116666-63-8 | Mibefradil dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$33.00	$23.00
5mg	97%	in stock	$77.00	$54.00
10mg	97%	in stock	$138.00	$97.00

Description

• Catalog Number: AA16588
• Chemical Name: Mibefradil dihydrochloride
• CAS Number: 116666-63-8
• Molecular Formula: C29H40Cl2FN3O3
• Molecular Weight: 568.5506
• MDL Number: MFCD00881804
• SMILES: COCC(=O)O[C@]1(CCN(CCCc2nc3c([nH]2)cccc3)C)CCc2c([C@@H]1C(C)C)ccc(c2)F.Cl.Cl

Computed Properties

• Complexity: 709
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 38
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 12

Upstream Synthesis Route

Acetic acid, 2-methoxy-, (1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, hydrochloride (1:2) is a compound commonly used in chemical synthesis as a key reagent in the development of pharmaceuticals and bioactive molecules. This complex molecule plays a crucial role in the formation of structurally intricate compounds through its ability to act as a versatile building block during synthetic processes. Its unique chemical structure allows for precise manipulation and control of reactions, enabling the synthesis of diverse and potentially valuable organic products.

Literature

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  Journal of cellular and molecular medicine 20121101

• Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice.

  British journal of pharmacology 20121001

• Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa.

  International journal of andrology 20121001

• T-type Ca²⁺ signalling downregulates MEK1/2 phosphorylation and cross-talk with the RAAS transcriptional response in cardiac myocytes.

  Journal of molecular and cellular cardiology 20120801

• The CatSper channel: a polymodal chemosensor in human sperm.

  The EMBO journal 20120404

• Functional expression of voltage-gated calcium channels in human melanoma.

  Pigment cell & melanoma research 20120301

• [Impact of calcium channel antagonists for estrogen action on the endometrial carcinoma HEC-1A cells].

  Zhonghua fu chan ke za zhi 20120301

• Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes.

  British journal of pharmacology 20120201

• Retrieval of context-associated memory is dependent on the Ca(v)3.2 T-type calcium channel.

  PloS one 20120101

• Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-n-[(1r)-1-(4-fluorophenyl)-2-methylpropyl]acetamide Derivatives as Novel Antihypertensive Agents.

  Chemical & pharmaceutical bulletin 20120101

• On the origin of rhythmic calcium transients in the ICC-MP of the mouse small intestine.

  American journal of physiology. Gastrointestinal and liver physiology 20111101

• Closure of multiple types of K+ channels is necessary to induce changes in renal vascular resistance in vivo in rats.

  Pflugers Archiv : European journal of physiology 20111101

• Coding movement direction by burst firing in electrosensory neurons.

  Journal of neurophysiology 20111001

• Sodium influx induced by external calcium chelation decreases human sperm motility.

  Human reproduction (Oxford, England) 20111001

• Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.

  Bioorganic & medicinal chemistry letters 20111001

• The sound of silence: ionic mechanisms encoding sound termination.

  Neuron 20110908

• Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.

  Hypertension (Dallas, Tex. : 1979) 20110901

• Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831

• Two structurally different T-type Ca 2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats.

  Fundamental & clinical pharmacology 20110801

• Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.

  The Journal of clinical investigation 20110801

• Mechanism-based inactivation of cytochrome P450 3A4 by mibefradil through heme destruction.

  Drug metabolism and disposition: the biological fate of chemicals 20110701

• Quantitative prediction of mechanism-based inhibition caused by mibefradil in rats.

  Drug metabolism and disposition: the biological fate of chemicals 20110701

• Synaptically driven state transitions in distal dendrites of striatal spiny neurons.

  Nature neuroscience 20110701

• Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.

  Cancer investigation 20110601

• The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm.

  Nature 20110317

• T-type voltage-gated calcium channels regulate the tone of mouse efferent arterioles.

  Kidney international 20110201

• Potassium-induced intermittent vasomotion in rat isolated pulmonary artery.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101

• Inhibitory actions of mibefradil on steroidogenesis in mouse Leydig cells: involvement of Ca(2+) entry via the T-type Ca(2+) channel.

  Asian journal of andrology 20101101

• Voltage-gated divalent currents in descending vasa recta pericytes.

  American journal of physiology. Renal physiology 20101001

• Effects of T-type calcium channel blockers on cocaine-induced hyperlocomotion and thalamocortical GABAergic abnormalities in mice.

  Psychopharmacology 20101001

• Biophysical properties of human medulloblastoma cells.

