130693-82-2 | Dorzolomide hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$8.00	$6.00
10mg	98%	in stock	$13.00	$9.00
50mg	98%	in stock	$38.00	$27.00
100mg	98%	in stock	$52.00	$36.00
250mg	98%	in stock	$92.00	$65.00
1g	98%	in stock	$208.00	$146.00
10g	98%	in stock	$560.00	$392.00

Description

• Catalog Number: AD31140
• Chemical Name: Dorzolomide hydrochloride
• CAS Number: 130693-82-2
• Molecular Formula: C10H17ClN2O4S3
• Molecular Weight: 360.901
• MDL Number: MFCD00884659
• SMILES: CCN[C@H]1C[C@H](C)S(=O)(=O)c2c1cc(s2)S(=O)(=O)N.Cl

Computed Properties

• Complexity: 534
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3

Literature

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  Chemical research in toxicology 20150518

• Topical drug delivery to the eye: dorzolamide.

  Acta ophthalmologica 20121101

• A novel and rapid validated stability-indicating UPLC method of related substances for dorzolamide hydrochloride and timolol maleate in ophthalmic dosage form.

  Journal of chromatographic science 20121001

• In vivo imaging reveals novel aspects of retinal disease progression in Rs1h(-/Y) mice but no therapeutic effect of carbonic anhydrase inhibition.

  Veterinary ophthalmology 20120901

• Fixed topical combinations in glaucomatous patients and ocular discomfort.

  Expert opinion on pharmacotherapy 20120901

• Comparison of dorzolamide/timolol and latanoprost/timolol fixed combinations on diurnal intraocular pressure control in primary open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120801

• The effects of a fixed combination of 0.5% timolol and 1% dorzolamide on optic nerve head blood circulation.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120801

• Retrobulbar hemodynamics before and after oculopression with and without dorzolamide.

  Current eye research 20120801

• Effects of ocular administration of ophthalmic 2% dorzolamide hydrochloride solution on aqueous humor flow rate and intraocular pressure in clinically normal cats.

  American journal of veterinary research 20120701

• The clinical efficacy of a topical dorzolamide in the management of cystoid macular edema in patients with retinitis pigmentosa.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20120601

• Diurnal and nocturnal variations in aqueous humor dynamics of patients with ocular hypertension undergoing medical therapy.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20120601

• [The rabbit's IOP values after instillation of the L-arginine HCL with selected antiglaucomatic drugs mixtures prepared in vitro. (comparative study of results of the experimental works)].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20120501

• Topical dorzolamide for treatment of cystoid macular edema in patients with choroideremia.

  Retina (Philadelphia, Pa.) 20120401

• Meta-analysis of α2-adrenergic agonists versus carbonic anhydrase inhibitors as adjunctive therapy.

  Current medical research and opinion 20120401

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  Journal of enzyme inhibition and medicinal chemistry 20120201

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  Acta ophthalmologica 20120201

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  Arquivos brasileiros de oftalmologia 20120101

• Regulation of retinal proteome by topical antiglaucomatous eye drops in an inherited glaucoma rat model.

  PloS one 20120101

• From dorzolamide 2%/timolol 0.5% to brinzolamide 1%/timolol 0.5% fixed combination: a 6-month, multicenter, open-label tolerability switch study.

  Expert opinion on pharmacotherapy 20111101

• Ocular pharmacokinetics of dorzolamide and brinzolamide after single and multiple topical dosing: implications for effects on ocular blood flow.

  Drug metabolism and disposition: the biological fate of chemicals 20110901

• Diurnal intraocular pressure efficacy of the timolol-brimonidine fixed combination and the timolol-dorzolamide fixed combination as a first choice therapy in patients with pseudoexfoliation glaucoma.

  Current eye research 20110901

• The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma.

  Veterinary ophthalmology 20110901

• In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment.

  International journal of pharmaceutics 20110830

• X-linked retinoschisis maculopathy treated with topical dorzolamide, and relationship to genotype.

  Eye (London, England) 20110701

• Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.

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• [Double-masked, phase III comparative study of the combination ophthalmic solution of the 1% dorzolamide hydrochloride/0.5% timolol maleate (MK-0507A) in patients with glaucoma and ocular hypertension].

