129830-38-2 | (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$73.00	$51.00
25mg	95%	in stock	$91.00	$64.00
100mg	99%	in stock	$141.00	$99.00
250mg	99%	in stock	$202.00	$141.00
1g	99%	in stock	$484.00	$339.00

Description

• Catalog Number: AA38342
• Chemical Name: (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
• CAS Number: 129830-38-2
• Molecular Formula: C14H23Cl2N3O
• Molecular Weight: 320.2579
• MDL Number: MFCD03490488
• SMILES: C[C@H]([C@@H]1CC[C@H](CC1)C(=O)Nc1ccncc1)N.Cl.Cl

Computed Properties

• Complexity: 268
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 3

Literature

• ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury.

  American journal of physiology. Heart and circulatory physiology 20141215

• Erythropoietin promotes axonal regeneration after optic nerve crush in vivo by inhibition of RhoA/ROCK signaling pathway.

  Neuropharmacology 20121101

• miRNAs can increase the efficiency of ex vivo platelet generation.

  Annals of hematology 20121101

• The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels.

  Naunyn-Schmiedeberg's archives of pharmacology 20121101

• High glucose enhances responsiveness of human airways smooth muscle via the Rho/ROCK pathway.

  American journal of respiratory cell and molecular biology 20121001

• Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20121001

• Bioengineered human IAS reconstructs with functional and molecular properties similar to intact IAS.

  American journal of physiology. Gastrointestinal and liver physiology 20120915

• Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20120901

• Aging impairs Ca2+ sensitization pathways in gallbladder smooth muscle.

  Age (Dordrecht, Netherlands) 20120801

• Cells lacking β-actin are genetically reprogrammed and maintain conditional migratory capacity.

  Molecular & cellular proteomics : MCP 20120801

• Soluble epoxide hydrolase: sex differences and role in endothelial cell survival.

  Arteriosclerosis, thrombosis, and vascular biology 20120801

• ROCK1 feedback regulation of the upstream small GTPase RhoA.

  Cellular signalling 20120701

• Atorvastatin inhibits myocardin expression in vascular smooth muscle cells.

  Hypertension (Dallas, Tex. : 1979) 20120701

• Arsenite activates NFκB through induction of C-reactive protein.

  Toxicology and applied pharmacology 20120615

• Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in the rat uterine artery.

  American journal of physiology. Heart and circulatory physiology 20120615

• The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells.

  Inflammation 20120601

• Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium.

  Allergology international : official journal of the Japanese Society of Allergology 20120601

• Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway.

  Journal of cardiovascular pharmacology 20120601

• Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle.

  Allergology international : official journal of the Japanese Society of Allergology 20120601

• The effect of Rho-associated protein kinase inhibitor on monkey Schlemm's canal endothelial cells.

  Investigative ophthalmology & visual science 20120522

• Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition.

  Developmental cell 20120515

• Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility.

  Experimental physiology 20120501

• Rho kinase (ROK)-related proteins in human cavernous arteries: an immunohistochemical and functional approach.

  The journal of sexual medicine 20120501

• The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries.

  Journal of hypertension 20120501

• Functional role of muscarinic receptor subtypes in calcium sensitization and their contribution to rho-kinase and protein kinase C pathways in contraction of human detrusor smooth muscle.

  Urology 20120501

• ROCKII Ser1366 phosphorylation reflects the activation status.

  The Biochemical journal 20120401

• Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle.

  Neurourology and urodynamics 20120401

• Inhibition of actin dynamics during epithelial-to-mesenchymal transition.

  Biochemical and biophysical research communications 20120309

• Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes.

  Glia 20120301

• Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells.

  Experimental & molecular medicine 20120227

• Progesterone enhances vascular endothelial cell migration via activation of focal adhesion kinase.

  Journal of cellular and molecular medicine 20120201

• Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?

  Journal of applied physiology (Bethesda, Md. : 1985) 20120201

• Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells.

  Cryobiology 20120201

• Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.

  Neurochemistry international 20120201

• Enucleation of human erythroblasts involves non-muscle myosin IIB.

  Blood 20120126

• A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.

  Nature neuroscience 20120115

• Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia.

  Biochemical and biophysical research communications 20120113

• Resolving the challenge of measuring ligand binding to membrane proteins by combining analytical ultracentrifugation and light scattering photometry.

  Journal of pharmaceutical sciences 20120101

• A possible mechanism of basic fibroblast growth factor-promoted scarless wound healing: the induction of myofibroblast apoptosis.

  European journal of dermatology : EJD 20120101

• Effect of simvastatin on transforming growth factor beta-1-induced myofibroblast differentiation and collagen production in nasal polyp-derived fibroblasts.

  American journal of rhinology & allergy 20120101

• RhoA: a therapeutic target for chronic myeloid leukemia.

  Molecular cancer 20120101

• Impaired myogenic tone in isolated cerebral and coronary resistance arteries from the goto-kakizaki rat model of type 2 diabetes.

  Journal of vascular research 20120101

• [Y-27632 induces calcium-independent glutamate release in rat brain synaptosomes by the mechanism which is distinct from exocytosis].

  Biofizika 20120101

• Different effect of Rho kinase inhibition on calcium signaling in rat isolated large and small arteries.

  Journal of vascular research 20120101

• RhoA-ROCK-Myosin pathway regulates morphological plasticity of cultured olfactory ensheathing cells.

  Experimental cell research 20111210

• Protective effects of dexpanthenol and y-27632 on stricture formation in a rat model of caustic esophageal injury.

  The Journal of surgical research 20111201

• The suppression of myosin light chain (MLC) phosphorylation during the response to lipopolysaccharide (LPS): beneficial or detrimental to endothelial barrier?

  Journal of cellular physiology 20111201

• Synthetic osteogenic growth peptide promotes differentiation of human bone marrow mesenchymal stem cells to osteoblasts via RhoA/ROCK pathway.

  Molecular and cellular biochemistry 20111201

• Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.

  Cellular signalling 20111201

• Depigmenting action of platycodin D depends on the cAMP/Rho-dependent signalling pathway.

  Experimental dermatology 20111201

• Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20111201

• Synchronous phosphorylation of CPI-17 and MYPT1 is essential for inducing Ca(2+) sensitization in intestinal smooth muscle.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111201

• Osteopontin is involved in urotensin II-induced migration of rat aortic adventitial fibroblasts.

  Peptides 20111201

• LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells.

  Journal of cellular physiology 20111101

• Electrically guiding migration of human induced pluripotent stem cells.

  Stem cell reviews 20111101

• Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells.

  American journal of physiology. Cell physiology 20111101

• The Rho kinase inhibitor Y-27632 increases erythrocyte deformability and low oxygen tension-induced ATP release.

  American journal of physiology. Heart and circulatory physiology 20111101

• Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated.

  American journal of surgery 20111101

• Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease.

  American journal of nephrology 20111101

• RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy.

  Current eye research 20111101

• Dynamic ordering of nuclei in syncytial embryos: a quantitative analysis of the role of cytoskeletal networks.

  Integrative biology : quantitative biosciences from nano to macro 20111101

• Rac-dependent doubling of HeLa cell area and impairment of cell migration and cell cycle by compounds from Iris germanica.

  Protoplasma 20111001

• Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi.

  American journal of respiratory cell and molecular biology 20111001

• Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes.

  Experimental eye research 20111001

• Rho kinase-related proteins in human vaginal arteries: an immunohistochemical and functional study.

  The journal of sexual medicine 20111001

• Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901

• In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes.

  Cell research 20110901

• Epithelial inducible nitric oxide synthase causes bacterial translocation by impairment of enterocytic tight junctions via intracellular signals of Rho-associated kinase and protein kinase C zeta.

  Critical care medicine 20110901

• ROCK inhibition prevents fetal serum-induced alteration in structure and function of organ-cultured mesenteric artery.

  Journal of muscle research and cell motility 20110901

• TGF-β2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20110901

• [Rho-kinase inhibitors].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110901

• Rho kinase as a therapeutic target in cardiovascular disease.

  Future cardiology 20110901

• Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.

  Biochemical and biophysical research communications 20110812

• Aldosterone induction of hepatic stellate cell contraction through activation of RhoA/ROCK-2 signaling pathway.

  Regulatory peptides 20110808

• A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells.

  Organic & biomolecular chemistry 20110807

• Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632.

  Pharmaceutical research 20110801

• Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells.

  American journal of physiology. Gastrointestinal and liver physiology 20110801

• Protective effects of Y-27632 on hypoxia/reoxygenation-induced intestinal injury in newborn rats.

  Journal of pediatric surgery 20110801

• [Activation of Rho-kinase pathway is involved in angiotensin II-induced contraction of human airway smooth muscle cells].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110801

• Functional, morphological and molecular characterization of bladder dysfunction in streptozotocin-induced diabetic mice: evidence of a role for L-type voltage-operated Ca2+ channels.

  British journal of pharmacology 20110701

• Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.

  American journal of physiology. Cell physiology 20110701

• Integrin α3 blockade enhances microtopographical down-regulation of α-smooth muscle actin: role of microtopography in ECM regulation.

  Integrative biology : quantitative biosciences from nano to macro 20110701

• Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.

  Japanese journal of ophthalmology 20110701

• Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.

  British journal of pharmacology 20110601

• Impaired Ca2+ handling in penile arteries from prediabetic Zucker rats: involvement of Rho kinase.

  American journal of physiology. Heart and circulatory physiology 20110601

• Reduction of fibrogenesis by selective delivery of a Rho kinase inhibitor to hepatic stellate cells in mice.

  The Journal of pharmacology and experimental therapeutics 20110601

• Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways.

  American journal of physiology. Gastrointestinal and liver physiology 20110601

• Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity.

  Cellular & molecular biology letters 20110601

• Sevoflurane inhibits angiotensin II-induced Rho kinase-mediated contraction of vascular smooth muscle from spontaneously hypertensive rat.

