1187874-94-7 | 4-Hydroxy-3-(trifluoromethyl)phenylboronic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$18.00	$13.00
1g	97%	in stock	$66.00	$47.00
5g	97%	in stock	$244.00	$171.00
10g	97%	in stock	$449.00	$315.00
25g	97%	in stock	$760.00	$532.00
100g	97%	in stock	$1,879.00	$1,316.00

Description

• Catalog Number: AE24866
• Chemical Name: 4-Hydroxy-3-(trifluoromethyl)phenylboronic acid
• CAS Number: 1187874-94-7
• Molecular Formula: C7H6BF3O3
• Molecular Weight: 205.9269
• MDL Number: MFCD18384143
• SMILES: OB(c1ccc(c(c1)C(F)(F)F)O)O

Computed Properties

• Complexity: 197
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1

Upstream Synthesis Route

The (4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid is a versatile compound widely employed in chemical synthesis. This boronic acid derivative serves as a valuable building block in the construction of various organic molecules, particularly in the field of medicinal chemistry and materials science.One of the key applications of (4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid is its use in Suzuki-Miyaura cross-coupling reactions. In this transformative synthetic method, the boronic acid functionality enables the selective formation of carbon-carbon bonds through the reaction with aryl halides or pseudo-halides. This process is essential for the creation of complex molecular structures, including pharmaceutical intermediates, agrochemicals, and functional materials.Furthermore, (4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid plays a crucial role in the development of fluorine-containing compounds. The trifluoromethyl group attached to the phenyl ring imparts unique physicochemical properties to the resulting molecules, such as increased lipophilicity and metabolic stability. As a result, the incorporation of this boronic acid derivative enables the modification of drug candidates and bioactive compounds to enhance their efficacy and pharmacokinetic profile.Overall, (4-Hydroxy-3-(trifluoromethyl)phenyl)boronic acid stands as a fundamental reagent in modern organic synthesis, driving innovation and enabling the efficient construction of diverse molecular architectures for various applications in the chemical industry.