  The Journal of membrane biology 20101001

• Altered protein kinase C regulation of pulmonary endothelial store- and receptor-operated Ca2+ entry after chronic hypoxia.

  The Journal of pharmacology and experimental therapeutics 20100901

• Comparative effects of T-type and L-type Ca(2+)-antagonists against noradrenaline-induced contractions of human vas deferens.

  BJU international 20100801

• Alpha1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium.

  American journal of physiology. Lung cellular and molecular physiology 20100701

• Changes in aortic stiffness related to elastic fiber network anomalies in the Brown Norway rat during maturation and aging.

  American journal of physiology. Heart and circulatory physiology 20100701

• Involvement of Src kinase in T-type calcium channel-dependent neuronal differentiation of NG108-15 cells by hydrogen sulfide.

  Journal of neurochemistry 20100701

• Upregulation of Ca(v)3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain.

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• Synaptic integration of rhythmogenic neurons in the locomotor circuitry: the case of Hb9 interneurons.

  Annals of the New York Academy of Sciences 20100601

• Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels.

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• T-type Ca(2+) channel modulation by otilonium bromide.

  American journal of physiology. Gastrointestinal and liver physiology 20100501

• Electrophysiological effects of neuropeptide S on rat ventromedial hypothalamic neurons in vitro.

  Peptides 20100401

• Electrical stimulation induces calcium-dependent release of NGF from cultured Schwann cells.

  Glia 20100401

• Transient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalis.

  The Journal of biological chemistry 20100305

• Effects of T-type calcium channel blockers and thalidomide on contractions of rat vas deferens.

  British journal of pharmacology 20100301

• The roles of T-type calcium channel in the development of neuropathic pain following chronic compression of rat dorsal root ganglia.

  Pharmacology 20100101

• Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2.

  Channels (Austin, Tex.) 20100101

• Voltage-dependent Ca2+ currents contribute to spontaneous Ca2+ waves in rabbit corpus cavernosum myocytes.

  The journal of sexual medicine 20091101

• A role of functional T-type Ca2+ channel in hepatocellular carcinoma cell proliferation.

  Oncology reports 20091101

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.

  Circulation 20090901

• Evaluating patients with persistent chest pain and no obstructive coronary artery disease.

  JAMA 20090812

• Is combined L- and T-channel blockade better than L-channel blockade in therapy?

  Hypertension (Dallas, Tex. : 1979) 20090701

• Luminal hydrogen sulfide plays a pronociceptive role in mouse colon.

  Gut 20090601

• Hydrogen sulfide as a novel mediator for pancreatic pain in rodents.

  Gut 20090601

• Heterogeneity of L- and T-channels in the vasculature: rationale for the efficacy of combined L- and T-blockade.

  Hypertension (Dallas, Tex. : 1979) 20090401

• Hyperalgesia induced by spinal and peripheral hydrogen sulfide: evidence for involvement of Cav3.2 T-type calcium channels.

  Pain 20090301

• Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels.

  Neuroscience 20090218

• Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs.

  The Journal of pharmacology and experimental therapeutics 20090201

• T-type calcium channels mediate rebound firing in intact deep cerebellar neurons.

  Neuroscience 20090123

• The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes.

  Journal of cellular and molecular medicine 20090101

• Excitatory effects of low-level lead exposure on action potential firing of pyramidal neurons in CA1 region of rat hippocampal slices.

  Journal of neuroscience research 20081201

• Effects of distension on airway inflammation and venular P-selectin expression.

  American journal of physiology. Lung cellular and molecular physiology 20081101

• Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels.

  Pflugers Archiv : European journal of physiology 20081001

• Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis.

  Molecular and cellular biochemistry 20080801

• Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.

  Bioorganic & medicinal chemistry letters 20080801

• Involvement of T-type Ca2+ channels in the potentiation of synaptic and visual responses during the critical period in rat visual cortex.

  The European journal of neuroscience 20080801

• The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil.

  Drug metabolism and disposition: the biological fate of chemicals 20080701

• Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes.

  Pflugers Archiv : European journal of physiology 20080601

• A selective T-type Ca2+ channel blocker R(-) efonidipine.

  Naunyn-Schmiedeberg's archives of pharmacology 20080601

• The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay.

  The Journal of pharmacology and experimental therapeutics 20080601

• T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites.

  Nature neuroscience 20080601

• Contributions of voltage- and Ca2+-activated conductances to GABA-induced depolarization in spider mechanosensory neurons.

