1282512-48-4 | Gdc-0032

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$18.00	$13.00
5mg	99%	in stock	$38.00	$27.00
10mg	99%	in stock	$54.00	$38.00
50mg	99%	in stock	$152.00	$106.00

Description

• Catalog Number: AA43738
• Chemical Name: Gdc-0032
• CAS Number: 1282512-48-4
• Molecular Formula: C24H28N8O2
• Molecular Weight: 460.5315
• MDL Number: MFCD26142641
• SMILES: Cc1nn(c(n1)c1cn2c(-c3ccc(cc3OCC2)c2cnn(c2)C(C(=O)N)(C)C)n1)C(C)C

Computed Properties

• Complexity: 751
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 1.8

Literature

• Taselisib, a selective inhibitor of PIK3CA, is highly effective on PIK3CA-mutated and HER2/neu amplified uterine serous carcinoma in vitro and in vivo.

  Gynecologic oncology 20141101

• Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.

  Journal of medicinal chemistry 20130613