129-56-6 | 1,9-Pyrazoloanthrone

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$6.00	$4.00
10mg	98%	in stock	$7.00	$5.00
100mg	98%	in stock	$27.00	$19.00
250mg	98%	in stock	$32.00	$22.00
1g	98%	in stock	$38.00	$27.00
5g	98%	in stock	$60.00	$42.00
25g	98%	in stock	$283.00	$198.00
100g	98%	in stock	$853.00	$597.00

Description

• Catalog Number: AA44849
• Chemical Name: 1,9-Pyrazoloanthrone
• CAS Number: 129-56-6
• Molecular Formula: C14H8N2O
• Molecular Weight: 220.2261
• MDL Number: MFCD00022289
• SMILES: O=C1c2ccccc2-c2c3c1cccc3[nH]n2
• NSC Number: 75890

Computed Properties

• Complexity: 343
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 2.7

Literature

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• Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway.

  Cellular signalling 20121101

• Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121101

• Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.

  Journal of lipid research 20121101

• Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes.

  Toxicology 20121028

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  European journal of nutrition 20121001

• Distinct functions of JNK and c-Jun in oxidant-induced hepatocyte death.

  Journal of cellular biochemistry 20121001

• JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure.

  Toxicological sciences : an official journal of the Society of Toxicology 20121001

• Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-κB pathway.

  Biochimica et biophysica acta 20121001

• Mitogen-activated protein kinases-dependent induction of hepatocyte growth factor production in human dermal fibroblasts by the antibiotic polymyxin B.

  Cytokine 20121001

• Transcriptional and translational regulation of COX-2 expression by cadmium in C6 glioma cells.

  International journal of molecular medicine 20121001

• Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways.

  European journal of pharmacology 20120905

• Protective role of metabolism by intestinal microflora in butyl paraben-induced toxicity in HepG2 cell cultures.

  Toxicology letters 20120903

• Preliminary evidence for the dedifferentiation of RAW 264.7 cells into mesenchymal progenitor-like cells by a purine analog.

  Tissue engineering. Part A 20120901

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  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• Sargachromanol G regulates the expression of osteoclastogenic factors in human osteoblast-like MG-63 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

• The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment.

  Molecular cancer research : MCR 20120901

• Pimaric acid from Aralia cordata has an inhibitory effect on TNF-α-induced MMP-9 production and HASMC migration via down-regulated NF-κB and AP-1.

  Chemico-biological interactions 20120830

• PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20120801

• Inhibitory effect of Styrax Japonica Siebold et al. Zuccarini glycoprotein (38 kDa) on interleukin-1β and induction proteins in chromium(VI)-treated BNL CL.2 cells.

  Molecular and cellular biochemistry 20120801

• Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation.

  Molecular and cellular biochemistry 20120801

• Suppression of adhesion molecule expression by phenanthrene-containing extract of bulbils of Chinese Yam in vascular smooth muscle cells through inhibition of MAPK, Akt and NF-κB.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801

• Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations.

  Journal of neurochemistry 20120801

• Inhibition of c-Jun N-terminal kinase prevents blood-brain barrier disruption and normalizes the expression of tight junction proteins clautin-5 and ZO-1 in a rat model of subarachnoid hemorrhage.

  Acta neurochirurgica 20120801

• cAMP-dependent proteolysis of GATA-6 is linked to JNK-signaling pathway.

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• Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines.

  Toxicology letters 20120707

• Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3.

  British journal of pharmacology 20120701

• Monocyte chemoattractant protein-1 mediates angiotensin II-induced vascular smooth muscle cell proliferation via SAPK/JNK and ERK1/2.

  Molecular and cellular biochemistry 20120701

• The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes.

  Archives of pharmacal research 20120701

• Evaluation of sirtuin role in neuroprotection of retinal ganglion cells in hypoxia.

  Investigative ophthalmology & visual science 20120628

• Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20120613

• Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells.

  Journal of cellular biochemistry 20120601

• Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation.

  Molecular & cellular proteomics : MCP 20120601

• Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

• Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways.

  Archives of toxicology 20120601

• Tumor necrosis factor-α and interleukin-1β expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7.

  Molecular oral microbiology 20120601

• [The protective effects of inhibition of c-Jun N-terminal kinase signal pathway on the intestinal barrier in rats with endotoxemia].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20120601

• Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.

  The Journal of biological chemistry 20120518

• Arecoline-induced death of human leukemia K562 cells is associated with surface up-modulation of TNFR2.

  Journal of cellular physiology 20120501

• Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells.

  Microvascular research 20120501

• Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.

  Pharmacology, biochemistry, and behavior 20120501

• Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis.

  Brain research 20120411

• Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways.

  Journal of applied toxicology : JAT 20120401

• Enhanced phosphorylation of MAPKs by NE promotes TNF-α production by macrophage through α adrenergic receptor.

  Inflammation 20120401

• IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells.

  Inflammation 20120401

• Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.

  Phytotherapy research : PTR 20120401

• Effects of c-Jun N-terminal kinase signaling pathway on severe acute pancreatitis-associated lung injury.

  Pancreas 20120401

• High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.

  The international journal of biochemistry & cell biology 20120401

• Daunorubicin induces cell death via activation of apoptotic signalling pathway and inactivation of survival pathway in muscle-derived stem cells.

  Cell biology and toxicology 20120401

• Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia.

  Biochimica et biophysica acta 20120401

• Cyclooxygenase-2 expression is up-regulated by 2-aminobiphenyl in a ROS and MAPK-dependent signaling pathway in a bladder cancer cell line.

  Chemical research in toxicology 20120319

• Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells.

  European journal of pharmacology 20120315

• Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model.

  Biochemical and biophysical research communications 20120302

• Involvement of calcium-sensing receptor in oxLDL-induced MMP-2 production in vascular smooth muscle cells via PI3K/Akt pathway.

  Molecular and cellular biochemistry 20120301

• Zinc oxide nanoparticles-induced intercellular adhesion molecule 1 expression requires Rac1/Cdc42, mixed lineage kinase 3, and c-Jun N-terminal kinase activation in endothelial cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20120301

• Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms.

  Carcinogenesis 20120301

• Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells.

  Toxicology and applied pharmacology 20120301

• P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.

  Free radical research 20120301

• Fructose-1,6-bisphosphate attenuates induction of nitric oxide synthase in microglia stimulated with lipopolysaccharide.

  Life sciences 20120227

• Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells.

  Toxicology letters 20120205

• Effect of donor JNK signal transduction inhibition on transplant outcome in brain dead rat model.

  Inflammation 20120201

• Quercetin supplementation suppresses the secretion of pro-inflammatory cytokines in the lungs of Mongolian gerbils and in A549 cells exposed to benzo[a]pyrene alone or in combination with β-carotene: in vivo and ex vivo studies.

  The Journal of nutritional biochemistry 20120201

• Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis.

  Inflammation 20120201

• Ischemia-induced stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransport involves p38 and JNK MAP kinases.

  American journal of physiology. Cell physiology 20120201

• Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage.

  Toxicology in vitro : an international journal published in association with BIBRA 20120201

• Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation.

  International journal of oncology 20120201

• Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies.

  Biochemical Society transactions 20120201

• SNP-induced apoptosis may be mediated with caspase inhibitor by JNK signaling pathways in rabbit articular chondrocytes.

  The Journal of toxicological sciences 20120201

• [Effect of expression of c-jun N-terminal kinase on neuron autophagy following diffuse brain injury in rats].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20120201

• Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells.

  Cancer letters 20120128

• Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20120115

• A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

  Toxicology and applied pharmacology 20120115

• c-Jun N-terminal kinase 2 phosphorylates endothelial nitric oxide synthase at serine 116 and regulates nitric oxide production.

  Biochemical and biophysical research communications 20120106

• Human foetal intestinal fibroblasts are hyper-responsive to lipopolysaccharide stimulation.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120101

• Involvement of JNK and NF-κB pathways in lipopolysaccharide (LPS)-induced BAG3 expression in human monocytic cells.

  Experimental cell research 20120101

• The dysregulation of the monocyte/macrophage effector function induced by isopropanol is mediated by the defective activation of distinct members of the AP-1 family of transcription factors.

  Toxicological sciences : an official journal of the Society of Toxicology 20120101

• Function of MAPK and downstream transcription factors in monomer-induced apoptosis.

  Biomaterials 20120101

• The saturated fatty acid palmitate induces human monocytic cell toxicity toward neuronal cells: exploring a possible link between obesity-related metabolic impairments and neuroinflammation.

  Journal of Alzheimer's disease : JAD 20120101

• Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells.

  Endocrinology 20120101

• SP600125 inhibits Orthopoxviruses replication in a JNK1/2 -independent manner: Implication as a potential antipoxviral.

  Antiviral research 20120101

• GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.

  PloS one 20120101

• miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene.

  PloS one 20120101

• Cyclin D1 induction preceding neuronal death via the excitotoxic NMDA pathway involves selective stimulation of extrasynaptic NMDA receptors and JNK pathway.

  Neuro-degenerative diseases 20120101

• Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.

  PloS one 20120101

• Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells.

  BMC research notes 20120101

• High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5.

  Molecular vision 20120101

• MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic smooth muscle cells.

  PloS one 20120101

• Curcumin enhances cytotoxic effects of bortezomib in human multiple myeloma H929 cells: potential roles of NF-κB/JNK.

  International journal of molecular sciences 20120101

• Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition.

  PloS one 20120101

• Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism.

  Journal of biomedicine & biotechnology 20120101

• Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells.

  The Journal of toxicological sciences 20120101

• Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer.

  PloS one 20120101

• [Effects of several inhibitors of intracellular signaling on production of cytokines and signal proteins in RAW 264.7 cells cultivated with low dose ammonium].

  Biofizika 20120101

• Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes.

  PloS one 20120101

• Mda-9/syntenin promotes human brain glioma migration through focal adhesion kinase (FAK)-JNK and FAK-AKT signaling.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• The apoptotic volume decrease is an upstream event of MAP kinase activation during Staurosporine-induced apoptosis in HeLa cells.

  International journal of molecular sciences 20120101

• Stressor-like effects of c-Jun N-terminal kinase (JNK) inhibition.

  PloS one 20120101

• Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)/calmodulin-dependent kinase II in retinal capillary endothelial cells.

  Molecular vision 20120101

• Green tea polyphenols induce p53-dependent and p53-independent apoptosis in prostate cancer cells through two distinct mechanisms.

  PloS one 20120101

• Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells.

  Blood cells, molecules & diseases 20111215

• Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells.

  Biochemical and biophysical research communications 20111202

• Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo.

  Journal of hepatology 20111201

• Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells.

  Biochimica et biophysica acta 20111201

• MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide.

  Biochimica et biophysica acta 20111201

• CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death.

  Journal of neurochemistry 20111201

• MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes.

  Placenta 20111201

• JNK inhibitors increase osteogenesis in Nf1-deficient cells.

  Bone 20111201

• Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization.

  Environmental science & technology 20111201

• Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide.

  Journal of endodontics 20111201

• Thymus peptides regulate activity of RAW 264.7 macrophage cells: inhibitory analysis and a role of signal cascades.

  Expert opinion on therapeutic targets 20111201

• Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.

  Journal of medicinal chemistry 20111124

• Ellipticine induces apoptosis in human endometrial cancer cells: the potential involvement of reactive oxygen species and mitogen-activated protein kinases.

  Toxicology 20111118

• Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death.

  Toxicology 20111118

• Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells.

  Chemico-biological interactions 20111115

• Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation.

  Journal of applied physiology (Bethesda, Md. : 1985) 20111101

• c-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice.

  Neuroscience research 20111101

• Thymosin β4 activates integrin-linked kinase and decreases endothelial progenitor cells apoptosis under serum deprivation.

  Journal of cellular physiology 20111101

• Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants.

  Bioorganic & medicinal chemistry 20111101

• The Ebolavirus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase.

  The Journal of infectious diseases 20111101

• FGF-2- and TGF-β1-induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway.

