1223403-58-4 | (S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$28.00	$19.00
5mg	97%	in stock	$53.00	$37.00
10mg	97%	in stock	$68.00	$47.00
100mg	97%	in stock	$519.00	$363.00

Description

• Catalog Number: AA55689
• Chemical Name: (S)-N-(5-((R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
• CAS Number: 1223403-58-4
• Molecular Formula: C21H22F2N6O2
• Molecular Weight: 428.4352
• MDL Number: MFCD28902192
• SMILES: O[C@H]1CCN(C1)C(=O)Nc1cnn2c1nc(cc2)N1CCC[C@@H]1c1cc(F)ccc1F

Computed Properties

• Complexity: 659
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 1.7

Upstream Synthesis Route

The compound (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide, commonly referred to as $name$, is a valuable tool in chemical synthesis. Its unique structure and properties make it ideal for use in the development of novel pharmaceuticals and biologically active molecules. In chemical synthesis, this compound serves as a versatile building block, allowing chemists to introduce specific functional groups and stereochemistry into target molecules with precision. By strategically incorporating $name$ into synthetic pathways, researchers can access a diverse range of structurally complex compounds, enabling the exploration of new therapeutic agents and research tools.

Literature

• Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.

  The New England journal of medicine 20180222

• Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain.

  Molecular pain 20100101