123334-07-6 | Cytidine-5'-triphosphoricaciddisodiumsalt

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$34.00	$24.00
1g	95%	in stock	$65.00	$46.00
5g	95%	in stock	$302.00	$211.00
10g	95%	in stock	$543.00	$380.00
25g	95%	in stock	$1,205.00	$844.00

Description

• Catalog Number: AX34877
• Chemical Name: Cytidine-5'-triphosphoricaciddisodiumsalt
• CAS Number: 123334-07-6
• Molecular Formula: C9H18N3NaO15P3
• Molecular Weight: 524.1614
• MDL Number: MFCD00078193
• SMILES: O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(nc1=O)N.[Na].O

Computed Properties

• Complexity: 855
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 14
• Hydrogen Bond Donor Count: 7
• Rotatable Bond Count: 8
• XLogP3: -5.6

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• Cosegregation of C-insertion at position 961 with the A1555G mutation of the mitochondrial 12S rRNA gene in a large Chinese family with maternally inherited hearing loss.

  American journal of medical genetics. Part A 20040115

• A fluorescent probe-labeled Escherichia coli aspartate transcarbamoylase that monitors the allosteric conformational state.

  The Journal of biological chemistry 20040109

• Control of pyrimidine biosynthesis in 'Pseudomonas alkanolytica' ATCC 21034.

  Journal of basic microbiology 20040101

• Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.

  Current topics in medicinal chemistry 20040101

• Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools.

  Clinical pharmacokinetics 20040101

• Preliminary investigation of electrodynamic charged droplet processing to couple capillary liquid chromatography with matrix-assisted laser desorption/ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• In vitro selection of human alpha-thrombin RNA aptamer using 4'-thioUTP and 4'-thioCTP.

  Nucleic acids symposium series (2004) 20040101

• Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1.

  Atherosclerosis 20031201

• Regeneration of cofactors for use in biocatalysis.

  Current opinion in biotechnology 20031201

• Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure.

  The EMBO journal 20031103

• Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes.

  Molecular cell 20031101

• Characterisation of Pt MYB1, an R2R3-MYB from pine xylem.

  Plant molecular biology 20031101

• Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals.

  AIDS (London, England) 20031017

• Trapping specific quaternary states of the allosteric enzyme aspartate transcarbamoylase in silica matrix sol-gels.

  Journal of the American Chemical Society 20030820

• Fold recognition, homology modeling, docking simulations, kinetics analysis and mutagenesis of ATP/CTP:tRNA nucleotidyltransferase from Methanococcus jannaschii.

  Proteins 20030815

• Nested cooperativity and salt dependence of the ATPase activity of the archaeal chaperonin Mm-cpn.

  FEBS letters 20030717

• [Research on motor dysfunction and the role of CTP after traumatic brain injury in rats].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20030701

• Phosphorylation of CTP synthetase on Ser36, Ser330, Ser354, and Ser454 regulates the levels of CTP and phosphatidylcholine synthesis in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20030606

• Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.

  The Journal of biological chemistry 20030523

• Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha.

  Biochemistry 20030506

• Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.

  European journal of biochemistry 20030501

• In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 1. RNA chain initiation, abortive initiation, and promoter escape at three bacteriophage promoters.

  Biochemistry 20030408

• In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 2. Formation and characterization of two distinct classes of initial transcribing complexes.

  Biochemistry 20030408

• In vitro studies of transcript initiation by Escherichia coli RNA polymerase. 3. Influences of individual DNA elements within the promoter recognition region on abortive initiation and promoter escape.

  Biochemistry 20030408

• Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.

  The Journal of biological chemistry 20030404

• CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values.

  Biochimica et biophysica acta 20030321

• NTP pattern of avian embryonic red cells: role of RNA degradation and AMP deaminase/5'-nucleotidase activity.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030301

• Modulation of IA currents by capsaicin in rat trigeminal ganglion neurons.

  Journal of neurophysiology 20030301

• Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis.

  The Journal of biological chemistry 20030227

• Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase.

  The Biochemical journal 20030201

• Neighbouring bases in template influence base-pairing of isoguanine.

  The Biochemical journal 20030201

• Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy.

