130-37-0 | Menadione sodium bisulfite

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$8.00	$5.00
25g	98%	in stock	$19.00	$13.00
100g	98%	in stock	$73.00	$51.00
500g	98%	in stock	$249.00	$175.00

Description

• Catalog Number: AI29249
• Chemical Name: Menadione sodium bisulfite
• CAS Number: 130-37-0
• Molecular Formula: C11H10NaO5S
• Molecular Weight: 277.24887
• MDL Number: MFCD00051456
• SMILES: O=C1CC(C)(C(=O)c2c1cccc2)S(=O)(=O)O.[Na]

Computed Properties

• Complexity: 466
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Undefined Atom Stereocenter Count: 1

Literature

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  Toxicology 20180115

• PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells.

  Toxicology letters 20170905

• NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) and cytochrome P450 oxidoreductase (CYP450OR) differentially regulate menadione-mediated alterations in redox status, survival and metabolism in pancreatic β-cells.

  Toxicology letters 20161116

• Sex-related effects of imidacloprid modulated by piperonyl butoxide and menadione in rats. Part II: genotoxic and cytotoxic potential.

  Drug and chemical toxicology 20160101

• Modulation of notch signaling pathway to prevent H2O2/menadione-induced SK-N-MC cells death by EUK134.

  Cellular and molecular neurobiology 20141001

• Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20140601

• The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

  Antimicrobial agents and chemotherapy 20130501

• Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach.

  Toxicology 20130405

• S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity.

  Chemico-biological interactions 20130225

• DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity.

  Cell death and differentiation 20121101

• Microplate analytical method for quinones by pulse photo-irradiation and chemiluminescence detection.

  The Analyst 20121021

• Structural understanding of the glutathione-dependent reduction mechanism of glutathionyl-hydroquinone reductases.

  The Journal of biological chemistry 20121019

• The effect of menadione on glutathione S-transferase A1 (GSTA1): c-Jun N-terminal kinase (JNK) complex dissociation in human colonic adenocarcinoma Caco-2 cells.

  Toxicology letters 20121002

• Influence of membrane organization on the interactions between persistent pollutants and model membranes.

  Bioelectrochemistry (Amsterdam, Netherlands) 20121001

• Distinct functions of JNK and c-Jun in oxidant-induced hepatocyte death.

  Journal of cellular biochemistry 20121001

• Two-dimensional nitrosylated protein fingerprinting by using poly (methyl methacrylate) microchips.

  Lab on a chip 20120921

• Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype.

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• Pretreatment with proteasome inhibitors protects against oxidative injuries via PPARα-dependent and -independent pathways in ARPE-19 cells.

  Investigative ophthalmology & visual science 20120831

• Selective synthesis of vitamin K3 over mesoporous NbSBA-15 catalysts synthesized by an efficient hydrothermal method.

  Dalton transactions (Cambridge, England : 2003) 20120828

• Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells.

  Investigational new drugs 20120801

• Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance.

  Toxicological sciences : an official journal of the Society of Toxicology 20120801

• 2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone™ therapy.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120801

• A novel role for Bcl-2 in regulation of cellular calcium extrusion.

  Current biology : CB 20120710

• New insights into redox response modulation in Fanconi's anemia cells by hydrogen peroxide and glutathione depletors.

  The FEBS journal 20120701

• Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase.

  Organic & biomolecular chemistry 20120628

• Carbonyl reduction of bupropion in human liver.

  Xenobiotica; the fate of foreign compounds in biological systems 20120601

• Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.

  Molecular nutrition & food research 20120601

• Prostaglandin E2 blocks menadione-induced apoptosis through the Ras/Raf/Erk signaling pathway in promonocytic leukemia cell lines.

  Molecules and cells 20120430

• Characterization of a putative thioredoxin peroxidase prx1 of Candida albicans.

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  Cancer letters 20120328

• The rolB gene suppresses reactive oxygen species in transformed plant cells through the sustained activation of antioxidant defense.

  Plant physiology 20120301

• Advantage of menadione-catalyzed chemiluminescent assay for the determination of viable mammalian cell number.

  Analytical biochemistry 20120215

• Antioxidant deficit in gills of Pacific oyster (Crassostrea gigas) exposed to chlorodinitrobenzene increases menadione toxicity.

  Aquatic toxicology (Amsterdam, Netherlands) 20120201

• The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion.

  Toxicology and applied pharmacology 20120115

• Comparative transcriptome analysis of the necrotrophic fungus Ascochyta rabiei during oxidative stress: insight for fungal survival in the host plant.

  PloS one 20120101

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• No role of homologous recombination in dealing with β-lapachone cytotoxicity in yeast.

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• Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.

  Bioorganic & medicinal chemistry 20111215

• Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C.

  Investigational new drugs 20111201

• Homology modeling and in silico screening of inhibitors for the substrate binding domain of human Siah2: implications for hypoxia-induced cancers.

  Journal of molecular modeling 20111201

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• ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum.

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• The phosphatase inhibitor menadione (vitamin K3) protects cells from EGFR inhibition by erlotinib and cetuximab.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20111101

• Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study.

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• Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury.

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• Adaptive stress response to menadione-induced oxidative stress in Saccharomyces cerevisiae KNU5377.

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  Molecular microbiology 20110301

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  Molecular microbiology 20110301

• A novel screening method based on menadione mediated rapid reduction of tetrazolium salt for testing of anti-mycobacterial agents.

  Journal of microbiological methods 20110201

• Immune responses to novel allergens and modulation of inflammation by vitamin K3 analogue: a ROS dependent mechanism.

  International immunopharmacology 20110201

• Decarbonylated cyclophilin A Cpr1 protein protects Saccharomyces cerevisiae KNU5377Y when exposed to stress induced by menadione.

  Cell stress & chaperones 20110101

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• Menadione degrades the optical quality and mitochondrial integrity of bovine crystalline lenses.

  Molecular vision 20110101

• Ascorbic acid prevents oxidant-induced increases in endothelial permeability.

  BioFactors (Oxford, England) 20110101

• Pre-exposure to 50 Hz magnetic fields modifies menadione-induced genotoxic effects in human SH-SY5Y neuroblastoma cells.

  PloS one 20110101

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  PloS one 20110101

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  International journal of molecular sciences 20110101

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  PloS one 20110101

• Different reactive oxygen species lead to distinct changes of cellular metal ions in the eukaryotic model organism Saccharomyces cerevisiae.