  Nippon Ganka Gakkai zasshi 20110601

• [Comparative study of the pressure lowering efficacy and variations in the ocular pulse amplitude between fixed combinations of dorzolamide/timolol and brinzolamide/timolol].

  Archivos de la Sociedad Espanola de Oftalmologia 20110501

• A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug.

  Biomedical materials (Bristol, England) 20110401

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  Vojnosanitetski pregled 20110301

• Electrophysiological consequences of experimental branch retinal vein occlusion in pigs and the effect of dorzolamide.

  Investigative ophthalmology & visual science 20110216

• The use of carbonic anhydrase inhibitors in the retreatment of cystic macular lesions in retinitis pigmentosa and X-linked retinoschisis.

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• Intraocular pressure and ocular hemodynamics in patients with primary open-angle glaucoma treated with the combination of morning dosing of bimatoprost and dorzolamide hydrochloride.

  Acta ophthalmologica 20110201

• Diagnostic and therapeutic challenges.

  Retina (Philadelphia, Pa.) 20110101

• The clinical impact of 2 different strategies for initiating therapy in patients with ocular hypertension.

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• Pharmacodynamic equivalence study of two preparations of eye drops containing dorzolamide and timolol in healthy volunteers.

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• [Assessment of visual function under treatment with topical antiglaucoma agents and systemic vasodilators. Clinical study on glaucoma patients].

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• The additive effect of dorzolamide hydrochloride (Trusopt) and a morning dose of bimatoprost (Lumigan) on intraocular pressure and retrobulbar blood flow in patients with primary open-angle glaucoma.

  The British journal of ophthalmology 20101001

• Cyclodextrin solubilization of carbonic anhydrase inhibitor drugs: formulation of dorzolamide eye drop microparticle suspension.

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• Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma.

  Current medical research and opinion 20100901

• Efficacy of sustained topical dorzolamide therapy for cystic macular lesions in patients with retinitis pigmentosa and usher syndrome.

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  Investigative ophthalmology & visual science 20100401

• Use of rituximab for periocular and intraocular mucosa-associated lymphoid tissue lymphoma.

  Ocular immunology and inflammation 20100401

• Simultaneous quantification of carteolol and dorzolamide in rabbit aqueous humor and ciliary body by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100315

• Effect of dorzolamide and timolol on ocular pressure: blood flow relationship in patients with primary open-angle glaucoma and ocular hypertension.

  Investigative ophthalmology & visual science 20100301

• Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy.

  Acta ophthalmologica 20100201

• Efficacy of sustained topical dorzolamide therapy for cystic macular lesions in patients with X-linked retinoschisis.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20100201

• Influence of various concentrations of terpene-4-ol enhancer and carbopol-934 mucoadhesive upon the in vitro ocular transport and the in vivo intraocular pressure lowering effects of dorzolamide ophthalmic formulations using albino rabbits.

  Journal of pharmaceutical sciences 20100101

• Skin eruption and thrombocytopaenia in a woman with glaucoma: a case report.

  The West Indian medical journal 20100101

• Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.

  Veterinary therapeutics : research in applied veterinary medicine 20100101

• Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation.

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• Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.

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• The effects of combination glaucoma medications on ocular surface epithelial cells.

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• Brimonidine tartrate 0.15%, dorzolamide hydrochloride 2%, and brinzolamide 1% compared as adjunctive therapy to prostaglandin analogs.

  Ophthalmology 20090901

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• Meta-analysis of medical intervention for normal tension glaucoma.

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• Effects of dorzolamide on choroidal blood flow, ciliary blood flow, and aqueous production in rabbits.

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• The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition.

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• Intraocular pressure lowering, change of antiapoptotic molecule expression, and neuroretinal changes by dorzolamide 2%/timolol 0.5% combination in a chronic ocular hypertension rat model.

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• A one-week comfort study of BID-dosed brinzolamide 1%/timolol 0.5% ophthalmic suspension fixed combination compared to BID-dosed dorzolamide 2%/timolol 0.5% ophthalmic solution in patients with open-angle glaucoma or ocular hypertension.

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• An eight-week, multicentric, randomized, interventional, open-label, phase 4, parallel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure.

  Journal of glaucoma 20081201

• Second-line therapy with dorzolamide/timolol or latanoprost/timolol fixed combination versus adding dorzolamide/timolol fixed combination to latanoprost monotherapy.

