1172133-28-6 | HO-3867

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$70.00	$49.00
10mg	97%	in stock	$118.00	$82.00
25mg	97%	in stock	$153.00	$107.00
50mg	97%	in stock	$259.00	$181.00

Description

• Catalog Number: AE11533
• Chemical Name: HO-3867
• CAS Number: 1172133-28-6
• Molecular Formula: C28H30F2N2O2
• Molecular Weight: 464.5468
• MDL Number: MFCD28143913
• SMILES: Fc1ccc(cc1)C=C1CN(C/C(=Cc2ccc(cc2)F)/C1=O)CC1=CC(N(C1(C)C)O)(C)C

Computed Properties

• Complexity: 816
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 2
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 4.1

Upstream Synthesis Route

HO-3867 is a highly versatile compound that finds valuable application in various chemical synthesis processes. With its unique chemical properties, HO-3867 serves as an essential catalyst in promoting a wide range of reactions, particularly in the realm of organic chemistry. This compound is crucial for facilitating key transformations in synthetic pathways, leading to the efficient creation of complex molecular structures. HO-3867 plays a pivotal role in promoting selective reactions, crucial for the success of many synthesis endeavors. Its ability to accelerate specific chemical processes with high efficiency makes it an indispensable tool for chemists striving to achieve precise control over their synthetic procedures. In summary, HO-3867's significance in chemical synthesis lies in its capacity to drive reactions forward, enabling the strategic construction of intricate molecular frameworks with precision and efficacy.

Literature

• HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.

  Cancer biology & therapy 20120701

• Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867.

  The Journal of pharmacology and experimental therapeutics 20111101

• HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.

  Cancer biology & therapy 20111101

• Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties.

  Cancer biology & therapy 20101115

• HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.

  Molecular cancer research : MCR 20100901

• Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts.

  Molecular cancer therapeutics 20100501

• Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression.

  The Journal of pharmacology and experimental therapeutics 20090601