  International journal of molecular sciences 20110101

• Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis.

  Free radical biology & medicine 20101215

• Real-time visualization of oxidative stress in a floating macrophyte Lemna minor L. exposed to cadmium, copper, menadione, and AAPH.

  Environmental toxicology 20101201

• Effects of menadione, hydrogen peroxide, and quercetin on apoptosis and delayed luminescence of human leukemia Jurkat T-cells.

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  Applied spectroscopy 20101001

• Measurement of menadione in urine by HPLC.

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  The Journal of biological chemistry 20100618

• Structure-activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: effects on heme oxygenase-1 induction and antioxidant activities.

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  Clinical and experimental immunology 20100501

• The role of reactive oxygen species in the induction of Ty1 retrotransposition in Saccharomyces cerevisiae.

  Yeast (Chichester, England) 20100501

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• Cell damage and death by autoschizis in human bladder (RT4) carcinoma cells resulting from treatment with ascorbate and menadione.

  Ultrastructural pathology 20100501

• alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate.

  British journal of cancer 20100413

• Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells.

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• Selection of thiol- and disulfide-containing proteins of Escherichia coli on activated thiol-Sepharose.

  Analytical biochemistry 20100315

• Exposure of the blue mussel, Mytilus edulis, to gold nanoparticles and the pro-oxidant menadione.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100301

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  BMC genomics 20090101

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  Autophagy 20080501

• Measurement of protein sulfhydryls in response to cellular oxidative stress using gel electrophoresis and multiplexed fluorescent imaging analysis.

  Chemical research in toxicology 20080501

• Loss of tafazzin in yeast leads to increased oxidative stress during respiratory growth.

  Molecular microbiology 20080501

• Hepatitis C core protein inhibits induction of heme oxygenase-1 and sensitizes hepatocytes to cytotoxicity.

  Cell biology and toxicology 20080401

• Simultaneous determination of five fat-soluble vitamins in feed by high-performance liquid chromatography following solid-phase extraction.

  Journal of chromatographic science 20080401

• Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

  Journal of medicinal chemistry 20080327

• The omlA gene is involved in multidrug resistance and its expression is inhibited by coumarins in Xanthomonas campestris pv. phaseoli.

  Archives of microbiology 20080301

• Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.

  Biochemical pharmacology 20080301

• Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic benefits.

  Parasitology research 20080301

• Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis.

  Free radical biology & medicine 20080301

• Topoisomerase inhibitors as anti-arthritic agents.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080301

• Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus.

  The Journal of biological chemistry 20080222

• Redox-cycling compounds can cause the permeabilization of mitochondrial membranes by mechanisms other than ROS production.

  Free radical biology & medicine 20080215

• The interaction mechanisms between Saccharomyces cerevisiae and menadione and its application in toxicology study.

  Talanta 20080215

• alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells.

  Molecular and cellular biochemistry 20080201

• Mitochondrial dysfunction is responsible for the intestinal calcium absorption inhibition induced by menadione.

  Biochimica et biophysica acta 20080201

• Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.

  The EMBO journal 20080123

• Fluorometric identification of 5-methylcytosine modification in DNA: combination of photosensitized oxidation and invasive cleavage.

  Bioconjugate chemistry 20080101

• The utility of vitamin K3 (menadione) against pancreatic cancer.

  Anticancer research 20080101

• A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy.

  International journal of medical sciences 20080101

• A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network.

  PloS one 20080101

• [Role of alpha-tocopherol in oxidative stress of rat thymocytes induced by hydrogen peroxide and menadione].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20080101

• Altered deoxyribonuclease activity in cancer cells and its role in non toxic adjuvant cancer therapy with mixed vitamins C and K3.

  Anticancer research 20080101

• Determination of high mitochondrial membrane potential in spermatozoa loaded with the mitochondrial probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) by using fluorescence-activated flow cytometry.

  Methods in molecular biology (Clifton, N.J.) 20080101

• Cytotoxicity mechanism of two naphthoquinones (menadione and plumbagin) in Saccharomyces cerevisiae.

  PloS one 20080101

• Identification and quantitation of vitamins K1 and K3 in cosmetic products for facial skin protection.

  Journal of cosmetic science 20080101

• Differential effects of redox-cycling and arylating quinones on trans-plasma membrane electron transport.

  BioFactors (Oxford, England) 20080101

• Targeting cancer cells by an oxidant-based therapy.

  Current molecular pharmacology 20080101

• Evaluation of the probe dihydrocalcein acetoxymethylester as an indicator of reactive oxygen species formation and comparison with oxidative DNA base modification determined by modified alkaline elution technique.

  Toxicology in vitro : an international journal published in association with BIBRA 20071201

• Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04.

  Toxicology in vitro : an international journal published in association with BIBRA 20071201

• Gamma-glutamyltransferase is upregulated after oxidative stress through the Ras signal transduction pathway in rat colon carcinoma cells.

  Free radical research 20071201

• Electrochemical insights into the ethanol tolerance of Saccharomyces cerevisiae.

  Bioelectrochemistry (Amsterdam, Netherlands) 20071101

• Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis.

  Antioxidants & redox signaling 20071101

• Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency.

  Bioscience, biotechnology, and biochemistry 20071101

• Vitamin K1 versus vitamin K3 for prevention of subclinical vitamin deficiency: a randomized controlled trial.

  Indian pediatrics 20071101

• A chemiluminescence biochemical oxygen demand measuring method.

  Analytica chimica acta 20071017

• Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model.

  Genetics and molecular research : GMR 20071005

• Improved analysis of hydroethidine and 2-hydroxyethidium by HPLC and electrochemical detection.

  Free radical biology & medicine 20071001

• Compounding of vitamin A, D3, E and K3 supplements for cystic fibrosis patients: formulation and stability study.

  Journal of clinical pharmacy and therapeutics 20071001

• Study on the inclusion interaction of p-sulfonated calix[n]arenes with Vitamin K3 using methylene blue as a spectral probe.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070901

• Chlamydomonas reinhardtii, a model system for functional validation of abiotic stress responsive genes.

  Planta 20070801

• Role of heat shock transcription factor in Saccharomyces cerevisiae oxidative stress response.

  Eukaryotic cell 20070801

• Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells.

  International journal of oncology 20070801

• Mycobacterium smegmatis mc2 155 fbiC and MSMEG_2392 are involved in triphenylmethane dye decolorization and coenzyme F420 biosynthesis.

