130641-38-2 | Bindarit

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$33.00	$23.00
5mg	98%	in stock	$121.00	$85.00
10mg	98%	in stock	$193.00	$135.00
25mg	98%	in stock	$322.00	$225.00
200mg	98%	in stock	$2,219.00	$1,553.00

Description

• Catalog Number: AA39636
• Chemical Name: Bindarit
• CAS Number: 130641-38-2
• Molecular Formula: C19H20N2O3
• Molecular Weight: 324.3737
• MDL Number: MFCD00866723
• SMILES: OC(=O)C(OCc1nn(c2c1cccc2)Cc1ccccc1)(C)C

Computed Properties

• Complexity: 434
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 3

Upstream Synthesis Route

2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid (referred to as $name$) is a versatile compound widely applied in chemical synthesis processes. This compound serves as a valuable building block in the creation of novel pharmaceuticals, agrochemicals, and materials due to its unique structural features. Its ability to act as a functional group precursor allows for the synthesis of structurally diverse molecules with enhanced biological activities. The presence of the benzyl-indazole moiety and the carboxylic acid group in $name$ enables strategic modifications and transformations, facilitating the development of new compounds with improved properties and functions. By incorporating $name$ into synthetic schemes, chemists can access a myriad of molecular scaffolds and pathways, expanding the possibilities for the design and discovery of biologically active compounds.

Literature

• Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].

  Annals of the New York Academy of Sciences 20120401

• Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis.

  Hepatobiliary & pancreatic diseases international : HBPD INT 20100401

• The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice.

  Cardiovascular research 20091201

• The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension.

  Journal of hypertension 20091001

• Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20081001

• Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins.

  European cytokine network 20080901

• Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft.

  The Journal of investigative dermatology 20070801

• Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis.

  American journal of physiology. Gastrointestinal and liver physiology 20050601

• Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNF-alpha production.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020501

• Advances in the treatment of lupus nephritis.

  Annual review of medicine 20010101