121343-82-6 | Fmoc-glu-oh

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$13.00	$9.00
25g	98%	in stock	$26.00	$18.00
100g	98%	in stock	$58.00	$40.00

Description

• Catalog Number: AD74692
• Chemical Name: Fmoc-glu-oh
• CAS Number: 121343-82-6
• Molecular Formula: C20H19NO6
• Molecular Weight: 369.368
• MDL Number: MFCD00237657
• SMILES: OC(=O)CC[C@@H](C(=O)O)NC(=O)OCC1c2ccccc2-c2c1cccc2

Computed Properties

• Complexity: 543
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 8
• XLogP3: 2.5

Upstream Synthesis Route

Fmoc-Glu-OH, also known as Fmoc-protected glutamic acid, is a key building block extensively used in peptide synthesis. It serves as a versatile tool in organic chemistry for the selective protection of the carboxyl group of glutamic acid, allowing for controlled synthesis of peptide chains.With its Fmoc protection, Fmoc-Glu-OH enables sequential addition of amino acids during solid-phase peptide synthesis. This process involves attaching the Fmoc-Glu-OH molecule to a solid support and subsequently adding amino acids in a stepwise fashion to build up the desired peptide sequence. The Fmoc group can be easily removed under mild acidic conditions to expose the free carboxyl group for further reactions, making it a valuable tool in peptide chemistry.In addition to its role in peptide synthesis, Fmoc-Glu-OH can also be utilized in the preparation of peptide mimetics, pharmaceuticals, and biochemical research. Its compatibility with standard peptide synthesis protocols and ease of manipulation make it a popular choice for chemists working in the field of drug discovery and development.Overall, Fmoc-Glu-OH offers precise control and efficient synthesis in the production of peptides and related compounds, making it a fundamental reagent in modern chemical synthesis practices.

Literature

• Application of triethylsilane and palladium-charcoal-induced reductions in the synthesis of Fmoc-glutamic acid analogues.

  Advances in experimental medicine and biology 20090101

• Labeling of steroids on solid phase.

  Bioconjugate chemistry 20040101