1255517-76-0 | Pf-4708671

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$17.00	$12.00
5mg	98%	in stock	$43.00	$30.00
10mg	98%	in stock	$64.00	$45.00
25mg	98%	in stock	$106.00	$74.00
50mg	98%	in stock	$180.00	$126.00
100mg	98%	in stock	$305.00	$214.00

Description

• Catalog Number: AE35765
• Chemical Name: Pf-4708671
• CAS Number: 1255517-76-0
• Molecular Formula: C19H21F3N6
• Molecular Weight: 390.4054495999999
• MDL Number: MFCD18086922
• SMILES: CCc1cncnc1N1CCN(CC1)Cc1nc2c([nH]1)cc(cc2)C(F)(F)F

Computed Properties

• Complexity: 510
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 3.2

Literature

• S6 inhibition contributes to isoflurane neurotoxicity in the developing brain.

  Toxicology letters 20150304

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.

  Amino acids 20120601

• S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

  The Biochemical journal 20120101

• Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

  The Biochemical journal 20101015