  The British journal of ophthalmology 20081101

• Effects of the timolol-dorzolamide fixed combination and latanoprost on circadian diastolic ocular perfusion pressure in glaucoma.

  Investigative ophthalmology & visual science 20081001

• The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients.

  Eye (London, England) 20080901

• Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma.

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• A comparison of dorzolamide/timolol-fixed combination versus bimatoprost in patients with open-angle glaucoma who are poorly controlled on latanoprost.

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• 24-hour control of intraocular pressure with 2% dorzolamide/0.5% timolol fixed-combination ophthalmic solution in open-angle glaucoma.

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  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20080701

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  Acta ophthalmologica 20080601

• Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: a single-center, 4-year, open-label study.

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• Effectiveness and safety of dorzolamide-timolol alone or combined with latanoprost in open-angle glaucoma or ocular hypertension.

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  Ophthalmology 20080101

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  Arquivos brasileiros de oftalmologia 20080101

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  Current medical research and opinion 20071201

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  Current medical research and opinion 20071201

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  Investigative ophthalmology & visual science 20071001

• Effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

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• Diuretics, placebos, and the European glaucoma prevention study.

  American journal of ophthalmology 20070801

• Ocular comfort of combination glaucoma therapies: brimonidine 0.2%/timolol 0.5% compared with dorzolamide 2%/timolol 0.5%.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801

• Hypotensive effect of profilin on rabbit intraocular pressure.

  European journal of pharmacology 20070712

• Continued use of dorzolamide for the treatment of cystoid macular oedema in patients with retinitis pigmentosa.

  The British journal of ophthalmology 20070601

• Retrobulbar haemodynamic effects of the latanoprost/timolol and the dorzolamide/timolol fixed combinations in newly diagnosed glaucoma patients.

  International journal of clinical practice 20070501

• X-linked retinoschisis: an update.

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• Acute visual loss due to serous retinal detachment from acquired optic pit may be a rare presentation of primary open-angle glaucoma.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070401

• Comparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressure.

  Current medical research and opinion 20070401

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• [Toxic epidermal necrolysis following eyedrop treatment for glaucoma].

  Annales de dermatologie et de venereologie 20070401

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  Ophthalmology 20070301

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  The British journal of ophthalmology 20070101

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  Ophthalmology 20070101

• Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study.

  Ophthalmology 20070101

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  Ophthalmic research 20070101

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  European journal of ophthalmology 20070101

• Pheochromocytoma presenting with bithalamic infarction, dementia, and increased intraocular pressure.

  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20070101

• Corneal edema after aqueous drainage device implantation.

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  American journal of ophthalmology 20061001

• The additive effect of topical dorzolamide and systemic acetazolamide in pediatric glaucoma.

  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20061001

• A comparative analysis of the effects of the fixed combination of timolol and dorzolamide versus latanoprost plus timolol on ocular hemodynamics and visual function in patients with primary open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001

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  Retina (Philadelphia, Pa.) 20060901

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  Nippon Ganka Gakkai zasshi 20060901

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  American journal of ophthalmology 20060701

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  American journal of ophthalmology 20060601

• Allergic contact dermatitis from timolol and dorzolamide eye drops.

  Contact dermatitis 20060601

• The in vitro effects of some pesticides on carbonic anhydrase activity of Oncorhynchus mykiss and Cyprinus carpio carpio fish.

  Journal of hazardous materials 20060520

• Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.

  American journal of ophthalmology 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060401

• Inhibition of apoptosis and reduction of intracellular pH decrease in retinal neural cell cultures by a blocker of carbonic anhydrase.

  Investigative ophthalmology & visual science 20060301

• Effect of topical dorzolamide on rabbit central corneal thickness.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060201

• Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells.

  The Kaohsiung journal of medical sciences 20060201

• A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients.

  Current medical research and opinion 20060101

• Switching from dorzolamide to brinzolamide: effect on intraocular pressure and patient comfort.

  Japanese journal of ophthalmology 20060101

• Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.

  Veterinary ophthalmology 20060101

• [Intraocular pressure after ND: YAG laser capsulotomy in pseudophakic patients with glaucoma].

  Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20060101

• Brimonidine/Timolol: a viewpoint by Francisco J. Goñi.

  Drugs & aging 20060101

• A comparison of latanoprost monotherapy with a combination therapy of timolol/dorzolamide in patients with primary open-angle glaucoma.

