1230487-00-9 | Siponimod

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$29.00
5mg	95%	in stock	$103.00	$73.00
25mg	95%	in stock	$175.00	$122.00
100mg	95%	in stock	$456.00	$319.00
250mg	95%	in stock	$660.00	$462.00

Description

• Catalog Number: AE35984
• Chemical Name: Siponimod
• CAS Number: 1230487-00-9
• Molecular Formula: C29H35F3N2O3
• Molecular Weight: 516.595
• MDL Number: MFCD26142651
• SMILES: CCc1cc(ccc1CN1CC(C1)C(=O)O)C(=NOCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)C

Computed Properties

• Complexity: 777
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 37
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 9
• XLogP3: 4.8

Literature

• Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human.

  Archives of toxicology 20180101

• The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures.

  Journal of neuroinflammation 20160101

• Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis.

  Journal of neuroinflammation 20160101

• Modulators of the Sphingosine 1-phosphate receptor 1.

  Bioorganic & medicinal chemistry letters 20131201

• Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.

  ACS medicinal chemistry letters 20130314

• The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.

  British journal of pharmacology 20121101