1214265-58-3 | N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$35.00	$25.00
5mg	98%	in stock	$62.00	$43.00
10mg	98%	in stock	$98.00	$69.00
25mg	98%	in stock	$183.00	$128.00
50mg	98%	in stock	$261.00	$183.00
100mg	98%	in stock	$375.00	$263.00
250mg	98%	in stock	$574.00	$402.00

Description

• Catalog Number: AE35820
• Chemical Name: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide
• CAS Number: 1214265-58-3
• Molecular Formula: C25H29ClN6O3
• Molecular Weight: 496.9891599999999
• MDL Number: MFCD28015100
• SMILES: CCC(=O)Nc1cccc(c1)Oc1nc(ncc1Cl)Nc1ccc(cc1OC)N1CCN(CC1)C

Computed Properties

• Complexity: 667
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8
• XLogP3: 4.1

Upstream Synthesis Route

The application of N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide in chemical synthesis involves its role as a key building block in the production of novel pharmaceutical compounds. This compound serves as a versatile intermediate that can be further modified through various chemical reactions to yield structurally diverse molecules with potential therapeutic properties. By incorporating N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide into synthetic pathways, chemists can access a wide range of molecular scaffolds for drug discovery and development purposes.

Literature

• Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8.

  Journal of cellular and molecular medicine 20170701

• Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

  The Biochemical journal 20140715

• Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.

  The Biochemical journal 20140101