  Annals of ophthalmology (Skokie, Ill.) 20060101

• Dorzolamide and timolol saves retinal ganglion cells in glaucomatous adult rats.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Comparison of latanoprost monotherapy and combined therapy of 0.5% timolol and 1% dorzolamide in chronic primary angle-closure glaucoma (CACG) in Japanese patients.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Toxic epidermal necrolysis secondary to timolol, dorzolamide, and latanoprost eyedrops.

  Journal of the American Academy of Dermatology 20051101

• Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension.

  The British journal of ophthalmology 20051001

• The efficacy and ocular discomfort of substituting brinzolamide for dorzolamide in combination therapy with latanoprost, timolol, and dorzolamide.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051001

• Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.

  Bioorganic & medicinal chemistry letters 20050901

• European Glaucoma Prevention Study.

  Ophthalmology 20050901

• A randomized trial assessing dorzolamide in patients with glaucoma who are younger than 6 years.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20050901

• Efficacy of the dorzolamide/timolol fixed combination versus latanoprost in the treatment of ocular hypertension or glaucoma: combined analysis of pooled data from two large randomized observer and patient-masked studies.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601

• Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model.

  The British journal of ophthalmology 20050401

• Topical dorzolamide increases pericentral visual function in age-related maculopathy: pilot study findings with short-wavelength automated perimetry.

  Acta ophthalmologica Scandinavica 20050401

• 24-hour intraocular pressures with brimonidine purite versus dorzolamide added to latanoprost in primary open-angle glaucoma subjects.

  Ophthalmology 20050401

• The efficacy and safety of topical brinzolamide and dorzolamide when added to the combination therapy of latanoprost and a beta-blocker in patients with glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050401

• An unusual appearance of limbal conjunctival follicles in a patient on brimonidine and dorzolamide.

  Eye (London, England) 20050301

• Results of the European Glaucoma Prevention Study.

  Ophthalmology 20050301

• Comparison of additional intraocular pressure-lowering effects of latanoprost vs brimonidine in primary open-angle glaucoma patients with intraocular pressure uncontrolled by timolol-dorzolamide combination.

  Eye (London, England) 20050201

• Alphagan allergy may increase the propensity for multiple eye-drop allergy.

  Eye (London, England) 20050201

• Comparison of the efficacy and safety of dorzolamide 2% when added to brimonidine 0.2% or timolol maleate 0.5% in patients with primary open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050201

• Contact dermatitis caused by allergy to dorzolamide.

  Contact dermatitis 20050201

• Carbonic anhydrase inhibition increases retinal oxygen tension and dilates retinal vessels.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050201

• Dorzolamide influences the autoregulation of major retinal vessels caused by artificial intraocular pressure elevation in patients with POAG: a clinical study.

  Current eye research 20050201

• Cyclodextrin formulation of dorzolamide and its distribution in the eye after topical administration.

  Journal of controlled release : official journal of the Controlled Release Society 20050120

• Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428].

  BMC ophthalmology 20050101

• Safety and efficacy of bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% fixed combination.

  European journal of ophthalmology 20050101

• Effect of apraclonidine versus dorzolamide on intraocular pressure after phacoemulsification.

  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20050101

• Comparative analysis of the efficacy and safety of latanoprost, travoprost and the fixed combination timolol-dorzolamide; a prospective, randomized, masked, cross-over design study.

  Oftalmologia (Bucharest, Romania : 1990) 20050101

• Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%.

  Eye (London, England) 20041201

• A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients.

  Acta ophthalmologica Scandinavica 20041201

• Two-year follow-up of latanoprost 0.005% monotherapy after changing from previous glaucoma therapies.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041201

• Influence of inorganic mobile phase additives on the retention, efficiency and peak symmetry of protonated basic compounds in reversed-phase liquid chromatography.

  Journal of chromatography. A 20040917

• Short-term ocular tolerability of dorzolamide 2% and brinzolamide 1% vs placebo in primary open-angle glaucoma and ocular hypertension subjects.

  Eye (London, England) 20040901

• [Impact of prostaglandin-F(2alpha)-analogues and carbonic anhydrase inhibitors on central corneal thickness -- a cross-sectional study on 403 eyes].

  Klinische Monatsblatter fur Augenheilkunde 20040901

• Comparing the fixed combination dorzolamide-timolol (Cosopt) to concomitant administration of 2% dorzolamide (Trusopt) and 0.5% timolol -- a randomized controlled trial and a replacement study.

