1257-08-5 | (-)-Epicatechin Gallate

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$12.00	$9.00
5mg	98%	in stock	$20.00	$14.00
10mg	98%	in stock	$29.00	$20.00
50mg	98%	in stock	$86.00	$60.00
100mg	98%	in stock	$131.00	$92.00
250mg	98%	in stock	$196.00	$137.00
1g	98%	in stock	$488.00	$341.00
5g	98%	in stock	$1,707.00	$1,195.00

Description

• Catalog Number: AB47447
• Chemical Name: (-)-Epicatechin Gallate
• CAS Number: 1257-08-5
• Molecular Formula: C22H18O10
• Molecular Weight: 442.3723
• MDL Number: MFCD00075936
• SMILES: Oc1cc(O)c2c(c1)O[C@@H]([C@@H](C2)OC(=O)c1cc(O)c(c(c1)O)O)c1ccc(c(c1)O)O

Computed Properties

• Complexity: 649
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 7
• Rotatable Bond Count: 4
• XLogP3: 1.5

Literature

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  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171201

• Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFκB p65 signal pathway.

  Toxicology in vitro : an international journal published in association with BIBRA 20151001

• A strategy for designing a concave Pt-Ni alloy through controllable chemical etching.

  Angewandte Chemie (International ed. in English) 20121207

• Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds.

  Phytotherapy research : PTR 20121001

• Influence of gallate and pyrogallol moieties on the intestinal absorption of (-)-epicatechin and (-)-epicatechin gallate.

  Journal of food science 20121001

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  Fitoterapia 20120901

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  Chemical communications (Cambridge, England) 20120828

• Catechins containing a galloyl moiety as potential anti-HIV-1 compounds.

  Drug discovery today 20120601

• Chitosan-based luminescent/magnetic hybrid nanogels for insulin delivery, cell imaging, and antidiabetic research of dietary supplements.

  International journal of pharmaceutics 20120510

• Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

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• Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase.

  Bioorganic & medicinal chemistry 20120401

• A new norisoprenoid and other compounds from Fuzhuan brick tea.

  Molecules (Basel, Switzerland) 20120319

• Glucuronidation and methylation of procyanidin dimers b2 and 3,3″-di-o-galloyl-b2 and corresponding monomers epicatechin and 3-o-galloyl-epicatechin in mouse liver.

  Pharmaceutical research 20120301

• (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry.

  Hepatology (Baltimore, Md.) 20120301

• A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.

  Toxicology and applied pharmacology 20120115

• Green tea catechin intervention of reactive oxygen species-mediated ERK pathway activation and chronically induced breast cell carcinogenesis.

  Carcinogenesis 20120101

• Simultaneous determination of catechin, epicatechin and epicatechin gallate in rat plasma by LC-ESI-MS/MS for pharmacokinetic studies after oral administration of Cynomorium songaricum extract.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120101

• Characterization of creaming precipitate of tea catechins and caffeine in aqueous solution.

  Chemical & pharmaceutical bulletin 20120101

• Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20111201

• Anti-staphylococcal activity and β-lactam resistance attenuating capacity of structural analogues of (-)-epicatechin gallate.

  Bioorganic & medicinal chemistry letters 20111201

• Analysis of binding interaction between (-)-epigallocatechin (EGC) and β-lactoglobulin by multi-spectroscopic method.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101

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• Pressurized liquid extraction of phenolic compounds from Anatolia propolis and their radical scavenging capacities.

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• Interaction of epicatechin gallate with phospholipid membranes as revealed by solid-state NMR spectroscopy.

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• Effect of girdling at various positions of 'Huang Zhi Xiang' tea tree (Camellia sinensis) on the contents of catechins and starch in fresh leaf.

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• Interactions of green tea catechins with organic anion-transporting polypeptides.

  Drug metabolism and disposition: the biological fate of chemicals 20110501

• Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells.

  Cancer science 20110401

• Potential O-acyl-substituted (-)-Epicatechin gallate prodrugs as inhibitors of DMBA/TPA-induced squamous cell carcinoma of skin in Swiss albino mice.

  Chemistry & biodiversity 20110401

• Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39.

  Biochemical and biophysical research communications 20110225

• Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate.

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• Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1.

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• Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins.

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• A comparative reverse docking strategy to identify potential antineoplastic targets of tea functional components and binding mode.

  International journal of molecular sciences 20110101

• Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties.

  Journal of natural products 20101227

• Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: a nested case-control study.

  Breast cancer research and treatment 20101201

• The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors.

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• Extraction of antioxidants and caffeine from green tea (Camelia sinensis) leaves: kinetics and modeling.