  Investigative ophthalmology & visual science 20111101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.

  The Journal of biological chemistry 20111021

• Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease.

  Chemical research in toxicology 20111017

• Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite.

  Toxicology letters 20111010

• Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species.

  Toxicology in vitro : an international journal published in association with BIBRA 20111001

• Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems.

  Glia 20111001

• Parathyroid hormone and the regulation of cell cycle in colon adenocarcinoma cells.

  Biochimica et biophysica acta 20111001

• JNK inhibition by SP600125 attenuates trans-10, cis-12 conjugated linoleic acid-mediated regulation of inflammatory and lipogenic gene expression.

  Lipids 20111001

• Fluvastatin enhances sorafenib cytotoxicity in melanoma cells via modulation of AKT and JNK signaling pathways.

  Anticancer research 20111001

• Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor.

  Journal of medicinal chemistry 20110922

• Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells.

  Biochemical and biophysical research communications 20110916

• Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes.

  British journal of pharmacology 20110901

• Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin.

  Journal of molecular medicine (Berlin, Germany) 20110901

• tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.

  Neurological research 20110901

• Arsenic increases lipopolysaccharide-dependent expression of interleukin-8 gene by stimulating a redox-sensitive pathway that strengthens p38-kinase activation.

  Molecular immunology 20110901

• Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.

  The Journal of biological chemistry 20110819

• Hepatocyte growth factor induces a proangiogenic phenotype and mobilizes endothelial progenitor cells by activating Nox2.

  Antioxidants & redox signaling 20110815

• Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells.

  Chemico-biological interactions 20110815

• Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis.

  Cancer biology & therapy 20110815

• MAPKs ERK and p38, but not JNK phosphorylation, modulate IL-6 and TNF-α secretion following OK-432 in vitro stimulation of purified human monocytes.

  Scandinavian journal of immunology 20110801

• Increased JNK1 activity contributes to the upregulation of ApoD in the apocrine secretory gland cells from axillary osmidrosis.

  Molecular and cellular biochemistry 20110801

• Critical role of c-Jun N-terminal kinase in regulating bFGF-induced angiogenesis in vitro.

  Journal of biochemistry 20110801

• A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells.

  Cancer biology & therapy 20110801

• P66Shc mediated ferritin degradation--a novel mechanism of ROS formation.

  Free radical biology & medicine 20110801

• Effects of downregulation of aquaporin1 by peptidoglycan and lipopolysaccharide via MAPK pathways in MeT-5A cells.

  Lung 20110801

• The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells.

  The Journal of biological chemistry 20110729

• Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride--a mechanism connected with activating JNK phosphorylation.

  Toxicology letters 20110728

• SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells.

  Stem cells and development 20110701

• 5-aminolevulinic acid induce apoptosis via NF-κB/JNK pathway in human oral cancer Ca9-22 cells.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20110701

• Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes.

  Molecular and cellular biochemistry 20110701

• ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers.

  American journal of physiology. Gastrointestinal and liver physiology 20110701

• Protective effects of SP600125 on renal ischemia-reperfusion injury in rats.

  The Journal of surgical research 20110701

• CXCL2 mediates lipopolysaccharide-induced osteoclastogenesis in RANKL-primed precursors.

  Cytokine 20110701

• Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.

  Biochimica et biophysica acta 20110701

• Identification of new inhibitors of protein kinase R guided by statistical modeling.

  Bioorganic & medicinal chemistry letters 20110701

• CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes.

  Biochemical and biophysical research communications 20110617

• Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradation.

  The Biochemical journal 20110615

• Toll-like receptor 2-mediated sequential activation of MyD88 and MAPKs contributes to lipopolysaccharide-induced sp-a gene expression in human alveolar epithelial cells.

  Immunobiology 20110601

• Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury.

  Shock (Augusta, Ga.) 20110601

• Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin.

  Experimental neurology 20110601

• The signalling axis mediating neuronal apoptosis in response to [Pt(O,O'-acac)(γ-acac)(DMS)].

  Biochemical pharmacology 20110601

• Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-mediated Jun N-terminal kinase activation.

  Biochimica et biophysica acta 20110601

• Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

  Toxicology and applied pharmacology 20110601

• Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells.

  Journal of dermatological science 20110601

• Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.

  Biochimica et biophysica acta 20110601

• Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression.

  Toxicology letters 20110530

• Targeting the JNK signaling pathway potentiates the antiproliferative efficacy of rapamycin in LS174T colon cancer cells.

  The Journal of surgical research 20110515

• Virtual screening and further development of novel ALK inhibitors.

  Bioorganic & medicinal chemistry 20110515

• Activation of the JNK pathway by nanosecond pulsed electric fields.

  Biochemical and biophysical research communications 20110513

• Cinnamaldehyde enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression in HepG2 cells.

  Journal of agricultural and food chemistry 20110511

• Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells.

  Biochimica et biophysica acta 20110501

• Regulation of JNK activity in the apoptotic response of intestinal epithelial cells.

  American journal of physiology. Gastrointestinal and liver physiology 20110501

• Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles.

  Journal of immunology (Baltimore, Md. : 1950) 20110501

• c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle.

  Yonsei medical journal 20110501

• Interference of the apoptotic signaling pathway in RGC stress response by SP600125 in moderate ocular hypertensive rats.

  The Chinese journal of physiology 20110430

• Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.

  Science (New York, N.Y.) 20110415

• 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected].

  European journal of pharmacology 20110410

• p,p'-Dichlorodiphenoxydichloroethylene induced apoptosis of Sertoli cells through oxidative stress-mediated p38 MAPK and mitochondrial pathway.

  Toxicology letters 20110410

• Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells.

  Digestive diseases and sciences 20110401

• Fluid shear stress induces renal epithelial gene expression through polycystin-2-dependent trafficking of extracellular regulated kinase.

  Nephron. Physiology 20110401

• Lithospermic acid B protects β-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1.

  Toxicology and applied pharmacology 20110401

• Insulin-induced oxidative stress up-regulates heme oxygenase-1 via diverse signaling cascades in the C2 skeletal myoblast cell line.

  Endocrinology 20110401

• Role of c-Jun N-terminal kinase activation in blastema formation during planarian regeneration.

  Development, growth & differentiation 20110401

• Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells.

  Biochemical and biophysical research communications 20110318

• Cadmium induces phosphorylation and stabilization of c-Fos in HK-2 renal proximal tubular cells.

  Toxicology and applied pharmacology 20110315

• Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.

  Bioorganic & medicinal chemistry 20110315

• Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.

  European journal of pharmacology 20110311

• Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway.

  Archives of toxicology 20110301

• Preantral follicle growth is regulated by c-Jun-N-terminal kinase (JNK) pathway.

  Reproductive sciences (Thousand Oaks, Calif.) 20110301

• Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1-42) associated with decrease of apoptotic factors.

  Behavioural brain research 20110301

• Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.

  Carcinogenesis 20110301

• Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway.

  Archives of biochemistry and biophysics 20110215

• JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201

• Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.

  Apoptosis : an international journal on programmed cell death 20110201

• Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells.

  Oncology reports 20110201

• Targeting transcription through inhibition of TBP.

  Oncotarget 20110201

• α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways.

  British journal of cancer 20110104

• Mitogen-activated protein kinase inhibitors improve heart function and prevent fibrosis in cardiomyopathy caused by mutation in lamin A/C gene.

  Circulation 20110104

• Fluid shear stress-induced JNK activity leads to actin remodeling for cell alignment.

  Journal of cellular physiology 20110101

• Gefitinib-induced epidermal growth factor receptor-independent keratinocyte apoptosis is mediated by the JNK activation pathway.

  The British journal of dermatology 20110101

• Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.

  Toxicology and applied pharmacology 20110101

• Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons.

  British journal of pharmacology 20110101

• Enteral arginine modulates inhibition of AP-1/c-Jun by SP600125 in the postischemic gut.

  Molecular and cellular biochemistry 20110101

• Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury.

  Journal of gastroenterology and hepatology 20110101

• The sequential combination of a JNK inhibitor and simvastatin protects porcine islets from peritransplant apoptosis and inflammation.

  Cell transplantation 20110101

• SP600125 inhibits cap-dependent translation independently of the c-Jun N-terminal kinase pathway.

  Cell structure and function 20110101

• [Effect of JNK pathway in apoptosis of PC12 cell by MPP+].

  Wei sheng yan jiu = Journal of hygiene research 20110101

• Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.

  Archives of pharmacal research 20110101

• Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells.

  BMC cancer 20110101

• Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension.

  Molecular vision 20110101

• Tumor necrosis factor-α enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells.

  Journal of biomedical science 20110101

• Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase.

  Mediators of inflammation 20110101

• CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.

  Arthritis research & therapy 20110101

• Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.

  PloS one 20110101

• Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice.

  Molecular medicine (Cambridge, Mass.) 20110101

• Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism.

  Cancer cell international 20110101

• Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells.

  Journal of neuroinflammation 20110101

• Resveratrol inhibits Cdk5 activity through regulation of p35 expression.

  Molecular pain 20110101

• Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response.

  Journal of biomedical science 20110101

• Unfertilized Xenopus eggs die by Bad-dependent apoptosis under the control of Cdk1 and JNK.

  PloS one 20110101

• Stretch-inducible expression of connective tissue growth factor (CTGF) in human osteoblasts-like cells is mediated by PI3K-JNK pathway.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Coordinated regulation of ATF2 by miR-26b in γ-irradiated lung cancer cells.

  PloS one 20110101

• c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells.

  Journal of translational medicine 20110101

• Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.

  PloS one 20110101

• Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways.

  Toxicology letters 20101215

• Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress.

  Free radical biology & medicine 20101215

• Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway.

  Journal of immunology (Baltimore, Md. : 1950) 20101215

• Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase.

  Cancer research 20101215

• p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation.

  Cell death and differentiation 20101201

• JNK-mediated transcriptional upregulation of RhoB is critical for apoptosis of HCT-116 colon cancer cells by a novel diarylsulfonylurea derivative.

  Apoptosis : an international journal on programmed cell death 20101201

• Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK.

  Toxicology and applied pharmacology 20101115

• Induction of DNA damage-inducible gene GADD45beta contributes to sorafenib-induced apoptosis in hepatocellular carcinoma cells.

  Cancer research 20101115

• Resveratrol enhances NK cell cytotoxicity: possible role for aryl hydrocarbon receptor.

  Journal of cellular physiology 20101101

• DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells.

  Cancer letters 20101101

• Icaritin induces apoptosis of HepG2 cells via the JNK1 signaling pathway independent of the estrogen receptor.

  Planta medica 20101101

• The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy.

  Journal of pineal research 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats.

  Brain research 20101021

• The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells.

  Toxicology letters 20101020

• Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes.

  Toxicology 20101009

• 3-Caffeoyl, 4-dihydrocaffeoylquinic acid from Salicornia herbacea inhibits tumor cell invasion by regulating protein kinase C-delta-dependent matrix metalloproteinase-9 expression.

  Toxicology letters 20101005

• SP600125, a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive deficit and oxidative stress in rats.

  Pharmacology, biochemistry, and behavior 20101001

• MCP-1 production in temporomandibular joint inflammation.

  Journal of dental research 20101001

• [Simvastatin suppress lipopolysaccharides induced upregulation of lipoprotein associated phospholipase A(2) expression in macrophages via inactivation of p38MAPK pathway].

  Zhonghua xin xue guan bing za zhi 20101001

• The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells.

  FEBS letters 20100924

• Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100901

• Lipid soluble smoke particles upregulate endothelin receptors in rat basilar artery.

  Toxicology letters 20100901

• Negative modulation of invariant natural killer T cell responses to glycolipid antigens by p38 MAP kinase.

  International immunopharmacology 20100901

• Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion.

  Molecular carcinogenesis 20100901

• Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100901

• Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen.

  Die Pharmazie 20100901

• HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity.

