117048-59-6 | Combretastatin A4

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$18.00	$12.00
5mg	98%	in stock	$25.00	$18.00
10mg	98%	in stock	$36.00	$25.00
25mg	98%	in stock	$62.00	$44.00
100mg	98%	in stock	$148.00	$103.00
250mg	98%	in stock	$266.00	$186.00
1g	98%	in stock	$689.00	$482.00
5g	98%	in stock	$2,323.00	$1,626.00

Description

• Catalog Number: AA17464
• Chemical Name: Combretastatin A4
• CAS Number: 117048-59-6
• Molecular Formula: C18H20O5
• Molecular Weight: 316.3484
• MDL Number: MFCD03453309
• SMILES: COc1cc(C=Cc2ccc(c(c2)O)OC)cc(c1OC)OC

Upstream Synthesis Route

Combretastatin A4, a natural product derived from the Combretum caffrum tree, has gained significant attention in the field of chemical synthesis due to its unique structural features and versatile reactivity. This compound is known for its potent antitumor and antiangiogenic properties, making it a valuable building block in the development of novel anticancer drugs and therapeutic agents.In chemical synthesis, Combretastatin A4 serves as a key intermediate for the construction of various biologically active compounds and pharmaceuticals. Its molecular structure contains reactive functional groups that allow for selective modifications and derivatizations, enabling the creation of diverse analogs with improved biological activities or enhanced pharmacokinetic profiles.Researchers have utilized Combretastatin A4 as a starting material to synthesize analogs with enhanced anti-cancer activities, improved solubility, or altered target selectivity. By strategically modifying the chemical structure of Combretastatin A4 through synthetic transformations such as functional group manipulations, cross-coupling reactions, and ring-closing methodologies, chemists can tailor the compound's properties to suit specific drug design requirements.Moreover, the unique reactivity of Combretastatin A4 has enabled the development of innovative synthetic methodologies and strategies in the field of organic chemistry. Its versatile nature and biological significance make it a valuable tool for exploring new synthetic approaches, catalytic reactions, and molecular transformations, thereby advancing the frontier of chemical synthesis and drug discovery.