  Journal of clinical pharmacy and therapeutics 20040801

• Dorzolamide-induced choroidal detachment in a surgically untreated eye.

  American journal of ophthalmology 20040801

• Assessment of retinal hemodynamics with the Canon laser blood flowmeter after a single dose of 2% dorzolamide hydrochloride eyedrops.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20040801

• Brimonidine purite 0.15% versus dorzolamide 2% each given twice daily to reduce intraocular pressure in subjects with open angle glaucoma or ocular hypertension.

  The British journal of ophthalmology 20040701

• Endothelial changes associated with topical dorzolamide do appear to be significant.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20040701

• Effects on aqueous flow of dorzolamide combined with either timolol or acetazolamide.

  Journal of glaucoma 20040601

• Trends in glaucoma surgery before and after the introduction of new topical glaucoma pharmacotherapies.

  Journal of glaucoma 20040601

• Accelerated idioventricular rhythm associated to ophthalmic timolol/dorzolamide solution.

  International journal of cardiology 20040601

• Lichenoid drug eruption secondary to topical timolol and dorzolamide eye-drops.

  The Australasian journal of dermatology 20040501

• Immediate postoperative use of a topical agent to prevent intraocular pressure elevation after pars plana vitrectomy with gas tamponade.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20040501

• Comparison of latanoprost with fixed-combination dorzolamide and timolol in adult patients with elevated intraocular pressure: an eight-week, randomized, open-label, parallel-group, multicenter study in Latin America.

  Clinical therapeutics 20040501

• [Comparison of the effectiveness of a mixture of 10% L-arginine and HCl combined with 0.5% Timoptol and with 2% Trusopt: and the individual components on intraocular pressure in an experiment on rabbits].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20040501

• Dorzolamide/Timolol fixed combination versus concomitant administration of brimonidine and timolol in patients with elevated intraocular pressure: a 3-month comparison of efficacy, tolerability, and patient-reported measures.

  Journal of glaucoma 20040401

• Comparison of the safety and efficacy of dorzolamide 2% and brimonidine 0.2% in patients with glaucoma or ocular hypertension.

  Journal of glaucoma 20040401

• [Efficiency of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers].

  Archivos de la Sociedad Espanola de Oftalmologia 20040401

• [Intraocular pressure in rabbits after administration of 10% L-arginine HCl in 2% Trusopt].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20040401

• The effect of carbonic anhydrase inhibition on leptin secretion by rat adipose tissue.

  Journal of enzyme inhibition and medicinal chemistry 20040401

• Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension.

  Investigative ophthalmology & visual science 20040301

• Studies on the mechanism of action of timolol and on the effects of suppression and redirection of aqueous flow on outflow facility.

  Experimental eye research 20040301

• Dorzolamide induces vasodilatation in isolated pre-contracted bovine retinal arteries.

  Experimental eye research 20040201

• Optic nerve oxygen tension: the effects of timolol and dorzolamide.

  The British journal of ophthalmology 20040201

• Aqueous humor flow in normal human eyes treated with brimonidine and dorzolamide, alone and in combination.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20040201

• Effects of dorzolamide hydrochloride on ocular tissues.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040201

• Efficacy and safety of the fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressure.

  Ophthalmology 20040201

• [Effect of various anti-glaucoma eyedrops on human corneal epithelial cells].

  Nippon Ganka Gakkai zasshi 20040201

• Binding affinity of bunazosin, dorzolamide, and timolol to synthetic melanin.

  Japanese journal of ophthalmology 20040101

• Comparison of latanoprost and dorzolamide in the treatment of patients with open angle glaucoma.

  Journal of Ayub Medical College, Abbottabad : JAMC 20040101

• [Timolol topical ophthalmic combination].

  Oftalmologia (Bucharest, Romania : 1990) 20040101

• [Structural and immunohistochemical changes of conjunctiva induced by topical glaucoma medication].

  Oftalmologia (Bucharest, Romania : 1990) 20040101

• [Neuroprotection and vasoprotection in glaucoma].

  Oftalmologia (Bucharest, Romania : 1990) 20040101

• [Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients].

  Klinika oczna 20040101

• Ocular factors relevant to anti-glaucomatous eyedrop-related keratoepitheliopathy.