  Journal of cellular and molecular medicine 20100801

• Pyrogallol-induced As4.1 juxtaglomerular cell death is attenuated by MAPK inhibitors via preventing GSH depletion.

  Archives of toxicology 20100801

• Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis.

  Free radical biology & medicine 20100801

• JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells.

  Cytokine 20100801

• Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100801

• Effect of hyperthermia in combination with TRAIL on the JNK-Bim signal transduction pathway and growth of xenograft tumors.

  Journal of cellular biochemistry 20100801

• The mechanism of fucoidan-induced apoptosis in leukemic cells: involvement of ERK1/2, JNK, glutathione, and nitric oxide.

  Molecular carcinogenesis 20100801

• Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.

  British journal of pharmacology 20100801

• N-acetylcysteine protects alveolar epithelial cells from hydrogen peroxide-induced apoptosis through scavenging reactive oxygen species and suppressing c-Jun N-terminal kinase.

  Experimental lung research 20100801

• Control of TrkA-induced cell death by JNK activation and differential expression of TrkA upon DNA damage.

  Molecules and cells 20100801

• 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.

  World journal of gastroenterology 20100721

• Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopamine receptor type 4.

  European heart journal 20100701

• Rolipram and SP600125 suppress the early increase in PTP1B expression during cerulein-induced pancreatitis in rats.

  Pancreas 20100701

• Mycophenolic acid attenuates tumor necrosis factor-alpha-induced endothelin-1 production in human aortic endothelial cells.

  Atherosclerosis 20100701

• Down-expression of PGC-1alpha partially mediated by JNK/c-Jun through binding to CRE site during apoptotic procedure in cerebellar granule neurons.

  Journal of neuroscience research 20100701

• Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis.

  Journal of neuroscience research 20100701

• Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways.

  Journal of cellular physiology 20100701

• Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion.

  Toxicological sciences : an official journal of the Society of Toxicology 20100701

• JNK inhibition arrests cotranslational degradation.

  Biochimica et biophysica acta 20100701

• Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100701

• c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.

  Toxicology and applied pharmacology 20100701

• PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.

  American journal of physiology. Heart and circulatory physiology 20100701

• Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.

  Endocrinology 20100701

• Protein tyrosine kinase pathway-derived ROS/NO productions contribute to G2/M cell cycle arrest in evodiamine-treated human cervix carcinoma HeLa cells.

  Free radical research 20100701

• Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor.

  Endocrinology 20100701

• Mechanisms of IL-12 synthesis by human dendritic cells treated with the chemical sensitizer NiSO4.

  Journal of immunology (Baltimore, Md. : 1950) 20100701

• The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions.

  Cell biochemistry and function 20100701

• p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17.

  The Journal of biological chemistry 20100625

• Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms.

  Biochemical pharmacology 20100615

• Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide.

  Toxicology and applied pharmacology 20100615

• Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells.

  European journal of pharmacology 20100610

• Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration.

  Blood 20100610

• The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP.

  Chemico-biological interactions 20100607

• Suppression of the androgen receptor function by quercetin through protein-protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells.

  Molecular and cellular biochemistry 20100601

• Manganese-mediated up-regulation of HIF-1alpha protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Deferoxamine mesylate is toxic for retinal pigment epithelium cells in vitro, and its toxicity is mediated by p38.

  Cutaneous and ocular toxicology 20100601

• JNK pathway is required for TNCB-induced IL-18 expression in murine keratinocytes.

  Toxicology in vitro : an international journal published in association with BIBRA 20100601

• Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage.

  Cardiovascular toxicology 20100601

• The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.

  Journal of endodontics 20100601

• Inhibition of the JNK signal cascade conserves hearing against electrode insertion trauma-induced loss.

  Cochlear implants international 20100601

• Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death.

  Toxicology letters 20100519

• Mycophenolic acid inhibits the phosphorylation of NF-kappaB and JNKs and causes a decrease in IL-8 release in H2O2-treated human renal proximal tubular cells.

  Chemico-biological interactions 20100514

• Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways.

  Journal of cellular physiology 20100501

• Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways.

  Atherosclerosis 20100501

• Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway.

  International journal of hematology 20100501

• Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100501

• SP600125, an inhibitor of c-Jun NH2-terminal kinase, blocks expression of angiotensin II-induced monocyte chemoattractant protein-1 in human mesangial cells.

  World journal of pediatrics : WJP 20100501

• TNF-alpha reduces the Na+/K+ ATPase activity in LLC-PK1 cells by activating caspases and JNK and inhibiting NF-kappaB.

  Cell biology international 20100427

• Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts.

  Toxicology and applied pharmacology 20100415

• Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes.

  Toxicology and applied pharmacology 20100415

• Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic beta-cell line.

  Regulatory peptides 20100409

• The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes.

  Leukemia research 20100401

• Betacellulin protects from pancreatitis by activating stress-activated protein kinase.

  Gastroenterology 20100401

• Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways.

  Molecular pharmacology 20100401

• Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway.

  Toxicological sciences : an official journal of the Society of Toxicology 20100401

• Peritonitis-induced peroxynitrite and lung damage depends on c-Jun NH2-terminal kinase signaling of hematopoietic cells.

  Critical care medicine 20100401

• Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR.

  Molecular oncology 20100401

• Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.

  The Journal of toxicological sciences 20100401

• Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells.

  Journal of periodontal research 20100401

• Proinflammatory effects of muramyldipeptide on human gingival fibroblasts.

  Journal of periodontal research 20100401

• Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation.

  Chemico-biological interactions 20100330

• Bisphenol A-induced aromatase activation is mediated by cyclooxygenase-2 up-regulation in rat testicular Leydig cells.

  Toxicology letters 20100315

• Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro.

  Neuroscience letters 20100303

• Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.

  Biochemistry 20100302

• Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.

  Cell death and differentiation 20100301

• Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.

  Neuroscience research 20100301

• Estradiol protects the cochlea against gentamicin ototoxicity through inhibition of the JNK pathway.

  Hearing research 20100301

• Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3.

  Endocrinology 20100301

• Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1.

  Free radical research 20100301

• Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.

  Cancer letters 20100227

• Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway.

  Chemico-biological interactions 20100212

• Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10.

  The Journal of biological chemistry 20100205

• Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation.

  Toxicology in vitro : an international journal published in association with BIBRA 20100201

• Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling.

  Molecular carcinogenesis 20100201

• Mechanisms involved in ultrafine carbon black-induced release of IL-6 from primary rat epithelial lung cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100201

• Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS.

  Cellular and molecular life sciences : CMLS 20100201

• Inhibition of Foxo1 mediates protective effects of ghrelin against lipotoxicity in MIN6 pancreatic beta-cells.

  Peptides 20100201

• Effects of UVA on TNF-alpha, IL-1beta, and IL-10 expression levels in human keratinocytes and intervention studies with an antioxidant and a JNK inhibitor.

  Photodermatology, photoimmunology & photomedicine 20100201

• Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death.

  Cell death & disease 20100201

• Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts.

  Experimental & molecular medicine 20100131

• Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species.

  Oncogene 20100128

• Calcium-stimulated mitogen-activated protein kinase activation elicits Bcl-xL downregulation and Bak upregulation in notexin-treated human neuroblastoma SK-N-SH cells.

  Journal of cellular physiology 20100101

• Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition.

  Gastroenterology 20100101

• Gene regulation of CYP4F11 in human keratinocyte HaCaT cells.

  Drug metabolism and disposition: the biological fate of chemicals 20100101

• c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways.

  Veterinary research 20100101

• JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells.

  American journal of physiology. Gastrointestinal and liver physiology 20100101

• Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line.

  Toxicological sciences : an official journal of the Society of Toxicology 20100101

• (-)-Epigallocatechin-3-gallate decreases thrombin/paclitaxel-induced endothelial tissue factor expression via the inhibition of c-Jun terminal NH2 kinase phosphorylation.

  Biochemical and biophysical research communications 20100101

• Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity.

  Frontiers in bioscience (Elite edition) 20100101

• Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors.

  Molecular pain 20100101

• Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils.

  Journal of inflammation (London, England) 20100101

• Induction of LRF-1/ATF3 by vasopressin in hepatocytes: role of MAP kinases.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Inhibition of c-Jun N-terminal kinase by SP600125: a cDNA microarray analysis.

  Cancer genomics & proteomics 20100101

• Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.

  Biochimica et biophysica acta 20100101

• Resveratrol differentially modulates inflammatory responses of microglia and astrocytes.

  Journal of neuroinflammation 20100101

• Protective role of taurine against arsenic-induced mitochondria-dependent hepatic apoptosis via the inhibition of PKCdelta-JNK pathway.

  PloS one 20100101

• Doxorubicin induces apoptosis in H9c2 cardiomyocytes: role of overexpressed eukaryotic translation initiation factor 5A.

  Biological & pharmaceutical bulletin 20100101

• Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.

  Molecular cancer 20100101

• Ligand-independent activation of the androgen receptor by insulin-like growth factor-I and the role of the MAPK pathway in skeletal muscle cells.

  Molecules and cells 20091231

• NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance.

  Neuroscience letters 20091225

• Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.

  Biochemistry 20091222

• Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.

  Journal of neuro-oncology 20091201

• Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells.

  Biochimica et biophysica acta 20091201

• Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent.

  Biology of reproduction 20091201

• c-Jun NH2-terminal kinase is crucially involved in renal tubulo-interstitial inflammation.

  The Journal of pharmacology and experimental therapeutics 20091201

• ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation.

  Free radical biology & medicine 20091201

• Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.

  American journal of physiology. Heart and circulatory physiology 20091201

• Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation.

  Endocrinology 20091201

• Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction.

  Endocrinology 20091201

• Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK.

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20091201

• Triclosan inhibits tumor necrosis factor-alpha-stimulated urokinase production in human gingival fibroblasts.

  Journal of periodontal research 20091201

• Abeta(31-35)-induced neuronal apoptosis is mediated by JNK-dependent extrinsic apoptosis pathway.

  Neuroscience bulletin 20091201

• Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells.

  Molecular cancer therapeutics 20091201

• c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines.

  European journal of oral sciences 20091201

• Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.

  The Journal of biological chemistry 20091127

• Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs.

  Journal of immunology (Baltimore, Md. : 1950) 20091115

• HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products.

  Journal of immunology (Baltimore, Md. : 1950) 20091115

• Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20091101

• Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production.

  American journal of respiratory and critical care medicine 20091101

• Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression.

  British journal of pharmacology 20091101

• Glucose-regulated protein 78 inhibits scavenger receptor A-mediated internalization of acetylated low density lipoprotein.

  Journal of molecular and cellular cardiology 20091101

• Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy.

  American journal of physiology. Gastrointestinal and liver physiology 20091101

• JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease.

  Journal of the neurological sciences 20091015

• Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells.

  Archives of biochemistry and biophysics 20091015

• Tpl2 is a key mediator of arsenite-induced signal transduction.

  Cancer research 20091015

• PDGF stimulation of Müller cell proliferation: Contributions of c-JNK and the PI3K/Akt pathway.

  Biochemical and biophysical research communications 20091009

• Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice.

  Journal of reproductive immunology 20091001

• JNK-dependent NFATc1 pathway positively regulates IL-13 gene expression induced by (-)-epigallocatechin-3-gallate in human basophilic KU812 cells.

  Free radical biology & medicine 20091001

• Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells.

  Prostaglandins, leukotrienes, and essential fatty acids 20091001

• Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway.

  Toxicology and applied pharmacology 20091001

• Anti-apoptotic action of hydrogen sulfide is associated with early JNK inhibition.

  Cell biology international 20091001

• Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation.

  Journal of cellular biochemistry 20091001

• Ketoconazole-induced JNK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20091001

• Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells.

  Biochimica et biophysica acta 20091001

• Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes.

  Molecular immunology 20091001

• A JNK inhibitor SP600125 induces defective cytokinesis and enlargement in P19 embryonal carcinoma cells.

  Cell biochemistry and function 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• [Effects of sp600125 on acetaldehyde stimulated hepatic stellate cells].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20091001

• JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis.

