131-55-5 | 2,2',4,4'-Tetrahydroxybenzophenone

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$15.00	$10.00
5g	97%	in stock	$18.00	$12.00
100g	97%	in stock	$27.00	$19.00

Description

• Catalog Number: AA40342
• Chemical Name: 2,2',4,4'-Tetrahydroxybenzophenone
• CAS Number: 131-55-5
• Molecular Formula: C13H10O5
• Molecular Weight: 246.2155
• MDL Number: MFCD00002278
• SMILES: Oc1ccc(c(c1)O)C(=O)c1ccc(cc1O)O
• NSC Number: 38556

Computed Properties

• Complexity: 278
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 2
• XLogP3: 2.4

Literature

• The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats.

  Toxicology 20180601

• Identification and Molecular Interaction Studies of Thyroid Hormone Receptor Disruptors among Household Dust Contaminants.

  Chemical research in toxicology 20160815

• Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughput in vitro Data, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling.

  Toxicological sciences : an official journal of the Society of Toxicology 20160501

• Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.

  Toxicology and applied pharmacology 20141001

• Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

  Scientific reports 20140101

• Pseudopolymorphism in hydroxybenzophenones: the dihydrate of 2,2',4,4'-tetrahydroxybenzophenone.

  Acta crystallographica. Section C, Crystal structure communications 20120401

• Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.

  Toxicological sciences : an official journal of the Society of Toxicology 20120201

• Ovariectomized mouse uterotrophic assay of 36 chemicals.

  The Journal of toxicological sciences 20120101

• Effect of 2,2',4,4'-tetrahydroxybenzophenone (BP2) on steroidogenesis in testicular Leydig cells.

  Toxicology 20111009

• Identification of classifiers for increase or decrease of thyroid peroxidase activity in the FTC-238/hTPO recombinant cell line.

  Environmental science & technology 20110915

• Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis.

  Environmental science & technology 20110901

• Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications.

  Toxicology letters 20100215

• True photoallergy to sunscreens is rare despite popular belief.

  Dermatitis : contact, atopic, occupational, drug 20100101

• Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) - an analysis with nonlinear isobolograms.

  Toxicology and applied pharmacology 20090101

• Simultaneous trace determination of nine organic UV-absorbing compounds (UV filters) in environmental samples.

  Journal of chromatography. A 20080815

• Pharmacokinetics and metabolism of benzophenone 2 in the rat.

  Toxicology 20080312

• Cloud point extraction combined with micellar electrokinetic capillary chromatography determination of benzophenones in cosmetic matrix.

  Electrophoresis 20080201

• Effects of the UV filter benzophenone-2 on reproduction in fish.

  Toxicology and applied pharmacology 20071215

• In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism.

  The Journal of urology 20071001

• The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase.

  Endocrinology 20070601

• Estrogenic activity of UV filter mixtures.

  Toxicology and applied pharmacology 20061115

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats.

  Archives of toxicology 20061001

• In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes.

  Immunopharmacology and immunotoxicology 20060101

• Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (E2) in ovariectomized (ovx) rats.

  Toxicology 20050915

• [Estrogenic activity of ultraviolet absorbers and the related compounds].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050801

• Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens.

  Toxicology and applied pharmacology 20050215

• Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment.

  Toxicology 20041201

• Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone.

  Toxicology 20041201

• Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats.

  Toxicology 20041201

• Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals.

  Toxicology letters 20030430

• Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals.

  Toxicology 20030201

• Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.

  Environmental health perspectives 20010201