  Journal of anesthesia 20110601

• Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.

  FEBS letters 20110506

• Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro.

  Journal of cellular physiology 20110501

• Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway.

  American journal of physiology. Cell physiology 20110501

• Rho signaling pathway and apical constriction in the early lens placode.

  Genesis (New York, N.Y. : 2000) 20110501

• Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration.

  Endocrinology 20110501

• [Production of connective tissue growth factor by angiotensin II in human embryonic lung fibroblast via RhoA-ROCK pathway].

  Zhonghua yi xue za zhi 20110426

• Ca2+ sensitization and PKC contribute to exercise training-enhanced contractility in porcine collateral-dependent coronary arteries.

  American journal of physiology. Heart and circulatory physiology 20110401

• Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth.

  The Journal of biological chemistry 20110311

• LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

  Cell stem cell 20110304

• Cryopreservation of human embryonic stem cells derived-cardiomyocytes induced by BMP2 in serum-free condition.

  Reproductive sciences (Thousand Oaks, Calif.) 20110301

• ROCK and cAMP promote lymphatic endothelial cell barrier integrity and modulate histamine and thrombin-induced barrier dysfunction.

  Lymphatic research and biology 20110301

• Advanced glycation end products induce moesin phosphorylation in murine brain endothelium.

  Brain research 20110210

• Rho-kinase signalling regulates trypsinogen activation and tissue damage in severe acute pancreatitis.

  British journal of pharmacology 20110201

• Effects of ischemic preconditioning on vascular reactivity and calcium sensitivity after hemorrhagic shock and their relationship to the RhoA–Rho-kinase pathway in rats.

  Journal of cardiovascular pharmacology 20110201

• Characteristics of myogenic reactivity in isolated rat mesenteric veins.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110201

• The Rho kinase pathway regulates mouse adult neural precursor cell migration.

  Stem cells (Dayton, Ohio) 20110201

• Thromboxane A2 induces contraction of human prostate smooth muscle by Rho kinase- and calmodulin-dependent mechanisms.

  European journal of pharmacology 20110115

• Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells.

  European journal of pharmacology 20110110

• Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.

  American journal of physiology. Renal physiology 20110101

• Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101

• RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.

  Pain 20110101

• Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study.

  Urologia internationalis 20110101

• The effect of lysophosphatidic acid and Rho-associated kinase patterning on adhesion of dental pulp cells.

  International endodontic journal 20110101

• ρ-Kinase inhibition reduces early microvascular leukocyte accumulation in the rat kidney following ischemia-reperfusion injury: roles of nitric oxide and blood flow.

  Nephron. Experimental nephrology 20110101

• Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners.

  Clinical and experimental rheumatology 20110101

• ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency.

  PloS one 20110101

• Actomyosin-dependent cortical dynamics contributes to the prophase force-balance in the early Drosophila embryo.

  PloS one 20110101

• Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells.

  Journal of pharmacological sciences 20110101

• [The effect of Rho-kinase inhibition depends on the nature of factors that modify endothelial permeability].

  Tsitologiia 20110101

• Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells.

  Molecular cancer 20110101

• Regulation of retinoschisin secretion in Weri-Rb1 cells by the F-actin and microtubule cytoskeleton.

  PloS one 20110101

• Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells.

  Molecular vision 20110101

• Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.

  PloS one 20110101

• Decreases in CD31 and CD47 levels on the cell surface during etoposide-induced Jurkat cell apoptosis.

  Biological & pharmaceutical bulletin 20110101

• Inhibition of Rho kinase regulates specification of early differentiation events in P19 embryonal carcinoma stem cells.

  PloS one 20110101

• Lipid A decreases human erythrocytes deformability by increasing intracellular Ca(2+): effects of verapamil, staurosporine and the rho-kinase inhibitor Y-27632.

  Clinical hemorheology and microcirculation 20110101

• Osteoclastogenic activity and RANKL expression are inhibited in osteoblastic cells expressing constitutively active Gα(12) or constitutively active RhoA.

  Journal of cellular biochemistry 20101215

• Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2.

  Apoptosis : an international journal on programmed cell death 20101201

• Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP₃ receptors.

  European journal of pharmacology 20101201

• Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.

  American journal of physiology. Heart and circulatory physiology 20101201

• Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery.

  American journal of physiology. Cell physiology 20101201

• Effect of the Rho kinase inhibitor Y-27632 on the proteome of hearts with ischemia-reperfusion injury.

  Proteomics 20101201

• Modulation of the Rho/ROCK pathway in heart and lung after thorax irradiation reveals targets to improve normal tissue toxicity.

  Current drug targets 20101101

• Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase.

  Journal of molecular and cellular cardiology 20101101

• Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells.

  International journal of oncology 20101101

• The origin recognition complex subunit, ORC3, is developmentally regulated and supports the expression of biochemical markers of neuronal maturation in cultured cerebellar granule cells.

  Brain research 20101028

• Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network.

  The Journal of biological chemistry 20101008

• Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response.

  Alcoholism, clinical and experimental research 20101001

• NF-κB as a common signaling pathway in ganglioside-induced autophagic cell death and activation of astrocytes.

  Journal of neuroimmunology 20100914

• Balamuthia mandrillaris: role of galactose in encystment and identification of potential inhibitory targets.

  Experimental parasitology 20100901

• Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography.

  Nature cell biology 20100901

• Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins.

  Oncogene 20100819

• Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.

  The Journal of biological chemistry 20100813

• The mechanism by which RhoA regulates vascular reactivity after hemorrhagic shock in rats.

  American journal of physiology. Heart and circulatory physiology 20100801

• Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips.

  European journal of pharmacology 20100725

• Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.

  Journal of applied physiology (Bethesda, Md. : 1985) 20100701

• Analysis of responses to the Rho-kinase inhibitor Y-27632 in the pulmonary and systemic vascular bed of the rat.

  American journal of physiology. Heart and circulatory physiology 20100701

• Acute hyperglycemia induces rapid, reversible increases in glomerular permeability in nondiabetic rats.

  American journal of physiology. Renal physiology 20100601

• Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.

  Bioorganic & medicinal chemistry letters 20100601

• Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation.

  Biotechnology progress 20100501

• RhoA-Rho kinase signaling mediates endothelium- and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction.

  American journal of physiology. Heart and circulatory physiology 20100501

• Stimulatory effect of Rho-associated coiled-coil kinase (ROCK) inhibitor on revivability of in vitro-produced bovine blastocysts after vitrification.

  Theriogenology 20100501

• [Effects of simvastatin on proliferation and transition of phenotype in PDGF-BB-induced pulmonary artery smooth muscle cells].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20100501

• Rho-kinase inhibitor attenuates cholestasis-induced CXC chemokine formation, leukocyte recruitment, and hepatocellular damage in the liver.

  The Journal of surgical research 20100401

• Roles of lysophosphatidic acid and the Rho-associated kinase pathway in the migration of dental pulp cells.

  Experimental cell research 20100401

• Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.

  The Journal of pharmacology and experimental therapeutics 20100401

• Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts.

  Bone 20100401

• Kupffer cell activation by hydrogen peroxide: a new mechanism of portal pressure increase.

  Shock (Augusta, Ga.) 20100401

• Rho kinase inhibitor y27632 alters the balance between pluripotency and early differentiation events in human embryonic stem cells.

  Current stem cell research & therapy 20100301

• Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.

  Stem cell reviews 20100301

• Rho kinase inhibitor Y-27632 facilitates recovery from experimental peripheral neuropathy induced by anti-cancer drug cisplatin.

  Neurotoxicology 20100301

• Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility.

  Journal of cell science 20100301

• ROCK inhibition facilitates tissue reconstitution from embryonic kidney cell suspensions.

  Kidney international 20100301

• Protective effects of Y-27632 on acute dichlorvos poisoning in rats.

  The American journal of emergency medicine 20100301

• Rho kinase inhibition protects CA1 cells in organotypic hippocampal slices during in vitro ischemia.

  Brain research 20100226

• N-acetylcysteine inhibits RhoA and promotes apoptotic cell clearance during intense lung inflammation.

  American journal of respiratory and critical care medicine 20100215

• Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia.

  Pediatric research 20100201

• Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro.

  Molecular immunology 20100201

• Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events.

  Journal of cell science 20100201

• Features of distinct contractions induced with a high and a low concentration of KCl, noradrenaline, and histamine in swine lingual artery.

  Naunyn-Schmiedeberg's archives of pharmacology 20100201

• Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis.

  Experimental cell research 20100115

• The suppressive effect of Rho kinase inhibitor, Y-27632, on oncogenic Ras/RhoA induced invasion/migration of human bladder cancer TSGH cells.

  Chemico-biological interactions 20100105

• Interactive role of protein phosphatase 2A and protein kinase Calpha in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery.

  Journal of vascular research 20100101

• Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm.

  Biomaterials 20100101

• New approaches to the treatment of pulmonary hypertension: from bench to bedside.

  Cardiology in review 20100101

• Rho kinases regulate the renewal and neural differentiation of embryonic stem cells in a cell plating density-dependent manner.

  PloS one 20100101

• Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL).

  Cellular immunology 20100101

• Adult rats are more sensitive to the vascular effects induced by hyperhomocysteinemia than young rats.

  Vascular pharmacology 20100101

• Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632.

  Journal of biochemical and molecular toxicology 20100101

• The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.

  PloS one 20100101

• Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells.

  Molecular and cellular neurosciences 20091201

• Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.

  Journal of molecular and cellular cardiology 20091201

• Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.

  Neurochemistry international 20091101

• Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells.

  Prostaglandins & other lipid mediators 20091101

• Inhibition of geranylgeranyltransferase inhibits bronchial smooth muscle hyperresponsiveness in mice.

  American journal of physiology. Lung cellular and molecular physiology 20091101

• ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK.