  Microbiology (Reading, England) 20070801

• The different behaviors of three oxidative mediators in probing the redox activities of the yeast Saccharomyces cerevisiae.

  Analytica chimica acta 20070730

• Effect of Plasmodium yoelii nigeriensis infection on hepatic and splenic glutathione-S-transferase(s) in Swiss albino and db/+ mice: efficacy of mefloquine and menadione in antimalarial chemotherapy.

  Parasitology 20070701

• Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins.

  American journal of physiology. Gastrointestinal and liver physiology 20070701

• One-electron photooxidation and site-selective strand cleavage at 5-methylcytosine in DNA by sensitization with 2-methyl-1,4-naphthoquinone-tethered oligonucleotides.

  Journal of the American Chemical Society 20070627

• Simultaneously monitoring the superoxide in the mitochondrial matrix and extramitochondrial space by micellar electrokinetic chromatography with laser-induced fluorescence.

  Analytical chemistry 20070615

• Cloning and functional expression of the mitochondrial alternative oxidase of Aspergillus fumigatus and its induction by oxidative stress.

  FEMS microbiology letters 20070601

• Diverse roles for histone H2A modifications in DNA damage response pathways in yeast.

  Genetics 20070501

• Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1.

  Yeast (Chichester, England) 20070501

• Near-UV photolysis of 2-methyl-1,4-naphthoquinone-DNA duplexes: characterization of reversible and stable interstrand cross-links between quinone and adenine moieties.

  Chemical research in toxicology 20070501

• Development of a new E. coli strain to detect oxidative mutation and its application to the fungicide o-phenylphenol and its metabolites.

  Mutation research 20070402

• Inhibition of PTEN and activation of Akt by menadione.

  Biochimica et biophysica acta 20070401

• Regulation of the expression of soluble guanylyl cyclase by reactive oxygen species.

  British journal of pharmacology 20070401

• Role of glycolysis inhibition and poly(ADP-ribose) polymerase activation in necrotic-like cell death caused by ascorbate/menadione-induced oxidative stress in K562 human chronic myelogenous leukemic cells.

  International journal of cancer 20070315

• High-dose methylprednisolone influences the physiology and virulence of Candida albicans ambiguously and enhances the candidacidal activity of the polyene antibiotic amphotericin B and the superoxide-generating agent menadione.

  FEMS yeast research 20070301

• Naphthoquinones as broad spectrum biocides for treatment of ship's ballast water: toxicity to phytoplankton and bacteria.

  Water research 20070301

• Screening of natural product biocides for control of non-indigenous species.

  Environmental technology 20070301

• Inactivation of lactate dehydrogenase by several chemicals: implications for in vitro toxicology studies.

  Toxicology in vitro : an international journal published in association with BIBRA 20070201

• Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases.

  Biochimica et biophysica acta 20070201

• Use of high inoculum for early metabolic signalling and rapid susceptibility testing of Aspergillus species.

  The Journal of antimicrobial chemotherapy 20070201

• Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: role of glutathione synthesis and regeneration.

  Planta medica 20070201

• Comparative proteomic analyses of the yeast Saccharomyces cerevisiae KNU5377 strain against menadione-induced oxidative stress.

  Journal of microbiology and biotechnology 20070201

• [Experiment research of nifedipine and vitamin K3 on ureteral action potential and urine flow in rabbits].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201

• A possible role of oxidative stress in the switch mechanism of the cell death mode from apoptosis to necrosis--studies on rho0 cells.

  Mitochondrion 20070101

• Highly enantioselective epoxidation of 2-methylnaphthoquinone (vitamin K3) mediated by new cinchona alkaloid phase-transfer catalysts.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• Menadione effect on l-cysteine desulfuration in U373 cells.

  Acta biochimica Polonica 20070101

• [Adaptation of the yeast Yarrowia lipolytica to heat shock].

  Mikrobiologiia 20070101

• A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents.

  Cancer detection and prevention 20070101

• The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.

  PloS one 20070101

• Oxidative stress response in eukaryotes: effect of glutathione, superoxide dismutase and catalase on adaptation to peroxide and menadione stresses in Saccharomyces cerevisiae.

  Redox report : communications in free radical research 20070101

• Site-selective strand cleavage at methylated cytosine: regional effect of naphthoquinone chromophore on the one-electron photooxidation of 5-methylcytosine and positive charge transfer in DNA.

  Nucleic acids symposium series (2004) 20070101

• Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.

  The Journal of biological chemistry 20061229

• DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione.

  Biochemical and biophysical research communications 20061110

• Calpain-induced endoplasmic reticulum stress and cell death following cytotoxic damage to renal cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20061101

• Introducing glutathione biosynthetic capability into Lactococcus lactis subsp. cremoris NZ9000 improves the oxidative-stress resistance of the host.

  Metabolic engineering 20061101

• A gold(I) complex with a vitamin K3 derivative: characterization and antitumoral activity.

  Journal of inorganic biochemistry 20061101

• Selective susceptibility of different populations of sympathetic neurons to diabetic neuropathy in vivo is reflected by increased vulnerability to oxidative stress in vitro.

  Neuroscience letters 20061030

• Redox proteomics in the blue mussel Mytilus edulis: carbonylation is not a pre-requisite for ubiquitination in acute free radical-mediated oxidative stress.

  Aquatic toxicology (Amsterdam, Netherlands) 20061012

• Vitamins C and K3 sensitize human urothelial tumors to gemcitabine.

  The Journal of urology 20061001

• H32, a non-quinone sulfone analog of vitamin K3, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK.

  Cancer biology & therapy 20061001

• Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

  Biochemical pharmacology 20060914

• Escherichia coli-catalyzed bioelectrochemical oxidation of acetate in the presence of mediators.

  Bioelectrochemistry (Amsterdam, Netherlands) 20060901

• A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts.

  Molecular pharmacology 20060901

• Inhibition of apoptosis by menadione on exposure to UVA.

  Cell biology and toxicology 20060901

• A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme.

  Journal of the American Chemical Society 20060823

• In vivo relevance of two critical levels for NAD(P)H:quinone oxidoreductase (NQO1)-mediated cellular protection against electrophile toxicity found in vitro.

  Toxicology in vitro : an international journal published in association with BIBRA 20060801

• Determination of intracellular reactive oxygen species and high mitochondrial membrane potential in Percoll-treated viable boar sperm using fluorescence-activated flow cytometry.

