1206711-16-1 | Dmh-1

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$49.00	$35.00
5mg	98%	in stock	$124.00	$87.00
10mg	98%	in stock	$168.00	$117.00
50mg	98%	in stock	$704.00	$493.00
100mg	98%	in stock	$1,192.00	$835.00

Description

• Catalog Number: AE10385
• Chemical Name: Dmh-1
• CAS Number: 1206711-16-1
• Molecular Formula: C24H20N4O
• Molecular Weight: 380.4418
• MDL Number: MFCD18384963
• SMILES: CC(Oc1ccc(cc1)c1cnc2n(c1)ncc2c1ccnc2c1cccc2)C

Computed Properties

• Complexity: 535
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• XLogP3: 4.6

Upstream Synthesis Route

DMH-1, a potent and selective inhibitor of the BMP (bone morphogenetic protein) type I receptor ALK2, has demonstrated significant utility in chemical synthesis as a versatile tool for manipulating cell signaling pathways. By targeting ALK2, DMH-1 offers researchers a precise means of modulating BMP signaling cascades, thereby influencing various cellular processes such as differentiation, proliferation, and apoptosis. In the realm of chemical synthesis, DMH-1 serves as a key component in studies investigating the role of BMP signaling in disease progression, developmental biology, and tissue engineering. Its ability to selectively block ALK2 activation makes it a valuable resource for elucidating the intricate molecular mechanisms underlying cell function and disease states. Researchers leverage the distinct properties of DMH-1 to engage in structure-activity relationship studies, drug discovery efforts, and pathway analysis, thereby advancing our understanding of biological systems and informing the development of innovative therapeutic strategies.

Literature

• Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.

  Bioorganic & medicinal chemistry letters 20130601