  The Journal of biological chemistry 20091023

• Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

  The Biochemical journal 20091023

• Comparative screening of glial cell types reveals extracellular matrix that inhibits retinal axon growth in a chondroitinase ABC-resistant fashion.

  Glia 20091001

• Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.

  Journal of viral hepatitis 20091001

• ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors.

  Molecular and cellular neurosciences 20091001

• Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle.

  American journal of physiology. Gastrointestinal and liver physiology 20091001

• In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction.

  Journal of cell science 20090901

• Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies.

  British journal of cancer 20090901

• Rho-mediated regulation of TGF-beta1- and FGF-2-induced activation of corneal stromal keratocytes.

  Investigative ophthalmology & visual science 20090801

• Cyclic mechanical stress and trabecular meshwork cell contractility.

  Investigative ophthalmology & visual science 20090801

• Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor.

  Investigative ophthalmology & visual science 20090801

• Carbohydrate analysis of Acanthamoeba castellanii.

  Experimental parasitology 20090801

• Impaired cAMP and Rac 1 signaling contribute to TNF-alpha-induced endothelial barrier breakdown in microvascular endothelium.

  Microcirculation (New York, N.Y. : 1994) 20090801

• Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.

  Canadian journal of physiology and pharmacology 20090801

• Rho GTPase signaling and PTH 3-34, but not PTH 1-34, maintain the actin cytoskeleton and antagonize bisphosphonate effects in mouse osteoblastic MC3T3-E1 cells.

  Bone 20090701

• Localization of diacylglycerol kinase epsilon on stress fibers in vascular smooth muscle cells.

  Cell and tissue research 20090701

• Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.

  International journal of molecular medicine 20090701

• Lysophosphatidylcholine induces glial cell activation: role of rho kinase.

  Glia 20090601

• The Rho-kinase inhibitor Y-27632 inhibits cholestasis-induced platelet interactions in the hepatic microcirculation.

  Microvascular research 20090601

• Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601

• Rho kinase inhibitor Y-27632 down-regulates norepinephrine synthesis and release in PC12 cells.

  Basic & clinical pharmacology & toxicology 20090601

• Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension.

  Journal of pharmacological sciences 20090601

• Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function.

  Endocrinology 20090501

• Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta.

  The Journal of pharmacology and experimental therapeutics 20090501

• Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling.

  American journal of physiology. Renal physiology 20090501

• A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT.

  American journal of physiology. Cell physiology 20090501

• The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.

  Critical care medicine 20090501

• Vascular dysfunction in septic shock--any ROCKing news?

  Critical care medicine 20090501

• ROCKs are expressed in brain tumors and are required for glioma-cell migration on myelinated axons.

  Glia 20090401

• Roles of focal adhesions and fibronectin-mediated cohesion in proliferation of confluent fibroblasts.

  Journal of cellular physiology 20090401

• Rho GTPases in hepatocellular carcinoma.

  Biochimica et biophysica acta 20090401

• Rho-kinase-mediated suppression of KDR current in cerebral arteries requires an intact actin cytoskeleton.

  American journal of physiology. Heart and circulatory physiology 20090401

• Participation of Rho-associated kinase in electrical stimulated and acetylcholine-induced contraction of feline esophageal smooth muscle.

  European journal of pharmacology 20090401

• Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle.

  Fundamental & clinical pharmacology 20090401

• Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus.

  European journal of pharmacology 20090315

• The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration.

  Investigative ophthalmology & visual science 20090301

• ROCK inhibitor improves survival of cryopreserved serum/feeder-free single human embryonic stem cells.

  Human reproduction (Oxford, England) 20090301

• Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization.

  Free radical biology & medicine 20090301

• Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production.

  The journal of sexual medicine 20090301

• Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts.

  American journal of hypertension 20090201

• Role of protease-activated receptor-1 in endothelial nitric oxide synthase-Thr495 phosphorylation.

  Experimental biology and medicine (Maywood, N.J.) 20090201

• Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090201

• EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.

  Journal of cell science 20090115

• Lipocalin-2 is an autocrine mediator of reactive astrocytosis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090107

• ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration.

  Journal of pineal research 20090101

• Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms.

  Cell calcium 20090101

• The small GTPase Rho mediates articular chondrocyte phenotype and morphology in response to interleukin-1alpha and insulin-like growth factor-I.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20090101

• Serofendic acid promotes stellation induced by cAMP and cGMP analogs in cultured cortical astrocytes.

  Journal of pharmacological sciences 20090101

• Possible mechanisms underlying statin-induced skeletal muscle toxicity in L6 fibroblasts and in rats.

  Journal of pharmacological sciences 20090101

• Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin.

  Reproductive biology and endocrinology : RB&E 20090101

• Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a Rho-kinase inhibitor on contraction of the porcine urinary bladder.

  Neurourology and urodynamics 20090101

• Obstruction alters muscarinic receptor-coupled RhoA/Rho-kinase pathway in the urinary bladder of the rat.

  Neurourology and urodynamics 20090101

• In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue.

  PloS one 20090101

• Signaling through Rho GTPase pathway as viable drug target.

  Current medicinal chemistry 20090101

• Contractility of diabetic human corpus cavernosum smooth muscle in response to serotonin mediated via Rho-kinase.

  Pharmacology 20090101

• Role of Rho/Rho-kinase and NO/cGMP signaling pathways in vascular function prior to atherosclerosis.

  Journal of atherosclerosis and thrombosis 20090101

• Y-27632 enhances differentiation of blastocyst like cystic human embryoid bodies to endocrinologically active trophoblast cells on a biomimetic platform.

  Journal of biomedical science 20090101

• Rearrangements of the actin cytoskeleton and E-cadherin-based adherens junctions caused by neoplasic transformation change cell-cell interactions.

  PloS one 20090101

• Concomitant inhibition of prolyl hydroxylases and ROCK initiates differentiation of mesenchymal stem cells and PC12 towards the neuronal lineage.

  Biochemical and biophysical research communications 20081212

• Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells.

  Experimental cell research 20081210

• The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway.

  Endocrine-related cancer 20081201

• Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery.

  Cardiovascular research 20081201

• Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries.

  Arteriosclerosis, thrombosis, and vascular biology 20081201

• The ROCK inhibitor Y-27632 enhances the survival rate of human embryonic stem cells following cryopreservation.

  Stem cells and development 20081201

• Y-27632 augments the isoflurane-induced relaxation of bronchial smooth muscle in rats.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20081201

• Apolipoprotein(a), through its strong lysine-binding site in KIV(10'), mediates increased endothelial cell contraction and permeability via a Rho/Rho kinase/MYPT1-dependent pathway.

  The Journal of biological chemistry 20081107

• Activation of Rho-kinase in the brainstem enhances sympathetic drive in mice with heart failure.

  Autonomic neuroscience : basic & clinical 20081103

• Dual pathway activated by tert-butyl hydroperoxide in human airway anion secretion.

  The Journal of pharmacology and experimental therapeutics 20081101

• Rho-associated kinase inhibitor Y-27632 promotes survival of cynomolgus monkey embryonic stem cells.

  Molecular human reproduction 20081101

• Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis.

  Arthritis and rheumatism 20081101

• Identification of the Rock-dependent transcriptome in rodent fibroblasts.

  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20081101

• Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells.

  Experimental cell research 20081015

• Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.

  European journal of pharmacology 20081010

• Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.

  The Journal of pharmacology and experimental therapeutics 20081001

• Effects of a selective Rho-kinase inhibitor Y-27632 on oxidative stress parameters in acute dichlorvos poisoning in rats.

  Cell biochemistry and function 20081001

• Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts.

  British journal of pharmacology 20081001

• RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells.

  Molecular cancer research : MCR 20081001

• [Human pluripotent stem cell and neural differentiation].

  Brain and nerve = Shinkei kenkyu no shinpo 20081001

• Detection of myosin light chain phosphorylation--a cell-based assay for screening Rho-kinase inhibitors.

  Biochemical and biophysical research communications 20080919

• Role of RhoA in activity-dependent cortical axon branching.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080910

• Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.

  British journal of pharmacology 20080901

• Regulation of polarity in cells devoid of actin bundle system after treatment with inhibitors of myosin II activity.

  Cell motility and the cytoskeleton 20080901

• Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression.

  Pharmacogenetics and genomics 20080901

• H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation.

  European journal of pharmacology 20080820

• Effects of endothelin-1 on calcium-independent contraction of bovine trabecular meshwork.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20080801

• Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons.

  Toxicological sciences : an official journal of the Society of Toxicology 20080801

• Rho kinases regulate corneal epithelial wound healing.

  American journal of physiology. Cell physiology 20080801

• Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo.

  American journal of physiology. Cell physiology 20080801

• High glucose-induced upregulation of Rho/Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells.

  Journal of molecular and cellular cardiology 20080801

• Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy.

  The British journal of surgery 20080801

• Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.

  Arthritis and rheumatism 20080801

• The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation.

  American journal of physiology. Lung cellular and molecular physiology 20080701

• Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.

  Neurotoxicology 20080701

• Adenosine-oligoarginine conjugate, a novel bisubstrate inhibitor, effectively dissociates the actin cytoskeleton.

  The FEBS journal 20080701

• Possible involvement of Rho-kinase in aldosterone-induced vascular smooth muscle cell remodeling.

  Hypertension research : official journal of the Japanese Society of Hypertension 20080701

• Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction.

  Anesthesia and analgesia 20080601

• Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells.

  Molecular cancer therapeutics 20080601

• [Optic nerve regeneration in adult mammals].

  Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20080601

• Melatonin restores impaired contractility in aged guinea pig urinary bladder.

  Journal of pineal research 20080501

• Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder.

  The journal of sexual medicine 20080501

• Prolactin stimulates transepithelial calcium transport and modulates paracellular permselectivity in Caco-2 monolayer: mediation by PKC and ROCK pathways.

  American journal of physiology. Cell physiology 20080501

• Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes.