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  Biotechnology journal 20101001

• Epicatechin gallate suppresses oxidative stress-induced MUC5AC overexpression by interaction with epidermal growth factor receptor.

  American journal of respiratory cell and molecular biology 20100901

• Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1).

  Biochemical pharmacology 20100815

• The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells.

  Molecular carcinogenesis 20100801

• Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2.

  The Journal of biological chemistry 20100730

• An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

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• Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin.

  Bioorganic & medicinal chemistry 20100715

• Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts.

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• Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts.

  Molecular nutrition & food research 20100701

• Binding affinity of tea catechins for HSA: characterization by high-performance affinity chromatography with immobilized albumin column.

  Molecular nutrition & food research 20100601

• Epicatechin gallate decreases the viability and subsequent embryonic development of mouse blastocysts.

  Taiwanese journal of obstetrics & gynecology 20100601

• The inhibition of collagenase induced degradation of collagen by the galloyl-containing polyphenols tannic acid, epigallocatechin gallate and epicatechin gallate.

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• Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.

  Journal of medicinal chemistry 20091112

• Epigallocatechin-3-gallate is an inhibitor of Na+, K(+)-ATPase by favoring the E1 conformation.

  Biochemical pharmacology 20091015

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• Green tea (-)-epigallocatechin gallate inhibits insulin stimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor pathway.

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• (-)-Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: implication in the anti-atherosclerotic actions of tea catechins.

  Biochemical and biophysical research communications 20080926

• Absorption and pharmacokinetics of green tea catechins in beagles.

  The British journal of nutrition 20080901

• Studies on the interaction of copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate with calf thymus DNA.

  Journal of inorganic biochemistry 20080901

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  The Journal of pharmacy and pharmacology 20080901

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• Stopped-flow kinetic study of the aroxyl radical-scavenging action of catechins and vitamin C in ethanol and micellar solutions.

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• Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells.

  The British journal of nutrition 20080601

• Diastereomeric difference of inclusion modes between (-)-epicatechin gallate, (-)-epigallocatechin gallate and (+)-gallocatechin gallate, with beta-cyclodextrin in aqueous solvent.

  Magnetic resonance in chemistry : MRC 20080501

• Effects of water-soluble natural antioxidants on photosensitized oxidation of conjugated linoleic acid in an oil-in-water emulsion system.

  Journal of food science 20080501

• Synthesis and biological activity of a 3,4,5-trimethoxybenzoyl ester analogue of epicatechin-3-gallate.

  Journal of medicinal chemistry 20080410

• Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme.

  Bioorganic & medicinal chemistry 20080401

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• Epicatechin gallate increases glutamate uptake and S100B secretion in C6 cell lineage.

  Molecular and cellular biochemistry 20080301

• The polyphenol (-)-epicatechin gallate disrupts the secretion of virulence-related proteins by Staphylococcus aureus.

  Letters in applied microbiology 20080201

• New polyphenols active on beta-amyloid aggregation.

  Bioorganic & medicinal chemistry letters 20080115

• Validation of green tea polyphenol biomarkers in a phase II human intervention trial.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

• Identification of a PKCepsilon-dependent regulation of myocardial contraction by epicatechin-3-gallate.

  American journal of physiology. Heart and circulatory physiology 20080101

• Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.

  Biopharmaceutics & drug disposition 20071201

• Structures of epicatechin gallate trimer and tetramer produced by enzymatic oxidation.

  Chemical & pharmaceutical bulletin 20071201

• Dynamic behavior of tea catechins interacting with lipid membranes as determined by NMR spectroscopy.

  Journal of agricultural and food chemistry 20071128

• Characterization of the constituents and antioxidant activity of Brazilian green tea (Camellia sinensis var. assamica IAC-259 cultivar) extracts.

  Journal of agricultural and food chemistry 20071114

• Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells.

  Journal of lipid research 20071101

• Green tea catechin (-)-epicatechin gallate induces tumour suppressor protein ATF3 via EGR-1 activation.

  European journal of cancer (Oxford, England : 1990) 20071101

• A new LC/MS/MS rapid and sensitive method for the determination of green tea catechins and their metabolites in biological samples.

  Journal of agricultural and food chemistry 20071031

• Catechin degradation with concurrent formation of homo- and heterocatechin dimers during in vitro digestion.

  Journal of agricultural and food chemistry 20071031

• Methylation suppresses the proteasome-inhibitory function of green tea polyphenols.

  Journal of cellular physiology 20071001

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  Leukemia research 20070901

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  Journal of biomedical science 20070901

• Common tea formulations modulate in vitro digestive recovery of green tea catechins.

