13171-25-0 | Trimetazidine DiHCl

Availability
Typically In Stock

Description

• Catalog Number: AA45961
• Chemical Name: Trimetazidine DiHCl
• CAS Number: 13171-25-0
• Molecular Formula: C14H24Cl2N2O3
• Molecular Weight: 339.258
• MDL Number: MFCD00243086
• SMILES: COc1c(ccc(c1OC)OC)CN1CCNCC1.Cl.Cl

Computed Properties

• Complexity: 259
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 5

Literature

• Trimetazidine protects cardiomyocytes against hypoxia-induced injury through ameliorates calcium homeostasis.

  Chemico-biological interactions 20150705

• Food effect on bioavailability of modified-release trimetazidine tablets.

  Journal of clinical pharmacology 20121001

• Effects of sheath injury and trimetazidine on endothelial dysfunction of radial artery after transradial catheterization.

  Journal of interventional cardiology 20120801

• Trimetazidine and inflammatory response in coronary artery bypass grafting.

  Arquivos brasileiros de cardiologia 20120801

• Randomized clinical trial France DMLA2: effect of trimetazidine on exudative and nonexudative age-relatedmacular degeneration.

  Retina (Philadelphia, Pa.) 20120401

• Extrapyramidal adverse drug reactions associated with trimetazidine: a series of 21 cases.

  Fundamental & clinical pharmacology 20120401

• Trimetazidine in the prevention of contrast induced nephropathy after coronary angiogram.

  Mymensingh medical journal : MMJ 20120401

• Additional use of trimetazidine in patients with chronic heart failure: a meta-analysis.

  Journal of the American College of Cardiology 20120306

• Reduction of postoperative adhesions by trimetazidine: an experimental study in a rat model.

  Archives of gynecology and obstetrics 20120301

• Effect of trimetazidine treatment on the transient outward potassium current of the left ventricular myocytes of rats with streptozotocin-induced type 1 diabetes mellitus.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120301

• Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20120201

• Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle.

  Journal of molecular medicine (Berlin, Germany) 20120101

• [Trimetazidine addition to antianginal therapy: effects on efficacy and quality of life in patients with stable angina treated outpatiently].

  Terapevticheskii arkhiv 20120101

• Trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation.

  PloS one 20120101

• Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment.

  Journal of biomedical science 20120101

• [Contrast nephropathy and prevention].

  Vnitrni lekarstvi 20120101

• Metabolic modulation: a new therapeutic target in treatment of heart failure.

  American journal of therapeutics 20111101

• Effect of diabetes on alteration of metabolism in cardiac myocytes: therapeutic implications.

  Diabetes technology & therapeutics 20111101

• Effect of partial inhibition of fatty acid oxidation by trimetazidine on whole body energy metabolism in patients with chronic heart failure.

  Heart (British Cardiac Society) 20110901

• Trimetazidine on ischemic injury and reperfusion in coronary artery bypass grafting.

  Arquivos brasileiros de cardiologia 20110901

• Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.

  American journal of physiology. Endocrinology and metabolism 20110701

• Evaluation of trimetazidine in angina pectoris by echocardiography and radionuclide angiography: a meta-analysis of randomized, controlled trials.

  Clinical cardiology 20110601

• Trimetazidine improves exercise performance in patients with peripheral arterial disease.

  Pharmacological research 20110401

• Treat the graft to improve the regenerative ability of the host.

  Medical hypotheses 20110401

• Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice.

  Naunyn-Schmiedeberg's archives of pharmacology 20110401

• Early administration of trimetazidine may prevent or ameliorate diabetic cardiomyopathy.

  Medical hypotheses 20110201

• Trimetazidine: a meta-analysis of randomised controlled trials in heart failure.

  Heart (British Cardiac Society) 20110201

• Metabolic modulation in heart failure: high time for a definitive clinical trial.

  Heart (British Cardiac Society) 20110201

• Would coronary collaterals to the infarct-related artery serve as a marker of viability in patients with prior myocardial infarction? A study with trimetazidine-(99m)Tc-sestamibi imaging.

  Cardiovascular revascularization medicine : including molecular interventions 20110101

• [Stabilization of cellular membranes as a target of vascular therapy].

  Kardiologiia 20110101

• [The (PRIMA) Study. Comparison of clinical effect of trimetazidine MR in men and women].

