125-33-7 | Primidone

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$34.00	$24.00
5g	98%	in stock	$47.00	$33.00
25g	98%	in stock	$128.00	$90.00

Description

• Catalog Number: AB78593
• Chemical Name: Primidone
• CAS Number: 125-33-7
• Molecular Formula: C12H14N2O2
• Molecular Weight: 218.2518
• MDL Number: MFCD00038662
• SMILES: CCC1(C(=O)NCNC1=O)c1ccccc1

Computed Properties

• Complexity: 279
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 0.9

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• Dose-dependent apoptotic and necrotic myocyte death induced by the beta2-adrenergic receptor agonist, clenbuterol.

  Muscle & nerve 20051201

• [Generic drugs in the treatment of epilepsy].

  Revista de neurologia 20051201

• The history of barbiturates a century after their clinical introduction.

  Neuropsychiatric disease and treatment 20051201

• Tremor in idiopathic distal acquired demyelinating symmetric neuropathy.

  Movement disorders : official journal of the Movement Disorder Society 20051101

• Benefits and risks of pharmacological and surgical treatments for essential tremor: disease mechanisms and current management.

  Expert opinion on drug safety 20050901

• Rhythmic EMG and EEG activity during voluntary movement in posthypoxic cortical action myoclonus.

  Journal of UOEH 20050901

• Simultaneous determination of phenytoin and dextromethorphan in urine by solid-phase extraction and HPLC-DAD.

  Journal of separation science 20050701

• Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology.

  Neurology 20050628

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Determination of levetiracetam in human plasma with minimal sample pretreatment.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050505

• Primidone is associated with interictal depression in patients with epilepsy.

  Epilepsy & behavior : E&B 20050501

• [Hyperhomocysteinemia and treatment with antiepileptic drugs. Effects of different doses of folic acid].

  Medicina clinica 20050416

• Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.

  The Journal of clinical investigation 20050301

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  Expert opinion on pharmacotherapy 20050301

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  Pediatric dermatology 20050101

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  Epilepsy research 20050101

• [Population pharmacokinetics of carbamazepine in adults with epilepsy].

  Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20050101

• RLIP76, a non-ABC transporter, and drug resistance in epilepsy.

  BMC neuroscience 20050101

• Population structure of the Brazilian southern green stink bug, Nezara viridula.

  Journal of insect science (Online) 20050101

• Initial treatment of epilepsy: special issues in treating the elderly.

  Neurology 20041123

• Fracture risk associated with use of antiepileptic drugs.

  Epilepsia 20041101

• Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines.

  The Lancet. Neurology 20041001

• Simple and rapid micellar electrokinetic capillary chromatographic method for simultaneous determination of four antiepileptics in human serum.

  Biomedical chromatography : BMC 20041001

• Pilot efficacy and tolerability: a randomized, placebo-controlled trial of levetiracetam for essential tremor.

  Movement disorders : official journal of the Movement Disorder Society 20041001

• Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.

  Epilepsia 20041001

• Discontinuation of Mysoline: lessons to be learned.

  Lancet (London, England) 20041001

• Epilepsy in the United Kingdom: seizure frequency and severity, anti-epileptic drug utilization and impact on life in 1652 people with epilepsy.

  Seizure 20040901

• Essential tremor. Epidemiology, diagnosis, and treatment.

  The neurologist 20040901

• Essential tremor in the older adult: coping with primary symptoms.

  Advance for nurse practitioners 20040901

• Fatal mix-up between prednisone and primidone.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040801

• Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models.

  Seizure 20040701

• Natural history and syndromic associations of orthostatic tremor: a review of 41 patients.

  Movement disorders : official journal of the Movement Disorder Society 20040701

• Antiepileptic drugs: indications other than epilepsy.

  Epileptic disorders : international epilepsy journal with videotape 20040601

• Spectrum of epilepsy in tuberous sclerosis.

  Neurology India 20040601

• Levetiracetam in focal epilepsy and hepatic porphyria: a case report.

  Epilepsia 20040501

• Key structural features of ligands for activation of human pregnane X receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20040401

• [Drug interactions with antiepileptic agents].

  Wiener klinische Wochenschrift 20040227

• Epilepsy and bone health in adults.

  Epilepsy & behavior : E&B 20040201

• Therapeutic drug monitoring of old and newer anti-epileptic drugs.