  Journal of animal science 20060801

• The role of Yap1p and Skn7p-mediated oxidative stress response in the defence of Saccharomyces cerevisiae against singlet oxygen.

  Yeast (Chichester, England) 20060730

• NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs.

  Biochemical pharmacology 20060728

• Cytoprotective effect of caffeic acid phenethyl ester (CAPE) and catechol ring-fluorinated CAPE derivatives against menadione-induced oxidative stress in human endothelial cells.

  Bioorganic & medicinal chemistry 20060715

• Higher activity of polymorphic NAD(P)H:quinone oxidoreductase in liver cytosols from blacks compared to whites.

  Toxicology letters 20060714

• Regioselective hydroxylation of adamantane by Streptomyces griseoplanus cells.

  Applied microbiology and biotechnology 20060701

• Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress.

  Clinical chemistry 20060701

• Effects of quinones and flavonoids on the reduction of all-trans retinal to all-trans retinol in pig heart.

  European journal of pharmacology 20060701

• Contrasting actions of prolonged mitogen-activated protein kinase activation on cell survival.

  Biochemical and biophysical research communications 20060630

• Metabolism of oxidants by blood from different mouse strains.

  Biochemical pharmacology 20060614

• Modulator of drug activity B from Escherichia coli: crystal structure of a prokaryotic homologue of DT-diaphorase.

  Journal of molecular biology 20060602

• [Glutathione plays an anti-oxidant role in Lactococcus lactis].

  Wei sheng wu xue bao = Acta microbiologica Sinica 20060601

• Relative contribution of homologous recombination and non-homologous end-joining to DNA double-strand break repair after oxidative stress in Saccharomyces cerevisiae.

  DNA repair 20060510

• Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.

  Journal of hepatology 20060501

• Nicotine prevents the apoptosis induced by menadione in human lung cancer cells.

  Biochemical and biophysical research communications 20060414

• [Menadione-catalyzed luminol chemiluminescence assay for the rapid detection of viable bacteria].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20060401

• Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases.

  FEBS letters 20060320

• Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species.

  Journal of cell science 20060315

• Stress stimulates AMP-activated protein kinase and meiotic resumption in mouse oocytes.

  Biology of reproduction 20060301

• Adaptive response of Bacillus sp. F26 to hydrogen peroxide and menadione.

  Current microbiology 20060301

• Trehalose protects Saccharomyces cerevisiae from lipid peroxidation during oxidative stress.

  Biochimica et biophysica acta 20060301

• Fetal hemoglobin induction by histone deacetylase inhibitors involves generation of reactive oxygen species.

  Experimental hematology 20060301

• Menadione is a metabolite of oral vitamin K.

  The British journal of nutrition 20060201

• Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids.

  FEBS letters 20060109

• Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome?

  Free radical biology & medicine 20060101

• Morphology and DNA degeneration during autoschizic cell death in bladder carcinoma T24 cells induced by ascorbate and menadione treatment.

  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20060101

• Inhibitory effects of Ruta graveolens L. extract on guinea pig liver aldehyde oxidase.

  Chemical & pharmaceutical bulletin 20060101

• Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes.

  Pharmacology 20060101

• Mutagenic and carcinogenic potential of menadione.

  Neoplasma 20060101

• [Tolerance of the yeast Yarrowia lipolytica to oxidative stress].

  Mikrobiologiia 20060101

• Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells.

  BioFactors (Oxford, England) 20060101

• Chemical modulation of physiological adaptation and cross-protective responses against oxidative stress in soil bacterium and phytopathogen, Xanthomonas.

  Journal of industrial microbiology & biotechnology 20051201

• Antimalarial efficacy of methylene blue and menadione and their effect on glutathione metabolism of Plasmodium yoelii-infected albino mice.

  Parasitology research 20051201

• Staphylococcus aureus small colony variants are resistant to the antimicrobial peptide lactoferricin B.

  The Journal of antimicrobial chemotherapy 20051201

• Effects of four oxidants, menadione, 1-chloro-2,4-dinitrobenzene, hydrogen peroxide and cumene hydroperoxide, on fission yeast Schizosaccharmoyces pombe.

  Journal of biochemistry 20051201

• Sir2 blocks extreme life-span extension.

  Cell 20051118

• Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair.

  Carcinogenesis 20051101

• Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity.

  Biochemical and biophysical research communications 20051021

• Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance.

  Eukaryotic cell 20051001

• Vitamin K3 triggers human leukemia cell death through hydrogen peroxide generation and histone hyperacetylation.

  Die Pharmazie 20051001

• Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice.

  Circulation research 20050916

• Differences in gene expression profiles in dermal fibroblasts from control and patients with age-related macular degeneration elicited by oxidative injury.

  Free radical biology & medicine 20050915

• Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation.

  Molecular pharmacology 20050901

• Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity.

  Bioorganic & medicinal chemistry 20050815

• Mitochondrial behaviour in the early stages of ROS stress leading to cell death in Arabidopsis thaliana.

  Annals of botany 20050801

• Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines.

  Diabetologia 20050801

• Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules.

  International journal of oncology 20050801

• Induction of phenotypes resembling CuZn-superoxide dismutase deletion in wild-type yeast cells: an in vivo assay for the role of superoxide in the toxicity of redox-cycling compounds.

  Chemical research in toxicology 20050801

• Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

  Chemical research in toxicology 20050801

• A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050701

• Effects of menadione and its derivative on cultured cardiomyocytes with mitochondrial disorders.

  Journal of molecular and cellular cardiology 20050701

• Enhancement of quinone redox cycling by ascorbate induces a caspase-3 independent cell death in human leukaemia cells. An in vitro comparative study.

  Free radical research 20050601

• Site-specific binding of quinones to proteins through thiol addition and addition-elimination reactions.

  Journal of the American Chemical Society 20050504

• Activation of nuclear factor-kappaB (NFkappaB) identifies a high-risk subset of hormone-dependent breast cancers.

  The international journal of biochemistry & cell biology 20050501

• Bacillus subtilis paraquat resistance is directed by sigmaM, an extracytoplasmic function sigma factor, and is conferred by YqjL and BcrC.

  Journal of bacteriology 20050501

• Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin-induced cell death.

  Molecular genetics and metabolism 20050501

• Combination of glycemic and oxidative stress in lens: implications in augmentation of cataract formation in diabetes.