  Kardiologiia 20110101

• Relative bioavailability and pharmacokinetic study of two trimetazidine modified release formulations in healthy Bangladeshi male volunteers.

  Arzneimittel-Forschung 20110101

• A simple and sensitive liquid chromatography method for the determination of low dihydrocodeine concentrations in human plasma: its application in Chinese healthy volunteers.

  Arzneimittel-Forschung 20110101

• [Myocardial cytoprotectors, a reserve therapeutic modality for patients with stable angina of effort].

  Klinicheskaia meditsina 20110101

• [Clinico-economical aspects of application of trimetazidine MB in patients with chronic heart failure and cardiac rhythm disturbances].

  Kardiologiia 20110101

• Comparative study between trimetazidine and ice slush hypothermia in protection against renal ischemia/reperfusion injury in a porcine model.

  International braz j urol : official journal of the Brazilian Society of Urology 20110101

• Efficacy comparison of trimetazidine with therapeutic alternatives in stable angina pectoris: a network meta-analysis.

  Cardiology 20110101

• Trimetazidine blocks store-operated Ca(2+) channels in HL-60 and THP-1 cell lines and inhibits the secretion of tumor necrosis factor.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Trimetazidine inhibits pressure overload-induced cardiac fibrosis through NADPH oxidase-ROS-CTGF pathway.

  Cardiovascular research 20101001

• [Is ejection fraction the best parameter for the assessment of ventricular function?].

  Arquivos brasileiros de cardiologia 20101001

• Floating tablet of trimetazidine dihydrochloride: an approach for extended release with zero-order kinetics.

  AAPS PharmSciTech 20100901

• Effects of trimetazidine, a partial inhibitor of fatty acid oxidation, on ventricular function and survival after myocardial infarction and reperfusion in the rat.

  Fundamental & clinical pharmacology 20100801

• Modulation of myocardial metabolism: an emerging therapeutic principle.

  Current opinion in cardiology 20100701

• Allopurinol for chronic stable angina: old drug, new tricks?

  Lancet (London, England) 20100619

• Effects of trimetazidine on endothelial dysfunction after sheath injury of radial artery.

  The American journal of cardiology 20100615

• Trimetazidine exerts protection against increasing current electroshock seizure test in mice.

  Seizure 20100601

• [Evaluation of the myocardial protection of trimetazidine during percutaneous coronary intervention: a multi-center randomized and controlled clinical study].

  Zhonghua nei ke za zhi 20100601

• Attenuation of gentamicin-induced nephrotoxicity: trimetazidine versus N-acetyl cysteine.

  Journal of applied toxicology : JAT 20100501

• Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling.

  The Journal of pharmacology and experimental therapeutics 20100501

• Improvement of mechanical heart function by trimetazidine in db/db mice.

  Acta pharmacologica Sinica 20100501

• Development and validation of a simple and sensitive liquid chromatography-tandem mass spectrometry method for quantifying trimetazidine in human plasma.

  Clinical and experimental pharmacology & physiology 20100401

• Demand-induced ischemia in volume expanded isolated rat heart; the effect of dichloroacetate and trimetazidine.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100401

• Trimetazidine: new French pharmacovigilance data.

  Prescrire international 20100401

• Trimetazidine shortens QTc interval in patients with ischemic heart failure.

  Journal of cardiovascular pharmacology and therapeutics 20100301

• Beneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failure.

  Journal of cardiovascular pharmacology and therapeutics 20100301

• Pharmacological strategies against cold ischemia reperfusion injury.

  Expert opinion on pharmacotherapy 20100301

• [A clinical experience of taurine and trimetazidine use in premenopausal women with chronic heart failure].

  Kardiologiia 20100101

• [Effect of therapy with trimetazidine modified release on quality of life of patients with stable effort angina survivors after acute myocardial infarction. Results of PRIMA study].

  Kardiologiia 20100101

• Trimetazidine activates paraoxonase.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101

• [Efficacy of ramipril, carvedilol, and trimetazidine MR in improvement of quality of life of patients after myocardial infarction].

  Kardiologiia 20100101

• Trimetazidine and N-acetylcysteine in attenuating hind-limb ischemia and reperfusion injuries: experimental study in rats.

  International angiology : a journal of the International Union of Angiology 20091001

• Effects of trimetazidine on atrial structural remodeling and platelet activation in dogs with atrial fibrillation.