  Journal of neurophysiology 20080401

• In vivo approach for the evaluation of mechanism-based inhibition of cytochrome P450 3A in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20080401

• Participation of low-threshold Ca2+ spike in the Purkinje cells complex spike.

  Neuroreport 20080212

• Voltage-gated Ca2+ currents are necessary for slow-wave propagation in the canine gastric antrum.

  American journal of physiology. Cell physiology 20071101

• T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy.

  Neuropharmacology 20070901

• Mutation of delta-sarcoglycan is associated with Ca(2+) -dependent vascular remodeling in the Syrian hamster.

  The American journal of pathology 20070701

• Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.

  The FEBS journal 20070601

• Cav3.1 (alpha1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20070401

• Validation of high throughput screening assays against three subtypes of Ca(v)3 T-type channels using molecular and pharmacologic approaches.

  Assay and drug development technologies 20070401

• Effects of genistein, resveratrol, and quercetin on steroidogenesis and proliferation of MA-10 mouse Leydig tumor cells.

  The Journal of endocrinology 20070301

• Mibefradil-sensitive component involved in the plateau potential in submucosal interstitial cells of the murine proximal colon.

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• Lead discovery and optimization of T-type calcium channel blockers.

  Bioorganic & medicinal chemistry 20070201

• Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test.

  Behavioural pharmacology 20070201

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  Neuroscience 20070119

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  Bioorganic & medicinal chemistry 20070115

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  The Journal of physiology 20070101

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  Circulation 20060926

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• Mibefradil, a T-type Ca2+ channel blocker, protects against mesenteric ischemia-reperfusion-induced oxidative injury and histologic alterations in intestinal mucosa in rats.

  Digestive diseases and sciences 20060801

• Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats.

  Endocrinology 20060701

• Sodium-, chloride-, and mibefradil-sensitive calcium channels in intestinal pacing in wild-type and W/WV mice.

  Canadian journal of physiology and pharmacology 20060601

• Synthesis and SAR studies of a novel series of T-type calcium channel blockers.

  Bioorganic & medicinal chemistry 20060515

• Inhibitory effects of L- and T-type calcium antagonists on contractions of human detrusor muscle.

  European journal of clinical pharmacology 20060501

• T-type CaV3.3 calcium channels produce spontaneous low-threshold action potentials and intracellular calcium oscillations.

  The European journal of neuroscience 20060501

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  Cell calcium 20060401

• Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.

  Molecular pharmacology 20060301

• Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.

  Circulation research 20060106

• Relaxant responses to calcium channel antagonists and potassium channel opener in human saphenous vein.

  Autonomic & autacoid pharmacology 20060101

• Early activation of internal medial smooth muscle cells in the rabbit aorta after mechanical injury: relationship with intimal thickening and pharmacological applications.

  Clinical and experimental pharmacology & physiology 20060101

• Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms.

  Pharmacology 20060101

• Role of high-voltage-activated calcium channels in glucose-regulated beta-cell calcium homeostasis and insulin release.

  American journal of physiology. Endocrinology and metabolism 20051101

• Pathophysiological significance of T-type Ca2+ channels: T-type Ca2+ channels and drug development.

  Journal of pharmacological sciences 20051101

• The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil.

  European journal of pharmacology 20051003

• Effects of calcium channel blocker, mibefradil, and potassium channel opener, pinacidil, on the contractile response of mid-pregnant goat myometrium.

  Indian journal of experimental biology 20050901

• T-type calcium channel trigger p21ras signaling pathway to ERK in Cav3.1-expressed HEK293 cells.

  Brain research 20050823

• Characterization of a proton-activated, outwardly rectifying anion channel.

  The Journal of physiology 20050815

• Effect of mibefradil on sodium and calcium currents.

  American journal of physiology. Gastrointestinal and liver physiology 20050801

• Involvement of different calcium channels in the depolarization-evoked release of noradrenaline from sympathetic neurones in rabbit carotid artery.

  Basic & clinical pharmacology & toxicology 20050801

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  Endocrinology 20050701

• Developmental downregulation of low-voltage-activated Ca2+ channels in Cajal-Retzius cells of the mouse visual cortex.

  The European journal of neuroscience 20050601

• Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney.

  The Keio journal of medicine 20050601

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  Journal of the Society for Gynecologic Investigation 20050501

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  Circulation research 20050429

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  Journal of neurophysiology 20050301

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  American journal of physiology. Cell physiology 20050301

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  American journal of physiology. Heart and circulatory physiology 20050201

• Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells.