  Journal of medical genetics 20030201

• Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.

  Antiviral chemistry & chemotherapy 20030101

• HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).

  Antiviral chemistry & chemotherapy 20030101

• Incorporation of (alpha-P-borano)-2',3'-dideoxycytidine 5'-triphosphate into DNA by drug-resistant MMLV reverse transcriptase and Taq DNA polymerase.

  Nucleosides, nucleotides & nucleic acids 20030101

• Iodine-125 radioprobing of E. coli RNA polymerase transcription elongation complexes.

  Methods in enzymology 20030101

• The role of intersubunit interactions for the stabilization of the T state of Escherichia coli aspartate transcarbamoylase.

  The Journal of biological chemistry 20021220

• Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP.

  Cell 20021213

• Stabilization of the R allosteric structure of Escherichia coli aspartate transcarbamoylase by disulfide bond formation.

  The Journal of biological chemistry 20021206

• Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase.

  Antiviral research 20021201

• Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors.

  Antiviral research 20021101

• Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis.

  European journal of biochemistry 20021001

• Differential processing of the Xenopus ATP(CTP):tRNA nucleotidyltransferase mRNA.

  Biochemical and biophysical research communications 20020927

• An assay for cytidine 5(')-triphosphate synthetase glutaminase activity using high performance liquid chromatography.

  Analytical biochemistry 20020915

• Distinct interactions of GTP, UTP, and CTP with G(s) proteins.

  The Journal of biological chemistry 20020913

• Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.

  FEBS letters 20020911

• A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools.

  Molecular pharmacology 20020901

• Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses.

  Hepatology (Baltimore, Md.) 20020901

• Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae.

  Glycobiology 20020901

• Severe pyridine nucleotide depletion in fibroblasts from Lesch-Nyhan patients.

  The Biochemical journal 20020815

• [Preliminary clinical study of application of cyntridini triphosphatis and dexamethasone in treatment of sudden deafness].

  Zhonghua er bi yan hou ke za zhi 20020801

• Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase.

  Biochimica et biophysica acta 20020718

• The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf135 protein.

  DNA repair 20020717

• 3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells.

  Biochemical pharmacology 20020715

• Substrate regulation of calcium binding in Ca2+-ATPase molecules of the sarcoplasmic reticulum. II. Effect of CTP, GTP, ITP, and UTP.

  The Journal of biological chemistry 20020705

• Argipressin(4-8) upregulate CTP: phosphocholine cytidylyltransferase in rat hippocampal neurons.

  Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20020701

• Polypeptide synthesis directed by DNA as a messenger in cell-free polypeptide synthesis by extreme thermophiles, Thermus thermophilus HB27 and Sulfolobus tokodaii strain 7.

  Journal of biochemistry 20020601

• Characterization of Streptococcus pneumoniae thymidylate kinase: steady-state kinetics of the forward reaction and isothermal titration calorimetry.

  The Biochemical journal 20020501

• Poly(C) synthesis by class I and class II CCA-adding enzymes.

  Biochemistry 20020409

• Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line.

  International journal of cancer 20020401

• Nucleotide specificity of an archaeal group II chaperonin from Thermococcus strain KS-1 with reference to the ATP-dependent protein folding cycle.

  FEBS letters 20020313

• Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins.

  Journal of molecular biology 20020208

• U2 small nuclear RNA is a substrate for the CCA-adding enzyme (tRNA nucleotidyltransferase).

  The Journal of biological chemistry 20020201

• Catalytic mechanism of CMP:2-keto-3-deoxy-manno-octonic acid synthetase as derived from complexes with reaction educt and product.

  Biochemistry 20020129

• Catabolism of pyrimidine nucleotides in the deep-sea tube worm Riftia pachyptila.

  The Journal of biological chemistry 20020104

• Novel direct detection method for quantitative determination of intracellular nucleoside triphosphates using weak anion exchange liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20020101

• Identification of lamin A/C ( LMNA) gene mutations in Korean patients with autosomal dominant Emery-Dreifuss muscular dystrophy and limb-girdle muscular dystrophy 1B.