  Clinical chemistry and laboratory medicine 20040101

• When breastfeeding mothers need CNS-acting drugs.

  The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20040101

• [Late compensation for a recalled drug].

  Ugeskrift for laeger 20031215

• [Antiepileptic primidone shortly to be withdrawn from sale: change medication now].

  Nederlands tijdschrift voor geneeskunde 20031122

• [Oxcarbazepine induced interstitial nephritis in a patient with drug hypersensitivity syndrome].

  Revista de neurologia 20031101

• Identification and prediction of promiscuous aggregating inhibitors among known drugs.

  Journal of medicinal chemistry 20031009

• Use of primidone in low doses (250 mg/day) versus high doses (750 mg/day) in the management of essential tremor. Double-blind comparative study with one-year follow-up.

  Parkinsonism & related disorders 20031001

• AstraZeneca postpones discontinuation of Mysoline.

  The Lancet. Neurology 20031001

• Sedation caused by primidone may exacerbate dementia.

  Epilepsy & behavior : E&B 20031001

• Antiepileptic drug pharmacokinetics during pregnancy and lactation.

  Neurology 20030901

• Essential tremor: diagnosis and treatment.

  Pharmacotherapy 20030901

• Comparison of human exposures to selected chemicals with thresholds from NTP carcinogenicity studies in rodents.

  Human & experimental toxicology 20030901

• Tremor.

  Current opinion in neurology 20030801

• Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs.

  The Lancet. Neurology 20030801

• Essential tremor: differential diagnosis and current therapy.

  The American journal of medicine 20030801

• Effects of barbiturates on human platelet aggregation differ depending on their chemical structures.

  Canadian journal of physiology and pharmacology 20030801

• Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs.

  The Lancet. Neurology 20030601

• The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?

  Epileptic disorders : international epilepsy journal with videotape 20030501

• Microemulsion electrokinetic chromatography applied for separation of levetiracetam from other antiepileptic drugs in polypharmacy.

  Electrophoresis 20030301

• Tremor--easily seen but difficult to describe and treat.

  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20030301

• Clinical features, assessment and treatment of essential tremor.

  The Journal of the Association of Physicians of India 20030301

• Orthostatic tremor: report of a case and review of the literature.

  Neurology India 20030301

• Effects of antiepileptic comedication on levetiracetam pharmacokinetics: a pooled analysis of data from randomized adjunctive therapy trials.

  Epilepsy research 20030201

• The absorption of gabapentin following high dose escalation.

  Seizure 20030101

• Drug treatment of epilepsy in elderly people: focus on valproic Acid.

  Drugs & aging 20030101

• Effects of concomitant antiepileptic drugs on serum carbamazepine concentration in epileptic patients: quantitative analysis based on extracellular water volume as a transforming factor.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030101

• Benefits and risks of pharmacological treatments for essential tremor.

  Drug safety 20030101

• Simultaneous plasma lamotrigine analysis with carbamazepine, carbamazepine 10,11 epoxide, primidone, phenytoin, phenobarbital, and PEMA by micellar electrokinetic capillary chromatography (MECC).

  Journal of analytical toxicology 20030101

• Low doses of topiramate are effective in essential tremor: a report of three cases.

  Clinical neuropharmacology 20030101

• Primary standardization of assays for anticonvulsant drugs: comparison of accuracy and precision.

  Clinical chemistry 20021101

• QT length and heart function in primidone hypocalcaemia.

  Acta cardiologica 20021001

• Prediction of adsorption from multicomponent solutions by activated carbon using single-solute parameters. Part II--Proposed equation.

  AAPS PharmSciTech 20020901

• Management of essential tremor.

  Current neurology and neuroscience reports 20020701

• Serum concentrations of topiramate in patients with epilepsy: influence of dose, age, and comedication.

  Therapeutic drug monitoring 20020601

• Clinical and electromyographic assessment of essential tremor treatment.

  Parkinsonism & related disorders 20020601

• Effect of antiepileptic drugs on bone density in ambulatory patients.

  Neurology 20020514

• Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.

  Toxicology letters 20020510

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Determination of lamotrigine simultaneously with carbamazepine, carbamazepine epoxide, phenytoin, phenobarbital, and primidone in human plasma by SPME-GC-TSD.

  Journal of chromatographic science 20020401

• The management of tremor.

  Journal of neurology, neurosurgery, and psychiatry 20020301

• Randomized trial comparing primidone initiation schedules for treating essential tremor.

