1196-57-2 | Quinoxaline-2-one

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$6.00	$4.00
25g	98%	in stock	$10.00	$7.00
500g	98%	in stock	$57.00	$40.00

Description

• Catalog Number: AA32539
• Chemical Name: Quinoxaline-2-one
• CAS Number: 1196-57-2
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.1460
• MDL Number: MFCD00006722
• SMILES: O=c1cnc2c([nH]1)cccc2
• NSC Number: 13154

Computed Properties

• Complexity: 200
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.8

Literature

• In vitro and in vivo studies on degradation of quinalphos in rats.

  Journal of hazardous materials 20120430

• Electrochemical behavior of quinoxalin-2-one derivatives at mercury electrodes and its analytical use.

  TheScientificWorldJournal 20120101

• Decay profile and metabolic pathways of quinalphos in water, soil and plants.

  Chemosphere 20111001

• Quinoxalin-2(1H)-one derivatives as inhibitors against hepatitis C virus.

  Journal of medicinal chemistry 20110825

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Melatonin metabolism in the central nervous system.

  Current neuropharmacology 20100901

• Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

• 3-[2-(3-Methyl-quinoxalin-2-yl-oxy)eth-yl]-1,3-oxazolidin-2-one.

  Acta crystallographica. Section E, Structure reports online 20100501

• The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus.

  International journal of pediatric endocrinology 20100101

• [Study on the interaction of DNA and norfloxacin by FT-Raman].

  Guang pu xue yu guang pu fen xi = Guang pu 20091101

• 3-[2-(3-Methyl-2-oxo-1,2-dihydro-quinoxalin-1-yl)eth-yl]oxazolidin-2-one.

  Acta crystallographica. Section E, Structure reports online 20090801

• Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines.

  Molecular cancer therapeutics 20090601

• Phenyl quinoxalin-2-yl ether.

  Acta crystallographica. Section E, Structure reports online 20080901

• Quinoxalin-2-yl o-tolyl ether.

  Acta crystallographica. Section E, Structure reports online 20080901

• 3D-QSAR CoMFA and CoMSIA study on benzodipyrazoles as cyclin dependent kinase 2 inhibitors.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

• Structure activity relationships of quinoxalin-2-one derivatives as platelet-derived growth factor-beta receptor (PDGFbeta R) inhibitors, derived from molecular modeling.

  Chemical & pharmaceutical bulletin 20080501

• Regioselective synthesis of asymmetrically substituted 2-quinoxalinol salen ligands.

  The Journal of organic chemistry 20071109

• Photocatalytic mechanisms of indoleamine destruction by the quinalphos metabolite 2-hydroxyquinoxaline: a study on melatonin and its precursors serotonin and N-acetylserotonin.

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20070801

• Systematic effect of benzo-annelation on oxo-hydroxy tautomerism of heterocyclic compounds. Experimental matrix-isolation and theoretical study.

  The journal of physical chemistry. A 20070614

• Toxicity of the quinalphos metabolite 2-hydroxyquinoxaline: growth inhibition, induction of oxidative stress, and genotoxicity in test organisms.

  Environmental toxicology 20070201

• Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques.

  Xenobiotica; the fate of foreign compounds in biological systems 20070201

• Benzofused tricycles based on 2-quinoxalinol.

  Journal of combinatorial chemistry 20070101

• Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure.

  Bioorganic & medicinal chemistry letters 20061001

• Melatonin in Alzheimer's disease and other neurodegenerative disorders.

  Behavioral and brain functions : BBF 20060101

• A new strategy for the selective determination of D-amino acids: enzymatic and chemical modifications for pre-column derivatization.

  Journal of chromatography. A 20050617

• Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug.

  Nutrition & metabolism 20050101

• Influence of two insecticides, chlorpyrifos and quinalphos, on arginine ammonification and mineralizable nitrogen in two tropical soil types.

  Journal of agricultural and food chemistry 20041201

• Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-alpha release on mouse macrophages in vitro.

  Journal of combinatorial chemistry 20040101

• Solution-phase reductive cyclization of 2-quinoxalinol analogs: systematic study of parallel synthesis.

  Molecular diversity 20040101

• Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: destruction of antioxidant vitamins and biogenic amines - implications of organic redox cycling.

  Redox report : communications in free radical research 20040101

• Dissipation of 14C carbaryl and quinalphos in soil under a groundnut crop (Arachis hypogaea L.) in semi-arid India.

  Chemosphere 20031201

• Synthesis of 1,4-diazines by ring expansion of 1,3-diazines.

  The Journal of organic chemistry 20030321

• [Study on the ultraviolet spectrum in a series of 2 (1H)-quinoxalin-2-one derivatives].

  Guang pu xue yu guang pu fen xi = Guang pu 20030201