  Journal of glaucoma 20031201

• Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops.

  Die Pharmazie 20031201

• Efficacy and safety of brimonidine, dorzolamide and latanoprost as adjunctive therapy in primary open angle glaucoma.

  International journal of clinical practice 20031201

• The efficacy and safety of dose escalation of dorzolamide used in combination with other topical antiglaucoma agents.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201

• Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients.

  Acta ophthalmologica Scandinavica 20031001

• A six-week, parallel, randomized, double-blind study comparing the efficacy and safety of the 0.5% timolol/2.0% MK-507 combination b.i.d. to the concomitant administration of 0.5% timolol b.i.d. and 2.0% MK-507 b.i.d.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031001

• Prescription of topical antiglaucoma agents for patients with contraindications to beta-blockers.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20031001

• Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat.

  Journal of cataract and refractive surgery 20030901

• [Effects of ocular hypotensive agents on the circadian rhythm in intraocular pressure in rabbits as measured by telemetry].

  Nippon Ganka Gakkai zasshi 20030901

• Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.

  Bioorganic & medicinal chemistry letters 20030901

• Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients.

  Acta ophthalmologica Scandinavica 20030801

• Topical dorzolamide and metabolic acidosis in a neonate.

  The British journal of ophthalmology 20030801

• Replacing maximum-tolerated medications with latanoprost versus adding latanoprost to maximum-tolerated medications: a two-center randomized prospective trial.

  Journal of glaucoma 20030801

• Twenty-four-hour diurnal curve comparison of commercially available latanoprost 0.005% versus the timolol and dorzolamide fixed combination.

  Ophthalmology 20030701

• Rapid and sensitive HPLC method for the simultaneous determination of dorzolamide hydrochloride and timolol maleate in eye drops with diode-array and UV detection.

  Die Pharmazie 20030701

• Patient persistency with pharmacotherapy in the management of glaucoma.

  European journal of ophthalmology 20030701

• Effects of twice daily application of 2% dorzolamide on intraocular pressure in normal cats.

  Veterinary ophthalmology 20030601

• The effects of dorzolamide on choroidal and retinal perfusion in non-exudative age related macular degeneration.

  The British journal of ophthalmology 20030601

• The effect of topical glaucoma medications evaluated by perimetry.

  The British journal of ophthalmology 20030601

• Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030601

• Unoprostone as adjunctive therapy to timolol: a double masked randomised study versus brimonidine and dorzolamide.

  The British journal of ophthalmology 20030501

• Short-term effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20030501

• Acute and chronic ocular symptoms of dorzolamide 2% compared with placebo.

  Journal of glaucoma 20030401

• Elevated intraocular pressure associated with steroid treatment for infantile spasms.

  Ophthalmology 20030401

• The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20030401

• Comparison of the efficacy of the fixed-combination timolol/dorzolamide versus concomitant administration of timolol and dorzolamide.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401

• Switching from systemic to the topical carbonic anhydrase inhibitor dorzolamide: effect on the quality of life of glaucoma patients with drug-related side effects.

  The Israel Medical Association journal : IMAJ 20030401

• Dorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy and tolerability.

  Ophthalmology 20030301

• Four years later: a clinical update on latanoprost.

  European journal of ophthalmology 20030301

• Timolol 0.5%/dorzolamide 2% fixed combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily to patients with primary open-angle glaucoma or ocular hypertension.

  American journal of ophthalmology 20030201

• Blockers of carbonic anhydrase can cause increase of retinal capillary diameter, decrease of extracellular and increase of intracellular pH in rat retinal organ culture.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030201

• [Glaucoma: an ocular blood flow disorder?].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20030201

• Cost-minimisation study of dorzolamide versus brinzolamide in the treatment of ocular hypertension and primary open-angle glaucoma: in four European countries.

  PharmacoEconomics 20030101

• The efficacy and safety of the timolol/dorzolamide fixed combination vs latanoprost in exfoliation glaucoma.

  Eye (London, England) 20030101

• Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients.

  European journal of ophthalmology 20030101

• Influence of dorzolamide on corneal endothelium.

  Japanese journal of ophthalmology 20030101

• Experience with COSOPT, the fixed combination of timolol and dorzolamide, gained in Swiss ophthalmologists' offices.

  Current medical research and opinion 20030101

• The free amino acids and the aqueous humor pH after antiglaucomatics in vitro.

