117-99-7 | 2-Hydroxybenzophenone

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$12.00	$9.00
5g	98%	in stock	$17.00	$12.00
10g	98%	in stock	$33.00	$24.00
25g	98%	in stock	$82.00	$58.00

Description

• Catalog Number: AA17337
• Chemical Name: 2-Hydroxybenzophenone
• CAS Number: 117-99-7
• Molecular Formula: C13H10O2
• Molecular Weight: 198.2173
• MDL Number: MFCD00002216
• SMILES: Oc1ccccc1C(=O)c1ccccc1
• NSC Number: 623

Computed Properties

• Complexity: 219
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 3.5

Upstream Synthesis Route

The compound (2-Hydroxyphenyl)(phenyl)methanone, also known as benzophenone phenol, finds key application in chemical synthesis as a valuable building block in organic chemistry. It serves as a versatile intermediate for the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals due to its unique structural features and reactivity. With its aromatic phenyl rings and a carbonyl group, this compound participates in a range of reactions such as Friedel-Crafts acylation, nucleophilic addition, and oxidative transformations. Its utility extends to the preparation of UV absorbers, fragrances, and dyes, making it a crucial component in the modern synthetic chemist's toolkit.

Literature

• Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.

  Journal of medicinal chemistry 20120412

• Pseudopolymorphism in hydroxybenzophenones: the dihydrate of 2,2',4,4'-tetrahydroxybenzophenone.

  Acta crystallographica. Section C, Crystal structure communications 20120401

• 2-[(E)-Phen-yl(2-phenyl-hydrazin-1-yl-idene)meth-yl]phenol.

  Acta crystallographica. Section E, Structure reports online 20120301

• 2-{[(4-{[(2-Hy-droxy-phen-yl)(phen-yl)methyl-idene]amino}-but-yl)imino](phen-yl)meth-yl}phenol.

  Acta crystallographica. Section E, Structure reports online 20120201

• Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1.

  PloS one 20120101

• 2-{[(4-{[(2-Hy-droxy-phen-yl)(phen-yl)methyl-idene]amino}-phen-yl)imino](phen-yl)meth-yl}phenol.

  Acta crystallographica. Section E, Structure reports online 20111201

• Domino reaction to functionalized 2-hydroxybenzophenones from electron-deficient chromones and 1,3-dicarbonyl compounds.

  The Journal of organic chemistry 20111021

• Rearrangement of 2-aryloxybenzaldehydes to 2-hydroxybenzophenones by rhodium-catalyzed cleavage of aryloxy C-O bonds.

  Angewandte Chemie (International ed. in English) 20110912

• Chiral phosphoric acid catalyzed enantioselective transfer hydrogenation of ortho-hydroxybenzophenone N-H ketimines and applications.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110822

• A facile synthesis of highly functionalized 4-arylcoumarins via Kostanecki reactions mediated by DBU.

  Molecules (Basel, Switzerland) 20110726

• Hexametallic manganese clusters with bulky derivatised salicylaldoximes.

  Dalton transactions (Cambridge, England : 2003) 20110227

• A monohydrate pseudopolymorph of 3,4-dihydroxybenzophenone and the role of water in the crystal assembly of benzophenones.

  Acta crystallographica. Section C, Crystal structure communications 20100901

• N,N'-Bis[(2-hydroxy-phen-yl)(phen-yl)methyl-idene]propane-1,2-diamine.

  Acta crystallographica. Section E, Structure reports online 20100601

• 2,2'-[(Propane-1,3-diyldinitrilo)bis-(phenyl-methyl-idyne)]diphenol.

  Acta crystallographica. Section E, Structure reports online 20100401

• DDQ oxidation of hydroxyisochromans and homologues.

  Natural product research 20100301

• Solid-phase extraction followed by liquid chromatography-tandem mass spectrometry for the determination of hydroxylated benzophenone UV absorbers in environmental water samples.

  Analytica chimica acta 20091110

• Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090115

• Synthesis and spectral feature of benzophenone-substituted thiosemicarbazones and their Ni(II) and Cu(II) complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090101

• Reaction of diphenyldiazomethane with singlet oxygen studied by time-resolved IR spectroscopy.

  The Journal of organic chemistry 20080919

• Simultaneous analysis of benzophenone sunscreen compounds in water sample by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry.

  Journal of chromatography. A 20080725

• Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003--2004.

  Environmental health perspectives 20080701

• Polymetallic clusters of iron(III) with derivatised salicylaldoximes.

  Dalton transactions (Cambridge, England : 2003) 20080421

• Measurement of benzophenones in human urine samples by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080101

• Spectroscopic, thermal and biological studies on some trivalent ruthenium and rhodium NS chelating thiosemicarbazone complexes.

  Bioinorganic chemistry and applications 20070101

• Novel laser-induced luminescence resulting from benzophenone/O-propylated p-tert-butylcalix[4]arene complexes. A diffuse reflectance study.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20031001