98%	in stock	$945.00	$661.00

Description

• Catalog Number: AA20056
• Chemical Name: 5-(t-Butyldimethylsilyloxy)-2-fluorophenylboronic acid
• CAS Number: 1150114-53-6
• Molecular Formula: C12H20BFO3Si
• Molecular Weight: 270.1803
• MDL Number: MFCD11855846
• SMILES: OB(c1cc(ccc1F)O[Si](C(C)(C)C)(C)C)O

Computed Properties

• Complexity: 281
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4

Upstream Synthesis Route

The (5-((tert-Butyldimethylsilyl)oxy)-2-fluorophenyl)boronic acid is a versatile compound commonly employed in chemical synthesis as a key building block for various organic reactions. Its unique chemical properties make it a valuable tool in the creation of complex molecules and materials.One of the primary applications of this compound is in cross-coupling reactions, where it serves as a boronic acid source for the introduction of the phenylboronic acid moiety into a target molecule. This process, known as Suzuki-Miyaura coupling, is widely used in pharmaceutical, agrochemical, and material science industries for the synthesis of biaryl compounds.Additionally, the tert-butyldimethylsilyl (TBDMS) group attached to the boronic acid provides protection for the hydroxyl group, allowing for selective reactions with other functional groups in a molecule. This selective deprotection strategy has been utilized in the synthesis of various natural products and pharmaceutical intermediates.Overall, the (5-((tert-Butyldimethylsilyl)oxy)-2-fluorophenyl)boronic acid plays a crucial role in modern organic synthesis, enabling chemists to access a wide range of structurally diverse compounds with high efficiency and selectivity.