  Free radical research 20050501

• Menadione protects gastric mucosa against ethanol-induced ulcers.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20050401

• Role of mitochondria in the switch mechanism of the cell death mode from apoptosis to necrosis--studies on rho0 cells.

  Journal of electron microscopy 20050401

• Absorption spectrometric and thermodynamic study of charge transfer complexes of menadione (Vitamin K3) with a series of phenols.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050301

• Rat hepatic CYP1A1 and CYP1A2 induction by menadione.

  Toxicology letters 20050215

• Vitamin B6 compounds prevent the death of yeast cells due to menadione, a reactive oxygen generator.

  Biochimica et biophysica acta 20050211

• Cleavage at 5-methylcytosine in DNA by photosensitized oxidation with 2-methyl-1,4-naphthoquinone tethered oligodeoxynucleotides.

  Bioorganic & medicinal chemistry letters 20050201

• Antioxidant enzyme activities and lipid peroxidation in the freshwater cladoceran Daphnia magna exposed to redox cycling compounds.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050201

• Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 3: Depletion of antioxidant defenses.

  Journal of toxicology and environmental health. Part A 20050108

• Copper alone, but not oxidative stress, induces copper-metallothionein gene in Neurospora crassa.

  FEMS microbiology letters 20050101

• Cell death by autoschizis in TRAMP prostate carcinoma cells as a result of treatment by ascorbate: menadione combination.

  Ultrastructural pathology 20050101

• Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.

  BMC genomics 20050101

• Detection of 5-methylcytosine in DNA by photo-functionalized oligodeoxynucleotides possessing 2-methyl-1,4-naphthoquinone chromophore.

  Nucleic acids symposium series (2004) 20050101

• Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality.

  Proceedings of the National Academy of Sciences of the United States of America 20041221

• 2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation.

  Archives of biochemistry and biophysics 20041215

• Electrochemical evaluation of the inhibitory effects of weak acids on Zygosaccharomyces bailii.

  Journal of agricultural and food chemistry 20041201

• Menadione-catalyzed luminol chemiluminescence assay for the rapid detection of viable bacteria in foods under aerobic conditions.

  Journal of food protection 20041201

• Spontaneous generation of reactive oxygen species in the mixture of cyanide and glycerol.

  Annals of the New York Academy of Sciences 20041201

• Influence of plasma total antioxidant ability on lipid and protein oxidation products in plasma and erythrocyte ghost obtained from developing and adult rats pretreated with two vitamin K formulations.

  Molecular and cellular biochemistry 20041201

• Characterization of oxidative stress-resistant mutants of Streptococcus thermophilus CNRZ368.

  Archives of microbiology 20041101

• Transcriptional regulation of glutathione synthetase in the fission yeast Schizosaccharomyces pombe.

  Molecules and cells 20041031

• Chemiluminescent assay for detection of viable microorganisms.

  Analytical biochemistry 20041015

• Menadione reduces rotenone-induced cell death in cerebellar granule neurons.

  Neuroreport 20041005

• Redox state alteration modulates astrocyte glucuronidation.

  Free radical biology & medicine 20041001

• Menadione induces a low conductance state of the mitochondrial inner membrane sensitive to bongkrekic acid.

  Free radical biology & medicine 20041001

• A transplasma membrane redox system in Phycomyces blakesleeanus: properties of a ferricyanide reductase activity regulated by iron level and vitamin K3.

  Journal of bioenergetics and biomembranes 20041001

• Crystal structure of quinone reductase 2 in complex with resveratrol.

  Biochemistry 20040914

• Medium-dependent electron and H atom transfer between 2'-deoxyadenosine and menadione: a magnetic field effect study.

  Journal of the American Chemical Society 20040901

• Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

  Diabetes 20040901

• Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival.

  Journal of neuroscience research 20040815

• Hepatocyte resistance to oxidative stress is dependent on protein kinase C-mediated down-regulation of c-Jun/AP-1.

  The Journal of biological chemistry 20040723

• Inhibition of the development of metastases by dietary vitamin C:K3 combination.

  Life sciences 20040709

• Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20040701

• Absorption spectrometric study of charge transfer complex formation between 4-acetamidophenol (paracetamol) and a series of quinones including vitamin K3.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040701

• The switch mechanism of the cell death mode from apoptosis to necrosis in menadione-treated human osteosarcoma cell line 143B cells.

  Microscopy research and technique 20040615

• Effects of genotoxic compounds on DNA and development of early and late grass shrimp embryo stages.

  Marine environmental research 20040601

• Simultaneous measurement of oxygenation in intracellular and extracellular compartments of lung microvascular endothelial cells.

  Antioxidants & redox signaling 20040601

• Autoschizis: a new form of cell death for human ovarian carcinoma cells following ascorbate:menadione treatment. Nuclear and DNA degradation.

  Tissue & cell 20040601

• Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli.

  European journal of biochemistry 20040601

• Anti-estrogenic activity of fifty chemicals evaluated by in vitro assays.

  Life sciences 20040507

• Toxicity and cell cycle effects of synthetic 8-prenylnaringenin and derivatives in human cells.

  Pharmacology 20040501

• Menadione kills trophozoites and cysts of Giardia intestinalis.

  Microbiology (Reading, England) 20040501

• Quinone analogues regulate mitochondrial substrate competitive oxidation.

  Biochemical and biophysical research communications 20040416

• Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart.

  American journal of physiology. Heart and circulatory physiology 20040401

• Hepatoprotective effect of Sabina przewalskii against menadione-induced toxicity.

  Phytotherapy research : PTR 20040401

• Preparation and in vitro synergistic anticancer effect of vitamin K3 and 1,8-diazabicyclo[5,4,0]undec-7-ene in poly(ethylene glycol)-diacyllipid micelles.

  International journal of pharmaceutics 20040319

• Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers.

  Biochemistry 20040316

• Role of reactive oxygen species, glutathione and NF-kappaB in apoptosis induced by 3,4-methylenedioxymethamphetamine ('Ecstasy') on hepatic stellate cells.

  Biochemical pharmacology 20040315

• Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death.

  Apoptosis : an international journal on programmed cell death 20040301

• Stress-dependent regulation of the gene encoding gamma-glutamylcysteine synthetase from the fission yeast.

  Molecular biology reports 20040301

• Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver.

  Bulletin of experimental biology and medicine 20040301

• Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase.