  Bratislavske lekarske listy 20030101

• Comparison of brimonidine/latanoprost and timolol/dorzolamide: two randomized, double-masked, parallel clinical trials.

  Advances in therapy 20030101

• Experience with Cosopt, the fixed combination of timolol and dorzolamide, after switch from free combination of timolol and dorzolamide, in Swiss ophthalmologists' offices.

  Current medical research and opinion 20030101

• Interventions for normal tension glaucoma.

  The Cochrane database of systematic reviews 20030101

• Hypotony and choroidal effusion induced by topical timolol and dorzolamide in patients with previous glaucoma drainage device implantation.

  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20030101

• Choroidal detachment induced by dorzolamide 20 years after cataract surgery.

  The British journal of ophthalmology 20021201

• An update on bimatoprost in glaucoma therapy.

  Expert opinion on pharmacotherapy 20021201

• The short-term IOP-lowering effect of brimonidine 0.2% and dorzolomide 2% combination in primary open-angle glaucoma.

  Acta ophthalmologica Scandinavica 20021201

• A comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucoma.

  Acta ophthalmologica Scandinavica 20021201

• Primary glaucoma in Burmese cats.

  Australian veterinary journal 20021101

• Functional analysis of retinal vessel diameter reaction to artificially raised intraocular pressure in glaucoma patients with and without dorzolamide therapy.

  VASA. Zeitschrift fur Gefasskrankheiten 20021101

• Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide.

  Investigative ophthalmology & visual science 20021001

• Dorzolamide X apraclonidine in the prevention of the intraocular pressure spike after Nd : YAG laser posterior capsulotomy.

  Current eye research 20021001

• The European glaucoma prevention study design and baseline description of the participants.

  Ophthalmology 20020901

• Reappraising first-line treatment in glaucoma management.

  Hospital medicine (London, England : 1998) 20020901

• The effect of latanoprost on circadian intraocular pressure.

  Survey of ophthalmology 20020801

• Latanoprost versus combined timolol and dorzolamide.

  Survey of ophthalmology 20020801

• [Weill-Marchesani syndrome. Late athalamia following antiglaucomatous surgery].

  Archivos de la Sociedad Espanola de Oftalmologia 20020701

• Rapid high-performance liquid chromatographic assay of dorzolamide in rabbit aqueous humor.

  Biomedical chromatography : BMC 20020601

• Additive intraocular pressure lowering effect of various medications with latanoprost.

  American journal of ophthalmology 20020601

• Inhibitors of NHE-1 Na+/H+ exchange reduce mouse intraocular pressure.

  Investigative ophthalmology & visual science 20020601

• Tolerability and efficacy of dorzolamide versus acetazolamide added to timolol.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020601

• [Comparison of latanoprost monotherapy with timolol-dorzolamide combination in patients with open-angle glaucoma or ocular hypertension].

  Journal francais d'ophtalmologie 20020601

• The effects of new topical treatments on management of glaucoma in Scotland: an examination of ophthalmological health care.

  The British journal of ophthalmology 20020501

• Simultaneous determination of dorzolamide HCL and timolol maleate in eye drops by two different spectroscopic methods.

  Journal of pharmaceutical and biomedical analysis 20020415

• Periorbital dermatitis as a side effect of topical dorzolamide.

  The British journal of ophthalmology 20020401

• Dorzolamide and ocular blood flow in previously untreated glaucoma patients: a controlled double-masked study.

  Acta ophthalmologica Scandinavica 20020401

• [Study on hypotensive effect of latanoprost vs timolol-dorzolamide association].

  Archivos de la Sociedad Espanola de Oftalmologia 20020401

• Effect of Xalatan(R) and Cosopt(R) on the vascular tone of quiescent isolated pig ciliary arteries.

  Klinische Monatsblatter fur Augenheilkunde 20020401

• Advances in topical glaucoma therapy.

  Veterinary ophthalmology 20020301

• [Corneal descompensation in patients with endothelial compromise treated with topical dorzolamide].

  Archivos de la Sociedad Espanola de Oftalmologia 20020301

• Application of TLC-densitometry, first-derivative UV-spectrophotometry and ratio derivative spectrophotometry for the determination of dorzolamide hydrochloride and timolol maleate.