  Journal of pharmacological sciences 20080501

• High glucose increases phosphocofilin via phosphorylation of LIM kinase due to Rho/Rho kinase activation in cultured pig proximal tubular epithelial cells.

  Diabetes research and clinical practice 20080401

• Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity.

  Cellular signalling 20080401

• Rho kinase is involved in Ca2+ entry of rat penile small arteries.

  American journal of physiology. Heart and circulatory physiology 20080401

• Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis.

  Kidney & blood pressure research 20080401

• Characterizations of sphingosylphosphorylcholine-induced scratching responses in ICR mice using naltrexon, capsaicin, ketotifen and Y-27632.

  European journal of pharmacology 20080331

• Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats.

  Brain research 20080327

• Proinsulin C-peptide constricts glomerular afferent arterioles in diabetic mice. A potential renoprotective mechanism.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080301

• Roles of Rho guanosine 5'-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1/2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast.

  Endocrinology 20080301

• Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis.

  Apoptosis : an international journal on programmed cell death 20080301

• Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle.

  American journal of physiology. Gastrointestinal and liver physiology 20080301

• Rho kinase inhibition: a new approach for treating diabetic nephropathy?

  Diabetes 20080301

• Purkinje cell survival in organotypic cultures: implication of Rho and its downstream effector ROCK.

  Journal of neuroscience research 20080215

• Aggrecan components differentially modulate nerve growth factor-responsive and neurotrophin-3-responsive dorsal root ganglion neurite growth.

  Journal of neuroscience research 20080215

• In vivo phosphorylation of regulatory light chain of myosin II in sea urchin eggs and its role in controlling myosin localization and function during cytokinesis.

  Cell motility and the cytoskeleton 20080201

• Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide.

  American journal of physiology. Lung cellular and molecular physiology 20080201

• The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression.

  American journal of physiology. Renal physiology 20080201

• The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes.

  Experimental eye research 20080201

• Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells.

  Journal of cardiovascular pharmacology 20080201

• Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20080101

• Changes in the smooth muscle of the corpora cavernosum related to reversal of partial bladder outlet obstruction in rabbits.

  Journal of andrology 20080101

• Heterogeneity in 5-HT-induced contractile and proliferative responses in rat pulmonary arterial bed.

  Journal of vascular research 20080101

• ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells.

  Brain : a journal of neurology 20080101

• Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.

  Cancer research 20080101

• Analysis of the pattern of subcellular force generation by corneal fibroblasts after Rho activation.

  Eye & contact lens 20080101

• Analysis of Rho-GTPase mimicry by a family of bacterial type III effector proteins.

  Methods in enzymology 20080101

• Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.

  Prostaglandins, leukotrienes, and essential fatty acids 20080101

• Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway.

  Journal of muscle research and cell motility 20080101

• A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells.

  Neural development 20080101

• Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons.

  Molecular brain 20080101

• [The contribution of protein kinase C and Rho-kinase to the control of the receptor-dependent artery contraction decreases with age independently of sympathetic innervation].

  Biofizika 20080101

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation.

  Journal of cardiovascular pharmacology 20071201

• Contraction of tubulointerstitial fibrosis tissue in diabetic nephropathy, as demonstrated in an in vitro fibrosis model.

  Virchows Archiv : an international journal of pathology 20071101

• Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis.

  Journal of gastroenterology and hepatology 20071101

• Attenuation of actinomyosinII contractile activity in growth cones accelerates filopodia-guided and microtubule-based neurite elongation.

  Brain research 20071024

• Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.

  Journal of cellular biochemistry 20071001

• Intracellular signalling pathways in the vasoconstrictor response of mouse afferent arterioles to adenosine.

  Acta physiologica (Oxford, England) 20071001

• Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo.

  Journal of neurochemistry 20071001

• Rho guanosine 5'-triphosphatases differentially regulate insulin-like growth factor I (IGF-I) receptor-dependent and -independent actions of IGF-II on human trophoblast migration.

  Endocrinology 20071001

• Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle.

  American journal of physiology. Gastrointestinal and liver physiology 20071001

• Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase.

  American journal of physiology. Cell physiology 20071001

• RhoA required for acid-induced stress fiber formation and trafficking and activation of NHE3.

  American journal of physiology. Renal physiology 20071001

• Optimizing nitric oxide production by time dependent L-arginine administration in isolated human corpus cavernosum.

  The Journal of urology 20071001

• Microtubule regulation of corneal fibroblast morphology and mechanical activity in 3-D culture.

  Experimental eye research 20071001

• [Advances in the study of Rho kinase and its inhibitors].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071001

• Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.

  British journal of pharmacology 20070901

• VIP induces the elongation of dendrites and axons in cultured hippocampal neurons: role of microtubules.

  Peptides 20070901

• Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes.

  Free radical research 20070901

• Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.

  Biochemical pharmacology 20070815

• Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.

  American journal of physiology. Lung cellular and molecular physiology 20070801

• Dynamics of actin filaments during tension-dependent formation of actin bundles.

  Biochimica et biophysica acta 20070801

• Rho inhibition induces migration of mesenchymal stromal cells.

  Stem cells (Dayton, Ohio) 20070801

• The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.

  Leukemia 20070801

• Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state.

  The American journal of pathology 20070801

• Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms.

  Journal of molecular and cellular cardiology 20070801

• Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats.

  Journal of hypertension 20070801

• Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.

  Nature reviews. Drug discovery 20070801

• Effects of Rho-kinase and Src protein tyrosine kinase inhibition on agonist-induced vasoconstriction of arteries and veins of the equine laminar dermis.

  American journal of veterinary research 20070801

• A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon.

  Pflugers Archiv : European journal of physiology 20070701

• Acute inhibition of Rho-kinase improves cardiac contractile function in streptozotocin-diabetic rats.

  Cardiovascular research 20070701

• Insulin increases the expression of contractile phenotypic markers in airway smooth muscle.

  American journal of physiology. Cell physiology 20070701

• Crosstalk between HIF-1 and ROCK pathways in neuronal differentiation of mesenchymal stem cells, neurospheres and in PC12 neurite outgrowth.

  Molecular and cellular neurosciences 20070701

• Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons.

  Pediatric research 20070701

• Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells.

  Journal of cell science 20070701

• Vasorelaxing effect of the Rho-kinase inhibitor, Y-27632, in isolated canine basilar arteries.

  Neurological research 20070701

• Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.

  Journal of cellular biochemistry 20070601

• Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.

  American journal of physiology. Heart and circulatory physiology 20070601

• The RISK of ROCK.

  American journal of physiology. Heart and circulatory physiology 20070601

• Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition.

  American journal of respiratory cell and molecular biology 20070601

• Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions.

  American journal of physiology. Heart and circulatory physiology 20070601

• Protein kinase A inhibits lysophosphatidic acid-induced migration of airway smooth muscle cells.

  The Journal of pharmacology and experimental therapeutics 20070601

• Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK.

  American journal of physiology. Gastrointestinal and liver physiology 20070601

• Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells.

  Cardiovascular research 20070601

• Roles of P2X receptors and Ca2+ sensitization in extracellular adenosine triphosphate-induced hyperresponsiveness in airway smooth muscle.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070601

• Somatostatin induces rapid contraction of neuroendocrine cells.

  FEBS letters 20070515

• Heat shock augments myosin phosphatase target-subunit phosphorylation.

  Biochemical and biophysical research communications 20070511

• Hypertonicity triggers RhoA-dependent assembly of myosin-containing striated polygonal actin networks in endothelial cells.

  American journal of physiology. Cell physiology 20070501

• Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease.

  American journal of physiology. Gastrointestinal and liver physiology 20070501

• Rho-family small GTPases are involved in forskolin-induced cell-cell contact formation of renal glomerular podocytes in vitro.

  Cell and tissue research 20070501

• Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts.

  Journal of cellular physiology 20070501

• A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.

  Experimental neurology 20070501

• The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12.

  Journal of cell science 20070501

• Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells.

  Investigative ophthalmology & visual science 20070501

• Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes.

  The journal of sexual medicine 20070501

• Small GTPase Rho signaling is involved in beta1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation.

  Biochemical and biophysical research communications 20070427

• Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.

  Circulation 20070403

• Oxytocin-induced phasic and tonic contractions are modulated by the contractile machinery rather than the quantity of oxytocin receptor.

  American journal of physiology. Endocrinology and metabolism 20070401

• Collagen gel contractility is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis-associated fibrosis.

  Human reproduction (Oxford, England) 20070401

• Hypotonicity causes actin reorganization and recruitment of the actin-binding ERM protein moesin in membrane protrusions in collecting duct principal cells.

  American journal of physiology. Cell physiology 20070401

• RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.

  The Journal of biological chemistry 20070316

• Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia.

  American journal of physiology. Lung cellular and molecular physiology 20070301

• Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors.

  American journal of physiology. Gastrointestinal and liver physiology 20070301

• Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.

  Experimental eye research 20070301

• Involvement of nuclear factor-kB activation through RhoA/Rho-kinase pathway in LPS-induced IL-8 production in human cervical stromal cells.

  Molecular human reproduction 20070301

• Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.

  Journal of molecular and cellular cardiology 20070301

• Direct effects of hydrogen peroxide on airway smooth muscle tone: roles of Ca2+ influx and Rho-kinase.

  European journal of pharmacology 20070205

• Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine.

  American journal of physiology. Gastrointestinal and liver physiology 20070201

• Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction.

  American journal of physiology. Lung cellular and molecular physiology 20070201

• Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors.

  Journal of hypertension 20070201

• Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070201

• A role for WASP Interacting Protein, WIP, in fibroblast adhesion, spreading and migration.

  The international journal of biochemistry & cell biology 20070101

• Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro.

  Inhalation toxicology 20070101

• RhoA activation and interaction with Caveolin-1 are critical for pressure-induced myogenic tone in rat mesenteric resistance arteries.

  Cardiovascular research 20070101

• RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate.

