120791-76-6 | Nalpha-[(9h-fluoren-9-ylmethoxy)carbonyl]-l-threonine tert-butyl ester

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$42.00	$29.00
5g	98%	in stock	$156.00	$109.00
10g	98%	in stock	$276.00	$193.00
25g	98%	in stock	$516.00	$361.00
100g	98%	in stock	$1,550.00	$1,085.00

Description

• Catalog Number: AB76994
• Chemical Name: Nalpha-[(9h-fluoren-9-ylmethoxy)carbonyl]-l-threonine tert-butyl ester
• CAS Number: 120791-76-6
• Molecular Formula: C23H27NO5
• Molecular Weight: 397.4642
• MDL Number: MFCD08276378
• SMILES: O=C(N[C@H](C(=O)OC(C)(C)C)[C@H](O)C)OCC1c2ccccc2-c2c1cccc2

Upstream Synthesis Route

Fmoc-Thr-OtBu, also known as Fmoc-protected threonine with t-butyl ester, is a widely used building block in chemical synthesis, particularly in solid-phase peptide synthesis (SPPS). This compound serves as an essential component for the controlled and efficient assembly of peptides and small proteins.In chemical synthesis, Fmoc-Thr-OtBu acts as a key intermediate for introducing threonine residues into peptide chains. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a temporary protective group, allowing for selective deprotection and subsequent coupling reactions during peptide elongation. The t-butyl ester moiety ensures stability and protection of the threonine amino acid until required for further manipulation in the synthesis process.By leveraging the versatility and reactivity of Fmoc-Thr-OtBu, chemists can systematically construct complex peptide sequences with precise control over the peptide bond formation. This strategic use of Fmoc-Thr-OtBu facilitates the stepwise assembly of peptides with specific sequences and functionalities, enabling the synthesis of bioactive peptides, pharmaceuticals, and peptide-based materials with high purity and efficiency.Moreover, the application of Fmoc-Thr-OtBu in chemical synthesis extends to the modification and functionalization of peptides for structure-activity relationship studies, drug development, and bioconjugation strategies. Its compatibility with modern peptide synthesis techniques makes Fmoc-Thr-OtBu an indispensable tool for researchers and chemists working in the field of peptide chemistry and drug discovery.