  Cell calcium 20050201

• Modulation of oral squamous cell carcinoma incidence in rats via diet and a novel calcium channel antagonist.

  Toxicologic pathology 20050101

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  Cardiovascular drug reviews 20050101

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  Renal failure 20050101

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  Molecular pharmacology 20041201

• The biochemical activation of T-type Ca2+ channels in HEK293 cells stably expressing alpha1G and Kir2.1 subunits.

  Biochemical and biophysical research communications 20041105

• Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.

  The American journal of cardiology 20041101

• Calcium channel blockers, either amlodipine or mibefradil, ameliorate renal injury in experimental diabetes.

  Kidney international 20040901

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  Biophysical journal 20040901

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  Microcirculation (New York, N.Y. : 1994) 20040901

• Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats.

  Journal of cardiovascular pharmacology 20040801

• Testosterone enhances calcium reabsorption by the kidney.

  Molecular and cellular endocrinology 20040730

• The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon.

  Journal of the American College of Cardiology 20040707

• 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.

  Bioorganic & medicinal chemistry letters 20040705

• Induction of apoptosis by the calcium antagonist mibefradil correlates with depolarization of the membrane potential and decreased integrin expression in human lens epithelial cells.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20040701

• Effects of calcium channel blockers on 'dynamic' and 'steady-state step' renal autoregulation.

  American journal of physiology. Renal physiology 20040601

• Comparison of cardioprotective effects of mibefradil and ramipril in stroke-prone spontaneously hypertensive rats.

  Acta pharmacologica Sinica 20040601

• Depolarization-induced calcium influx in rat mesenteric small arterioles is mediated exclusively via mibefradil-sensitive calcium channels.

  British journal of pharmacology 20040601

• Characterization of T-type calcium current and its contribution to electrical activity in rabbit urethra.

  American journal of physiology. Cell physiology 20040501

• Expression and differential cell distribution of low-threshold Ca(2+) channels in mammalian male germ cells and sperm.

  FEBS letters 20040409

• NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels.

  The Journal of pharmacology and experimental therapeutics 20040401

• Identification of channels promoting calcium spikes and waves in HT1080 tumor cells: their apparent roles in cell motility and invasion.

  Cancer research 20040401

• Mibefradil is more effective than verapamil for restoring post-ischemic function of isolated hearts of guinea pigs with acute renal failure.

  European journal of pharmacology 20040319

• T-type calcium channels in the regulation of afferent and efferent arterioles in rats.

  American journal of physiology. Renal physiology 20040201

• Functional expression of L- and T-type Ca2+ channels in murine HL-1 cells.

  Journal of molecular and cellular cardiology 20040101

• Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.

  Neuroscience 20040101

• The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens.

  The Journal of physiology 20031201

• Cellular mechanism for mibefradil-induced vasodilation of renal microcirculation: studies in the isolated perfused hydronephrotic kidney.

  Journal of cardiovascular pharmacology 20031201

• Mechanism of active repolarization of inhibitory junction potential in murine colon.

  American journal of physiology. Gastrointestinal and liver physiology 20031101

• Thalamic control of visceral nociception mediated by T-type Ca2+ channels.

  Science (New York, N.Y.) 20031003

• Effect of mibefradil on CYP3A4 in vivo.

  Journal of clinical pharmacology 20031001

• Reversal of experimental neuropathic pain by T-type calcium channel blockers.

  Pain 20030901

• Cav3.1 (alpha1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation.

  Circulation research 20030822

• A T-type calcium channel required for normal function of a mammalian mechanoreceptor.

  Nature neuroscience 20030701

• Mibefradil: 'Has the baby been thrown out with the bath water?'.

  American heart journal 20030701

• Inhibition of collateral artery growth by mibefradil: possible role of volume-regulated chloride channels.

  Endothelium : journal of endothelial cell research 20030101

• Different effects of mibefradil and amlodipine on coronary vessels and during beta-adrenergic stimulation in conscious dogs.

  Journal of cardiovascular pharmacology 20021201

• Effects of mibefradil on uterine contractility.

  European journal of pharmacology 20021122

• Ca2+ entry via P/Q-type Ca2+ channels and the Na+/Ca2+ exchanger in rat and human neocortical synaptosomes.

  Naunyn-Schmiedeberg's archives of pharmacology 20021101

• Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries.

  British journal of pharmacology 20021101

• Involvement of T-type calcium channels in the mechanism of action of 5-HT in rat glomerulosa cells: a novel signaling pathway for the 5-HT7 receptor.