  Experimental & molecular medicine 20090930

• SP600125, an inhibitor of Jnk pathway, reduces viability of relatively resistant cancer cells to doxorubicin.

  Biochemical and biophysical research communications 20090925

• JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis.

  The Journal of biological chemistry 20090925

• 1,3-Dinitrobenzene induces apoptosis in TM4 mouse Sertoli cells: Involvement of the c-Jun N-terminal kinase (JNK) MAPK pathway.

  Toxicology letters 20090910

• FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling.

  FEBS letters 20090903

• Silencing of TNF-alpha receptors coordinately suppresses TNF-alpha expression through NF-kappaB activation blockade in THP-1 macrophage.

  FEBS letters 20090903

• Interferon-gamma priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages.

  Immunology 20090901

• Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways.

  Molecular biology reports 20090901

• Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin.

  Oral oncology 20090901

• Biphasic effect of cadmium on cell proliferation in human embryo lung fibroblast cells and its molecular mechanism.

  Toxicology in vitro : an international journal published in association with BIBRA 20090901

• Involvement of C-jun NH2-terminal kinase and apoptosis induced factor in apoptosis induced by deglycosylated bleomycin in laryngeal carcinoma cells.

  Cell biology international 20090901

• Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.

  Hepatology (Baltimore, Md.) 20090901

• Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression.

  American journal of physiology. Cell physiology 20090901

• The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090901

• Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death.

  Molecular cancer research : MCR 20090901

• [Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20090901

• Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1.

  Toxicology 20090821

• Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells.

  Toxicology letters 20090810

• Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line.

  Environmental toxicology 20090801

• Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells.

  Biochimica et biophysica acta 20090801

• Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis.

  Biochemical pharmacology 20090801

• Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway.

  European journal of pharmacology 20090801

• Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema.

  American journal of physiology. Lung cellular and molecular physiology 20090801

• Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.

  Annals of the New York Academy of Sciences 20090801

• Ginkgolide B induces apoptosis via activation of JNK and p21-activated protein kinase 2 in mouse embryonic stem cells.

  Annals of the New York Academy of Sciences 20090801

• Gallic acid induces neuronal cell death through activation of c-Jun N-terminal kinase and downregulation of Bcl-2.

  Annals of the New York Academy of Sciences 20090801

• Cobalt protoporphyrin inhibition of lipopolysaccharide or lipoteichoic acid-induced nitric oxide production via blocking c-Jun N-terminal kinase activation and nitric oxide enzyme activity.

  Chemico-biological interactions 20090715

• Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells.

  Toxicology 20090710

• Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes.

  Molecular and cellular biochemistry 20090701

• Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.

  Journal of cellular physiology 20090701

• Upregulation of proinflammatory cytokines and NO production in BV-activated avian macrophage-like cell line (HD11) requires MAPK and NF-kappaB pathways.

  International immunopharmacology 20090701

• Block-copolymer micelles as carriers of cell signaling modulators for the inhibition of JNK in human islets of Langerhans.

  Biomaterials 20090701

• Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.

  Carcinogenesis 20090701

• Blocking UV-induced eIF2alpha phosphorylation with small molecule inhibitors of GCN2.

  Chemical biology & drug design 20090701

• JNK/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20090701

• Cadmium stimulates the expression of vascular cell adhesion molecule-1 (VCAM-1) via p38 mitogen-activated protein kinase (MAPK) and JNK activation in cerebrovascular endothelial cells.

  Journal of pharmacological sciences 20090701

• Effects of polychlorinated biphenyls on the neutrophil NADPH oxidase system.

  Toxicology letters 20090622

• NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells.

  Toxicology letters 20090622

• Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells.

  The Journal of biological chemistry 20090619

• Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes.

  Free radical biology & medicine 20090615

• Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells.

  Toxicology and applied pharmacology 20090615

• Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination.

  Toxicology and applied pharmacology 20090615

• Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy.

  Fertility and sterility 20090601

• Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway.

  The international journal of biochemistry & cell biology 20090601

• The inhibition of JNK and p38 MAPKs downregulates IL-10 and differentially affects c-Jun gene expression in human monocytes.

  Immunopharmacology and immunotoxicology 20090601

• Inhibition of uncoupling protein 2 by genipin reduces insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

  Archives of biochemistry and biophysics 20090601

• The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.

  The Journal of pharmacology and experimental therapeutics 20090601

• Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma.

  Hepatology (Baltimore, Md.) 20090601

• Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.

  The Journal of clinical investigation 20090601

• Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.

  Journal of immunotoxicology 20090601

• PHR regulates growth cone pausing at intermediate targets through microtubule disassembly.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090520

• Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity.

  Free radical biology & medicine 20090515

• Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent.

  Toxicology and applied pharmacology 20090515

• Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression.

  Cancer chemotherapy and pharmacology 20090501

• JNK and p38 MAPK are independently involved in tributyltin-mediated cell death in rainbow trout (Oncorhynchus mykiss) RTG-2 cells.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090501

• JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

  Gut 20090501

• Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.

  The Journal of biological chemistry 20090501

• JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125.

  The Journal of pathology 20090501

• Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase.

  Journal of gastroenterology and hepatology 20090501

• NaF activates MAPKs and induces apoptosis in odontoblast-like cells.

  Journal of dental research 20090501

• Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media.

  Experimental & molecular medicine 20090430

• Inhibition of JNK enhances TGF-beta1-activated Smad2 signaling in mouse embryonic lung.

  Pediatric research 20090401

• Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells.

  The Journal of pharmacology and experimental therapeutics 20090401

• The TAK1-JNK cascade is required for IRF3 function in the innate immune response.

  Cell research 20090401

• Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.

  Neurobiology of disease 20090401

• N-acetyl cysteine mediates protection from 2-hydroxyethyl methacrylate induced apoptosis via nuclear factor kappa B-dependent and independent pathways: potential involvement of JNK.

  Toxicological sciences : an official journal of the Society of Toxicology 20090401

• TGF-beta effects on airway smooth muscle cell proliferation, VEGF release and signal transduction pathways.

  Respirology (Carlton, Vic.) 20090401

• Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways.

  Placenta 20090401

• Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling.

  American journal of physiology. Cell physiology 20090401

• A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.

  Nature neuroscience 20090401

• Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts.

  International journal of molecular medicine 20090401

• Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway.

  The FEBS journal 20090401

• Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry.

  Neuroscience 20090331

• Angiotensin II induces MMP 2 activity via FAK/JNK pathway in human endothelial cells.

  Biochemical and biophysical research communications 20090320

• Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.

  Free radical biology & medicine 20090315

• Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress.

  FEBS letters 20090304

• Glial fibrillary acidic protein promoter targets pancreatic stellate cells.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090301

• Role of mitogen-activated protein kinase cascades in inducible nitric oxide synthase expression by lipopolysaccharide in a rat Schwann cell line.

  Neurochemical research 20090301

• Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation.

  Clinica chimica acta; international journal of clinical chemistry 20090301

• Metallic haptens induce differential phenotype of human dendritic cells through activation of mitogen-activated protein kinase and NF-kappaB pathways.

  Toxicology in vitro : an international journal published in association with BIBRA 20090301

• Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway.

  Journal of biochemistry 20090301

• Sanguinarine induces apoptosis in A549 human lung cancer cells primarily via cellular glutathione depletion.

  Toxicology in vitro : an international journal published in association with BIBRA 20090301

• Regulation of endothelin-1-induced interleukin-6 production by Ca2+ influx in human airway smooth muscle cells.

  European journal of pharmacology 20090301

• TNF-alpha reduces the level of Staphylococcus epidermidis internalization by bovine endothelial cells.

  FEMS microbiology letters 20090301

• C-jun N-terminal kinase-mediated signaling is essential for Staphylococcus aureus-induced U937 apoptosis.

  Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20090301

• Role of MAPKs in platinum-induced neuronal apoptosis.

  Neurotoxicology 20090301

• The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells.

  Oncogene 20090212

• Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivation.

  Amino acids 20090201

• Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B.

  Journal of cellular physiology 20090201

• Differential roles of MAPKs and MSK1 signalling pathways in the regulation of c-Jun during phenylephrine-induced cardiac myocyte hypertrophy.

  Molecular and cellular biochemistry 20090201

• c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer.

  Carcinogenesis 20090201

• Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.

  American journal of physiology. Gastrointestinal and liver physiology 20090201

• Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway.

  Biomedical and environmental sciences : BES 20090201

• SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression.

  FEBS letters 20090105

• 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells.

  Journal of vascular research 20090101

• TNF-alpha production in the skin.

  Archives of dermatological research 20090101

• Enhanced induction of LPS-induced fibroblast MCP-1 by interferon-gamma: involvement of JNK and MAPK phosphatase-1.

  Cellular immunology 20090101

• AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.

  Virus research 20090101

• Oxidative stress resistance through blocking Hsp60 translocation followed by SAPK/JNK inhibition in aged human diploid fibroblasts.

  Cell biochemistry and function 20090101

• Induction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinase.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090101

• Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes.

  Journal of pharmacological sciences 20090101

• Activation of c-Jun N-terminal kinase cascades is involved in part of the neuronal degeneration induced by trimethyltin in cortical neurons of mice.

  Journal of pharmacological sciences 20090101

• Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways.

  Molecular vision 20090101

• Cisplatin primes murine peritoneal macrophages for enhanced expression of nitric oxide, proinflammatory cytokines, TLRs, transcription factors and activation of MAP kinases upon co-incubation with L929 cells.

  Immunobiology 20090101

• The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea.

  The Journal of international medical research 20090101

• The JNK pathway amplifies and drives subcellular changes in tau phosphorylation.

  Neuropharmacology 20090101

• Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.

  PloS one 20090101

• The proliferation and migration effects of huangqi on RSC96 Schwann cells.

  The American journal of Chinese medicine 20090101

• Protective effects of SP600125 in a diet-induced rat model of non-alcoholic steatohepatitis.

  Scandinavian journal of gastroenterology 20090101

• Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin.

  Experimental & molecular medicine 20081231

• Cardiotrophin-1 induces intercellular adhesion molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells.

  Chinese medical journal 20081220

• Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation.

  Cancer research 20081215

• Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements.

  Molecular and cellular biochemistry 20081201

• Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells.

  Cell biology international 20081201

• Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.

  Neuropharmacology 20081201

• o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways.

  Toxicology and applied pharmacology 20081201

• Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: possible implications for GAI pathogenesis.

  Neurobiology of disease 20081201

• In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway.

  Apoptosis : an international journal on programmed cell death 20081201

• Phosphatidylinositol acts through mitogen-activated protein kinase to stimulate hepatic apolipoprotein A-I secretion.

  Metabolism: clinical and experimental 20081201

• [Impact of PTEN gene knockout in human breast carcinoma MCF-7 cells on activity of JNK pathway].

  Ai zheng = Aizheng = Chinese journal of cancer 20081201

• [The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081201

• Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells.

  Journal of endocrinological investigation 20081201

• JNK1 regulates histone acetylation in trigeminal neurons following chemical stimulation.

  Biochemical and biophysical research communications 20081128

• Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells.

  FEBS letters 20081126

• Virtual screening to successfully identify novel janus kinase 3 inhibitors: a sequential focused screening approach.

  Journal of medicinal chemistry 20081113

• Selenium attenuates pro-inflammatory gene expression in macrophages.

  Molecular nutrition & food research 20081101

• Egr-1 mRNA induction by medium flow involves mRNA stabilization and is enhanced by the p38 inhibitor SB203580 in osteoblast-like cells.

  Acta physiologica (Oxford, England) 20081101

• Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II.

  Journal of cellular physiology 20081101

• IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.

  Journal of cellular physiology 20081101

• Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition.

  Gut 20081101

• Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line.

  Experimental cell research 20081101

• Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling.

  The Journal of steroid biochemistry and molecular biology 20081101

• Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissues.

  Spine 20081101

• Activation of peripheral ephrinBs/EphBs signaling induces hyperalgesia through a MAPKs-mediated mechanism in mice.

