1246525-60-9 | SR-1078

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$9.00	$6.00
5mg	99%	in stock	$13.00	$9.00
10mg	99%	in stock	$17.00	$12.00
50mg	99%	in stock	$56.00	$39.00
100mg	99%	in stock	$83.00	$58.00
250mg	99%	in stock	$159.00	$111.00

Description

• Catalog Number: AE34872
• Chemical Name: SR-1078
• CAS Number: 1246525-60-9
• Molecular Formula: C17H10F9NO2
• Molecular Weight: 431.25242879999985
• MDL Number: MFCD18782737
• SMILES: O=C(c1ccc(cc1)C(F)(F)F)Nc1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O

Computed Properties

• Complexity: 555
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 4.8

Literature

• Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.

  The Journal of biological chemistry 20170825

• Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.

  Pharmacological research 20150901

• Regulation of p53 stability and apoptosis by a ROR agonist.

  PloS one 20120101

• Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.

  ACS chemical biology 20101119