1174043-16-3 | AZD2461

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
5mg	98%	in stock	$41.00	$29.00
10mg	98%	in stock	$57.00	$40.00
25mg	98%	in stock	$95.00	$67.00
50mg	98%	in stock	$134.00	$94.00
100mg	98%	in stock	$202.00	$141.00
250mg	98%	in stock	$496.00	$347.00
1g	98%	in stock	$1,272.00	$891.00

Description

• Catalog Number: AE11126
• Chemical Name: AZD2461
• CAS Number: 1174043-16-3
• Molecular Formula: C22H22FN3O3
• Molecular Weight: 395.4268
• MDL Number: MFCD24386811
• SMILES: COC1CCN(CC1)C(=O)c1cc(ccc1F)Cc1n[nH]c(=O)c2c1cccc2

Upstream Synthesis Route

AZD2461 is a powerful and selective inhibitor of poly(ADP-ribose) polymerase (PARP). This molecule plays a crucial role in various cellular processes, particularly in DNA repair mechanisms. In chemical synthesis, AZD2461 is used as a valuable tool for studying the impact of PARP inhibition on cellular functions and for investigating potential therapeutic applications in cancer treatment. By blocking the activity of PARP, AZD2461 can induce synthetic lethality in cancer cells with deficiencies in DNA repair pathways, making it a promising candidate for combination therapy strategies. Additionally, AZD2461 has shown efficacy in enhancing the sensitivity of cancer cells to DNA-damaging agents, highlighting its potential as a chemosensitizer in the development of novel treatment approaches. Overall, the application of AZD2461 in chemical synthesis holds great promise for advancing our understanding of DNA repair mechanisms and for developing innovative strategies for combatting cancer.