  Pain 20081031

• Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1.

  The Journal of biological chemistry 20081031

• IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells.

  Immunology letters 20081030

• The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells.

  Journal of cellular physiology 20081001

• (-)-Epigallocatechin gallate inhibits basic fibroblast growth factor-stimulated interleukin-6 synthesis in osteoblasts.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081001

• Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro.

  Histochemistry and cell biology 20081001

• TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.

  Cancer investigation 20081001

• The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.

  Molecular pharmacology 20081001

• A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines.

  Leukemia 20081001

• Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5.

  Free radical biology & medicine 20081001

• A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation.

  Lung cancer (Amsterdam, Netherlands) 20080901

• Proinflammatory effect of sodium 4-phenylbutyrate in deltaF508-cystic fibrosis transmembrane conductance regulator lung epithelial cells: involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-terminal kinase signaling.

  The Journal of pharmacology and experimental therapeutics 20080901

• 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20080829

• Activation of endothelial cells to pathological status by down-regulation of connexin43.

  Cardiovascular research 20080801

• Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080801

• Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.

  The Biochemical journal 20080801

• Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.

  The Journal of biological chemistry 20080801

• Characterization of early events involved in human dendritic cell maturation induced by sensitizers: cross talk between MAPK signalling pathways.

  Toxicology and applied pharmacology 20080801

• The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: implications in Parkinson's disease.

  Neuroscience research 20080801

• JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis.

  Pigment cell & melanoma research 20080801

• BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn.

  Experimental neurology 20080801

• Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart.

  The Journal of experimental biology 20080801

• Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases.

  Oncology reports 20080801

• P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state.

  FEBS letters 20080723

• Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK.

  The Journal of nutritional biochemistry 20080701

• Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3',5'-cyclic adenosine 5'-monophosphate response element-binding protein and the generation of reactive oxygen species.

  Endocrinology 20080701

• JNK as a positive regulator of angiogenic potential in endothelial cells.

  Cell biology international 20080701

• Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors.

  American journal of physiology. Heart and circulatory physiology 20080701

• c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice.

  Cancer research 20080701

• Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms.

  Molecular cancer therapeutics 20080701

• Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells.

  Experimental & molecular medicine 20080630

• Bcl-2 overexpression attenuates SP600125-induced apoptosis in human leukemia U937 cells.

  Cancer letters 20080618

• The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080601

• Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts.

  Toxicological sciences : an official journal of the Society of Toxicology 20080601

• Prevotella intermedia induces matrix metalloproteinase-9 expression in human periodontal ligament cells.

  FEMS microbiology letters 20080601

• Transforming growth factor {beta}1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20080601

• 25-hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3beta in PC12 cells.

  Free radical research 20080601

• Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are not appropriate tools for studies of drug metabolism because they activate aryl hydrocarbon receptor.

  General physiology and biophysics 20080601

• [Redox-dependent regulation of apoptosis as a function of intracellular reactive oxygen species in oxidative stress].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20080601

• Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury.

  The Journal of biological chemistry 20080516

• JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro.

  American journal of physiology. Endocrinology and metabolism 20080501

• Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.

  Laboratory investigation; a journal of technical methods and pathology 20080501

• Cruzipain and SP600125 induce p38 activation, alter NO/arginase balance and favor the survival of Trypanosoma cruzi in macrophages.

  Acta tropica 20080501

• In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity.

  Anesthesia and analgesia 20080501

• The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells.

  Cancer biology & therapy 20080501

• Role of recombinant mitogen-activated protein kinases JNK and p38 in the regulation of apoptosis in blood mononuclear cells under conditions of oxidative stress in vitro.

  Bulletin of experimental biology and medicine 20080501

• Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells.

  Toxicology 20080418

• Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells.

  Toxicology and applied pharmacology 20080415

• Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

  Bioorganic & medicinal chemistry 20080415

• MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis.

  Journal of neurochemistry 20080401

• Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats.

  Biochimica et biophysica acta 20080401

• Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively.

  The FEBS journal 20080401

• Anti-fas activating antibody enhances trophoblast outgrowth on endometrial epithelial cells by induction of P38 MAPK/JNK-mediated apoptosis.

  Placenta 20080401

• Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts.

  Free radical research 20080401

• Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20080401

• [Effect of staurosporine induced apoptosis of MCF7/GFP-Bax stable cell line on Bax translocation from cytosol into mitochondria].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080401

• Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS.

  Innate immunity 20080401

• Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD.

  Toxicology and applied pharmacology 20080315

• Cytotoxic effects of metal protoporphyrins in glioblastoma cells: roles of albumin, reactive oxygen species, and heme oxygenase-1.

  Toxicology letters 20080315

• Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenström's macroglobulinemia.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080315

• Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080301

• The role of redox-sensitive transcription factors NF-kappaB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper.

  Free radical biology & medicine 20080301

• Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice.

  Hepatology (Baltimore, Md.) 20080301

• Mycoplasma genitalium-derived lipid-associated membrane proteins induce activation of MAPKs, NF-kappaB and AP-1 in THP-1 cells.

  FEMS immunology and medical microbiology 20080301

• Blockade of c-Jun N-terminal kinase activation abrogates hyperglycemia-induced yolk sac vasculopathy in vitro.

  American journal of obstetrics and gynecology 20080301

• Role of mitogen-activated protein kinases in the iNOS production and cytokine secretion by Salmonella enterica serovar Typhimurium porins.

  Cytokine 20080301

• Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells.

  American journal of physiology. Cell physiology 20080301

• p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression.

  Cancer research 20080301

• Stress-activated protein kinase inhibition to ameliorate lung ischemia reperfusion injury.

  The Journal of thoracic and cardiovascular surgery 20080301

• MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells.

  Life sciences 20080227

• SP600125 inhibits Kv channels through a JNK-independent pathway in cancer cells.

  Biochemical and biophysical research communications 20080222

• The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus.

  Virology 20080220

• c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway.

  Journal of cellular biochemistry 20080215

• Interleukin-1beta gene in orange-spotted grouper, Epinephelus coioides: molecular cloning, expression, biological activities and signal transduction.

  Molecular immunology 20080201

• c-Jun N-terminal kinases trigger both degeneration and neurite outgrowth in primary hippocampal and cortical neurons.

  Journal of neurochemistry 20080201

• Transient and sustained oxidative stress differentially activate the JNK1/2 pathway and apoptotic phenotype in H9c2 cells.

  Molecular and cellular biochemistry 20080201

• JNK signaling pathway is required for bFGF-mediated surface cadherin downregulation on HUVEC.

  Experimental cell research 20080201

• Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta.

  Scandinavian journal of immunology 20080201

• Rapid and bi-directional regulation of AMPA receptor phosphorylation and trafficking by JNK.

  The EMBO journal 20080123

• JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes.

  Biochemical pharmacology 20080115

• Basal c-Jun N-terminal kinases promote mitotic progression through histone H3 phosphorylation.

  Cell cycle (Georgetown, Tex.) 20080115

• 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas.

  Biochemistry 20080108

• Human TAO kinase 1 induces apoptosis in SH-SY5Y cells.

  Cell biology international 20080101

• c-Jun N-terminal kinase inhibitor II (SP600125) activates Mullerian inhibiting substance type II receptor-mediated signal transduction.

  Endocrinology 20080101

• Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors.

  Experimental hematology 20080101

• Inhibitors of c-Jun N-terminal kinases: JuNK no more?

  Biochimica et biophysica acta 20080101

• Role of JNK-dependent serine phosphorylation of paxillin in migration of corneal epithelial cells during wound closure.

  Investigative ophthalmology & visual science 20080101

• High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities.

  The Journal of endocrinology 20080101

• Involvement of ROS/ASMase/JNK signalling pathway in inhibiting UVA-induced apoptosis of HaCaT cells by polypeptide from Chlamys farreri.

  Free radical research 20080101

• Inhibition of c-Jun N-terminal kinase pathway attenuates cerebral vasospasm after experimental subarachnoid hemorrhage through the suppression of apoptosis.

  Acta neurochirurgica. Supplement 20080101

• Membrane initiated signaling by 1,25alpha-dihydroxyvitamin D3 in LNCaP prostate cancer cells.

  Advances in experimental medicine and biology 20080101

• JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin.

  Journal of inflammation (London, England) 20080101

• Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.

  Journal of bone and mineral metabolism 20080101

• NF-kappaB and AP-1 are key signaling pathways in the modulation of NAD(P)H:quinone oxidoreductase 1 gene by mercury, lead, and copper.

  Journal of biochemical and molecular toxicology 20080101

• Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.

  Prostaglandins, leukotrienes, and essential fatty acids 20080101

• Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways.

  BMC cardiovascular disorders 20080101

• Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes.

  Immunological investigations 20080101

• Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells.

  Journal of experimental & clinical cancer research : CR 20080101

• Phorbol 12-myristate 13-acetate-activated protein kinase C increased migratory activity of subconjunctival fibroblasts via stress-activated protein kinase pathways.

  Molecular vision 20071221

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes.

  Biochemical and biophysical research communications 20071207

• MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201

• Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.

  Journal of pharmacological sciences 20071201

• Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.

  European journal of pharmacology 20071114

• Berberine-induced LDLR up-regulation involves JNK pathway.

  Biochemical and biophysical research communications 20071103

• EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase.

  Toxicology and applied pharmacology 20071101

• Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.

  Neurochemical research 20071101

• Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

  The Biochemical journal 20071101

• Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation.

  Toxicological sciences : an official journal of the Society of Toxicology 20071101

• Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70.

  Molecular pharmacology 20071101

• Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases.

  Molecular and cellular neurosciences 20071101

• Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone.

  Apoptosis : an international journal on programmed cell death 20071101

• Mechanistic roles of leptin in osteogenic stimulation in thoracic ligament flavum cells.

  The Journal of biological chemistry 20071012

• Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase.

  The Journal of biological chemistry 20071012

• Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells.

  FEBS letters 20071002

• Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells.

  Leukemia research 20071001

• Patterns of kinase activation induced by injury in the murine femoral artery.

  The Journal of surgical research 20071001

• Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20071001

• Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells.

  Drug metabolism and pharmacokinetics 20071001

• House dust mite induces expression of intercellular adhesion molecule-1 in EoL-1 human eosinophilic leukemic cells.

  Journal of Korean medical science 20071001

• Tumor necrosis factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins.

  The Journal of biological chemistry 20070928

• Manganese chloride stimulates rat microglia to release hydrogen peroxide.

  Toxicology letters 20070910

• Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.

  Toxicology 20070905

• IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells.

  Journal of cellular physiology 20070901

• Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury.

  Cellular signalling 20070901

• Inhibition of c-Jun N-terminal kinase in the CA1 region of the dorsal hippocampus blocks extinction of inhibitory avoidance memory.

  Behavioural pharmacology 20070901

• Ras pathway activation in malignant mesothelioma.

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20070901

• Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.

  Free radical biology & medicine 20070815

• Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6.

  The Journal of biological chemistry 20070803

• Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis.

  Annals of the rheumatic diseases 20070801

• Effect of JNK inhibition on cisplatin-induced renal damage.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070801

• Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.

  International immunopharmacology 20070801

• Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages.

  International immunopharmacology 20070801

• Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia.

  International immunopharmacology 20070801

• Interleukin-1beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells.

  The Journal of endocrinology 20070801

• Expression and function of mixed lineage kinases in dendritic cells.

  International immunology 20070801

• [Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070801

• Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.

  The Biochemical journal 20070715

• c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons.

  Neuroscience 20070713

• PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK.

  Neuroscience letters 20070705

• Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.

  Gut 20070701

• Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets.

  Carcinogenesis 20070701

• Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity.

  Endocrinology 20070701

• Attenuation of ozone-induced airway inflammation and hyper-responsiveness by c-Jun NH2 terminal kinase inhibitor SP600125.

  The Journal of pharmacology and experimental therapeutics 20070701

• TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naïve PC12 cells.