  The Journal of biological chemistry 20040227

• CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling.

  Hepatology (Baltimore, Md.) 20040201

• Role of NAD(P)H:quinone oxidoreductase encoded by drgA gene in reduction of exogenous quinones in cyanobacterium Synechocystis sp. PCC 6803 cells.

  Biochemistry. Biokhimiia 20040201

• Cell cycle arrest and autoschizis in a human bladder carcinoma cell line following Vitamin C and Vitamin K3 treatment.

  Biochemical pharmacology 20040115

• Study of charge transfer complexes of menadione (vitamin K3) with a series of anilines.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040101

• Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation.

  Xenotransplantation 20040101

• Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation.

  Methods in enzymology 20040101

• Quinones and glutathione metabolism.

  Methods in enzymology 20040101

• In vivo exposure of Dreissena polymorpha mussels to the quinones menadione and lawsone: menadione is more toxic to mussels than lawsone.

  Journal of applied toxicology : JAT 20040101

• Development of an in vitro model for vascular injury with human endothelial cells.

  ALTEX 20040101

• A possible involvement of plasma membrane NAD(P)H oxidase in the switch mechanism of the cell death mode from apoptosis to necrosis in menadione-induced cell injury.

  Acta biochimica Polonica 20040101

• Partial characterization of human choriocarcinoma cell line JAR cells in regard to oxidative stress.

  Acta biochimica Polonica 20040101

• Aging-associated increase of gelsolin for apoptosis resistance.

  Biochemical and biophysical research communications 20031226

• Glucose 6-phosphate dehydrogenase is required for sucrose and trehalose to be efficient osmoprotectants in Sinorhizobium meliloti.

  FEMS microbiology letters 20031212

• Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses.

  Aquatic toxicology (Amsterdam, Netherlands) 20031210

• Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents.

  Prostaglandins, leukotrienes, and essential fatty acids 20031201

• [Mechanism of arsenic trioxide-induced cytotoxicity on multiple myeloma cells].

  Ai zheng = Aizheng = Chinese journal of cancer 20031201

• Gelsolin for senescence-associated resistance to apoptosis.

  Annals of the New York Academy of Sciences 20031201

• L-Deprenyl as an inhibitor of menadione-induced permeability transition in liver mitochondria.

  Biochemical pharmacology 20031101

• Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling.

  Free radical biology & medicine 20031015

• Menadione enhances oxyradical formation in earthworm extracts: vulnerability of earthworms to quinone toxicity.

  Aquatic toxicology (Amsterdam, Netherlands) 20031008

• Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases.

  The Journal of biological chemistry 20031003

• Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress.

  Eukaryotic cell 20031001

• Recombinogenic effects of DNA-damaging agents are synergistically increased by transcription in Saccharomyces cerevisiae. New insights into transcription-associated recombination.

  Genetics 20031001

• Amplification of a reactive oxygen species signal in axotomized retinal ganglion cells.

  Antioxidants & redox signaling 20031001

• Atypical adaptive and cross-protective responses against peroxide killing in a bacterial plant pathogen, Agrobacterium tumefaciens.

  Current microbiology 20031001

• Protection of cells from menadione-induced apoptosis by inhibition of lipid peroxidation.

  Toxicology 20030930

• Acquisition of heat shock tolerance by regulation of intracellular redox states.

  Biochimica et biophysica acta 20030923

• Control of ascorbic acid efflux in rat luteal cells: role of intracellular calcium and oxygen radicals.

  American journal of physiology. Cell physiology 20030901

• Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein.

  Free radical biology & medicine 20030901

• Effect of menadione sodium bisulfite, an inducer of plant defenses, on the dynamic of banana phytoalexin accumulation during pathogenesis.

  Journal of agricultural and food chemistry 20030827

• The role of quinone reductase (NQO1) and quinone chemistry in quercetin cytotoxicity.

  Toxicology in vitro : an international journal published in association with BIBRA 20030801

• Protective roles of mitochondrial manganese-containing superoxide dismutase against various stresses in Candida albicans.

  Yeast (Chichester, England) 20030801

• Microscopic aspects of autoschizic cell death in human ovarian carcinoma (2774) cells following vitamin C, vitamin K3 or vitamin C:K3 treatment.

  Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 20030801

• The anticancer effects of vitamin K.

  Alternative medicine review : a journal of clinical therapeutic 20030801

• Effects of a single dose of menadione on the intestinal calcium absorption and associated variables.

  The Journal of nutritional biochemistry 20030801

• [Heat shock inhibits the induced expression of the SOS genes and SoxRS regulons in Escherichia coli].

  Genetika 20030801

• Physiological responses of chemostat cultures of Aspergillus niger (B1-D) to simulated and actual oxidative stress.

  Biotechnology and bioengineering 20030620

• Menadione causes endothelial barrier failure by a direct effect on intracellular thiols, independent of reactive oxidant production.

  Biochimica et biophysica acta 20030617

• Oxidant-mediated AA release from astrocytes involves cPLA(2) and iPLA(2).

  Free radical biology & medicine 20030615

• Redox regulation of HIF-1alpha levels and HO-1 expression in renal medullary interstitial cells.

  American journal of physiology. Renal physiology 20030601

• Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening.

  Journal of molecular and cellular cardiology 20030601

• Regulation of the gene encoding glutathione synthetase from the fission yeast.

  Journal of biochemistry and molecular biology 20030531

• Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney.

  The Journal of infectious diseases 20030515

• Involvement of the electrophile responsive element and p53 in the activation of hepatic stellate cells as a response to electrophile menadione.

  Archives of biochemistry and biophysics 20030515

• Oral administration of trans-resveratrol to guinea pigs increases cardiac DT-diaphorase and catalase activities, and protects isolated atria from menadione toxicity.

  Life sciences 20030502

• Cyclosporin A disrupts bradykinin signaling through superoxide.

  Hypertension (Dallas, Tex. : 1979) 20030501

• Immunoglobulins G could prevent adherence of Candida albicans to polystyrene and extracellular matrix components.

  Journal of medical microbiology 20030501

• The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy.

  European journal of medicinal chemistry 20030501

• Synthesis and antifilarial evaluation of N1,Nn- xylofuranosylated diaminoalkanes.

  Bioorganic & medicinal chemistry 20030417

• Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis.

  The Journal of biological chemistry 20030411

• Induction of peroxide and superoxide protective enzymes and physiological cross-protection against peroxide killing by a superoxide generator in Vibrio harveyi.