  Molecular nutrition & food research 20070901

• (-)-Epicatechin-3-gallate, a green tea polyphenol is a potent agent against UVB-induced damage in HaCaT keratinocytes.

  Molecules (Basel, Switzerland) 20070814

• Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties.

  Molecular nutrition & food research 20070801

• Uniformly-sized, molecularly imprinted polymers for (-)-epigallocatechin gallate, -epicatechin gallate and -gallocatechin gallate by multi-step swelling and polymerization method.

  Journal of chromatography. A 20070713

• The beta-lactam-resistance modifier (-)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureus.

  Microbiology (Reading, England) 20070701

• Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea.

  Journal of agricultural and food chemistry 20070613

• Structure-reactivity relationships of flavan-3-ols on product generation in aqueous glucose/glycine model systems.

  Journal of agricultural and food chemistry 20070502

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  Molecular nutrition & food research 20070501

• Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20070501

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  The Journal of nutritional biochemistry 20070301

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  Journal of medicinal chemistry 20070222

• Determination of rutin, catechin, epicatechin, and epicatechin gallate in buckwheat Fagopyrum esculentum Moench by micro-high-performance liquid chromatography with electrochemical detection.

  Journal of agricultural and food chemistry 20070221

• Antimalarial properties of green tea.

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  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070201

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  Journal of medicinal chemistry 20070125

• Food components inhibiting recombinant human histidine decarboxylase activity.

  Journal of agricultural and food chemistry 20070124

• Synthesis and preliminary anticancer activity studies of C4 and C8-modified derivatives of catechin gallate (CG) and epicatechin gallate (ECG).

  The Journal of organic chemistry 20061222

• Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells.

  European journal of cancer (Oxford, England : 1990) 20061201

• Epicatechin gallate, a component of green tea, reduces halotolerance in Staphylococcus aureus.

  International journal of food microbiology 20061001

• Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome beta5 subunit.

  International journal of molecular medicine 20061001

• Differential alterations in metabolic pattern of the spliceosomal UsnRNAs during pre-malignant lung lesions induced by benzo(a)pyrene: modulation by tea polyphenols.

  Molecular and cellular biochemistry 20060901

• Sex- and strain-dependent effects of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) in the mouse.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060901

• Bioassay-guided purification and identification of antimicrobial components in Chinese green tea extract.

  Journal of chromatography. A 20060901

• Copper complexes of (-)-epicatechin gallate and (-)-epigallocatechin gallate act as inhibitors of Ribonuclease A.

  FEBS letters 20060821

• Kinetic study of the thermal stability of tea catechins in aqueous systems using a microwave reactor.

  Journal of agricultural and food chemistry 20060809

• Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

  Journal of medicinal chemistry 20060601

• Determination of the predominant catechins in Acacia catechu by liquid chromatography/electrospray ionization-mass spectrometry.

  Journal of agricultural and food chemistry 20060503

• Electrofocusing of methanolic extracts for identification of individual flavonol biomolecules in Camellia species.

  Journal of agricultural and food chemistry 20060419

• The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells.

  Oncogene 20060323

• Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols.

  Journal of agricultural and food chemistry 20060322

• Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins.

  Free radical biology & medicine 20060215

• Novel inhibitors of fatty-acid synthase from green tea (Camellia sinensis Xihu Longjing) with high activity and a new reacting site.

  Biotechnology and applied biochemistry 20060101

• A quantitative approach to the free radical interaction between alpha-tocopherol or ascorbate and flavonoids.

  In vivo (Athens, Greece) 20060101

• Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions.

  BioFactors (Oxford, England) 20060101

• The comparison of effect of catechins and green tea extract on oxidative modification of LDL in vitro.

  Advances in medical sciences 20060101

• Stereoselective oxidation at C-4 of flavans by the endophytic fungus Diaporthe sp. isolated from a tea plant.

  Chemical & pharmaceutical bulletin 20051201

• Antiviral effect of catechins in green tea on influenza virus.

  Antiviral research 20051101

• Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells.

  International journal of molecular medicine 20051001

• Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution.

  Free radical biology & medicine 20050915

• Antimycobacterial agents from selected Mexican medicinal plants.

  The Journal of pharmacy and pharmacology 20050901

• Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials.

  Journal of natural products 20050901

• Separation of catechin constituents from five tea cultivars using high-speed counter-current chromatography.

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• Seasonal variations of phenolic compounds in Australia-grown tea (Camellia sinensis).

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• Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression.

  Cardiovascular research 20050801

• Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols.