  Endocrine research 20021101

• Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker.

  Brain research 20021004

• Modulation by mibefradil of the histamine-induced Ca2+ entry in human aortic endothelial cells.

  Japanese journal of pharmacology 20021001

• Blood pressure response to antihypertensive agents related to baseline blood pressure.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20021001

• Local electric stimulation causes conducted calcium response in rat interlobular arteries.

  American journal of physiology. Renal physiology 20020901

• Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.

  Acta physiologica Scandinavica 20020901

• Differential involvement of Ca(2+) channels in survival and neurite outgrowth of cultured embryonic cockroach brain neurons.

  Journal of neurophysiology 20020901

• [Functional analysis of the alpha1G subunit of the T-type calcium channel in cellular proliferation].

  Shi yan sheng wu xue bao 20020901

• Neuronal T-type alpha 1H calcium channels induce neuritogenesis and expression of high-voltage-activated calcium channels in the NG108-15 cell line.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020815

• The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.

  Molecular pharmacology 20020801

• Fractal pharmacokinetics of the drug mibefradil in the liver.

  Physical review. E, Statistical, nonlinear, and soft matter physics 20020801

• T-Type calcium channel alpha1G and alpha1H subunits in human retinoblastoma cells and their loss after differentiation.

  Journal of neurophysiology 20020701

• Selective L-type, T-type, and nonspecific calcium-channel blockers for stable angina pectoris.

  American heart journal 20020701

• Randomized comparison of T-type versus L-type calcium-channel blockade on exercise duration in stable angina: results of the Posicor Reduction of Ischemia During Exercise (PRIDE) trial.

  American heart journal 20020701

• The role of T-type calcium channels in morphine analgesia, development of antinociceptive tolerance and dependence to morphine, and morphine abstinence syndrome.

  Life sciences 20020628

• Voltage-dependent inward currents of interstitial cells of Cajal from murine colon and small intestine.

  The Journal of physiology 20020615

• Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic ganglion neurons.

  Journal of neurophysiology 20020601

• A post-marketing observational study to assess the safety of mibefradil in the community in England.

  International journal of clinical pharmacology and therapeutics 20020601

• Mibefradil improves beta-adrenergic responsiveness and intracellular Ca(2+) handling in hypertrophied rat myocardium.

  Experimental biology and medicine (Maywood, N.J.) 20020501

• Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501

• Impaired mechanisms of leukocyte adhesion in vitro by the calcium channel antagonist mibefradil.

  Cardiovascular drugs and therapy 20020501

• Impaired mechanisms of leukocyte adhesion in vitro by the calcium channel antagonist mibefradil.

  Cardiovascular drugs and therapy 20020501

• Antioxidant effect of T-type calcium channel blockers in gastric injury.

  Digestive diseases and sciences 20020401

• Single-channel pharmacology of mibefradil in human native T-type and recombinant Ca(v)3.2 calcium channels.

  Molecular pharmacology 20020301

• Effect of nitric oxide synthase inhibitor N(omega) nitro-L-arginine methyl ester on relaxant responses to calcium channel antagonists in isolated aortic rings from Dahl normotensive and hypertensive rats.

  Journal of cardiovascular pharmacology 20020301

• [Good and bad fortunes of drugs].

  La Revue du praticien 20020301

• Acute effects of L- and T-type calcium channel antagonists on cardiovascular reflexes in conscious rabbits.

  Clinical and experimental pharmacology & physiology 20020101

• Comparison of L-type and mixed L- and T-type calcium channel blockers on kidney injury caused by deoxycorticosterone-salt hypertension in rats.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20011201

• Protective effect of T-type calcium channel blocker in histamine-induced paw inflammation in rat.

  Pharmacological research 20011201

• Low-voltage-activated calcium channels are not involved in capacitation and biological response to progesterone in human sperm.

  International journal of andrology 20011201

• Low threshold T-type calcium current in rat embryonic chromaffin cells.

  The Journal of physiology 20011115

• State-dependent inhibition of inactivation-deficient Ca(V)1.2 and Ca(V)2.3 channels by mibefradil.

  The Journal of membrane biology 20011115

• Divergent renal vasodilator action of L- and T-type calcium antagonists in vivo.

  Journal of hypertension 20011101

• Evidence against an action of mibefradil at N-type voltage-operated calcium channels.

  Naunyn-Schmiedeberg's archives of pharmacology 20011101

• T-type Ca(2+) channels mediate neurotransmitter release in retinal bipolar cells.

