1191951-57-1 | PHT-427

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$10.00	$7.00
10mg	98%	in stock	$42.00	$30.00

Description

• Catalog Number: AA23518
• Chemical Name: PHT-427
• CAS Number: 1191951-57-1
• Molecular Formula: C20H31N3O2S2
• Molecular Weight: 409.609
• MDL Number: MFCD18384970
• SMILES: CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc1nncs1

Computed Properties

• Complexity: 474
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 14
• XLogP3: 7.4

Upstream Synthesis Route

4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide is a versatile compound widely utilized in chemical synthesis for its unique properties and functionalities. In the realm of organic chemistry, this compound serves as a crucial building block in the synthesis of various sulfonamide derivatives. By incorporating this compound into reactions, chemists can effectively introduce the 1,3,4-thiadiazole moiety into the molecular structure, enabling the creation of novel compounds with diverse applications.Additionally, 4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide plays a pivotal role in medicinal chemistry by serving as a precursor for the synthesis of potential pharmaceutical agents. Its sulfonamide group confers important biological activities and pharmacological properties, making it a valuable starting material for drug discovery and development. Through strategic chemical modifications and derivatization, researchers can explore the pharmacological potential of this compound and its derivatives for the treatment of various diseases and disorders.Furthermore, in materials science, the incorporation of 4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide into polymer matrices can lead to the development of functional materials with tailored properties. Its sulfonamide functionality can provide enhanced interactions within polymeric systems, leading to improved mechanical strength, thermal stability, or other desired characteristics. By harnessing the synthetic versatility of this compound, researchers can innovate in the design and fabrication of advanced materials for a wide range of applications.

Literature

• Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

  Molecular cancer therapeutics 20100301

• Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

  Bioorganic & medicinal chemistry 20091001

• In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

  Cancer research 20090615

• Structure, regulation and function of PKB/AKT--a major therapeutic target.

  Biochimica et biophysica acta 20040311

• Role of Akt signaling in vascular homeostasis and angiogenesis.

  Circulation research 20020628