  British journal of pharmacology 20050801

• The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats.

  The British journal of nutrition 20050801

• Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41.

  Biochimica et biophysica acta 20050525

• Kinetics of the inhibition of bovine liver dihydrofolate reductase by tea catechins: origin of slow-binding inhibition and pH studies.

  Biochemistry 20050524

• Synthesis and antibacterial activity of hydrolytically stable (-)-epicatechin gallate analogues for the modulation of beta-lactam resistance in Staphylococcus aureus.

  Bioorganic & medicinal chemistry letters 20050516

• Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies.

  Biochemical pharmacology 20050515

• Structure-activity relationship of the tocopherol-regeneration reaction by catechins.

  Free radical biology & medicine 20050501

• Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats.

  Bioscience, biotechnology, and biochemistry 20050501

• Protective effects of (-)-epicatechin-3-gallate on UVA-induced damage in HaCaT keratinocytes.

  Archives of dermatological research 20050401

• Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.

  The Journal of biological chemistry 20050304

• Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity.

  Toxicology in vitro : an international journal published in association with BIBRA 20050301

• Flavanols in somatic cell division and male meiosis of tea (Camellia sinensis) anthers.

  Plant biology (Stuttgart, Germany) 20050301

• Pharmacokinetics of TJ-8117(Onpi-to), a drug for renal failure (II): effects of food, repeated administration and renal failure to plasma concentration of [3H]-(-)epicatechin 3-O-gallate in rats.

  European journal of drug metabolism and pharmacokinetics 20050101

• Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model.

  International journal of pharmaceutics 20041209

• Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells.

  Carcinogenesis 20041201

• Ellipsometry analysis of the in vitro adsorption of tea polyphenols onto salivary pellicles.

  European journal of oral sciences 20041201

• Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts.

  Journal of natural products 20041201

• Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus.

  Planta medica 20041201

• [Preparation and component analysis of tea pigments].

  Wei sheng yan jiu = Journal of hygiene research 20041101

• Anticancer activity of 3-O-acyl and alkyl-(-)-epicatechin derivatives.

  Bioorganic & medicinal chemistry letters 20041018

• Prooxidative activities of tea catechins in the presence of Cu2+.

  Bioscience, biotechnology, and biochemistry 20040901

• Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes.

  Free radical research 20040901

• Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors.

  Bioorganic & medicinal chemistry 20040701

• Effects of epicatechin gallate on wound healing and scar formation in a full thickness incisional wound healing model in rats.

  The American journal of pathology 20040701

• Effect of tea catechins on the change of glutathione levels caused by Pb(++) in PC12 cells.

  Chemical research in toxicology 20040701

• Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats.

  Free radical biology & medicine 20040515

• Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates.

  International journal of antimicrobial agents 20040501

• Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis.

  Oral microbiology and immunology 20040401

• [MDR-reversing effect of two components of catechin on human hepatocellular carcinoma BEL-7404/Adr in vitro].

  Ai zheng = Aizheng = Chinese journal of cancer 20040401

• Role of hydrogen peroxide in bactericidal action of catechin.

  Biological & pharmaceutical bulletin 20040301

• (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.

  The Journal of pharmacy and pharmacology 20040201

• Unravelling green tea's mechanisms of action: more than meets the eye.

  Molecular pharmacology 20040101

• Pharmacokinetics of TJ-8117 (Onpi-to), a drug for renal failure (I): Plasma concentration, distribution and excretion of [3H]-(-)epicatechin 3-O-gallate in rats and dogs.

  European journal of drug metabolism and pharmacokinetics 20040101

• A difference between epigallocatechin-3-gallate and epicatechin-3-gallate on anti-allergic effect is dependent on their distinct distribution to lipid rafts.

  BioFactors (Oxford, England) 20040101

• Tea polyphenols inhibit the transport of dietary phenolic acids mediated by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers.

  Journal of agricultural and food chemistry 20031203

• Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate.

  Journal of agricultural and food chemistry 20031203

• Epigallocatechin gallate modulates CYP450 isoforms in the female Swiss-Webster mouse.

  Toxicological sciences : an official journal of the Society of Toxicology 20031201

• The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase.

  Biochemical pharmacology 20031115

• Cellular uptake and efflux of the tea flavonoid (-)epicatechin-3-gallate in the human intestinal cell line Caco-2.

  The Journal of pharmacology and experimental therapeutics 20031101

• Catechins and the treatment of breast cancer: possible utility and mechanistic targets.

  IDrugs : the investigational drugs journal 20031101

• Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding.

