118399-86-3 | 6-Bromo-2-methylpyridin-3-ol

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$9.00	$7.00
250mg	97%	in stock	$19.00	$14.00
1g	97%	in stock	$32.00	$23.00
5g	97%	in stock	$154.00	$108.00
10g	97%	in stock	$308.00	$215.00
25g	97%	in stock	$768.00	$537.00

Description

• Catalog Number: AE16876
• Chemical Name: 6-Bromo-2-methylpyridin-3-ol
• CAS Number: 118399-86-3
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.02194
• MDL Number: MFCD11044277
• SMILES: Brc1ccc(c(n1)C)O

Computed Properties

• Complexity: 99.1
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.9

Upstream Synthesis Route

To synthesize 6-Bromo-2-methylpyridin-3-ol, one could employ the following upstream synthesis route:

1. Start with 2-Methylpyridine as the base compound.
2. Perform a hydroxylation reaction at the 3-position of the pyridine ring using an appropriate oxidizing agent such as potassium permanganate (KMnO₄) in an alkaline medium to yield 2-methyl-3-hydroxypyridine.
3. Further react the 2-methyl-3-hydroxypyridine with a brominating agent like N-Bromosuccinimide (NBS) in the presence of a radical initiator and at a controlled temperature to selectively brominate the 6-position.
4. Purify the product, 6-Bromo-2-methylpyridin-3-ol, using appropriate methods like column chromatography to ensure the removal of byproducts and unreacted starting materials.

Throughout the process, maintain close monitoring of reaction conditions such as temperature and pH, and use an inert atmosphere if necessary to prevent side reactions. Ensure proper workup and purification steps are conducted to obtain the desired compound with high purity and yield.