116539-60-7 | (R)-duloxetine

Availability
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Description

• Catalog Number: AJ16854
• Chemical Name: (R)-duloxetine
• CAS Number: 116539-60-7
• Molecular Formula: C18H19NOS
• Molecular Weight: 297.4146
• MDL Number: MFCD09750959
• SMILES: CNCC[C@H](c1cccs1)Oc1cccc2c1cccc2

Computed Properties

• Complexity: 312
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 4.3

Upstream Synthesis Route

(R)-Duloxetine is a versatile chiral compound that finds application in various chemical synthesis processes. Its enantiopure form is particularly valuable in asymmetric synthesis, where it serves as a key building block for the creation of complex molecules with high stereochemical control. This enantiomer of duloxetine exhibits specific interactions and reactivity that can be leveraged to selectively form desired products in the presence of other chiral compounds. By incorporating (R)-Duloxetine into a synthetic scheme, chemists can access a powerful tool for enhancing the efficiency and selectivity of their reactions, ultimately leading to the synthesis of valuable intermediates and target compounds with enhanced biological activity or pharmaceutical potential.

Literature

• Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression.

  Bioorganic & medicinal chemistry 20091001

• 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.

  Bioorganic & medicinal chemistry letters 20090101

• Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.

  Bioorganic & medicinal chemistry letters 20031215