119-24-4 | Pteroic acid

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$8.00	$5.00
250mg	98%	in stock	$10.00	$7.00
1g	98%	in stock	$19.00	$13.00
10g	98%	in stock	$129.00	$90.00
25g	98%	in stock	$268.00	$187.00

Description

• Catalog Number: AB65592
• Chemical Name: Pteroic acid
• CAS Number: 119-24-4
• Molecular Formula: C14H12N6O3
• Molecular Weight: 312.2835
• MDL Number: MFCD27967230
• SMILES: OC(=O)c1ccc(cc1)NCc1cnc2c(n1)c(=O)[nH]c(n2)N
• NSC Number: 14972

Computed Properties

• Complexity: 503
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 4
• XLogP3: -0.3

Literature

• A novel (68)Ga-labeled pteroic acid-based pet tracer for tumor imaging via the folate receptor.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20130101

• Electrochemically synthesized polymers in molecular imprinting for chemical sensing.

  Analytical and bioanalytical chemistry 20120401

• Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.

  Toxicology 20120127

• Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20120116

• The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters.

  The Journal of biological chemistry 20111230

• Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol.

  International journal of pharmaceutics 20111125

• Structure-based design of ricin inhibitors.

  Toxins 20111001

• 7-Substituted pterins provide a new direction for ricin A chain inhibitors.

  European journal of medicinal chemistry 20110901

• Use of ribosome-inactivating proteins from Sambucus for the construction of immunotoxins and conjugates for cancer therapy.

  Toxins 20110501

• Electropolymerized molecularly imprinted polymer films of a bis-terthiophene dendron: folic acid quartz crystal microbalance sensing.

  ACS applied materials & interfaces 20110201

• Development of a quantitative RT-PCR assay to examine the kinetics of ribosome depurination by ribosome inactivating proteins using Saccharomyces cerevisiae as a model.

  RNA (New York, N.Y.) 20110101

• Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.

  Arthritis research & therapy 20110101

• Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate.

  BMC structural biology 20110101

• Ligand based virtual screening to find novel inhibitors against plant toxin Ricin by using the ZINC database.

  Bioinformation 20110101

• Targeting of nanoparticles: folate receptor.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis.

  PloS one 20100101

• Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor.

  Pharmaceutical research 20090601

• Calculation of absolute ligand binding free energy to a ribosome-targeting protein as a function of solvent model.

  The journal of physical chemistry. B 20081023

• Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP.

  Acta crystallographica. Section D, Biological crystallography 20080701

• Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site.

  Biochemistry 20080226

• Reactivity of conjugated and unconjugated pterins with singlet oxygen (O2(1Deltag)): physical quenching and chemical reaction.

  Photochemistry and photobiology 20070101

• Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site.

  BMC structural biology 20070101

• Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting.

  European journal of nuclear medicine and molecular imaging 20060901

• Targeting the tumor-associated folate receptor with an 111In-DTPA conjugate of pteroic acid.

  Journal of the American Chemical Society 20050525

• Substituent effects on the photophysical properties of pterin derivatives in acidic and alkaline aqueous solutions.

  Photochemistry and photobiology 20050101

• Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: mechanism and novel inhibitor design.

  Structure (London, England : 1993) 20040901

• Chemiluminescence quenching of pteroic acid-N-sulfonyl-acridinium-9-carboxamide conjugates by folate binding protein.

  Bioorganic & medicinal chemistry letters 20040503

• Folate-liposome-mediated antisense oligodeoxynucleotide targeting to cancer cells: evaluation in vitro and in vivo.

  Bioconjugate chemistry 20030101

• Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding.

  Archives of biochemistry and biophysics 20020601

• Synthesis of N-acetyl-D-galactosamine and folic acid conjugated ribozymes.

  Bioconjugate chemistry 20020101

• 2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l.

  Proteins 20010515

• Synthesis and evaluation of pteroic acid-conjugated nitroheterocyclic phosphoramidates as folate receptor-targeted alkylating agents.

  Journal of medicinal chemistry 20010104