  Cell cycle (Georgetown, Tex.) 20070615

• Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK.

  Cancer letters 20070608

• Involvement of c-Jun N-terminal kinases activation in diabetic embryopathy.

  Biochemical and biophysical research communications 20070608

• Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes.

  Neurochemistry international 20070601

• Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.

  Journal of cellular biochemistry 20070601

• Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation.

  International journal of cancer 20070601

• Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

  European journal of pharmacology 20070601

• Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells.

  Cancer research 20070601

• Suppression of alloreactivity and allograft rejection by SP600125, a small molecule inhibitor of c-Jun N-terminal kinase.

  Transplantation 20070527

• The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation.

  The Journal of biological chemistry 20070518

• SP600125, a selective JNK inhibitor, protects ischemic renal injury via suppressing the extrinsic pathways of apoptosis.

  Life sciences 20070508

• Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase.

  Brain research 20070507

• c-Jun N-terminal kinase mediates AML1-ETO protein-induced connexin-43 expression.

  Biochemical and biophysical research communications 20070504

• Induced secretion of insulin-like growth factor binding protein-1 (IGFBP-1) in human hepatoma cell HepG2 by rubratoxin B.

  Archives of toxicology 20070501

• Inhibitory effect of TNF-alpha on the intestinal absorption of galactose.

  Journal of cellular biochemistry 20070501

• P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells.

  Cellular signalling 20070501

• c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation.

  Cell death and differentiation 20070501

• Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase.

  Molecular pharmacology 20070501

• The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro.

  Laboratory investigation; a journal of technical methods and pathology 20070501

• IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation.

  Critical care medicine 20070501

• Celecoxib decreases fatty acid synthase expression via down-regulation of c-Jun N-terminal kinase-1.

  Experimental biology and medicine (Maywood, N.J.) 20070501

• [CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20070501

• Hydroquinone, a reactive metabolite of benzene, reduces macrophage-mediated immune responses.

  Molecules and cells 20070430

• Kinetic characterization of human JNK2alpha2 reaction mechanism using substrate competitive inhibitors.

  Biochemistry 20070424

• (-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.

  FEBS letters 20070403

• Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells.

  FEBS letters 20070403

• Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling.

  Molecular and cellular biochemistry 20070401

• Inhibition of JNK activation prolongs survival after smoke inhalation from fires.

  American journal of physiology. Lung cellular and molecular physiology 20070401

• TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new 'hot' cancer treatment.

  Biochimica et biophysica acta 20070401

• Interleukin-1 mediates thermal injury-induced lung damage through C-Jun NH2-terminal kinase signaling.

  Critical care medicine 20070401

• Interleukin-1 in thermal injury: what is next?

  Critical care medicine 20070401

• Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway.

  Lasers in surgery and medicine 20070401

• c-Jun N-terminal kinase inhibitor SP600125 modulates the period of mammalian circadian rhythms.

  Neuroscience 20070330

• Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.

  European journal of pharmacology 20070322

• An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins.

  Life sciences 20070313

• Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1.

  Journal of leukocyte biology 20070301

• Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070301

• REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer.

  International journal of molecular medicine 20070301

• Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2.

  Journal of biochemistry 20070301

• Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth.

  Biochemical and biophysical research communications 20070216

• p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion.

  Biochemical and biophysical research communications 20070216

• Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070215

• Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070207

• Inhibitory effect of obovatol on nitric oxide production and activation of NF-kappaB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells.

  European journal of pharmacology 20070205

• Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats.

  Cell death and differentiation 20070201

• Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death.

  Journal of leukocyte biology 20070201

• A novel pathway for transcriptional regulation of alpha-synuclein.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070201

• The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice.

  Hepatology (Baltimore, Md.) 20070201

• Macrophage migration inhibitory factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20070201

• Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.

  British journal of cancer 20070115

• Neurotoxicity assessment using zebrafish.

  Journal of pharmacological and toxicological methods 20070101

• Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells.

  Biochemical pharmacology 20070101

• Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress.

  Apoptosis : an international journal on programmed cell death 20070101

• JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1.

  The European journal of neuroscience 20070101

• Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection.

  Thrombosis research 20070101

• Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis.

  Journal of vascular research 20070101

• c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability.

  BMC cell biology 20070101

• The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures.

  BMC plant biology 20070101

• Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts.

  Biochemical and biophysical research communications 20061229

• Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes.

  Cancer letters 20061208

• Involvement of MAP kinases in lipopolysaccharide-induced histamine production in RAW 264 cells.

  Life sciences 20061203

• Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis.

  Cell death and differentiation 20061201

• Involvement of p38 MAP kinase and Smad3 in TGF-beta-mediated mast cell functions.

  Cellular signalling 20061201

• Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis.

  Journal of cellular physiology 20061201

• The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells.

  British journal of haematology 20061201

• Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor.

  European journal of immunology 20061201

• JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation.

  Hepatology (Baltimore, Md.) 20061201

• Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors.

  Cancer research 20061201

• Interleukin-1beta up-regulates inducible nitric oxide by way of phosphoinositide 3-kinase-dependent in a cochlear cell model.

  The Laryngoscope 20061201

• In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20061201

• [Amelioration of insulin resistance after scald by c-Jun N-terminal kinase inhibitor in rat].

  Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20061201

• [The role of MAPK/ERK1/2 signaling pathway in aldosterone stimulated transforming growth factor-beta1 synthesis in renal tubular epithelial cells].

  Zhonghua yi xue za zhi 20061128

• Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).

  Life sciences 20061125

• Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes.

  Toxicology and applied pharmacology 20061115

• Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis.

  Oncogene 20061109

• Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.

  Carcinogenesis 20061101

• Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells.

  The Journal of pharmacology and experimental therapeutics 20061101

• Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells.

  Apoptosis : an international journal on programmed cell death 20061101

• Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase.

  Journal of thrombosis and haemostasis : JTH 20061101

• P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells.

  Apoptosis : an international journal on programmed cell death 20061101

• Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.

  Development (Cambridge, England) 20061101

• Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model.

  Journal of immunology (Baltimore, Md. : 1950) 20061101

• Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate-dependent mechanisms.

  Molecular pharmacology 20061001

• Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma.

  Leukemia 20061001

• Regulation by Jun N-terminal kinase/stress activated protein kinase of cytokine expression in Mycobacterium avium subsp paratuberculosis-infected bovine monocytes.

  American journal of veterinary research 20061001

• Transcriptional regulation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) by retinoic acid in human glioblastoma tumor cell line.

  Biochimica et biophysica acta 20061001

• Induction of apoptosis and cell cycle arrest by a specific c-Jun NH2-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers.

  Cancer letters 20060928

• Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation.

  The Journal of surgical research 20060901

• Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.

  The Journal of clinical endocrinology and metabolism 20060901

• p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis.

  Biochemical and biophysical research communications 20060901

• Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125.

  Genes to cells : devoted to molecular & cellular mechanisms 20060901

• PPARgamma phosphorylation mediated by JNK MAPK: a potential role in macrophage-derived foam cell formation.

  Acta pharmacologica Sinica 20060901

• Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.

  Arthritis and rheumatism 20060901

• SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury.

  Experimental & molecular medicine 20060831

• Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death.

  Experimental & molecular medicine 20060831

• Acquired tolerance in cadmium-adapted lung epithelial cells: roles of the c-Jun N-terminal kinase signaling pathway and basal level of metallothionein.

  Toxicology and applied pharmacology 20060815

• atRA-induced apoptosis of mouse embryonic palate mesenchymal cells involves activation of MAPK pathway.

  Toxicology and applied pharmacology 20060815

• TNFalpha and GM-CSF-induced activation of the CAEV promoter is independent of AP-1.

  Virology 20060815

• Ligustilide inhibits vascular smooth muscle cells proliferation.

  European journal of pharmacology 20060807

• Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein.

  Toxicology and applied pharmacology 20060801

• Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema.

  The Journal of pharmacology and experimental therapeutics 20060801

• Copper-induced stimulation of extracellular signal-regulated kinase in trout hepatocytes: the role of reactive oxygen species, Ca2+, and cell energetics and the impact of extracellular signal-regulated kinase signaling on apoptosis and necrosis.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• Esculetin induces mitochondria-mediated apoptosis in 3T3-L1 adipocytes.

  Apoptosis : an international journal on programmed cell death 20060801

• c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa.

  Free radical biology & medicine 20060801

• Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily.

  Prostaglandins, leukotrienes, and essential fatty acids 20060801

• c-Jun N-terminal kinase negatively regulates dsRNA and RSV induction of tumor necrosis factor- alpha transcription in human epithelial cells.

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20060801

• p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells.

  Brain research 20060712

• Manganese modulates pro-inflammatory gene expression in activated glia.

  Neurochemistry international 20060701

• Nuclear factor-kappa B-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase-1 by the c-jun N-terminal kinase/activator protein-1 pathway.

  The Journal of pharmacology and experimental therapeutics 20060701

• Essential role of c-Jun-NH2-terminal kinase on synergy induction of apoptosis by TRAIL plus ADM in ADM resistant MCF-7/ADM cells.

  Apoptosis : an international journal on programmed cell death 20060701

• Perfusion-culture-based secreted bioluminescence reporter assay in living cells.

  Analytical biochemistry 20060701

• Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20060701

• c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

  Gastroenterology 20060701

• Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.

  The Journal of biological chemistry 20060630

• Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway.

  Oncogene 20060622

• Synaptogenesis regulates axotomy-induced activation of c-Jun-activator protein-1 transcription.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060614

• Mitogen-activated protein kinases mediate arsenic-induced down-regulation of survivin in human lung adenocarcinoma cells.

  Archives of toxicology 20060601

• JNK inhibitor SP600125 reduces COX-2 expression by attenuating mRNA in activated murine J774 macrophages.

  International immunopharmacology 20060601

• Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells.

  Molecular cancer research : MCR 20060601

• Dracorhodin perchlorate induces apoptosis in HL-60 cells.

  Journal of Asian natural products research 20060601

• Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis.

  Brain research 20060530

• Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1.

  Experimental cell research 20060515

• Regression of aortic aneurysms through pharmacologic therapy?

  The New England journal of medicine 20060511

• Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury.

  Neuroscience letters 20060508

• N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells.

  Oncogene 20060504

• Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503

• Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells.

  Carcinogenesis 20060501

• Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.

  Journal of hepatology 20060501

• Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20060501

• Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells.

  Neuroscience letters 20060501

• Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells.

  Molecular pharmacology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing.

  European journal of immunology 20060501

• The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis.

  Immunology 20060501

• MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells.

  Brain research 20060501

• The novel antioxidant 3-O-caffeoyl-1-methylquinic acid induces Nrf2-dependent phase II detoxifying genes and alters intracellular glutathione redox.

  Free radical biology & medicine 20060415

• The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines.

  International journal of oncology 20060401

• Involvement of protein kinases on the upregulation of endothelin receptors in rat basilar and mesenteric arteries.

  Experimental biology and medicine (Maywood, N.J.) 20060401

• Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA.

  The Journal of endocrinology 20060401

• S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism.

  World journal of gastroenterology 20060328

• Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species.

  Journal of cell science 20060315

• Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.

  Molecular and cellular endocrinology 20060309

• Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cells.

  World journal of gastroenterology 20060307

• Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling.

  Toxicological sciences : an official journal of the Society of Toxicology 20060301

• Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster.

  Cardiovascular research 20060301

• Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

• Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease.

  International journal of molecular medicine 20060301

• Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest.

  Thyroid : official journal of the American Thyroid Association 20060301

• FADD phosphorylation is critical for cell cycle regulation in breast cancer cells.

  British journal of cancer 20060227

• Inhibition of apolipoprotein AI gene expression by tumor necrosis factor alpha: roles for MEK/ERK and JNK signaling.

  Biochemistry 20060221

• Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase.

  Cardiovascular research 20060215

• As2O3-induced c-Src/EGFR/ERK signaling is via Sp1 binding sites to stimulate p21WAF1/CIP1 expression in human epidermoid carcinoma A431 cells.

