125313-92-0 | 3-(1-Methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Packsize	Purity	Availability	Price	Discounted Price
5mg	99%	1 week	$276.00	$193.00
10mg	99%	1 week	$410.00	$287.00
25mg	99%	1 week	$650.00	$455.00
50mg	99%	1 week	$950.00	$665.00
100mg	99%	1 week	$1,310.00	$917.00

Description

• Catalog Number: AA30238
• Chemical Name: 3-(1-Methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• CAS Number: 125313-92-0
• Molecular Formula: C22H16N4O4
• Molecular Weight: 400.38684
• MDL Number: MFCD28122814
• SMILES: O=C1NC(=O)C(=C1c1cn(c2c1ccc(c2)N(=O)=O)C)c1cn(c2c1cccc2)C

Computed Properties

• Complexity: 805
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.6

Literature

• A phase 2 study of oral MKC-1, an inhibitor of importin-β, tubulin, and the mTOR pathway in patients with unresectable or metastatic pancreatic cancer.

  Investigational new drugs 20120801

• The first design and synthesis of [11C]MKC-1 ([11C]Ro 31-7453), a new potential PET cancer imaging agent.

  Nuclear medicine and biology 20101001

• A phase I clinical and pharmacokinetic study of Ro 31-7453 given as a 7- or 14-day oral twice daily schedule every 4 weeks in patients with solid tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040701