1188910-76-0 | CEP-32496

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$31.00	$22.00
5mg	95%	in stock	$44.00	$31.00
10mg	95%	in stock	$77.00	$54.00
50mg	95%	in stock	$226.00	$159.00

Description

• Catalog Number: AB52464
• Chemical Name: CEP-32496
• CAS Number: 1188910-76-0
• Molecular Formula: C24H22F3N5O5
• Molecular Weight: 517.4571896
• MDL Number: MFCD22124524
• SMILES: COc1cc2c(ncnc2cc1OC)Oc1cccc(c1)NC(=O)Nc1noc(c1)C(C(F)(F)F)(C)C

Computed Properties

• Complexity: 776
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 37
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 7
• XLogP3: 5

Upstream Synthesis Route

Urea, N-[3-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]- is commonly utilized in chemical synthesis as a versatile building block. Its unique chemical structure enables it to participate in various reactions, allowing for the synthesis of complex organic compounds. This compound serves as a key intermediate in the production of pharmaceuticals, agrochemicals, and materials with specialized properties. In addition, its specific functional groups make it a valuable tool for creating diverse molecular architectures in the laboratory.

Literature

• Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

  Journal of medicinal chemistry 20120209