  Movement disorders : official journal of the Movement Disorder Society 20020301

• Some common issues in the use of antiepileptic drugs.

  Seminars in neurology 20020301

• Essential tremor.

  The New England journal of medicine 20020227

• Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate.

  Neurology 20020226

• [Primary orthostatic tremor].

  La Revue de medecine interne 20020201

• Primidone-induced hyperammonemic encephalopathy in a patient with cerebral astrocytoma.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20020101

• Unverricht-Lundborg disease with cystatin B gene abnormalities.

  Pediatric neurology 20020101

• Antiepileptic hypersensitivity syndrome: clinicians beware and be aware.

  Current allergy and asthma reports 20020101

• Ecological data of Travassosnema travassosi travassosi (Dracunculoidea: Guyanemidae) from the humour of the eyes of Acestrorhynchus lacustris from Tibagi River, Paraná, Brazil.

  Memorias do Instituto Oswaldo Cruz 20020101

• Anticonvulsant hypersensitivity syndrome.

  Pediatric dermatology 20020101

• [Evaluation of antiepileptic therapy during pregnancy].

  Ginekologia polska 20020101

• Treatment of epilepsy in women of reproductive age: pharmacokinetic considerations.

  Clinical pharmacokinetics 20020101

• Fate of pharmaceuticals during indirect potable reuse.

  Water science and technology : a journal of the International Association on Water Pollution Research 20020101

• Prolonged anticonvulsant hypersensitivity syndrome related to lamotrigine in a patient with human immunodeficiency virus.

  Allergy and asthma proceedings 20020101

• Rapid cycling bipolar disorder.

  Expert opinion on pharmacotherapy 20011201

• Antiepileptic drugs as independent predictors of plasma total homocysteine levels.

  Epilepsy research 20011101

• Clinical practice. Essential tremor.

  The New England journal of medicine 20010920

• Antiepileptic drug utilization: a Danish prescription database analysis.

  Acta neurologica Scandinavica 20010701

• Neural tube defects in relation to use of folic acid antagonists during pregnancy.

  American journal of epidemiology 20010515

• Linking toxicology and epidemiology: the role of mechanistic modelling.

  Statistics in medicine 20010501

• [Febrile convulsions, Treatment and prognosis].

  Ugeskrift for laeger 20010219

• Pharmacologic management of epilepsy in the elderly.

  Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) 20010101

• Adverse effects of antiepileptic drugs on bone structure: epidemiology, mechanisms and therapeutic implications.

  CNS drugs 20010101

• Effects of encapsulation of primidone on its oxidative metabolism in rats.

  Drug metabolism and drug interactions 20010101

• Primary Generalized Epilepsies.

  Current treatment options in neurology 20001101

• The 'forgotten' cross-tolerance between phenobarbital and primidone: it can prevent acute primidone-related toxicity.

  Epilepsia 20001001

• Seizure-inducing paradoxical reaction to antiepileptic drugs.

  Brain & development 20000601

• A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy.

  Epilepsia 20000201

• Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.

  Pharmacology & toxicology 20000201

• Giant cell myocarditis as a manifestation of drug hypersensitivity.

  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20000101

• Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents.

  Epilepsia 19990901

• The use of primidone in the treatment of refractory bipolar disorder.

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 19990601

• Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants.

  Journal of the American Veterinary Medical Association 19980301

• Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.

  Acta paediatrica (Oslo, Norway : 1992) 19960601

• Two cases of risperidone-induced neuroleptic malignant syndrome.

  The American journal of psychiatry 19950801

• Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.

  Journal of intellectual disability research : JIDR 19941201

• Primidone and rapid cycling affective disorders.

  Lancet (London, England) 19931009

• Hydantoin syndrome with holoprosencephaly: a possible rare teratogenic effect.

  Teratology 19930701

• Treatment of essential tremor with methazolamide.

  Mayo Clinic proceedings 19911001

• Loss of therapeutic control in congenital adrenal hyperplasia due to interaction between dexamethasone and primidone.

  Acta paediatrica Scandinavica 19910101

• Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.

  Journal of medicinal chemistry 19900101

• Primidone in drug-induced tremor.

  Journal of clinical psychopharmacology 19891201

• Primidone/phenobarbital-induced periodic alternating nystagmus.

  Annals of ophthalmology 19890601

• Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats.

