1204144-28-4 | (5Z)-5-({2-[(3R)-3-Aminopiperidin-1-yl]-3-phenylphenyl}methylidene)-1,3-thiazolidine-2,4-dione

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$29.00
5mg	95%	in stock	$101.00	$71.00
10mg	95%	in stock	$141.00	$99.00
100mg	95%	in stock	$222.00	$156.00
250mg	95%	in stock	$361.00	$253.00
1g	95%	in stock	$945.00	$661.00

Description

• Catalog Number: AE11125
• Chemical Name: (5Z)-5-({2-[(3R)-3-Aminopiperidin-1-yl]-3-phenylphenyl}methylidene)-1,3-thiazolidine-2,4-dione
• CAS Number: 1204144-28-4
• Molecular Formula: C21H21N3O2S
• Molecular Weight: 379.4753
• MDL Number: MFCD25976757
• SMILES: N[C@@H]1CCCN(C1)c1c(cccc1c1ccccc1)/C=C/1SC(=O)NC1=O

Computed Properties

• Complexity: 602
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 3.6

Upstream Synthesis Route

AZD1208 is a potent and selective inhibitor of Pim kinases, which are a family of oncogenic serine/threonine kinases involved in cell survival, proliferation, and differentiation. In chemical synthesis, AZD1208 can be utilized as a molecular tool to investigate the role of Pim kinases in various cellular processes. Its ability to specifically target these kinases makes it a valuable compound for studying signaling pathways, protein phosphorylation events, and potential therapeutic interventions in cancer and other diseases. By incorporating AZD1208 into experimental designs, researchers can gain insights into the molecular mechanisms underlying disease progression and identify new strategies for drug development.

Literature

• Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

  Journal of medicinal chemistry 20151112

• Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

  ACS medicinal chemistry letters 20131212