121-43-7 | Trimethyl borate

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$26.00	$18.00
25g	95%	in stock	$34.00	$24.00
100g	95%	in stock	$74.00	$52.00
500g	95%	in stock	$127.00	$89.00

Description

• Catalog Number: AB47228
• Chemical Name: Trimethyl borate
• CAS Number: 121-43-7
• Molecular Formula: C3H9BO3
• Molecular Weight: 103.9128
• MDL Number: MFCD00008346
• SMILES: COB(OC)OC
• NSC Number: 777

Computed Properties

• Complexity: 31.7
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3

Upstream Synthesis Route

Trimethyl borate, also known as TMB, is a versatile chemical compound that finds wide application in chemical synthesis processes. It serves as a valuable reagent in various organic reactions due to its unique chemical properties.One key application of trimethyl borate in chemical synthesis is its use as a boron source in the synthesis of complex organic molecules. By serving as a boron donor, TMB participates in a variety of transformations such as Suzuki-Miyaura cross-coupling reactions, which are essential for linking aromatic compounds. Additionally, it can be employed in the synthesis of boronic acid derivatives, which have numerous applications in pharmaceuticals, agrochemicals, and materials science.Furthermore, trimethyl borate can act as a mild Lewis acid catalyst in various organic reactions. Its Lewis acidic nature allows it to activate certain substrates and facilitate the formation of new bonds, making it a valuable tool in the synthesis of organic compounds. This catalytic activity makes TMB particularly useful in processes like transesterification, polymerization, and ring-opening reactions.Overall, the application of trimethyl borate in chemical synthesis spans a wide range of reactions, making it an indispensable tool for organic chemists and researchers seeking to access new molecules and materials through efficient and selective transformations.

Literature

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  Journal of the American Society for Mass Spectrometry 20120101

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  Journal of the American Society for Mass Spectrometry 20110601

• A practical synthesis of novel α-dibromoalkyl- and trimethylsilylmethyl-aminoboranes and derivatives.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110301

• Comparison of functional group selective ion-molecule reactions of trimethyl borate in different ion trap mass spectrometers.

  Journal of the American Society for Mass Spectrometry 20110301

• Identification and counting of carbonyl and hydroxyl functionalities in protonated bifunctional analytes by using solution derivatization prior to mass spectrometric analysis via ion-molecule reactions.

  Journal of the American Society for Mass Spectrometry 20100501

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  Journal of the American Chemical Society 20050209

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  Journal of the American Chemical Society 20040929

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  Organic & biomolecular chemistry 20040521

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  The Journal of organic chemistry 20031226

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  Journal of the American Society for Mass Spectrometry 20030801

• Versatile synthesis of 3,5-disubstituted 2-fluoropyridines and 2-pyridones.

  The Journal of organic chemistry 20030418

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  Journal of the American Society for Mass Spectrometry 20030401

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  Chemical communications (Cambridge, England) 20021207

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  Analytical and bioanalytical chemistry 20021001

• Gas phase reactions of trimethyl borate with phosphates and their non-covalent complexes.

  Journal of the American Society for Mass Spectrometry 20020901

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  The Journal of organic chemistry 20020208