  European journal of pharmacology 19890321

• Valproic acid prenatal exposure. Association with lipomyelomeningocele.

  Clinical pediatrics 19890201

• [A clinical case of severe megaloblastic anemia during treatment with primidone].

  Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma 19890101

• Clinical side effects of phenobarbital, primidone, phenytoin, carbamazepine, and valproate during monotherapy in children.

  Epilepsia 19880101

• Seizures during barbiturate withdrawal: relation to blood level.

  Annals of neurology 19871101

• Overflow urinary incontinence due to carbamazepine.

  The Journal of urology 19851001

• Primidone in essential tremor of the hands and head: a double blind controlled clinical study.

  Journal of neurology, neurosurgery, and psychiatry 19850901

• Goldenhar syndrome, anterior encephalocele, and aqueductal stenosis following fetal primidone exposure.

  Teratology 19850801

• Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.

  The New England journal of medicine 19850718

• Hepatic cirrhosis associated with long-term primidone therapy in a dog.

  Journal of the American Veterinary Medical Association 19850501

• [How effective is the treatment schedule in children with infantile spasms?].

  Klinische Padiatrie 19850101

• Parkinsonism induced by phenytoin.

  Clinical neuropharmacology 19850101

• Todd's paralysis following an interscalene block.

  Anesthesiology 19840901

• Compromised hepatic function in dogs treated with anticonvulsant drugs.

  Journal of the American Veterinary Medical Association 19840215

• Dementia in epilepsy.

  Acta neurologica Scandinavica. Supplementum 19840101

• Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice.

  Neurology 19830301

• Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice.

  Neurology 19830301

• Chorea in long-term use of pemoline.

  Annals of neurology 19830201

• Primidone-induced catatonic schizophrenia.

  Drug intelligence & clinical pharmacy 19830101

• Anticonvulsant peripheral neuropathy: a clinical and electrophysiological study of patients on single drug treatment with phenytoin, carbamazepine or barbiturates.

  Journal of neurology, neurosurgery, and psychiatry 19820701

• Carbamazepine-induced choreoathetoid dyskinesias.

  Journal of neurology, neurosurgery, and psychiatry 19820601

• Essential tremor.

  Canadian Medical Association journal 19811101

• Peripheral neuropathy in epileptic patients.

  Neurology 19810701

• A case of petit mal epilepsy aggravated by lithium.

  The American journal of psychiatry 19810501

• Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome.

  Epilepsia 19810201

• Primidone-induced 'uraemic flap'.

  Lancet (London, England) 19791208

• Schizophrenia-like psychosis associated with anticonvulsant toxicity.

  The American journal of psychiatry 19790701

• Downbeat nystagmus due to anticonvulsant toxicity.

  Annals of neurology 19781101

• Athetosis and phenytoin toxicity.

  American journal of diseases of children (1960) 19770101

• Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.

  Journal of neurology, neurosurgery, and psychiatry 19761201

• Involuntary movements caused by phenytoin intoxication in epileptic patients.

  Journal of neurology, neurosurgery, and psychiatry 19750301

• Do anticonvulsants have a teratogenic effect?

  Archives of neurology 19741201

• Letter: Toxic reaction to phenytoin.

  British medical journal 19740727

• Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.

  Neurology 19740501

• Serum anticonvulsant concentrations in epileptic patients with mental symptoms. A preliminary report.

  The British journal of psychiatry : the journal of mental science 19740501

• Choreo-athetosis and encephalopathy induced by phenytoin.

  British medical journal 19740427

• Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.

  Lancet (London, England) 19731117

• Toxic epidermal necrolysis provoked by barbiturates.

  The British journal of dermatology 19730301

• Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.

  Neurology 19730201

• Megaloblastic anemia after anticonvulsive therapy.

  The New England journal of medicine 19721109

• Myasthenia gravis syndrome associated with trimethadione.

  JAMA 19700629

• Pseudodegenerative disease due to diphenylhydantoin intoxication.

  Archives of neurology 19691201

• Intolerance to diphenylhydantoin in five cases of Vogt-Spielmeyer disease.

  Journal of mental deficiency research 19691201

• Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate.

  JAMA 19690317

• Neuropsychiatric aspects of anticonvulsant megaloblastic anaemia.

  Lancet (London, England) 19680224

• [Megaloblastic anemia in the course of treatment by mysoline. Treatment with folic acid].

  Journal de medecine de Lyon 19670720