  Neurourology and urodynamics 20070101

• Lysophosphatidic acid stimulation of platelets rapidly induces Ca2+-dependent dephosphorylation of cofilin that is independent of dense granule secretion and aggregation.

  Blood cells, molecules & diseases 20070101

• Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy.

  BMC cell biology 20070101

• Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.

  European journal of pharmacology 20061215

• Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca2+ handling and Rho/ROCK signaling.

  American journal of physiology. Lung cellular and molecular physiology 20061201

• Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.

  American journal of respiratory cell and molecular biology 20061201

• Non-muscle myosin-II-B filament regulation of paracellular resistance in cervical epithelial cells is associated with modulation of the cortical acto-myosin.

  Journal of the Society for Gynecologic Investigation 20061201

• Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway.

  Molecular cancer therapeutics 20061201

• A Rho-kinase inhibitor, Y-27632, reduces cholinergic contraction but not neurotransmitter release.

  European journal of pharmacology 20061121

• Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets.

  The Biochemical journal 20061115

• Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung.

  American journal of physiology. Lung cellular and molecular physiology 20061101

• Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells.

  Stem cells (Dayton, Ohio) 20061101

• Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation.

  Cardiovascular research 20061101

• Rho-kinase-mediated regulation of receptor-agonist-stimulated smooth muscle contraction.

  Pflugers Archiv : European journal of physiology 20061101

• Quantitative assessment of local collagen matrix remodeling in 3-D culture: the role of Rho kinase.

  Experimental cell research 20061101

• Changes of Rho kinase activity after hemorrhagic shock and its role in shock-induced biphasic response of vascular reactivity and calcium sensitivity.

  Shock (Augusta, Ga.) 20061101

• Rho kinase regulates phagocytosis, surface expression of GlcNAc, and Golgi fragmentation of apoptotic PC12 cells.

  Experimental cell research 20061015

• Myosin-based contraction is not necessary for cardiac c-looping in the chick embryo.

  Anatomy and embryology 20061001

• Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin.

  American journal of physiology. Cell physiology 20061001

• Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons.

  The Journal of pharmacology and experimental therapeutics 20061001

• Internal mammary artery smooth muscle cells resist migration and possess high antioxidant capacity.

  Cardiovascular research 20061001

• Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes.

  Cardiovascular research 20061001

• Ovariectomy augments hypertension through rho-kinase activation in the brain stem in female spontaneously hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20061001

• Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20060927

• Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway.

  Respiratory medicine 20060901

• Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.

  American journal of physiology. Heart and circulatory physiology 20060901

• HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1.

  Life sciences 20060829

• Thrombin-induced contraction in alveolar epithelial cells probed by traction microscopy.

  Journal of applied physiology (Bethesda, Md. : 1985) 20060801

• Chronic fluvastatin treatment alters vascular contraction by inhibiting the Rho/Rho-kinase pathway.

  Clinical and experimental pharmacology & physiology 20060801

• Rho-kinase inhibitor, Y-27632, has an antinociceptive effect in mice.

  European journal of pharmacology 20060710

• Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

  International journal of cancer 20060701

• Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats.

  The Journal of pharmacology and experimental therapeutics 20060701

• Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation.

  Cell motility and the cytoskeleton 20060701

• Contribution of Rho-kinase in human gallbladder contractions.

  European journal of pharmacology 20060701

• Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes.

  Stroke 20060701

• Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells.

  Journal of cell science 20060701

• The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null mice.

  Journal of hypertension 20060701

• An MLCK-dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK-p70S6K pathway.

  Hepatology (Baltimore, Md.) 20060701

• Rho A/Rho kinase: human umbilical artery mRNA expression in normal and pre eclamptic pregnancies and functional role in isoprostane-induced vasoconstriction.

  Reproduction (Cambridge, England) 20060701

• Rho-kinase contributes to hypoxia/reoxygenation-induced cerebral endothelial dysfunction.

  Journal of cardiovascular pharmacology 20060701

• Phosphoryl transfer is not rate-limiting for the ROCK I-catalyzed kinase reaction.

  Biochemistry 20060627

• Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction.

  The Journal of urology 20060601

• Myosin light chain kinase plays a role in the regulation of epithelial cell survival.

  Journal of cell science 20060601

• Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation.

  Experimental cell research 20060515

• Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury.

  Journal of leukocyte biology 20060501

• A role for Rho kinase in vascular contraction evoked by sodium fluoride.

  Biochemical and biophysical research communications 20060428

• Involvement of Rho signaling in PAR2-mediated regulation of neutrophil adhesion to lung epithelial cells.

  European journal of pharmacology 20060424

• Tubuloglomerular feedback-dependent modulation of renal myogenic autoregulation by nitric oxide.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060401

• Differential Rho-kinase dependency of full and partial muscarinic receptor agonists in airway smooth muscle contraction.

  British journal of pharmacology 20060401

• Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat.

  Naunyn-Schmiedeberg's archives of pharmacology 20060401

• Sphingosine-1-phosphate modulates spiral modiolar artery tone: A potential role in vascular-based inner ear pathologies?

  Cardiovascular research 20060401

• Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.

  Autonomic & autacoid pharmacology 20060401

• Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells.

  European journal of pharmacology 20060327

• Stretch-induced triphosphorylation of myosin light chain and myogenic tone in canine basilar artery.

  European journal of pharmacology 20060318

• Role of Rho-kinase in guinea-pig gallbladder smooth muscle contraction.

  European journal of pharmacology 20060318

• Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells.

  Experimental eye research 20060301

• Increased basal phosphorylation of detrusor smooth muscle myosin in alloxan-induced diabetic rabbit is mediated by upregulation of Rho-kinase beta and CPI-17.

  American journal of physiology. Renal physiology 20060301

• The role of Rho-associated kinase in differential regulation by statins of interleukin-1beta- and lipopolysaccharide-mediated nuclear factor kappaB activation and inducible nitric-oxide synthase gene expression in vascular smooth muscle cells.

  Molecular pharmacology 20060301

• Pregnancy-induced modulation of calcium mobilization and down-regulation of Rho-kinase expression contribute to attenuated vasopressin-induced contraction of the rat aorta.

  Vascular pharmacology 20060301

• Centaureidin promotes dendrite retraction of melanocytes by activating Rho.

  Biochimica et biophysica acta 20060301

• Heat shock-induced augmentation of vascular contractility is independent of rho-kinase.

  Clinical and experimental pharmacology & physiology 20060301

• Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity.

  Journal of pharmacological sciences 20060301

• Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats.

  Gastroenterology 20060301

• Developmental regulation of nerve and receptor mediated contractions of mammalian urinary bladder smooth muscle.

  European journal of pharmacology 20060217

• Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.

  Experimental cell research 20060215

• Inhibition of Rho-kinase normalizes nonspecific hyperresponsiveness in passively sensitized airway smooth muscle preparations.

  European journal of pharmacology 20060215

• Involvement of rho kinase in the ouabain-induced contractions of the rat renal arteries.

  Biochemical and biophysical research communications 20060210

• Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats.

  American journal of physiology. Lung cellular and molecular physiology 20060201

• Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage.

  American journal of physiology. Heart and circulatory physiology 20060201

• Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells.

  Cardiovascular research 20060201

• Rho/ROCK pathway as a target of tumor therapy.

  Journal of neuroscience research 20060201

• Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060201

• The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.

  The Journal of biological chemistry 20060106

• Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060101

• Role of protein kinases in mediating diabetes-induced augmented vasoconstriction to endothelin-1 in the renal arteries of STZ-diabetic rats.

  Cell biochemistry and function 20060101

• RhoA- and PKC-alpha-mediated phosphorylation of MYPT and its association with HSP27 in colonic smooth muscle cells.

  American journal of physiology. Gastrointestinal and liver physiology 20060101

• Rho kinase regulates fragmentation and phagocytosis of apoptotic cells.

  Experimental cell research 20060101

• Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro.

  Reproduction (Cambridge, England) 20060101

• Mechanism of increased alpha-adrenoceptor-mediated contraction in small resistance arteries of rats with heart failure.

  Clinical and experimental pharmacology & physiology 20060101

• Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.

  Protein and peptide letters 20060101

• Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity.

  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20060101

• Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells.

  Cellular & molecular biology letters 20060101

• Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction.

  Respiratory research 20060101

• Rho kinase expression and its central role in ovine gallbladder contractions elicited by a variety of excitatory stimuli.

  European journal of pharmacology 20051228

• 5-Hydroxytryptamine as a potent migration enhancer of human aortic endothelial cells.

  FEBS letters 20051219

• Lysophosphatidic acid induces histamine release from mast cells and skin fragments.

  Pharmacology 20051201

• Role of Rho-kinase in reexpansion pulmonary edema in rabbits.

  American journal of physiology. Lung cellular and molecular physiology 20051201

• Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle.

  American journal of physiology. Lung cellular and molecular physiology 20051201

• Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing.

  Journal of neurochemistry 20051201

• Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury.

  Experimental neurology 20051201

• [The role of specific ROCK inhibitor in the prevention of experimental PVR in rabbits].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20051201

• Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.

  American journal of physiology. Heart and circulatory physiology 20051101

• Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro.

  British journal of pharmacology 20051101

• Inhibition of the RhoA/Rho kinase system attenuates catecholamine biosynthesis in PC 12 rat pheochromocytoma cells.

  Biochimica et biophysica acta 20051030

• Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

  European journal of pharmacology 20051003

• Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.

  Cardiovascular research 20051001

• 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase.

  Journal of applied physiology (Bethesda, Md. : 1985) 20051001

• Proerectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis.

  The Journal of pharmacology and experimental therapeutics 20051001

• Okadaic acid induces phosphorylation and translocation of myosin phosphatase target subunit 1 influencing myosin phosphorylation, stress fiber assembly and cell migration in HepG2 cells.

  Cellular signalling 20051001

• Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue.

