1150617-54-1 | 6-Bromo-1H-pyrazolo[4,3-b]pyridine

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$8.00	$5.00
250mg	97%	in stock	$9.00	$6.00
1g	97%	in stock	$18.00	$12.00
2.5g	97%	in stock	$42.00	$29.00
5g	97%	in stock	$48.00	$33.00
10g	97%	in stock	$95.00	$66.00
25g	97%	in stock	$236.00	$165.00

Description

• Catalog Number: AA20306
• Chemical Name: 6-Bromo-1H-pyrazolo[4,3-b]pyridine
• CAS Number: 1150617-54-1
• Molecular Formula: C6H4BrN3
• Molecular Weight: 198.0201
• MDL Number: MFCD12024534
• SMILES: Brc1cc2[nH]ncc2nc1

Computed Properties

• Complexity: 130
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.3

Upstream Synthesis Route

To synthesize 6-Bromo-1H-pyrazolo[4,3-b]pyridine, start with the appropriate pyrazolopyridine precursor. The upstream synthesis route involves the following steps:

1. Synthesis of Pyrazolopyridine Core:
- Condense an aminopyridine with a suitable β-diketone under acidic conditions to obtain the pyrazolopyridine core.

2. Bromination:
- Subject the pyrazolopyridine core to bromination using a brominating agent such as N-Bromosuccinimide (NBS) in the presence of a solvent like dichloromethane (DCM) at 0°C to room temperature.
- Ensure the reaction is carried out under anhydrous conditions to prevent side reactions with water.

3. Purification:
- After bromination, purify the product via column chromatography or recrystallization to obtain the desired 6-Bromo-1H-pyrazolo[4,3-b]pyridine with high purity.

Further specifics of the reaction conditions would need to be optimized based on the particular starting materials and desired scale of the synthesis.