  Journal of pharmaceutical and biomedical analysis 20020201

• Effects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucoma.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20020101

• Clinical pharmacokinetics of dorzolamide.

  Clinical pharmacokinetics 20020101

• Cutaneous drug reaction case reports: from the world literature.

  American journal of clinical dermatology 20020101

• Topical bimatoprost: a review of its use in open-angle glaucoma and ocular hypertension.

  Drugs & aging 20020101

• Comparison of latanoprost, brimonidine and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with primary open-angle glaucoma and ocular hypertension.

  Acta ophthalmologica Scandinavica. Supplement 20020101

• The pulsatile ocular blood flow behaviour in open angle glaucoma patients after replacing timolol therapy with timolol and dorzolamide fixed combination: preliminary study.

  Acta ophthalmologica Scandinavica. Supplement 20020101

• Contact dermatitis to topical drugs for glaucoma.

  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20011201

• Refractive change after dorzolamide use in patients with primary open-angle glaucoma and ocular hypertension.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20011201

• Retrobulbar blood flow in glaucoma patients with nocturnal over-dipping in systemic blood pressure.

  American journal of ophthalmology 20011101

• Drug points. Exacerbation of angina associated with latanoprost.

  BMJ (Clinical research ed.) 20011006

• Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma.

  American journal of ophthalmology 20011001

• Allergic contact blepharoconjunctivitis from dorzolamide.

  Contact dermatitis 20011001

• [Innovative glaucoma therapy. Glaucoma therapy with topical carbonic anhydrase inhibitors].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001

• [Prevention of early postoperative increase in intraocular pressure after phacoemulsification. Comparison of different antiglaucoma drugs].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001

• [The pH reaction in aqueous humor to antiglaucoma agents of various concentrations and pH levels].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20010901

• Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension.

  American journal of ophthalmology 20010801

• Comparison of the additive intraocular pressure-lowering effect of latanoprost and dorzolamide when added to timolol in patients with open-angle glaucoma or ocular hypertension: a randomized, open-label, multicenter study in Greece.

  Journal of glaucoma 20010801

• Allergic contact dermatitis due to dorzolamide eyedrops.

  Contact dermatitis 20010701

• Treatment of intraocular pressure elevation after photorefractive keratectomy.

  Journal of cataract and refractive surgery 20010701

• [Additive effects of topical carbonic anhydrase inhibitors].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20010701

• Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs.

  American journal of veterinary research 20010601

• [Severe hyperglycemia caused by dorzolamide].

  Archivos de la Sociedad Espanola de Oftalmologia 20010601

• Effect of topical administration of 2% dorzlamide hydrochloride or 2% dorzlamide hydrochloride-0.5% timolol maleate on intraocular pressure in clinically normal horses.

  American journal of veterinary research 20010501

• Intraindividual comparison of the effects of a fixed dorzolamide-timolol combination and latanoprost on intraocular pressure after small incision cataract surgery.

  Journal of cataract and refractive surgery 20010501

• [Ocular hemodynamics and visual field in glaucoma treated with dorzolamide].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20010501

• Update on topical carbonic anhydrase inhibitors.

  Current opinion in ophthalmology 20010401

• Dorzolamide-induced immune thrombocytopenia: a case report and literature review.

  Journal of glaucoma 20010401

• Efficacy of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers in adult patients with glaucoma or ocular hypertension.

  Clinical therapeutics 20010401

• Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs.

  Veterinary ophthalmology 20010301

• Latanoprost versus combined therapy with timolol plus dorzolamide: IOP-lowering effect in open-angle glaucoma.

  Acta ophthalmologica Scandinavica 20010201

• Management of glaucoma in pregnancy and lactation.

  Survey of ophthalmology 20010101

• Comparisons of intraocular-pressure- lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

• Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties.

  Journal of enzyme inhibition 20010101

• The one-month effects of topical betaxolol, dorzolamide and apraclonidine on ocular blood flow velocities in patients with newly diagnosed primary open-angle glaucoma.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

• [Clinical evaluation of isopropyl unoprostone (Rescula), in the adjunctive treatment of primary open angle glaucoma].

  Klinika oczna 20010101

• Dorzolamide, a 40-year wait. From an oral to a topical carbonic anhydrase inhibitor for the treatment of glaucoma.

  Pharmaceutical biotechnology 19980101

• Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension.

  Drugs & aging 19970501