  Cellular signalling 20060201

• A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids.

  Journal of lipid research 20060201

• Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line.

  Journal of leukocyte biology 20060201

• Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells.

  Cardiovascular research 20060201

• The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis.

  International immunopharmacology 20060201

• Porphyromonas gingivalis-related cardiac cell apoptosis was majorly co-activated by p38 and extracellular signal-regulated kinase pathways.

  Journal of periodontal research 20060201

• Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

  Cancer research 20060201

• c-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle.

  Journal of pharmacological sciences 20060201

• Brain ischemia/reperfusion-induced expression of DP5 and its interaction with Bcl-2, thus freeing Bax from Bcl-2/Bax dimmers are mediated by c-Jun N-terminal kinase (JNK) pathway.

  Neuroscience letters 20060130

• Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.

  FEBS letters 20060123

• NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation.

  Biochemical and biophysical research communications 20060106

• Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity.

  Journal of biomedical science 20060101

• c-Jun NH2-terminal kinase mediates interleukin-1beta-induced inhibition of lacrimal gland secretion.

  Journal of neurochemistry 20060101

• c-Jun N-terminal kinase inhibition and alpha-tocopherol protect midbrain dopaminergic neurons from interferon-gamma/lipopolysaccharide-induced injury without affecting nitric oxide production.

  Journal of neuroscience research 20060101

• Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal.

  Free radical biology & medicine 20060101

• NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription.

  Journal of immunology (Baltimore, Md. : 1950) 20060101

• Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA.

  Cellular microbiology 20060101

• Activation of c-Jun N-terminal kinase (JNK) signalling in experimentally induced gastric lesions in rats.

  Clinical and experimental immunology 20060101

• Thermal injury-induced peroxynitrite production and pulmonary inducible nitric oxide synthase expression depend on JNK/AP-1 signaling.

  Critical care medicine 20060101

• [Effects of sp600125 on proliferation and protein expression of bcl-2 and c-myc in hepatic stellate cells].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20060101

• Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells.

  Basic & clinical pharmacology & toxicology 20060101

• Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression.

  BMC pharmacology 20060101

• Inhibition of UVA-induced c-Jun N-terminal kinase activity results in caspase-dependent apoptosis in human keratinocytes.

  Photochemistry and photobiology 20060101

• C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform.

  Antioxidants & redox signaling 20060101

• Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells.

  Respiratory research 20060101

• Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis.

  Arthritis research & therapy 20060101

• JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.

  Mediators of inflammation 20060101

• Up-regulation of P-glycoprotein expression by catalase via JNK activation in HepG2 cells.

  Redox report : communications in free radical research 20060101

• Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis.

  Cancer research 20051215

• Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway.

  Cellular signalling 20051201

• Gaseous nitrogen oxide repressed benzo[a]pyrene-induced human lung fibroblast cell apoptosis via inhibiting JNK1 signals.

  Archives of toxicology 20051201

• Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression.

  American journal of physiology. Gastrointestinal and liver physiology 20051201

• KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells.

  Journal of lipid research 20051201

• Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase.

  Nature medicine 20051201

• Aneurysm treatments expand.

  Nature medicine 20051201

• X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1).

  The Journal of biological chemistry 20051118

• Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.

  The Journal of biological chemistry 20051118

• Arsenite enhances tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1.

  Toxicology and applied pharmacology 20051115

• The role of p38 MAP kinase and c-Jun N-terminal protein kinase signaling in the differentiation and apoptosis of immortalized neural stem cells.

  Mutation research 20051111

• Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation.

  Leukemia 20051101

• Regulation of B7.1 costimulatory molecule is mediated by the IFN regulatory factor-7 through the activation of JNK in lipopolysaccharide-stimulated human monocytic cells.

  Journal of immunology (Baltimore, Md. : 1950) 20051101

• Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.

  Expert opinion on investigational drugs 20051101

• [Role of MAPK in the migration of human coronary artery smooth muscle cell into three-dimensional fibrin gel].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101

• Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes.

  Mediators of inflammation 20051024

• The role of p-c-Jun in survival and outgrowth of developing sensory neurons.

  Neuroreport 20051017

• Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells.

  Life sciences 20051014

• Regulation of cAMP-induced arylalkylamine N-acetyltransferase, Period1, and MKP-1 gene expression by mitogen-activated protein kinases in the rat pineal gland.

  Brain research. Molecular brain research 20051003

• Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

  European journal of pharmacology 20051003

• Effects of the JNK inhibitor anthra[1,9-cd]pyrazol-6(2H)-one (SP-600125) on soluble guanylyl cyclase alpha1 gene regulation and cGMP synthesis.

  American journal of physiology. Cell physiology 20051001

• Phosphorylation of the retinoid x receptor at the omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity.

  Cellular signalling 20051001

• Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase.

  Cellular signalling 20051001

• Advanced glycosylation end products might promote atherosclerosis through inducing the immune maturation of dendritic cells.

  Arteriosclerosis, thrombosis, and vascular biology 20051001

• Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite.

  Molecular and cellular biology 20051001

• JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells.

  Cellular and molecular life sciences : CMLS 20051001

• Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation.

  The Journal of clinical investigation 20051001

• Mitomycin-C induces the apoptosis of human Tenon's capsule fibroblast by activation of c-Jun N-terminal kinase 1 and caspase-3 protease.

  Investigative ophthalmology & visual science 20051001

• Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.

  The Journal of biological chemistry 20050923

• c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity.

  Biochemical and biophysical research communications 20050916

• Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.

  Molecular biology of the cell 20050901

• Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells.

  Journal of toxicology and environmental health. Part A 20050901

• Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells.

  Cell cycle (Georgetown, Tex.) 20050901

• Ablation of the spindle assembly checkpoint by a compound targeting Mps1.

  EMBO reports 20050901

• Inhibition of inflammatory bone erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation.

  Arthritis and rheumatism 20050901

• Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB.

  American journal of respiratory cell and molecular biology 20050801

• Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling.

  Bone 20050801

• HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells.

  Free radical biology & medicine 20050801

• Multiple anti-apoptotic pathways stimulated by EGF in cytotrophoblasts.

  Placenta 20050801

• Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism.

  Journal of neurochemistry 20050801

• Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest.

  Cancer research 20050801

• Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes.

  Archives of pharmacal research 20050801

• Histamine induces tissue factor expression: implications for acute coronary syndromes.

  Circulation 20050719

• Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.

  Biochemical and biophysical research communications 20050715

• Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines.

  Free radical biology & medicine 20050715

• Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells.

  Cancer research 20050715

• Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway.

  Life sciences 20050708

• P-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone].

  The Journal of pharmacology and experimental therapeutics 20050701

• Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis.

  Journal of cellular biochemistry 20050701

• CD437, a synthetic retinoid, induces apoptosis in human respiratory epithelial cells via caspase-independent mitochondrial and caspase-8-dependent pathways both up-regulated by JNK signaling pathway.

  Experimental cell research 20050701

• Polypeptide from Chlamys farreri inhibits murine thymocytes apoptosis and modulates UVB induced signaling pathway activation.

  Life sciences 20050701

• Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage.

  Stroke 20050701

• Inflammatory responses of corneal epithelial cells to Pseudomonas aeruginosa infection.

  Current eye research 20050701

• Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts.

  The Journal of biological chemistry 20050617

• Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors.

  Archives of biochemistry and biophysics 20050615

• Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.

  Toxicology and applied pharmacology 20050615

• Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway.

  Biochemical and biophysical research communications 20050603

• c-Jun NH2-terminal kinase mediation of angiotensin II-induced proliferation of human mesangial cells.

  American journal of physiology. Renal physiology 20050601

• Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050601

• Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells.

  Journal of neuroscience research 20050601

• DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation.

  Molecular and cellular biology 20050601

• Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.

  The Journal of endocrinology 20050601

• Inflammatory pathway analysis using a high content screening platform.

  Assay and drug development technologies 20050601

• Activation of c-Jun N-terminal kinase is required for neurite outgrowth of dopaminergic neuronal cells.

  Neuroreport 20050531

• 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process.

  Oncogene 20050526

• Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina.

  Brain research 20050524

• Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8.

  The Journal of biological chemistry 20050513

• Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta.

  American journal of respiratory cell and molecular biology 20050501

• Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx.

  American journal of respiratory and critical care medicine 20050501

• Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages.

  International immunopharmacology 20050501

• Pepsin-digested bovine lactoferrin induces apoptotic cell death with JNK/SAPK activation in oral cancer cells.

  Journal of pharmacological sciences 20050501

• c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413

• Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation.

  Life sciences 20050408

• Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase.

  The Journal of pharmacology and experimental therapeutics 20050401

• Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells.

  Biochemical and biophysical research communications 20050401

• Cigarette smoke extract induces endothelial cell injury via JNK pathway.

  Biochemical and biophysical research communications 20050401

• Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells.

  The Journal of allergy and clinical immunology 20050401

• Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha.

  Oncogene 20050331

• Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth.

  Virology 20050315

• A small molecule-kinase interaction map for clinical kinase inhibitors.

  Nature biotechnology 20050301

• Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.

  Molecular cancer therapeutics 20050301

• SAPK/JNK plays a role in transforming growth factor-beta-induced VEGF synthesis in osteoblasts.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050301

• The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways.

  Brain research 20050221

• Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050202

• Cypermethrin blocks a mitochondria-dependent apoptotic signal initiated by deficient N-linked glycosylation within the endoplasmic reticulum.

  Cellular signalling 20050201

• Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line.

  Cellular signalling 20050201

• Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• c-Jun N-terminal kinase is involved in mercuric ions-mediated interleukin-4 secretion in mast cells.

  International archives of allergy and immunology 20050201

• Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes.

  European journal of pharmacology 20050131

• Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.

  Toxicology 20050115

• Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha.

  Toxicology 20050115

• Negative regulation of adipogenesis from human mesenchymal stem cells by Jun N-terminal kinase.

  Biochemical and biophysical research communications 20050114

• Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125.

  European journal of pharmacology 20050104

• Synthesis of the Na-K-ATPase gamma-subunit is regulated at both the transcriptional and translational levels in IMCD3 cells.

  American journal of physiology. Renal physiology 20050101

• Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells.

  Hypertension (Dallas, Tex. : 1979) 20050101

• Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK.

  Neurobiology of aging 20050101

• Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

  Gastroenterology 20050101

• Interleukin-1beta-induced transdifferentiation of renal proximal tubular cells is mediated by activation of JNK and p38 MAPK.

  Nephron. Experimental nephrology 20050101

• Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons.

  Neuroscience 20050101

• Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.

  Respiratory research 20050101

• JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine.

  The Journal of biological chemistry 20041231

• Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells.

  Experimental & molecular medicine 20041231

• Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages.

  Free radical biology & medicine 20041215

• p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling.

  Journal of cell science 20041215

• c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia.

  Cancer research 20041215

• Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways.

  American journal of physiology. Cell physiology 20041201

• Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells.

  International immunology 20041201

• Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts.

  Prostaglandins, leukotrienes, and essential fatty acids 20041201

• Induction of serine racemase by inflammatory stimuli is dependent on AP-1.

  Annals of the New York Academy of Sciences 20041201

• Microtubule disarray in primary cultures of human hepatocytes inhibits transcriptional activity of the glucocorticoid receptor via activation of c-jun N-terminal kinase.

  Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20041201

• KR-31378 protects cardiac H9c2 cells from chemical hypoxia-induced cell death via inhibition of JNK/p38 MAPK activation.

  The Japanese journal of physiology 20041201

• c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK).

  Oncogene 20041125

• Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress.

  Molecular cell 20041119

• UV-induced apoptosis in SH-SY5Y cells: contribution to apoptosis by JNK signaling and cytochrome c.

  Journal of neuroscience research 20041115

• Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death, by SP600125, an inhibitor of JNK: implications in cancer immunotherapy.

  Journal of immunology (Baltimore, Md. : 1950) 20041115

• Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.