  FEMS microbiology letters 20030411

• H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae. An experimental and theoretical approach.

  European journal of biochemistry 20030401

• Recruitment of the interleukin-1 receptor (IL-1RI)-associated kinase IRAK to the IL-1RI is redox regulated.

  Biological chemistry 20030401

• Targets of oxidative stress in yeast sod mutants.

  Biochimica et biophysica acta 20030317

• Sequential inactivation of reactive oxygen species by combined overexpression of SOD isoforms and catalase in insulin-producing cells.

  Free radical biology & medicine 20030315

• Ascorbic acid blunts oxidant stress due to menadione in endothelial cells.

  Archives of biochemistry and biophysics 20030301

• Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells.

  Archives of biochemistry and biophysics 20030301

• Discriminating redox cycling and arylation pathways of reactive chemical toxicity in trout hepatocytes.

  Toxicological sciences : an official journal of the Society of Toxicology 20030301

• Cell proliferation induced by reactive oxygen species is mediated via mitogen-activated protein kinase in Chinese hamster lung fibroblast (V79) cells.

  Molecules and cells 20030227

• Regulation of antioxidant enzymes gene expression in the yeast Saccharomyces cerevisiae during stationary phase.

  Free radical biology & medicine 20030201

• Hydroxyl radical is not the main reactive species involved in the degradation of DNA bases by copper in the presence of hydrogen peroxide.

  Chemical research in toxicology 20030201

• Characterization of the redox properties of poplar glutaredoxin.

  Antioxidants & redox signaling 20030201

• Reactive quinones differentially regulate SAPK/JNK and p38/mHOG stress kinases.

  Antioxidants & redox signaling 20030201

• MRP1-transfected cells do not show increased resistance against oxidative stress.

  Free radical research 20030201

• Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolism.

  Biochemistry 20030114

• Paraquat and menadione exposure of rainbow trout (Oncorhynchus mykiss)--studies of effects on the pentose-phosphate shunt and thiamine levels in liver and kidney.

  Chemico-biological interactions 20030106

• Development of novel copper(II) complexes of benzothiazole- N-sulfonamides as protective agents against superoxide anion. Crystal structures of [Cu( N-2-(4-methylbenzothiazole)benzenesulfonamidate)(2)(py)(2)] and [Cu( N-2-(6-nitrobenzothiazole)naphthalenesulfonamidate)(2)(py)(2)].

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030101

• Serum markers variation consistent with autoschizis induced by ascorbic acid-menadione in patients with prostate cancer.

  Medical oncology (Northwood, London, England) 20030101

• Coenzyme Q releases the inhibitory effect of free fatty acids on mitochondrial glycerophosphate dehydrogenase.

  Acta biochimica Polonica 20030101

• Autoschizis of human ovarian carcinoma cells: scanning electron and light microscopy of a new cell death induced by sodium ascorbate: menadione treatment.

  Scanning 20030101

• Ultrastructural basis for the transition of cell death mode from apoptosis to necrosis in menadione-treated osteosarcoma 143B cells.

  Journal of electron microscopy 20030101

• Role of gamma-glutamyltransferase in the homeostasis of glutathione during oxidative and nitrosative stress.

  BioFactors (Oxford, England) 20030101

• The in vitro antitumor activity of vitamins C and K3 against ovarian carcinoma.

  Anticancer research 20030101

• [Participation of beta-carotene in antioxidant defense of bacterial cells].

  Prikladnaia biokhimiia i mikrobiologiia 20030101

• [Intermolecular interactions of dipeptide triterpene derivatives and natural quinones with alpha-tocopherol].

  Biomeditsinskaia khimiia 20030101

• Participation of chloroplasts in plant apoptosis.

  Bioscience reports 20030101

• Enhanced menadione cytotoxicity in platelets isolated from streptozotocin-induced diabetic rats.

  Thrombosis research 20030101

• Kinetics of the spectral changes during reduction of the Na+-motive NADH:quinone oxidoreductase from Vibrio harveyi.

  Biochimica et biophysica acta 20021202

• A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells.

  Biochemical pharmacology 20021201

• Potential therapeutic application of the association of vitamins C and K3 in cancer treatment.

  Current medicinal chemistry 20021201

• Control of demand-driven biosynthesis of glutathione in green Arabidopsis suspension culture cells.

  Plant physiology 20021201

• The impact of oxidative stress on Arabidopsis mitochondria.

  The Plant journal : for cell and molecular biology 20021201

• Dihydroisotanshinone I protects against menadione-induced toxicity in a primary culture of rat hepatocytes.

  Planta medica 20021201

• Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity.

  The Journal of biological chemistry 20021129

• Mechanisms for the formation of major oxidation products of adenine upon 365-nm irradiation with 2-methyl-1,4-naphthoquinone as a sensitizer.

  The Journal of organic chemistry 20021129

• Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: bioassay-directed isolation and characterization of active principles.

  Journal of agricultural and food chemistry 20021120

• Effects of redox cycling compounds on glutathione content and activity of glutathione-related enzymes in rainbow trout liver.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20021101

• Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.

  Cancer research 20021101

• Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence.

  Microbiology (Reading, England) 20021101

• Regulation of the manganese-containing superoxide dismutase gene from fission yeast.

  Molecules and cells 20021031

• Transaldolase exhibits a protective role against menadione toxicity in Xanthomonas campestris pv. phaseoli.

  Biochemical and biophysical research communications 20021004

• Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6.

  Yeast (Chichester, England) 20021001

• Detection of two distinct substrate-dependent catabolic responses in yeast cells using a mediated electrochemical method.

  Applied microbiology and biotechnology 20021001

• Temperature-dependent quinone cytotoxicity in platelets involves arylation.

  Journal of toxicology and environmental health. Part A 20020927

• Role of an endoplasmic reticulum Ca(2+)-independent phospholipase A(2) in oxidant-induced renal cell death.

  American journal of physiology. Renal physiology 20020901

• 2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade.

  Cancer research 20020901

• The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart.

  Cardiovascular research 20020815

• Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo.

  The Plant journal : for cell and molecular biology 20020801

• The unorthodox histidine kinases BvgS and EvgS are responsive to the oxidation status of a quinone electron carrier.

  European journal of biochemistry 20020701

• Inter-strain variability in aldehyde oxidase activity in the mouse.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020701

• Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells.