  Cardiovascular research 20051001

• Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.

  Stroke 20051001

• Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery.

  Clinical and experimental pharmacology & physiology 20051001

• Cooling-induced contraction of the rat gastric fundus: mediation via transient receptor potential (TRP) cation channel TRPM8 receptor and Rho-kinase activation.

  Clinical and experimental pharmacology & physiology 20051001

• Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1.

  Cancer research 20051001

• Redundant mechanisms for anaphase chromosome movements: crane-fly spermatocyte spindles normally use actin filaments but also can function without them.

  Protoplasma 20051001

• A key role for Abl family kinases in EphA receptor-mediated growth cone collapse.

  Molecular and cellular neurosciences 20050901

• Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells.

  Journal of cell science 20050901

• Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration.

  Breast cancer research and treatment 20050901

• PHI-1 induced enhancement of myosin phosphorylation in chicken smooth muscle.

  FEBS letters 20050815

• RhoA-Rho kinase pathway mediates thrombin- and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle cells.

  American journal of physiology. Cell physiology 20050801

• Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats.

  Hypertension (Dallas, Tex. : 1979) 20050801

• Intrathecal administration of Y-27632, a specific rho-associated kinase inhibitor, for rat neoplastic meningitis.

  Molecular cancer research : MCR 20050801

• Cdc42 contributes to phorbol ester-induced Ca2+-independent contraction of pulmonary artery smooth muscle.

  The Journal of veterinary medical science 20050801

• Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle.

  European journal of pharmacology 20050711

• ROK-induced cross-link formation stiffens passive muscle: reversible strain-induced stress softening in rabbit detrusor.

  American journal of physiology. Cell physiology 20050701

• Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

  The Journal of biological chemistry 20050701

• Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin.

  Pharmacology 20050701

• Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells.

  The Journal of biological chemistry 20050610

• Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632.

  American journal of respiratory cell and molecular biology 20050601

• Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.

  Experimental eye research 20050601

• Trapidil inhibits platelet-derived growth factor-induced migration via protein kinase A and RhoA/Rho-associated kinase in rat vascular smooth muscle cells.

  European journal of pharmacology 20050516

• Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats.

  European journal of pharmacology 20050509

• Contractile properties of the cultured vascular smooth muscle cells: the crucial role played by RhoA in the regulation of contractility.

  Circulation research 20050429

• Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427

• Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells.

  Biochimica et biophysica acta 20050415

• Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction.

  Cardiovascular research 20050401

• Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632.

  European journal of pharmacology 20050307

• Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

  American journal of respiratory and critical care medicine 20050301

• Small guanine nucleotide-binding protein Rho and myocardial function.

  Acta pharmacologica Sinica 20050301

• Tocolytic effect of a Rho-kinase inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery.

  American journal of obstetrics and gynecology 20050301

• Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer.

  The Journal of pharmacy and pharmacology 20050301

• Differential inhibition by the Rho kinase inhibitor Y-27632 of the increases in contractility and Ca2+ transients induced by endothelin-1 in rabbit ventricular myocytes.

  Naunyn-Schmiedeberg's archives of pharmacology 20050301

• Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050202

• RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability.

  American journal of physiology. Lung cellular and molecular physiology 20050201

• Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway.

  Cellular signalling 20050201

• Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes.

  Stroke 20050201

• Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys.

  Experimental eye research 20050201

• Rho-kinase and myosin II activities are required for cell type and environment specific migration.

  Genes to cells : devoted to molecular & cellular mechanisms 20050201

• Extracellular signal-regulated kinase1/2 in contraction of vascular smooth muscle.

  Life sciences 20050107

• Effects of Y-27632, a selective Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats.

  Biochemical pharmacology 20050101

• Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model.

  Journal of vascular research 20050101

• Cardioprotective mechanisms of Rho-kinase inhibition associated with eNOS and oxidative stress-LOX-1 pathway in Dahl salt-sensitive hypertensive rats.

  Journal of hypertension 20050101

• Attenuated noradrenaline-induced contraction of pulmonary arteries from rats treated with monocrotaline: role of rho kinase.

  Journal of vascular research 20050101

• The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner.

  The Journal of biological chemistry 20041224

• RhoA and Rac1 are both required for efficient wound closure of airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20041201

• Vasoconstrictor mechanisms in the cerebral circulation are unaffected by insulin resistance.

  American journal of physiology. Regulatory, integrative and comparative physiology 20041201

• Rho-kinase inhibition enhances axonal plasticity and attenuates cold hyperalgesia after dorsal rhizotomy.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

• N-cadherin juxtamembrane domain modulates voltage-gated Ca2+ current via RhoA GTPase and Rho-associated kinase.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

• Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.

  The Journal of biological chemistry 20041105

• The role of Rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein.

  The Journal of pharmacology and experimental therapeutics 20041101

• Differential regulation of human lung epithelial and endothelial barrier function by thrombin.

  American journal of respiratory cell and molecular biology 20041101

• HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.

  Cardiovascular research 20041101

• The permeability-reducing effects of prostacyclin and inhibition of Rho kinase do not counteract endotoxin-induced increase in permeability in cat skeletal muscle.

  Microvascular research 20041101

• Differential interplay between protein kinase C and Rho-kinase in the endothelin-1-induced and pressure-induced contractions of rat posterior cerebral artery.

  Journal of cardiovascular pharmacology 20041101

• Cell type-specific regulation of RhoA activity during cytokinesis.

  The Journal of biological chemistry 20041022

• Rho/ROCK and Cdk5 effects on phosphorylation of a beta-thymosin repeat protein in Hermissenda.

  Biochemical and biophysical research communications 20041015

• Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors.

  The Journal of biological chemistry 20041008

• Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats.

  American journal of physiology. Lung cellular and molecular physiology 20041001

• Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway.

  American journal of physiology. Lung cellular and molecular physiology 20041001

• KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase.

  American journal of physiology. Lung cellular and molecular physiology 20041001

• Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms.

  Journal of cellular physiology 20041001

• Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.

  British journal of pharmacology 20041001

• Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta.

  American journal of physiology. Heart and circulatory physiology 20041001

• [Role of ROK in contraction of rat femoral arteries after 14 d tail suspension].

  Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering 20041001

• Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho family small GTPases in hippocampal neurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040929

• A role for hippocampal Rho-ROCK pathway in long-term spatial memory.

  Biochemical and biophysical research communications 20040924

• Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin.

  Circulation research 20040917

• Upregulation of Rho-kinase (ROCK-2) expression and enhanced contraction to endothelin-1 in the mesenteric artery from lipopolysaccharide-treated rats.

  European journal of pharmacology 20040913

• Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes.

  The Journal of biological chemistry 20040910

• Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities.

  The Journal of biological chemistry 20040910

• Evidence that estrogen suppresses rho-kinase function in the cerebral circulation in vivo.

  Stroke 20040901

• Itch-scratch responses induced by lysophosphatidic acid in mice.

  Pharmacology 20040901

• Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.

  Cardiovascular research 20040901

• Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro.

  BJU international 20040901

• The small GTPase Rac is involved in clustering of hippocampal neurons and fasciculation of their neurites.

  Naunyn-Schmiedeberg's archives of pharmacology 20040901

• Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization.

  The Journal of biological chemistry 20040813

• Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitro.

  American journal of physiology. Heart and circulatory physiology 20040801

• Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments.

  Arteriosclerosis, thrombosis, and vascular biology 20040801

• Chronic mevastatin modulates receptor-dependent vascular contraction in eNOS-deficient mice.

  American journal of physiology. Regulatory, integrative and comparative physiology 20040801

• Ca2+ sensitization in contraction of human bladder smooth muscle.

  The Journal of urology 20040801

• Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca²⁺ sensitization in smooth muscle.

  The Journal of biological chemistry 20040709

• Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase.

  American journal of physiology. Lung cellular and molecular physiology 20040701

• An essential role of Cav1.2 L-type calcium channel for urinary bladder function.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040701

• P-cresol, a uremic retention solute, alters the endothelial barrier function in vitro.

  Thrombosis and haemostasis 20040701

• Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants.

  Biophysical journal 20040701

• CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.

  The Journal of biological chemistry 20040625

• Partial protective effect of Y-27632, a Rho kinase inhibitor, against hepatic ischemia-reperfusion injury in rats.

  European journal of pharmacology 20040616

• Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20040601

• Rho/Rho kinase and phosphoinositide 3-kinase are parallel pathways in the development of spontaneous arterial tone in deoxycorticosterone acetate-salt hypertension.

  The Journal of pharmacology and experimental therapeutics 20040601

• The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho.

  Journal of leukocyte biology 20040601

• Mechanisms involved in carbachol-induced Ca(2+) sensitization of contractile elements in rat proximal and distal colon.

  British journal of pharmacology 20040601

• Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice.

  Hypertension (Dallas, Tex. : 1979) 20040501

• Female pig urethral tone is dependent on Rho guanosine triphosphatases and Rho-associated kinase.

  The Journal of urology 20040501

• Role of ERK and Rho kinase pathways in central pressor action of urotensin II.

  Journal of hypertension 20040501

• GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions.

  Circulation research 20040430

• Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.

  European journal of pharmacology 20040426

• Length control is determined by the pattern of cytoskeleton.

  Journal of cell science 20040415

• Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401

• Development of a microplate bioassay for monocyte chemoattractant protein-1 based on activation of p44/42 mitogen-activated protein kinase.

  Analytical biochemistry 20040401

• The role of the cytoskeleton in cellular adhesion molecule expression in tumor necrosis factor-stimulated endothelial cells.

  Journal of cellular biochemistry 20040401

• Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats.

  International journal of impotence research 20040401

• Rho kinase inhibition initiates apoptosis in human airway epithelial cells.

  American journal of respiratory cell and molecular biology 20040301

• Pyrimidine nucleotides suppress KDR currents and depolarize rat cerebral arteries by activating Rho kinase.