  Journal of human genetics 20020101

• On-line microdialysis for enhanced resolution and sensitivity during electrospray mass spectrometry of non-covalent complexes and competitive binding studies.

  Rapid communications in mass spectrometry : RCM 20020101

• Purification and characterization of acyl-acyl carrier protein synthetase from oleaginous yeast and its role in triacylglycerol biosynthesis.

  The Biochemical journal 20011201

• Inhibition of purified recombinant reverse transcriptase from wild-type and zidovudine-resistant clinical isolates of human immunodeficiency virus type 1 by zidovudine, stavudine, and lamivudine triphosphates.

  The Journal of infectious diseases 20011115

• Collaboration between CC- and A-adding enzymes to build and repair the 3'-terminal CCA of tRNA in Aquifex aeolicus.

  Science (New York, N.Y.) 20011109

• Delineation of the allosteric mechanism of a cytidylyltransferase exhibiting negative cooperativity.

  Nature structural biology 20011101

• The cytostatic- and differentiation-inducing effects of cyclopentenyl cytosine on neuroblastoma cell lines.

  Biochemical pharmacology 20011015

• Cyclopentenyl cytosine induces apoptosis and increases cytarabine-induced apoptosis in a T-lymphoblastic leukemic cell-line.

  Leukemia research 20011001

• Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

• The structure of CMP:2-keto-3-deoxy-manno-octonic acid synthetase and of its complexes with substrates and substrate analogs.

  Journal of molecular biology 20010907

• Glutamine synthetase from Acetobacter diazotrophicus: properties and regulation.

  FEMS microbiology letters 20010821

• Novel method for enzymatic synthesis of CMP-NeuAc.

  Bioscience, biotechnology, and biochemistry 20010801

• Mechanistic studies on phosphopantothenoylcysteine decarboxylase.

  Journal of the American Chemical Society 20010704

• Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.

  Nature structural biology 20010701

• Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma.

  The Journal of biological chemistry 20010629

• Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs.

  The Journal of biological chemistry 20010629

• Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1).

  The Journal of biological chemistry 20010518

• Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis.

  The Biochemical journal 20010515

• Effects of purine and pyrimidine nucleotides on intracellular Ca2+ in human eosinophils: activation of purinergic P2Y receptors.

  The Journal of allergy and clinical immunology 20010501

• NDP kinase reactivity towards 3TC nucleotides.

  Antiviral research 20010501

• Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.

  The Journal of biological chemistry 20010427

• Non-templated addition of nucleotides to the 3' end of nascent RNA during RNA editing in Physarum.

  The EMBO journal 20010315

• Effect of gestational age and hypoxia on activity of ribonucleic acid polymerase in fetal guinea pig brain.

  American journal of obstetrics and gynecology 20010301

• Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP.

  The Journal of biological chemistry 20010223

• Fidelity of nucleotide insertion at 8-oxo-7,8-dihydroguanine by mammalian DNA polymerase delta. Steady-state and pre-steady-state kinetic analysis.

  The Journal of biological chemistry 20010209

• Destabilization of neutrophil NADPH oxidase by ATP and other trinucleotides and its prevention by Mg(2+).

  Biochimica et biophysica acta 20010209

• Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635.

  European journal of cancer (Oxford, England : 1990) 20010101

• In vitro selection of RNA aptamers carrying multiple biotin groups in the side chains.

  Bioconjugate chemistry 20010101

• CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.

  The Journal of biological chemistry 20001124

• ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor.

  Molecular pharmacology 20000501

• The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids.

  Journal of virology 19990401

• Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein.

  The Journal of general virology 19990301

• Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism.

  Proceedings of the National Academy of Sciences of the United States of America 19981110

• The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.

  Antimicrobial agents and chemotherapy 19930801

• Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.

  The Journal of biological chemistry 19930205

• RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria.

  Journal of virology 19930201

• Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.

  Cancer research 19910501

• Nucleoside triphosphates promote the transformation of Ah receptor to its DNA-binding form.

  The Biochemical journal 19910301

• Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors.

  Antiviral research 19900301

• The quantitative determination of 2'-deoxycytidine-5'-triphosphate in cell extracts by radioimmunoassay.

  Analytical biochemistry 19860401