118488-18-9 | Fmoc-D-Tyr(tBu)-OH

Packsize	Purity	Availability	Price	Discounted Price
250mg	96%	in stock	$7.00	$5.00
1g	96%	in stock	$10.00	$7.00
5g	98%	in stock	$20.00	$14.00
10g	98%	in stock	$29.00	$20.00
25g	98%	in stock	$70.00	$49.00
100g	98%	in stock	$279.00	$195.00

Description

• Catalog Number: AB46171
• Chemical Name: Fmoc-D-Tyr(tBu)-OH
• CAS Number: 118488-18-9
• Molecular Formula: C28H29NO5
• Molecular Weight: 459.5336
• MDL Number: MFCD00065684
• SMILES: O=C(N[C@@H](C(=O)O)Cc1ccc(cc1)OC(C)(C)C)OCC1c2ccccc2c2c1cccc2

Computed Properties

• Complexity: 673
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 9
• XLogP3: 5.6

Upstream Synthesis Route

O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine is a versatile compound widely used in chemical synthesis. Its unique chemical structure, incorporating a tert-butyl group, a fluorenyl moiety, and a tyrosine residue, imparts specific functional properties that make it valuable for various synthetic applications.In organic synthesis, O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine serves as a key intermediate in the production of peptide-based drugs and biomolecules. Due to the presence of the fluorenyl carbamate protecting group, this compound facilitates the selective protection of the tyrosine residue during peptide assembly. The tert-butyl group enhances the compound's stability and allows for controlled deprotection under mild conditions, ensuring the preservation of the desired peptide sequence.Furthermore, O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine is employed in the synthesis of peptide mimetics and peptidomimetics, which are used in drug discovery and development. The unique structural features of this compound enable the modification of peptide structures to improve bioavailability, stability, and target specificity, leading to the design of novel therapeutic agents with enhanced pharmacological properties.Overall, O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine plays a crucial role in chemical synthesis by providing a strategic building block for the construction of peptide-based molecules with diverse applications in pharmaceuticals, biotechnology, and materials science.

Literature

• In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.

  Journal of medicinal chemistry 20021219