  Chinese medical journal 20090920

• Trimetazidine: the future of cardiac function?

  Future cardiology 20090901

• Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity.

  Experimental neurology 20090801

• The effects of trimetazidine on heart rate variability in patients with heart failure.

  Arquivos brasileiros de cardiologia 20090801

• Improved left and right ventricular functions with trimetazidine in patients with heart failure: a tissue Doppler study.

  Heart and vessels 20090701

• Cardiac lesions induced by testosterone: protective effects of dexrazoxane and trimetazidine.

  Cardiovascular toxicology 20090601

• Trimetazidine may protect the myocardium during cardiac surgery.

  The heart surgery forum 20090601

• [Clinical outcomes of trimetazidine in patients with acute ST segment elevation myocardial infarction without ST segment resolution after primary percutaneous coronary intervention].

  Zhonghua yi xue za zhi 20090526

• [Effects of Trimetazidine upon ventricular remodeling and GLUT4 in diabetic rats after myocardial infarction].

  Zhonghua yi xue za zhi 20090512

• Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression.

  The Journal of pharmacology and experimental therapeutics 20090501

• Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy.

  Advances in therapy 20090401

• Trimetazidine: abnormal movements and hallucinations. Should be withdrawn from the market.

  Prescrire international 20090401

• Re: Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy.

  Circulation 20090324

• S 35171 exerts protective effects in spontaneously hypertensive stroke-prone rats by preserving mitochondrial function.

  European journal of pharmacology 20090214

• The effects of trimetazidine on p-wave duration and dispersion in heart failure patients.

  Pacing and clinical electrophysiology : PACE 20090201

• Effects of carvedilol, losartan and trimetazidin on functional parameters of isolated heart of rats at oxidative stress.

  Georgian medical news 20090201

• Effects of trimetazidine on crush injury of the sciatic nerve in rats: a biochemical and stereological study.

  Brain research 20090109

• [Clinical-pharmacoeconomic aspects of trimetazidine modified release use in patients with ischemic heart disease undergoing coronary artery bypass grafting].

  Kardiologiia 20090101

• The metabolic treatment of coronary artery disease and heart failure.

  Current pharmaceutical design 20090101

• The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina.

  Current pharmaceutical design 20090101

• The metabolic approach in patients with heart failure: effects on left ventricle remodeling.

  Current pharmaceutical design 20090101

• Effects of metabolic approach in diabetic patients with coronary artery disease.

  Current pharmaceutical design 20090101

• Prognostic relevance of metabolic approach in patients with heart failure.

  Current pharmaceutical design 20090101

• [Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications].

  Giornale italiano di cardiologia (2006) 20090101

• Trimetazidine selectively inhibits SOC channels in plasma membranes of human HL-60 cells and does not affect the intracellular Ca2+ stores.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20090101

• Effect of liver hypothermic preservation: exploration and protection.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20090101

• [Coronary-ventricular sinusoid communications].

  Medicina 20090101

• New nonextractive and highly sensitive high-performance liquid chromatographic method for determination of paroxetine in plasma after offline precolumn derivatization with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.

  Journal of AOAC International 20090101

• Effects of topical mitomycin and trimetazidine on myringosclerosis.

  Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 20081201

• The effects of trimetazidine on lipid peroxidation in patients with end-stage renal disease.

  Methods and findings in experimental and clinical pharmacology 20081201

• Trimetazidine: transparency. Information withheld from patients.

  Prescrire international 20081201

• Characterization of mitochondrial trifunctional protein and its inactivation study for medicine development.

  Biochimica et biophysica acta 20081101

• Trimetazidine potentiates the effects of exercise training in patients with ischemic cardiomyopathy referred for cardiac rehabilitation.

  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology 20081001

• The role of trimetazidine after acute myocardial infarction.

  Current vascular pharmacology 20081001

• Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy.

  Circulation 20080916

• Chronic stable angina pectoris.

  Disease-a-month : DM 20080901

• Cardioprotective effects of trimetazidine and a combination of succinic and malic acids in acute myocardial ischemia.

  Bulletin of experimental biology and medicine 20080801

• Metabolic agents in the management of diabetic coronary patients: a new era.

  International journal of cardiology 20080623

• Metabolic agents in the management of diabetic coronary patients: a new era.

  International journal of cardiology 20080623

• [Trimetazidine-induced encephalopathy with choreiform disorders: a case report].