  Free radical biology & medicine 20020601

• Role of antioxidant defences in the species-specific response of isolated atria to menadione.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601

• Menadione biphasically controls JNK-linked cell death in leukemia Jurkat T cells.

  Antioxidants & redox signaling 20020601

• Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress.

  Biochemical pharmacology 20020501

• Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.

  Current genetics 20020501

• A second stress-inducible glutathione S-transferase gene from Schizosaccharomyces pombe.

  Biochimica et biophysica acta 20020412

• Spectrophotometric methods for the rapid determination of menadione and menadione sodium bisulphite and their application in pharmaceutical preparations.

  Journal of pharmaceutical and biomedical analysis 20020401

• Oxidant stress induces gamma-glutamylcysteine synthetase and glutathione synthesis in human bronchial epithelial NCI-H292 cells.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020401

• Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1).

  Free radical research 20020401

• Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress.

  The Journal of biological chemistry 20020315

• Major adenine products from 2-methyl-1,4-naphthoquinone-sensitized photoirradiation at 365 nm.

  Biochemical and biophysical research communications 20020315

• Oxidative stress-independent depletion of epidermal vitamin A by UVA.

  The Journal of investigative dermatology 20020301

• The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress.

  Molecular and cellular biochemistry 20020301

• Generation of oxygen free radicals in thyroid cells and inhibition of thyroid peroxidase.

  Experimental biology and medicine (Maywood, N.J.) 20020201

• The adaptive response of Saccharomyces cerevisiae to mercury exposure.

  Yeast (Chichester, England) 20020201

• Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore.

  Journal of cell science 20020201

• Role of MAP kinase activation in Nramp1 mRNA stability in RAW264.7 macrophages expressing Nramp1(Gly169).

  Cellular immunology 20020201

• Inhibition of Ca2+-activated and voltage-dependent K+ currents by 2-mercaptophenyl-1,4-naphthoquinone in pituitary GH3 cells: contribution to its antiproliferative effect.

  Life sciences 20020125

• Glutathione and p53 independently mediate responses against oxidative stress in ES cells.

  Free radical biology & medicine 20020115

• Role of redox status on the activation of mitogen-activated protein kinase cascades by NSAIDs.

  Biochemical pharmacology 20020115

• Transplasma membrane electron transport in Leishmania donovani promastigotes.

  The Journal of eukaryotic microbiology 20020101

• [Superoxide dismutase and catalase activities in carotenoid-synthesizing fungi Blakeslea trispora and Neurospora crassa under the oxidative stress].

  Prikladnaia biokhimiia i mikrobiologiia 20020101

• Menadione-catalyzed luminol chemiluminescent assay for viability of Mycobacterium bovis.

  Microbiology and immunology 20020101

• Increased resistance towards oxidative stress accompanies enhancement of metastatic potential obtained by repeated in vivo passage of colon carcinoma cells in syngeneic rats.

  Clinical & experimental metastasis 20020101

• Evidence that oxidative stress-induced apoptosis by menadione involves Fas-dependent and Fas-independent pathways.

  Clinical immunology (Orlando, Fla.) 20011201

• The antioxidant potential of pyruvate in the amitochondriate diplomonads Giardia intestinalis and Hexamita inflata.

  Microbiology (Reading, England) 20011201

• Microspectrofluorometry of autofluorescence emission from human leukemic living cells under oxidative stress.

  Biology of the cell 20011101

• Induction of cytochrome P450 1A1 gene expression by a vitamin K3 analog in mouse hepatoma Hepa-1c1c7 cells.

  Molecules and cells 20011031

• Recruitment of a foreign quinone into the A1 site of photosystem I. In vivo replacement of plastoquinone-9 by media-supplemented naphthoquinones in phylloquinone biosynthetic pathway mutants of Synechocystis sp. PCC 6803.

  The Journal of biological chemistry 20011026

• Rat aortic smooth muscle cell density affects activation of MAP kinase and Akt by menadione and PDGF homodimer BB.

  The Journal of surgical research 20011001

• Determination of menadione sodium bisulfite in pharmaceutical preparations by flow-injection on-line photochemical spectrofluorometry.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20011001

• Divergent effects of different oxidants on glutathione homeostasis and protein damage in erythrocytes from diabetic patients: effects of high glucose.

  Molecular and cellular biochemistry 20010901

• Menadione induces endothelial dysfunction mediated by oxidative stress and arylation.

  Chemico-biological interactions 20010831

• Production of pyridoxal phosphate by a mutant strain of Schizosaccharomyces pombe.

  Bioscience, biotechnology, and biochemistry 20010801

• Dietary vitamin K1 requirement and comparison of biopotency of different vitamin K sources for young turkeys.

  Poultry science 20010501

• Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells.

  Ultrastructural pathology 20010101

• Menadione-catalyzed O2- production by Escherichia coli cells: application of rapid chemiluminescent assay to antimicrobial susceptibility testing.

  Microbiology and immunology 20010101

• Base excision repair of mitochondrial DNA damage in mammalian cells.

  Progress in nucleic acid research and molecular biology 20010101

• Vitamins D and K in the treatment of osteoporosis secondary to graft-versus-host disease following bone-marrow transplantation.

  The Journal of international medical research 20010101

• Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines.

  Anticancer research 20010101

• Autoschizis: another cell death for cancer cells induced by oxidative stress.

  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 20010101

• Multiple oxidative stress parameters are modulated in vitro by oxygenated polycyclic aromatic hydrocarbons identified in river sediments.

  Advances in experimental medicine and biology 20010101

• Menadione-catalyzed luminol chemiluminescent assay for the viability of Escherichia coli ATCC 25922.

  Microbiology and immunology 20010101

• Synergistic cytotoxic action of vitamin C and vitamin K3.

  Anticancer research 20010101

• BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production.

  Redox report : communications in free radical research 20010101

• [Menadione and roboxin as inducers of immunomodulating activity of erythrocyte stroma].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• Menadione-induced apoptosis and the degradation of lamin-like proteins in tobacco protoplasts.

  Cellular and molecular life sciences : CMLS 19990201

• Comparative effects of vitamin K2 and vitamin E on experimental arteriosclerosis.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 19990101

• [Effect of protein synthesis inhibitors on the vicasol-induced change in the content of the thermostable antifactor Xa in the blood serum].

  Voprosy meditsinskoi khimii 19800101