1157849-50-7 | (3R)-1-Methylpiperidin-3-amine dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$26.00	$18.00
1g	95%	in stock	$27.00	$19.00
5g	95%	in stock	$75.00	$53.00
10g	95%	in stock	$145.00	$101.00
25g	95%	in stock	$316.00	$222.00
50g	95%	in stock	$556.00	$389.00
100g	95%	in stock	$928.00	$649.00

Description

• Catalog Number: AA21656
• Chemical Name: (3R)-1-Methylpiperidin-3-amine dihydrochloride
• CAS Number: 1157849-50-7
• Molecular Formula: C6H16Cl2N2
• Molecular Weight: 187.1106
• MDL Number: MFCD20926141
• SMILES: CN1CCC[C@H](C1)N.Cl.Cl

Computed Properties

• Complexity: 72.9
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 3

Upstream Synthesis Route

The upstream synthesis of (3R)-1-Methylpiperidin-3-amine dihydrochloride can be achieved through the following steps:

1. Synthesis of 3-Methylpiperidine: The precursor 3-Methylpiperidine can be synthesized through the cyclization of γ-(methylamino)butyraldehyde using a suitable acid catalyst such as hydrochloric acid, followed by a reduction step.

2. Resolution of Enantiomers: The resulting racemic 3-Methylpiperidine can be subjected to enantioselective resolution to isolate the (3R)-enantiomer. This may involve the formation of diastereomeric salts with a chiral acid, followed by fractional crystallization.

3. N-Alkylation: Enantiomerically pure (3R)-3-Methylpiperidine is then alkylated using methylamine and a suitable reagent, commonly an alkylating agent like methyl iodide, to introduce the amine group, yielding (3R)-1-Methylpiperidin-3-amine.

4. Salt Formation: Finally, the free base of (3R)-1-Methylpiperidin-3-amine is treated with hydrochloric acid to form the dihydrochloride salt, giving the desired end product, (3R)-1-Methylpiperidin-3-amine dihydrochloride.

It should be noted that each step may require optimization of reaction conditions, including temperature, solvents, and reaction time, to achieve the desired purity and enantiomeric excess. Safety measures should be strictly followed due to the reactivity of the chemicals involved and the potential formation of hazardous by-products.