1215493-56-3 | Rg2833

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$7.00	$5.00
10mg	95%	in stock	$19.00	$14.00
25mg	95%	in stock	$33.00	$23.00
250mg	95%	in stock	$160.00	$112.00

Description

• Catalog Number: AE35780
• Chemical Name: Rg2833
• CAS Number: 1215493-56-3
• Molecular Formula: C20H25N3O2
• Molecular Weight: 339.4314
• MDL Number: MFCD25976845
• SMILES: O=C(Nc1ccccc1N)CCCCCNC(=O)c1ccc(cc1)C

Computed Properties

• Complexity: 419
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 8
• XLogP3: 2.8

Upstream Synthesis Route

RG2833 is a potent and selective histone deacetylase (HDAC) inhibitor that plays a crucial role in chemical synthesis. This compound is commonly utilized in the field of medicinal chemistry for its ability to modulate gene expression by targeting specific enzymes involved in chromatin remodeling. By inhibiting HDAC activity, RG2833 can induce changes in histone acetylation patterns, leading to altered gene transcription and potential therapeutic benefits. In chemical synthesis, RG2833 can serve as a valuable tool for investigating epigenetic modifications and their impact on biological processes. Moreover, its targeted mechanism of action makes it a promising candidate for the development of novel drugs and treatment strategies.

Literature

• Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.

  PloS one 20100101