  The Journal of allergy and clinical immunology 20031101

• Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

  Biochemical and biophysical research communications 20031010

• Tea catechins protect against lead-induced ROS formation, mitochondrial dysfunction, and calcium dysregulation in PC12 cells.

  Chemical research in toxicology 20030901

• A combination effect of epigallocatechin gallate, a major compound of green tea catechins, with antibiotics on Helicobacter pylori growth in vitro.

  Current microbiology 20030901

• Identification of metabolites of (-)-epicatechin gallate and their metabolic fate in the rat.

  Journal of agricultural and food chemistry 20030827

• A novel convenient process to obtain a raw decaffeinated tea polyphenol fraction using a lignocellulose column.

  Journal of agricultural and food chemistry 20030507

• Pharmacokinetics of (-)-epicatechin-3-O-gallate, an active component of Onpi-to, in rats.

  Biological & pharmaceutical bulletin 20030501

• Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX).

  Pharmacology & toxicology 20030501

• Protective activity of (-)-epicatechin 3-O-gallate against peroxynitrite-mediated renal damage.

  Free radical research 20030501

• Inhibition of adenovirus infection and adenain by green tea catechins.

  Antiviral research 20030401

• The relationship between the antioxidant and the antibacterial properties of galloylated catechins and the structure of phospholipid model membranes.

  Free radical biology & medicine 20030315

• Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis.

  Anticancer research 20030101

• Direct scavenging of nitric oxide and superoxide by green tea.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021201

• Green tea polyphenols inhibit metalloproteinase activities in the skin, muscle, and blood of rainbow trout.

  Journal of agricultural and food chemistry 20021120

• Tea enhances insulin activity.

  Journal of agricultural and food chemistry 20021120

• Polyphenol-induced inhibition of the response of na(+)/glucose cotransporter expressed in Xenopus oocytes.

  Journal of agricultural and food chemistry 20020828

• Spectrofluorometric determination of catechins with 1,2-diphenylethylenediamine.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020801

• Effects of tea components on the response of GABA(A) receptors expressed in Xenopus Oocytes.

  Journal of agricultural and food chemistry 20020703

• Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells.

  Bioscience, biotechnology, and biochemistry 20020701

• Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020601

• Study of non-covalent complexation between catechin derivatives and peptides by electrospray ionization mass spectrometry.

  Journal of mass spectrometry : JMS 20020601

• Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline.

  Biological trace element research 20020501

• Protective activity of green tea against free radical- and glucose-mediated protein damage.

  Journal of agricultural and food chemistry 20020410

• Enhancement of inward Ca(2+) currents in bovine chromaffin cells by green tea polyphenol extracts.

  Neurochemistry international 20020201

• Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation.

  Cancer research 20020115

• Kinetic analysis and mechanistic aspects of autoxidation of catechins.

  Biochimica et biophysica acta 20020115

• Plasma concentrations of individual tea catechins after a single oral dose in humans.

  Xenobiotica; the fate of foreign compounds in biological systems 20011201

• Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues.

  Biochemical pharmacology 20011101

• Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase.

  Bioorganic & medicinal chemistry letters 20011022

• Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450.

  Mutation research 20010808

• Prolyl endopeptidase inhibitors from green tea.

  Archives of pharmacal research 20010801

• Stereospecificity in membrane effects of catechins.

  Chemico-biological interactions 20010314

• The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro.

  Cytokine 20010307

• Structural features of procyanidin interactions with salivary proteins.

  Journal of agricultural and food chemistry 20010201

• Degradation of green tea catechins in tea drinks.

  Journal of agricultural and food chemistry 20010101

• Pharmacokinetics and system linearity of tea catechins in rat.

  Xenobiotica; the fate of foreign compounds in biological systems 20010101

• Influence of metal ions on flavonoid protection against asbestos-induced cell injury.

  Archives of biochemistry and biophysics 20010101

• Green tea and its catechins inhibit breast cancer xenografts.

  Nutrition and cancer 20010101

• Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures.

  Nutrition and cancer 20010101

• Prolyl endopeptidase inhibitory activity of fourteen Kampo formulas and inhibitory constituents of Tokaku-joki-to.

  Chemical & pharmaceutical bulletin 20000701

• Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols.

  The Journal of investigative dermatology 19950901

• Inhibition of HIV infection by flavanoids.

  Antiviral research 19931001

• Inhibition of human immunodeficiency viral replication by tannins and related compounds.

  Antiviral research 19920501

• Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases.

  Biochemistry 19900320

• Differential inhibition of HIV-reverse transcriptase and various DNA and RNA polymerases by some catechin derivatives.

  Nucleic acids symposium series 19890101