  Circulation research 20041112

• Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

• Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK.

  Biochemical and biophysical research communications 20041105

• Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways.

  Brain research. Molecular brain research 20041104

• Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.

  Carcinogenesis 20041101

• Inhibition of c-Jun phosphorylation reduces axonal outgrowth of adult rat nodose ganglia and dorsal root ganglia sensory neurons.

  Molecular and cellular neurosciences 20041101

• Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis.

  American journal of reproductive immunology (New York, N.Y. : 1989) 20041101

• Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis.

  Life sciences 20041029

• Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20041015

• Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells.

  Journal of applied physiology (Bethesda, Md. : 1985) 20041001

• Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets.

  Endocrinology 20041001

• Calcium-mediated activation of c-Jun NH2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages.

  Toxicological sciences : an official journal of the Society of Toxicology 20041001

• MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury.

  Journal of cellular physiology 20041001

• Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells.

  Journal of biomechanics 20041001

• High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment.

  The Journal of veterinary medical science 20041001

• Anti-apoptotic and pro-apoptotic effect of NEPP11 on manganese-induced apoptosis and JNK pathway activation in PC12 cells.

  Brain research 20040924

• Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.

  European journal of pharmacology 20040913

• Regulation of tumor necrosis factor-alpha in glioma cells by lead and lipopolysaccharide: involvement of common signaling pathway.

  Toxicology letters 20040910

• Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons.

  Neuroscience letters 20040909

• The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908

• Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.

  Circulation 20040907

• Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages.

  The Journal of general virology 20040901

• Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.

  Molecular pharmacology 20040901

• Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.

  Circulation research 20040820

• Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.

  The Journal of clinical investigation 20040816

• p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.

  Biochemical and biophysical research communications 20040806

• A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells.

  The Journal of pharmacology and experimental therapeutics 20040801

• Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines.

  Blood 20040801

• JNK MAP kinase is involved in the humoral immune response of the greater wax moth larvae Galleria mellonella.

  Archives of insect biochemistry and physiology 20040801

• Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040801

• The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway.

  The Journal of biological chemistry 20040730

• Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.

  The Journal of biological chemistry 20040716

• Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.

  Experimental cell research 20040715

• Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.

  European journal of pharmacology 20040714

• JNK signaling involved in the effects of cyclic AMP on IL-1beta plus IFNgamma-induced inducible nitric oxide synthase expression in hepatocytes.

  Cellular signalling 20040701

• Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway.

  Cardiovascular research 20040701

• Effect of an inhibitor of Jun N-terminal protein kinase, SP600125, in single allergen challenge in sensitized rats.

  Immunology 20040701

• C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression.

  Drug metabolism and disposition: the biological fate of chemicals 20040701

• Macrophage-mediated renal injury is dependent on signaling via the JNK pathway.

  Journal of the American Society of Nephrology : JASN 20040701

• Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin.

  Molecular cancer therapeutics 20040701

• Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner.

  Circulation research 20040611

• Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.

  Oncogene 20040603

• Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

  The EMBO journal 20040602

• BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.

  The EMBO journal 20040602

• Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.

  Journal of the American Society of Nephrology : JASN 20040601

• Involvement of SAPK/JNK in prostaglandin E(1)-induced VEGF synthesis in osteoblast-like cells.

  Molecular and cellular endocrinology 20040531

• Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway.

  The Journal of biological chemistry 20040521

• Involvement of stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK) in prostaglandin F2alpha-induced heat shock protein 27 in osteoblasts.

  Prostaglandins, leukotrienes, and essential fatty acids 20040501

• The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.

  Experimental cell research 20040501

• Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells.

  Journal of cellular biochemistry 20040501

• Dimethylaminopurine inhibits metabolic effects of insulin in primary adipocytes.

  The Journal of nutritional biochemistry 20040501

• Involvement of ROS and JNK1 in selenite-induced apoptosis in Chang liver cells.

  Experimental & molecular medicine 20040430

• JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells.

  The Journal of biological chemistry 20040423

• Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells.

  Toxicology and applied pharmacology 20040415

• Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040401

• The role of c-Jun N-terminal kinase in the A beta-mediated impairment of LTP and regulation of synaptic transmission in the hippocampus.

  Neuropharmacology 20040401

• MAPK signaling pathways modulate IL-1beta expression in human keratinocytes.

  Archives of biochemistry and biophysics 20040401

• Inhibition of AP-1 transcription activator induces myc-dependent apoptosis in HL60 cells.

  Journal of cellular biochemistry 20040401

• Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation.

  Molecular pharmacology 20040401

• Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331

• Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways.

  The Journal of biological chemistry 20040319

• Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent.

  The Journal of biological chemistry 20040319

• Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.

  Biochimica et biophysica acta 20040311

• Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways.

  The Journal of biological chemistry 20040305

• Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition.

  Molecular and cellular biochemistry 20040301

• Thombospondin-1 disrupts estrogen-induced endothelial cell proliferation and migration and its expression is suppressed by estradiol.

  Molecular cancer research : MCR 20040301

• Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase.

  American journal of respiratory and critical care medicine 20040215

• Bcl-2 enhances neurite extension via activation of c-Jun N-terminal kinase.

  Biochemical and biophysical research communications 20040206

• Sphingomyelinase of Helicobacter pylori-induced cytotoxicity in AGS gastric epithelial cells via activation of JNK kinase.

  Biochemical and biophysical research communications 20040206

• c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart.

  American journal of physiology. Heart and circulatory physiology 20040201

• DEP-induced fra-1 expression correlates with a distinct activation of AP-1-dependent gene transcription in the lung.

  American journal of physiology. Lung cellular and molecular physiology 20040201

• SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease.

  Neuroscience research 20040201

• Regulation of polyamine analogue cytotoxicity by c-Jun in human MDA-MB-435 cancer cells.

  Molecular cancer research : MCR 20040201

• 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione.

  The Journal of biological chemistry 20040130

• All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells.

  Oncogene 20040115

• Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death.

  European journal of pharmacology 20040112

• An apoptotic signaling pathway in the interferon antiviral response mediated by RNase L and c-Jun NH2-terminal kinase.

  The Journal of biological chemistry 20040109

• Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040107

• Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1.

  The Journal of biological chemistry 20040102

• Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells.

  Carcinogenesis 20040101

• Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.

  Carcinogenesis 20040101

• Retinoblastoma protein and CCAAT/enhancer-binding protein beta are required for 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL60 cells.

  Cancer research 20040101

• Erianin induces a JNK/SAPK-dependent metabolic inhibition in human umbilical vein endothelial cells.

  In vivo (Athens, Greece) 20040101

• Characterization of Cd-induced molecular events prior to cellular damage in primary rat hepatocytes in culture: activation of the stress activated signal protein JNK and transcription factor AP-1.

  Journal of biochemical and molecular toxicology 20040101

• Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury.

  Respiratory research 20040101

• p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons.

  Neuroscience letters 20031226

• IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.

  Cellular signalling 20031201

• Verotoxin activates mitogen-activated protein kinase in human peripheral blood monocytes: role in apoptosis and proinflammatory cytokine release.

  British journal of pharmacology 20031201

• Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase.

  British journal of pharmacology 20031201

• Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin).

  Toxicology and applied pharmacology 20031201

• N-nitrosocarbofuran induces apoptosis in mouse brain microvascular endothelial cells (bEnd.3).

  Journal of pharmacological sciences 20031201

• Biologic sequelae of c-Jun NH(2)-terminal kinase (JNK) activation in multiple myeloma cell lines.

  Oncogene 20031127

• Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis.

  International journal of cancer 20031120

• Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor-mediated inhibition of c-Jun phosphorylation.

  FEBS letters 20031120

• C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect.

  Transplantation 20031115

• Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.

  Cytokine 20031107

• Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase.

  American journal of physiology. Regulatory, integrative and comparative physiology 20031101

• The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20031101

• Mitogen activated protein kinases selectively regulate palytoxin-stimulated gene expression in mouse keratinocytes.

  Toxicology and applied pharmacology 20031101

• Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20031101

• Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes.

  The Journal of biological chemistry 20031010

• Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.

  Neuropharmacology 20031001

• Involvement of the JNK-like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus.

  Insect molecular biology 20031001

• Inhibition of the SAPK/JNK pathway blocks the stimulatory effects of glutamine on fluid secretion by the Malpighian tubules of Rhodnius prolixus.

  Journal of insect physiology 20031001

• The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

  The Journal of pharmacology and experimental therapeutics 20030901

• Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts.

  European journal of endocrinology 20030901

• Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis.

  Archives of pharmacal research 20030901

• The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration.

  The EMBO journal 20030815

• SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway.

  Biochemical and biophysical research communications 20030808

• Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinases.

  American journal of physiology. Lung cellular and molecular physiology 20030801

• The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.

  Carcinogenesis 20030801

• c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages.

  Molecular pharmacology 20030801

• Induction of matrix metalloproteinases-14 and -2 by cyclical mechanical stretch is mediated by tumor necrosis factor-alpha in cultured human umbilical vein endothelial cells.

  Cardiovascular research 20030801

• Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase.

  Surgery 20030801

• The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.

  Chemistry & biology 20030801

• c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production.

  Journal of immunology (Baltimore, Md. : 1950) 20030715

• c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells.

  The Journal of biological chemistry 20030711

• JNK phosphorylates paxillin and regulates cell migration.

  Nature 20030710

• Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation.

  The Journal of biological chemistry 20030704

• Effects of transforming growth factor-[beta] and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells.

  American journal of respiratory cell and molecular biology 20030701

• Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis.

  Genes & development 20030701

• The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression.

  Neoplasia (New York, N.Y.) 20030701

• JNK-independent activation of c-Jun during neuronal apoptosis induced by multiple DNA-damaging agents.

  The Journal of biological chemistry 20030620

• The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair.

  The Journal of biological chemistry 20030606

• C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts.

  American journal of respiratory cell and molecular biology 20030601

• Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes.

  Hepatology (Baltimore, Md.) 20030601

• Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes.

  The Journal of biological chemistry 20030516

• JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.

  The Journal of biological chemistry 20030516

• Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA.

  Journal of immunology (Baltimore, Md. : 1950) 20030515

• Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK.

  Cardiovascular drugs and therapy 20030501

• The specificities of protein kinase inhibitors: an update.

  The Biochemical journal 20030401

• c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration.

  Hepatology (Baltimore, Md.) 20030401

• Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030401

• Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts.

  The Journal of endocrinology 20030401

• Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF.

  Oncogene 20030327

• Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.

  The Journal of biological chemistry 20030307

• Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.

  Oncogene 20030306

• Type 2 deiodinase expression is stimulated by growth factors in human vascular smooth muscle cells.

  Molecular and cellular endocrinology 20030227

• Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

  Blood 20030215

• Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells.

  Molecular pharmacology 20030201

• Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.

  Journal of neurochemistry 20030201

• Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task.

  The European journal of neuroscience 20030201

• Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.

  The Journal of biological chemistry 20030103

• A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1beta and long-term depression in the rat dentate gyrus in vitro.

  Neuroscience 20030101

• p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth.

  Molecular cancer 20030101

• Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.

  The Biochemical journal 20021115

• [Synergetic effect of mitogen-activated protein kinase pathway on expression of tumor necrosis factor alpha gene in RAW 264.7 cells induced by lipopolysaccharide].

  Zhonghua yi xue za zhi 20021025

• c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes.

  Circulation research 20021004

• Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase.

  Archives of biochemistry and biophysics 20020915

• An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression.

  Biochimica et biophysica acta 20020508

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts.

  Journal of cellular biochemistry 20020101

• Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.

  Cancer biology & therapy 20020101

• Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes.

  American journal of physiology. Cell physiology 20011201

• SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase.

  Proceedings of the National Academy of Sciences of the United States of America 20011120

• TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells.

  Hepatology (Baltimore, Md.) 20011101

• c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.

  The Journal of clinical investigation 20010701

• Mixed lineage kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation.

  Molecular endocrinology (Baltimore, Md.)