  American journal of physiology. Heart and circulatory physiology 20040301

• Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability.

  American journal of physiology. Heart and circulatory physiology 20040301

• Characterization of G proteins involved in activation of nonselective cation channels and arachidonic acid release by norepinephrine/alpha1A-adrenergic receptors.

  American journal of physiology. Cell physiology 20040301

• ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium.

  Developmental dynamics : an official publication of the American Association of Anatomists 20040301

• [Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].

  Nihon rinsho. Japanese journal of clinical medicine 20040301

• HSP27 regulates fibroblast adhesion, motility, and matrix contraction.

  Cell stress & chaperones 20040301

• The apolipoprotein(a) component of lipoprotein(a) stimulates actin stress fiber formation and loss of cell-cell contact in cultured endothelial cells.

  The Journal of biological chemistry 20040220

• A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line.

  Biochemical and biophysical research communications 20040206

• High glucose-induced upregulation of osteopontin is mediated via Rho/Rho kinase pathway in cultured rat aortic smooth muscle cells.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• Myosin-mediated cytoskeleton contraction and Rho GTPases regulate laminin-5 matrix assembly.

  Cell motility and the cytoskeleton 20040201

• Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.

  Hypertension (Dallas, Tex. : 1979) 20040201

• Involvement of rho-kinase pathway in contractile activity of rabbit RPE cells in vivo and in vitro.

  Investigative ophthalmology & visual science 20040201

• [Rho-kinase inhibitor].

  Nihon rinsho. Japanese journal of clinical medicine 20040201

• Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.

  World journal of gastroenterology 20040115

• Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites.

  The Journal of biological chemistry 20040102

• Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts.

  American journal of physiology. Cell physiology 20040101

• Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder.

  British journal of pharmacology 20040101

• Induction of neurites by the regulatory domains of PKCdelta and epsilon is counteracted by PKC catalytic activity and by the RhoA pathway.

  Experimental cell research 20040101

• The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis.

  Drug news & perspectives 20040101

• Rho-ROCK signal pathway regulates microtubule-based process formation of cultured podocytes--inhibition of ROCK promoted process elongation.

  Nephron. Experimental nephrology 20040101

• Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery.

  Cell biochemistry and biophysics 20040101

• Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway.

  Current biology : CB 20031216

• Engulfment of apoptotic cells is negatively regulated by Rho-mediated signaling.

  The Journal of biological chemistry 20031212

• Rho kinase inhibitors block activation of pancreatic stellate cells.

  British journal of pharmacology 20031201

• Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells.

  The Journal of urology 20031201

• Role of Rho kinase and actin filament in the increased vascular permeability of skin venules in rats after scalding.

  Burns : journal of the International Society for Burn Injuries 20031201

• Edaravone, a radical scavenger, may enhance or produce antiproliferative effects of fluvastatin, amlodipine, ozagrel, GF109203X and Y27632 on cultured basilar artery smooth muscle cells.

  Biological & pharmaceutical bulletin 20031201

• Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.

  Structure (London, England : 1993) 20031201

• The role of rho and rho-dependent kinase in serotonin-induced contraction observed in bovine middle cerebral artery.

  The Tohoku journal of experimental medicine 20031201

• Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.

  Science (New York, N.Y.) 20031114

• Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton.

  The Journal of biological chemistry 20031107

• Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.

  American journal of physiology. Gastrointestinal and liver physiology 20031101

• Rho inhibition decreases TNF-induced endothelial MAPK activation and monolayer permeability.

  Journal of applied physiology (Bethesda, Md. : 1985) 20031101

• Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery.

  British journal of pharmacology 20031101

• Comparison of effects of Y-27632 and Isoproterenol on release of cytokines from human peripheral T cells.

  International immunopharmacology 20031101

• Lysophosphatidic acid induces process retraction in CG-4 line oligodendrocytes and oligodendrocyte precursor cells but not in differentiated oligodendrocytes.

  Journal of neurochemistry 20031101

• Different migratory and proliferative properties of smooth muscle cells of coronary and femoral artery.

  Atherosclerosis 20031101

• Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice.

  Circulation research 20031031

• Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells.

  International journal of oncology 20031001

• Vasoconstrictor responses, and underlying mechanisms, to isoprostanes in human and porcine bronchial arterial smooth muscle.

  British journal of pharmacology 20031001

• Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens.

  British journal of pharmacology 20031001

• Novel agents for sexual dysfunction.

  BJU international 20031001

• Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways.

  Respiratory physiology & neurobiology 20030916

• Rho-dependent kinase is involved in agonist-activated calcium entry in rat arteries.

  The Journal of physiology 20030915

• ROCK-dependent and ROCK-independent control of cochlear outer hair cell electromotility.

  The Journal of biological chemistry 20030912

• Caspase activation during phorbol ester-induced apoptosis requires ROCK-dependent myosin-mediated contraction.

  Journal of cell science 20030901

• Sevoflurane inhibits guanosine 5'-[gamma-thio]triphosphate-stimulated, Rho/Rho-kinase-mediated contraction of isolated rat aortic smooth muscle.

  Anesthesiology 20030901

• Therapeutic significance of Y-27632, a Rho-kinase inhibitor, on the established liver fibrosis.

  The Journal of surgical research 20030901

• Receptor-independent activation of Rho-kinase-mediated calcium sensitisation in smooth muscle.

  British journal of pharmacology 20030802

• Erectile physiological and pathophysiological pathways involved in erectile dysfunction.

  The Journal of urology 20030801

• Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice.

  European journal of pharmacology 20030711

• Implication of Rho-associated kinase in the elevation of extracellular dopamine levels and its related behaviors induced by methamphetamine in rats.

  Journal of neurochemistry 20030701

• Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension.

  Circulation research 20030627

• CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant up-regulation of Cdc42 and Rac activities.

  Blood 20030615

• Astrocyte stellation induced by Rho kinase inhibitors in culture.

  Brain research. Developmental brain research 20030612

• Improved erectile function after Rho-kinase inhibition in a rat castrate model of erectile dysfunction.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030601

• Sertoli-germ cell adherens junction dynamics in the testis are regulated by RhoB GTPase via the ROCK/LIMK signaling pathway.

  Biology of reproduction 20030601

• Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump activity in isolated lymph vessels.

  American journal of physiology. Heart and circulatory physiology 20030601

• Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat.

  Kidney international 20030601

• P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.

  Journal of immunology (Baltimore, Md. : 1950) 20030601

• Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA.

  Journal of the American Society of Nephrology : JASN 20030601

• Modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle.

  The Journal of urology 20030601

• Intracellular signal transduction modulating expression of plasminogen activator inhibitor-1 in adipocytes.

  Biochemical pharmacology 20030601

• Deactivation of ROCK-II by Y-27632 enhances basolateral pancreatic enzyme secretion and acute pancreatitis induced by CCK analogues.

  Biochemical and biophysical research communications 20030530

• Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis.

  Gastroenterology 20030501

• Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production.

  British journal of pharmacology 20030501

• Inhibition of high K+-induced contraction by the ROCKs inhibitor Y-27632 in vascular smooth muscle: possible involvement of ROCKs in a signal transduction pathway.

  Journal of pharmacological sciences 20030501

• Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.

  Circulation research 20030418

• A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1.

  Journal of cell science 20030415

• RhoA and ROCK promote migration by limiting membrane protrusions.

  The Journal of biological chemistry 20030411

• Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus.

  Biochemical and biophysical research communications 20030411

• Rapid actin transport during cell protrusion.

  Science (New York, N.Y.) 20030404

• Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution.

  American journal of physiology. Cell physiology 20030401

• Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.

  Cardiovascular research 20030401

• Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells.

  The Journal of physiology 20030315

• Prevention of ischemia-reperfusion-induced hepatic microcirculatory disruption by inhibiting stellate cell contraction using rock inhibitor.

  Transplantation 20030315

• Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.

  Circulation research 20030307

• Microtubule-disruption-induced and chemotactic-peptide-induced migration of human neutrophils: implications for differential sets of signalling pathways.

  Journal of cell science 20030301

• The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar.

  Molecular and cellular neurosciences 20030301

• Rho kinase inhibition enhances axonal regeneration in the injured CNS.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030215

• Independent roles of Rho-GTPases in growth cone and axonal behavior.

  Journal of neurobiology 20030205

• Inhibition of Rho-kinase reduces renal Na-H exchanger activity and causes natriuresis in rat.

  The Journal of pharmacology and experimental therapeutics 20030201

• Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

• Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 during Ca2+ sensitization in rabbit smooth muscle.

  The Journal of physiology 20030201

• A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats.

  Surgery 20030201

• Cardiovascular effects of Y-27632, a selective Rho-associated kinase inhibitor, assessed in the halothane-anesthetized canine model.

  European journal of pharmacology 20030126

• A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.

  Brain research 20030103

• Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo.

  Journal of the American Society of Nephrology : JASN 20030101

• The Rho-kinase inhibitor Y-27632 and the soluble guanylyl cyclase activator BAY41-2272 relax rabbit vaginal wall and clitoral corpus cavernosum.

  British journal of pharmacology 20030101

• Inhibition of rho-associated kinase reduces MLC20 phosphorylation and contractility of intact myometrium and attenuates agonist-induced Ca2+ sensitization of force of permeabilized rat myometrium.

  The Journal of veterinary medical science 20030101

• Comparison of inhibitory effects of Y-27632, a Rho kinase inhibitor, in strips of small and large mesenteric arteries from spontaneously hypertensive and normotensive Wistar-Kyoto rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20030101

• Lysophosphatidic acid enhances in vivo infiltration and activation of guinea pig eosinophils and neutrophils via a Rho/Rho-associated protein kinase-mediated pathway.

  Journal of pharmacological sciences 20030101

• Rho and p38 MAP kinase signaling pathways mediate LPA-stimulated hepatic myofibroblast migration.

  Journal of biomedical science 20030101

• Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells.

