115761-61-0 | 1-(3-Biphenylyl)piperazine

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$90.00	$63.00
1g	95%	in stock	$195.00	$136.00
5g	95%	in stock	$729.00	$510.00

Description

• Catalog Number: AA21608
• Chemical Name: 1-(3-Biphenylyl)piperazine
• CAS Number: 115761-61-0
• Molecular Formula: C16H18N2
• Molecular Weight: 238.3275
• MDL Number: MFCD06201887
• SMILES: N1CCN(CC1)c1cccc(c1)c1ccccc1

Computed Properties

• Complexity: 242
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.7

Upstream Synthesis Route

1-Biphenyl-3-yl-piperazine is a versatile compound widely used in chemical synthesis for its unique structural features and reactivity. This compound serves as a key building block in the preparation of various biologically active molecules and complex organic compounds. Its rigid biphenyl backbone and piperazine moiety provide a scaffold for functional group manipulations, enabling the synthesis of diverse target molecules with specific properties.In pharmaceutical chemistry, 1-Biphenyl-3-yl-piperazine is commonly employed in the development of new drug candidates, particularly in the design of central nervous system (CNS) agents and serotonin receptor ligands. The piperazine ring in this compound plays a crucial role in modulating the interactions with target receptors, influencing the pharmacological profile and biological activity of the final compounds. Moreover, the biphenyl group offers enhanced stability and structural rigidity, which are favorable characteristics for drug design and optimization.In organic synthesis, 1-Biphenyl-3-yl-piperazine can participate in various reactions such as substitution, oxidation, and coupling reactions to introduce different functional groups onto its framework. Its ability to undergo diverse transformations makes it a valuable intermediate in the synthesis of complex molecules, natural products, and materials with specific properties. By judiciously modifying the molecular structure of 1-Biphenyl-3-yl-piperazine, chemists can access a wide range of chemical derivatives with tailored properties for various applications in the fields of medicinal chemistry, materials science, and chemical biology.

Literature

• Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.

  Journal of medicinal chemistry 20120726