119139-23-0 | Bisindolylmaleimide iv

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$61.00	$43.00
250mg	97%	in stock	$101.00	$71.00
1g	97%	in stock	$249.00	$174.00

Description

• Catalog Number: AA32405
• Chemical Name: Bisindolylmaleimide iv
• CAS Number: 119139-23-0
• Molecular Formula: C20H13N3O2
• Molecular Weight: 327.3361
• MDL Number: MFCD23701474
• SMILES: O=C1NC(=O)C(=C1c1c[nH]c2c1cccc2)c1c[nH]c2c1cccc2

Computed Properties

• Complexity: 576
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: 2.8

Upstream Synthesis Route

The compound 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, also known as $name$, serves as a crucial building block in chemical synthesis processes. This multifunctional molecule is versatile and finds applications in various organic reactions, especially in the creation of complex organic compounds. With its distinct chemical structure, $name$ acts as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and materials with diverse properties. Its presence in a reaction mechanism can enable the formation of intricate molecular architectures and functional groups, offering chemists a powerful tool for designing and constructing novel compounds. In chemical synthesis, $name$ plays a pivotal role in facilitating the assembly of intricate molecular structures, making it an indispensable component for researchers and synthetic chemists seeking to explore new frontiers in organic chemistry.

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  Neuropharmacology 20030201

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  Brain research. Molecular brain research 20030131

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  Diabetes research and clinical practice 20030101

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  Journal of cardiovascular pharmacology 20030101

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  Antonie van Leeuwenhoek 20030101

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  Life sciences 20021129

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  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

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  Brain research 20020927

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  The Journal of biological chemistry 20020920

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  The Journal of biological chemistry 20020906

• Role of protein phosphatases in hypoxic preconditioning.

  American journal of physiology. Heart and circulatory physiology 20020901

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  The Journal of biological chemistry 20020809

• Acid- and bile-induced PGE(2) release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent.

  American journal of physiology. Gastrointestinal and liver physiology 20020801

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  Biochemical and biophysical research communications 20020719

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  Anesthesiology 20020701

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  Pflugers Archiv : European journal of physiology 20020701

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  Molecular pharmacology 20020601

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  Journal of neurochemistry 20020601

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  American journal of physiology. Cell physiology 20020401

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  Oral microbiology and immunology 20020401

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  Endocrinology 20020201

• myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.

  The Biochemical journal 20020201

• Time-dependent potentiation of the beta-cell is a Ca2+-independent phenomenon.

  The Journal of endocrinology 20020201

• Regulation of transepithelial phosphate transport by PTH in chicken proximal tubule epithelium.

  American journal of physiology. Regulatory, integrative and comparative physiology 20020101

• Role of PKC in isoflurane-induced biphasic contraction in skinned pulmonary arterial strips.

  Anesthesiology 20020101

• The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils.

  Cellular immunology 20020101

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  American journal of physiology. Cell physiology 20011201

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  Clinical and experimental immunology 20011201

• Different subtypes of alpha1-adrenoceptor modulate different K+ currents via different signaling pathways in canine ventricular myocytes.

  The Journal of biological chemistry 20011102

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  The Journal of pharmacology and experimental therapeutics 20011101

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  Neurobiology of learning and memory 20011101

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  Bioorganic & medicinal chemistry letters 20011022

• Protein kinase c increases the apparent affinity of the release machinery to Ca2+ by enhancing the release machinery downstream of the Ca2+ sensor.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20011015

• Agonist-induced signaling, desensitization, and internalization of a phosphorylation-deficient AT1A angiotensin receptor.

  The Journal of biological chemistry 20011012

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  Apoptosis : an international journal on programmed cell death 20011001

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  Pediatric research 20011001

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  Biological chemistry 20011001

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  Brain research 20010928

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  Cell death and differentiation 20010901

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  Clinical and experimental pharmacology & physiology 20010901

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  Hypertension (Dallas, Tex. : 1979) 20010901

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  Thyroid : official journal of the American Thyroid Association 20010901

• Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.

  American journal of hypertension 20010901

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  American journal of respiratory cell and molecular biology 20010901

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  Journal of neuroscience research 20010815

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  Biochemical and biophysical research communications 20010727

• Evidence that protein kinase C (PKC) participates in the meiosis I to meiosis II transition in mouse oocytes.

  Developmental biology 20010715

• In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries.

  The Journal of physiology 20010715

• Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010701

• Antigonadotropic action of adenosine triphosphate in human granulosa-luteal cells: involvement of protein kinase Calpha.

  The Journal of clinical endocrinology and metabolism 20010701

• Albumin in the mg/l-range activates NF-kappaB in renal proximal tubule-derived cell lines via tyrosine kinases and protein kinase C.

  European journal of medical research 20010628

• Receptor-mediated inhibition of G protein-coupled inwardly rectifying potassium channels involves G(alpha)q family subunits, phospholipase C, and a readily diffusible messenger.

  The Journal of biological chemistry 20010518

• Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.

  Blood 20010415

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  European journal of pharmacology 20010413

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  Experimental eye research 20010401

• Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.

  European journal of immunology 20010401

• The role of protein kinase C in the regulation of serotonin-2A receptor expression.

  Journal of neurochemistry 20010401

• Cyclization strategies for the synthesis of macrocyclic bisindolylmaleimides.

  The Journal of organic chemistry 20010323

• Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.

  Virology 20010301

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  The Prostate 20010301

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  Cellular signalling 20010301

• Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c.

  Biochemistry 20010227

• Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Differential sensitivity of breast cancer cells to tumor necrosis factor-alpha: involvement of protein kinase C.

  Biochemical and biophysical research communications 20010126

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  American journal of physiology. Cell physiology 20010101

• Induction of vanilloid receptor channel activity by protein kinase C.

  Nature 20001201

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  The Biochemical journal 20001001

• Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate.

  The Journal of biological chemistry 19991224

• Tumor necrosis factor-alpha stimulates attachment of small cell lung carcinoma to endothelial cells.

  The Journal of laboratory and clinical medicine 19990301

• Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine.

  The Journal of pharmacology and experimental therapeutics 19980901

• Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure.

  Bioorganic & medicinal chemistry letters 19980505

• Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction.

  Molecular pharmacology 19980401

• Transcriptional activity of the hamster CYP11B2 promoter in NCI-H295 cells stimulated by angiotensin II, potassium, forskolin and bisindolylmaleimide.

  Journal of molecular endocrinology 19980401

• Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.

  Biochemical and biophysical research communications 19971229