  Neuron 20011011

• Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis.

  Clinical science (London, England : 1979) 20011001

• Torsades de pointes caused by Mibefradil.

  European journal of heart failure 20011001

• Effect of T-type selective calcium antagonist on renal microcirculation: studies in the isolated perfused hydronephrotic kidney.

  Hypertension (Dallas, Tex. : 1979) 20010901

• Selectivity of blocking of low- versus high-voltage activated calcium currents by the dihydropyridine derivatives Bay E5759 and Bay A4339 in neuroblastoma--glioma NG 108-15 cells.

  Pharmacological research 20010801

• The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure.

  International journal of cardiology 20010801

• L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective mu opioid agonist, but not to selective delta and kappa agonist at the level of the spinal cord in mice.

  Pain 20010701

• Inhibition of lens epithelial cell adhesion by the calcium antagonist Mibefradil correlates with impaired integrin distribution and organization of the cytoskeleton.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010701

• Novel voltage-dependent non-selective cation conductance in murine colonic myocytes.

  The Journal of physiology 20010601

• Inhibition of T-type and L-type calcium channels by mibefradil: physiologic and pharmacologic bases of cardiovascular effects.

  Journal of cardiovascular pharmacology 20010601

• Molecular identification of a TTX-sensitive Ca(2+) current.

  American journal of physiology. Cell physiology 20010501

• Blocking swelling-activated chloride current inhibits mouse liver cell proliferation.

  The Journal of physiology 20010501

• Comparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model.

  Hypertension (Dallas, Tex. : 1979) 20010501

• Role of membrane depolarization and T-type Ca2+ channels in angiotensin II and K+ stimulated aldosterone secretion.

  Molecular and cellular endocrinology 20010425

• Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs.

  Cardiovascular research 20010301

• Comparison of sympathetic modulation induced by single oral doses of mibefradil, amlodipine, and nifedipine in healthy volunteers.

  Clinical pharmacology and therapeutics 20010301

• Conducted vasoconstriction in rat mesenteric arterioles: role for dihydropyridine-insensitive Ca(2+) channels.

  American journal of physiology. Heart and circulatory physiology 20010201

• Comparative effects of mibefradil and nifedipine gastrointestinal transport system on autonomic function in patients with mild to moderate essential hypertension.

  Journal of hypertension 20010201

• Calcium channel blockade limits cardiac remodeling and improves cardiac function in myocardial infarction-induced heart failure in rats.

  Journal of cardiovascular pharmacology 20010101

• Effects of the T-type calcium channel blockade with oral mibefradil on the electrophysiologic properties of the human heart.

  Medical science monitor : international medical journal of experimental and clinical research 20010101

• Effects of mibefradil, a T- and L-type calcium channel blocker, on cardiac remodeling in the UM-X7.1 cardiomyopathic hamster.

  Cardiovascular drugs and therapy 20010101

• The evaluation of pharmacologic therapy in humans: a brief summary of the drug evaluation process and guidelines for clinical trials as they related to women.

  The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 20010101

• Different effects of calcium antagonist and beta-blocker therapy on left-ventricular diastolic function in ischemic heart disease. A direct comparison of the impact of mibefradil and atenolol.

  Cardiology 20010101

• Mibefradil block of cloned T-type calcium channels.

  The Journal of pharmacology and experimental therapeutics 20001001

• Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels.

  Neuropharmacology 20000101

• Combination of calcium channel blockers and beta blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. The Netherlands Working Group on Cardiovascular Research (WCN).

  Angiology 19990601

• Structure and functional characterization of a novel human low-voltage activated calcium channel.

  Journal of neurochemistry 19990201

• Mibefradil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the management of hypertension and angina pectoris.

  Drugs 19971101

• Cardiovascular alterations in rat fetuses exposed to calcium channel blockers.

  Reproductive toxicology (Elmsford, N.Y.) 19970101

• Comparative antihypertensive effectiveness of once-daily mibefradil and diltiazem CD. Mibefradil Hypertension Study Group.

  Clinical therapeutics 19970101

• Comparative efficacy and tolerability of two long-acting calcium antagonists, mibefradil and amlodipine, in essential hypertension. Mibefradil Hypertension Study Group.

  Clinical therapeutics 19970101

• Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism.

  Hypertension (Dallas, Tex. : 1979) 19960901

• The novel calcium antagonist Ro 40-5967 limits myocardial infarct size in the dog.

  Cardiovascular research 19941001