1234480-84-2 | Lrrk2-in-1

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$30.00	$21.00
5mg	99%	in stock	$62.00	$44.00
10mg	99%	in stock	$95.00	$67.00
25mg	99%	in stock	$189.00	$133.00
50mg	99%	in stock	$311.00	$218.00
100mg	99%	in stock	$451.00	$316.00

Description

• Catalog Number: AE35717
• Chemical Name: Lrrk2-in-1
• CAS Number: 1234480-84-2
• Molecular Formula: C31H38N8O3
• Molecular Weight: 570.6852
• MDL Number: MFCD22683805
• SMILES: COc1cc(ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C)C(=O)N1CCC(CC1)N1CCN(CC1)C

Computed Properties

• Complexity: 939
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 42
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 3

Literature

• The development of CNS-active LRRK2 inhibitors using property-directed optimisation.

  Bioorganic & medicinal chemistry letters 20130701

• Brain Penetrant LRRK2 Inhibitor.

  ACS medicinal chemistry letters 20120809

• Characterization of TAE684 as a potent LRRK2 kinase inhibitor.

  Bioorganic & medicinal chemistry letters 20120301

• Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

  Nature chemical biology 20110401