117106-20-4 | (2S,3R)-3-(tert-butoxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino}butanoic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$46.00	$32.00
5g	98%	in stock	$228.00	$159.00
10g	98%	in stock	$453.00	$317.00
25g	98%	in stock	$1,130.00	$791.00

Description

• Catalog Number: AA17611
• Chemical Name: (2S,3R)-3-(tert-butoxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino}butanoic acid
• CAS Number: 117106-20-4
• Molecular Formula: C24H29NO5
• Molecular Weight: 411.4908
• MDL Number: MFCD02094431
• SMILES: OC(=O)[C@@H](N(C(=O)OCC1c2ccccc2-c2c1cccc2)C)[C@H](OC(C)(C)C)C

Upstream Synthesis Route

Fmoc-N-Me-Thr(tBu)-OH is a key reagent in chemical synthesis, commonly utilized in peptide synthesis and solid phase peptide synthesis (SPPS) techniques. This reagent is particularly valued for its ability to selectively protect the hydroxyl group of threonine while allowing for subsequent chemical modifications elsewhere in the peptide chain.One crucial application of Fmoc-N-Me-Thr(tBu)-OH is in the stepwise assembly of peptides on solid support. By incorporating this reagent at specific stages of the synthesis process, chemists can control the order of amino acids in the peptide sequence and prevent unwanted side reactions. The Fmoc group, together with the t-butyl and methyl groups, shield the threonine residue from undesired interactions, providing chemoselectivity and enabling precise peptide construction.Moreover, the introduction of Fmoc-N-Me-Thr(tBu)-OH plays a pivotal role in enhancing the overall yield and purity of synthesized peptides. Its efficient protection strategy ensures that the threonine residue remains intact during the various chemical transformations involved in peptide elongation. This aids in the production of high-quality peptides with minimal impurities, making it an indispensable tool for researchers and chemists working in the field of peptide synthesis.