  Journal of atherosclerosis and thrombosis 20030101

• Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone.

  Journal of vascular research 20030101

• RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction.

  British journal of pharmacology 20021201

• Small guanosine triphospatase RhoA and Rho-associated kinase as regulators of trophoblast migration.

  The Journal of clinical endocrinology and metabolism 20021201

• Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide.

  Stroke 20021201

• ROCK inhibitor Y-27632 prevents primary graft non-function caused by warm ischemia/reperfusion in rat liver transplantation.

  Transplant international : official journal of the European Society for Organ Transplantation 20021201

• Role of rho-kinase activity in angiotensin II-induced contraction of rabbit clitoral cavernosum smooth muscle.

  International journal of impotence research 20021201

• Beneficial effects of a Rho-associated coiled-coli forming protein serine/threonine kinase inhibitor, Y-27632, on survival of recipients in rat liver transplantation following warm ischemia.

  Transplantation proceedings 20021101

• Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin.

  European journal of pharmacology 20021025

• Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells.

  Experimental cell research 20021015

• Translocation of Na(+),K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells.

  Biochemical and biophysical research communications 20021011

• Acute and chronic NOS inhibition enhances alpha(2)- adrenoreceptor-stimulated RhoA and Rho kinase in rat aorta.

  American journal of physiology. Heart and circulatory physiology 20021001

• Myosin light chain phosphorylation and growth cone motility.

  Journal of neurobiology 20020905

• Mechanisms of NOS2 regulation by Rho GTPase signaling in airway epithelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20020901

• Requirement for RhoA kinase activation in leukocyte de-adhesion.

  Journal of immunology (Baltimore, Md. : 1950) 20020901

• Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells.

  Journal of biochemistry 20020901

• Role of Rho kinase signalling in healthy and varicose human saphenous veins.

  British journal of pharmacology 20020901

• Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway.

  Prostaglandins & other lipid mediators 20020901

• Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells.

  Oncogene 20020829

• Rho signaling pathway targeted to promote spinal cord repair.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020801

• Effects of cell tension on the small GTPase Rac.

  The Journal of cell biology 20020708

• Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells.

  Experimental cell research 20020701

• Inhibition of Rho-kinase induces alphaB-crystallin expression in lens epithelial cells.

  Biochemical and biophysical research communications 20020628

• Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.

  The Journal of physiology 20020615

• Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes.

  Biochimica et biophysica acta 20020612

• Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.

  The Biochemical journal 20020601

• Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway.

  Neurological research 20020601

• Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.

  The Journal of biological chemistry 20020510

• Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats.

  The Journal of pharmacology and experimental therapeutics 20020501

• Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo.

  Journal of hypertension 20020501

• Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration.

  The Journal of biological chemistry 20020405

• Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo.

  Pharmacology 20020401

• Regulation of capacitative and noncapacitative receptor-operated Ca2+ entry by rho-kinase in tracheal smooth muscle.

  American journal of respiratory cell and molecular biology 20020401

• Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

  Journal of neurochemistry 20020401

• Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection.

  European journal of pharmacology 20020329

• Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.

  The Journal of biological chemistry 20020308

• Long-term effects of benidipine on cerebral vasoreactivity in hypertensive rats.

  European journal of pharmacology 20020308

• RhoA/Rho kinase and nitric oxide modulate the agonist-induced pulmonary artery diameter response time.

  American journal of physiology. Heart and circulatory physiology 20020301

• The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase.

  The Journal of pharmacology and experimental therapeutics 20020301

• Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.

  Journal of cardiovascular pharmacology 20020301

• Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs.

  Japanese journal of pharmacology 20020301

• Cardiac effects of a selective rho-associated kinase inhibitor, Y-27632, assessed in canine isolated, blood-perfused heart preparations.

  Japanese journal of pharmacology 20020301

• HMG-CoA reductase inhibitors reduce interleukin-6 synthesis in human vascular smooth muscle cells.

  Cardiovascular drugs and therapy 20020301

• HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells.

  Circulation 20020226

• Expression and modulation of Rho kinase in human pregnant myometrium.

  Molecular human reproduction 20020201

• Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Circumferential stretching of saphenous vein smooth muscle enhances vasoconstrictor responses by Rho kinase-dependent pathways.

  Cardiovascular research 20020101

• A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis.

  Journal of immunology (Baltimore, Md. : 1950) 20020101

• Thromboxane receptor signalling in human myometrial cells.

  Prostaglandins & other lipid mediators 20020101

• Microtubule-dependent regulation of vasomotor tone requires Rho-kinase.

  Journal of vascular research 20020101

• Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1).

  Blood 20011215

• Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins.

  The Journal of biological chemistry 20011214

• Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation.

  European journal of pharmacology 20011214

• Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells.

  American journal of physiology. Renal physiology 20011201

• Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm.

  Stroke 20011201

• Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats.

  International journal of impotence research 20011201

• A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes.

  Journal of immunology (Baltimore, Md. : 1950) 20011115

• Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion.

  American journal of physiology. Renal physiology 20011101

• The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils.

  Journal of immunology (Baltimore, Md. : 1950) 20011015

• Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells.

  Journal of hepatology 20011001

• Thrombin-induced activation of RhoA in platelet shape change.

  Biochemical and biophysical research communications 20010914

• Effects of Y-27632 on acetylcholine-induced contraction of intact and permeabilized intrapulmonary bronchial smooth muscles in rats.

  European journal of pharmacology 20010907

• Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation.

  Journal of applied physiology (Bethesda, Md. : 1985) 20010901

• Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels.

  British journal of pharmacology 20010901

• Role of Rho-associated protein kinase in tone and calcium sensitivity of cannulated rat mesenteric small arteries.

  Experimental physiology 20010901

• Role of lysophosphatidylcholine in the desensitization of beta-adrenergic receptors by Ca(2+) sensitization in tracheal smooth muscle.

  American journal of respiratory cell and molecular biology 20010901

• Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms.

  The Journal of biological chemistry 20010803

• Alpha1-adrenoceptor-Gq-RhoA signaling is upregulated to increase myofibrillar Ca2+ sensitivity in failing hearts.

  American journal of physiology. Heart and circulatory physiology 20010801

• Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase.

  Biology of reproduction 20010801

• Involvement of Rho-kinase and the actin filament network in angiotensin II-induced contraction and extracellular signal-regulated kinase activity in intact rat mesenteric resistance arteries.

  Arteriosclerosis, thrombosis, and vascular biology 20010801

• Inhibition of neurite extension by overexpression of individual domains of LIM kinase 1.

  Journal of neurochemistry 20010801

• Involvement of a calcium-independent pathway in plasmin-induced platelet shape change.

  Life sciences 20010713

• Regulation by GDI of RhoA/Rho-kinase-induced Ca2+ sensitization of smooth muscle myosin II.

  American journal of physiology. Cell physiology 20010701

• Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats.

  British journal of pharmacology 20010701

• Distinct pathways of Ca(2+) sensitization in porcine coronary artery: effects of Rho-related kinase and protein kinase C inhibition on force and intracellular Ca(2+).

  Circulation research 20010622

• Thiophosphorylation-induced Ca(2+) sensitization of guinea-pig ileum contractility is not mediated by Rho-associated kinase.

  The Journal of physiology 20010615

• Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).

  Experimental cell research 20010610

• Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase.

  Circulation research 20010608

• Possible involvement of Rho kinase in Ca2+ sensitization and mobilization by MCh in tracheal smooth muscle.

  American journal of physiology. Lung cellular and molecular physiology 20010601

• Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum.

  British journal of pharmacology 20010601

• Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase.

  Current eye research 20010601

• Involvement of Rho-kinase and tyrosine kinase in hypotonic stress-induced ATP release in bovine aortic endothelial cells.

  The Journal of physiology 20010501

• Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.

  Circulation research 20010427

• Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways.

  Atherosclerosis 20010401

• Rho and Rac but not Cdc42 regulate endothelial cell permeability.

  Journal of cell science 20010401

• Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

  Investigative ophthalmology & visual science 20010401

• Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cells.

  Japanese journal of cancer research : Gann 20010401

• A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.

  Journal of hepatology 20010401

• Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.

  FEBS letters 20010330

• Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.

  Hepatology (Baltimore, Md.) 20010301

• Alternatives to Viagra.

  Trends in molecular medicine 20010301

• Rho-kinase is involved in the sustained phosphorylation of myosin and the irreversible platelet aggregation induced by PAR1 activating peptide.

  Thrombosis and haemostasis 20010301

• RhoA/rho-associated kinase mediates fibroblast contractile force generation.

  Biochemical and biophysical research communications 20010209

• Small GTPase Rho regulates thrombin-induced platelet aggregation.

  Biochemical and biophysical research communications 20010202

• Enhancement of Rho/Rho-kinase system in regulation of vascular smooth muscle contraction in tachycardia-induced heart failure.

  Cardiovascular research 20010201

• Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase.

  Pflugers Archiv : European journal of physiology 20010201

• Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.

  The Journal of biological chemistry 20010105

• Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization.

  The Journal of biological chemistry 20010105

• Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.

  Investigative ophthalmology & visual science 20010101

• Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway.

  British journal of pharmacology 20010101

• Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle.

  Journal of muscle research and cell motility 20010101

• Importance of Rho-kinase-mediated phosphorylation of myosin light chain in vasospasm.

  Acta neurochirurgica. Supplement 20010101

• Enhanced relaxation to the rho-kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats.

  Pharmacology 20010101

• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  The Biochemical journal 20001001

• Y-27632 potentiates relaxant effects of beta 2-adrenoceptor agonists in bovine tracheal smooth muscle.

  European journal of pharmacology 20000211

• Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.

  Nature 19971030

• Androgens induce nongenomic stimulation of colonic contractile activity through induction of calcium sensitization and phosphorylation of LC20 and CPI-17.

  Molecular endocrinology (Baltimore, Md.)