1222780-33-7 | TPPU

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$35.00	$24.00
5mg	99%	in stock	$89.00	$62.00
10mg	99%	in stock	$170.00	$119.00
25mg	99%	in stock	$348.00	$243.00
50mg	99%	in stock	$510.00	$357.00

Description

• Catalog Number: AE34861
• Chemical Name: TPPU
• CAS Number: 1222780-33-7
• Molecular Formula: C16H20F3N3O3
• Molecular Weight: 359.3435095999999
• MDL Number: MFCD26142949
• SMILES: CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)OC(F)(F)F

Upstream Synthesis Route

The compound TPPU, or N-[1-(2-oxo-6-phenylimidazo[2,1-b] [1,3] thiazol-3(2H)-yl)ethyl]-3-phenylpropanamide, is a potent and selective inhibitor of soluble epoxide hydrolase (sEH), an enzyme involved in the metabolism of various fatty acids. In chemical synthesis, TPPU has found significant utility as a tool for modulating lipid metabolism and studying the biological effects of sEH inhibition. TPPU's ability to block sEH activity leads to the accumulation of epoxyeicosatrienoic acids (EETs), which are known to possess anti-inflammatory and cardiovascular protective properties. As such, TPPU has been employed in research settings to investigate the impact of altered EET levels on biological processes related to inflammation, hypertension, and other pathological conditions. Additionally, TPPU's selectivity towards sEH makes it a valuable compound for elucidating the specific role of this enzyme in various cellular pathways and disease states.