1196-57-2 | Quinoxaline-2-one

Packsize	Purity	Availability	Price	Discounted Price
100g	98%	in stock	$16.00	$11.00

Description

• Catalog Number: AA32539
• Chemical Name: Quinoxaline-2-one
• CAS Number: 1196-57-2
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.146
• MDL Number: MFCD00006722
• SMILES: O=c1cnc2c([nH]1)cccc2
• NSC Number: 13154

Computed Properties

• Complexity: 200
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.8

Upstream Synthesis Route

2-Quinoxalinol is a versatile compound widely used in chemical synthesis due to its unique structure and reactivity. As a key building block in organic chemistry, 2-Quinoxalinol serves as a valuable intermediate in the preparation of various pharmaceuticals, agrochemicals, and fine chemicals. Its inherent aromaticity and functional groups provide a platform for diverse synthetic routes and molecular modifications, making it an essential tool for designing novel compounds with specific properties and biological activities. 2-Quinoxalinol is particularly valuable in the development of new drug candidates, where its structural features can be tailored to enhance bioavailability, target specificity, and pharmacological efficacy. Additionally, its incorporation into coordination complexes and metal-organic frameworks expands its utility in catalysis, material science, and supramolecular chemistry. In summary, the application of 2-Quinoxalinol in chemical synthesis underscores its significance as a versatile and indispensable building block for advancing research and innovation in various fields of chemistry.

Literature

• In vitro and in vivo studies on degradation of quinalphos in rats.

  Journal of hazardous materials 20120430

• Electrochemical behavior of quinoxalin-2-one derivatives at mercury electrodes and its analytical use.

  TheScientificWorldJournal 20120101

• Decay profile and metabolic pathways of quinalphos in water, soil and plants.

  Chemosphere 20111001

• Quinoxalin-2(1H)-one derivatives as inhibitors against hepatitis C virus.

  Journal of medicinal chemistry 20110825

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Melatonin metabolism in the central nervous system.

  Current neuropharmacology 20100901

• Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

• 3-[2-(3-Methyl-quinoxalin-2-yl-oxy)eth-yl]-1,3-oxazolidin-2-one.

  Acta crystallographica. Section E, Structure reports online 20100501

• The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus.

  International journal of pediatric endocrinology 20100101

• [Study on the interaction of DNA and norfloxacin by FT-Raman].

  Guang pu xue yu guang pu fen xi = Guang pu 20091101

• 3-[2-(3-Methyl-2-oxo-1,2-dihydro-quinoxalin-1-yl)eth-yl]oxazolidin-2-one.

  Acta crystallographica. Section E, Structure reports online 20090801

• Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines.

  Molecular cancer therapeutics 20090601

• Phenyl quinoxalin-2-yl ether.

  Acta crystallographica. Section E, Structure reports online 20080901

• Quinoxalin-2-yl o-tolyl ether.

  Acta crystallographica. Section E, Structure reports online 20080901

• 3D-QSAR CoMFA and CoMSIA study on benzodipyrazoles as cyclin dependent kinase 2 inhibitors.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

• Structure activity relationships of quinoxalin-2-one derivatives as platelet-derived growth factor-beta receptor (PDGFbeta R) inhibitors, derived from molecular modeling.

  Chemical & pharmaceutical bulletin 20080501

• Regioselective synthesis of asymmetrically substituted 2-quinoxalinol salen ligands.

  The Journal of organic chemistry 20071109

• Photocatalytic mechanisms of indoleamine destruction by the quinalphos metabolite 2-hydroxyquinoxaline: a study on melatonin and its precursors serotonin and N-acetylserotonin.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20070801

• Systematic effect of benzo-annelation on oxo-hydroxy tautomerism of heterocyclic compounds. Experimental matrix-isolation and theoretical study.

  The journal of physical chemistry. A 20070614

• Toxicity of the quinalphos metabolite 2-hydroxyquinoxaline: growth inhibition, induction of oxidative stress, and genotoxicity in test organisms.

  Environmental toxicology 20070201

• Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques.

  Xenobiotica; the fate of foreign compounds in biological systems 20070201

• Benzofused tricycles based on 2-quinoxalinol.

  Journal of combinatorial chemistry 20070101

• Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure.

  Bioorganic & medicinal chemistry letters 20061001

• Melatonin in Alzheimer's disease and other neurodegenerative disorders.

  Behavioral and brain functions : BBF 20060101

• A new strategy for the selective determination of D-amino acids: enzymatic and chemical modifications for pre-column derivatization.

  Journal of chromatography. A 20050617

• Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug.

  Nutrition & metabolism 20050101

• Influence of two insecticides, chlorpyrifos and quinalphos, on arginine ammonification and mineralizable nitrogen in two tropical soil types.

  Journal of agricultural and food chemistry 20041201

• Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-alpha release on mouse macrophages in vitro.

  Journal of combinatorial chemistry 20040101

• Solution-phase reductive cyclization of 2-quinoxalinol analogs: systematic study of parallel synthesis.

  Molecular diversity 20040101

• Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: destruction of antioxidant vitamins and biogenic amines - implications of organic redox cycling.

  Redox report : communications in free radical research 20040101

• Dissipation of 14C carbaryl and quinalphos in soil under a groundnut crop (Arachis hypogaea L.) in semi-arid India.

  Chemosphere 20031201

• Synthesis of 1,4-diazines by ring expansion of 1,3-diazines.

  The Journal of organic chemistry 20030321

• [Study on the ultraviolet spectrum in a series of 2 (1H)-quinoxalin-2-one derivatives].

  Guang pu xue yu guang pu fen xi = Guang pu 20030201