  La Revue de medecine interne 20080601

• Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats.

  Endocrinology 20080601

• Effects of trimetazidine on myocardial perfusion and left ventricular systolic function in type 2 diabetic patients with ischemic cardiomyopathy.

  Journal of cardiovascular pharmacology 20080601

• [Effects of chronic trimetazidine treatment on atrial energy metabolism in a canine model of chronic atrial fibrillation].

  Zhonghua xin xue guan bing za zhi 20080601

• Anti-oxidant activity mediated neuroprotective potential of trimetazidine on focal cerebral ischaemia-reperfusion injury in rats.

  Clinical and experimental pharmacology & physiology 20080501

• Effect of trimetazidine on xanthine oxidoreductase expression in rat kidney with ischemia--reperfusion injury.

  Archives of medical research 20080501

• Trimetazidine reduces early and long-term effects of experimental renal warm ischemia: a dose effect study.

  Journal of vascular surgery 20080401

• The pathophysiology of heart failure: a tale of two old paradigms revisited.

  Clinical medicine (London, England) 20080401

• Trimetazidine protective effect against ischemia-induced susceptibility to ventricular fibrillation in pigs.

  Cardiovascular drugs and therapy 20080201

• [Effect of combination therapy with preduktal and prestarium on the left ventricular function in the postinfarction period].

  Georgian medical news 20080201

• [New possibilities in the pharmacologic prevention of age-related macular degeneration].

  Orvosi hetilap 20080120

• Intracellular GSH levels rather than ROS levels are tightly related to AMA-induced HeLa cell death.

  Chemico-biological interactions 20080110

• Transdermal permeation of trimetazidine from nerodilol-based HPMC gel drug reservoir system across rat epidermis.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101

• Limonene enhances the in vitro and in vivo permeation of trimetazidine across a membrane-controlled transdermal therapeutic system.

  Current drug delivery 20080101

• [Efficacy of long-term therapy with trimetazidine in patients with ischemic heart disease in combination with chronic obstructive pulmonary disease].

  Kardiologiia 20080101

• Trimetazidine revisited: a comprehensive review of the pharmacological effects and analytical techniques for the determination of trimetazidine.

  Cardiovascular therapeutics 20080101

• Computer-assisted optimization and validation of LC analysis of trimetazidine dihydrochloride and its impurities.

  Journal of chromatographic science 20080101

• Sensitive and rapid method to determine trimetazidine in human plasma by liquid chromatography/tandem mass spectrometry.

  Journal of AOAC International 20080101

• The effect of trimetazidine added to maximal anti-ischemic therapy in patients with advanced coronary artery disease.

  Cardiology journal 20080101

• [Clinicopathogenetic features of coronary heart disease combined with chronic obstructive pulmonary diseases and efficiency of therapy with trimetazidin].

  Klinicheskaia meditsina 20080101

• [Oxidative stress in myocardial infarction and the efficiency of its correction with the drug Trimetazidine].

  Klinicheskaia meditsina 20080101

• Trimetazidine as cardioplegia addictive without pre-treatment does not improve myocardial protection: study in a swine working heart model.

  Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular 20080101

• Liquid chromatography-tandem mass spectrometry method for the determination of trimetazidine in human plasma.

  Arzneimittel-Forschung 20080101

• Nonextractive procedure and precolumn derivatization with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole for trace determination of trimetazidine in plasma by high-performance liquid chromatography with fluorescence detection.

  Journal of AOAC International 20080101

• Metabolic therapy of heart failure.

  Current pharmaceutical design 20080101

• [The PRIMA study: trimetazidin in the treatment of patients with stable angina pectoris after myocardial infarction. Epidemiological and clinical phases].

  Kardiologiia 20080101

• [Effects of trimetazidine on myocardial metabolism evaluated by PET-CT in patients with ischemic cardiomyopathy].

  Zhonghua xin xue guan bing za zhi 20080101

• [Principle energy substrate changing as a technique of myocardium protection against ischemic damage in experimental mechanic cardiac contusion].

  Patologicheskaia fiziologiia i eksperimental'naia terapiia 20080101

• [Genesis of systemic changes in hemodynamics in cardiac contusion].

  Anesteziologiia i reanimatologiia 20080101

• Trimetazidine modulates AMPA/kainate receptors in rat vestibular ganglion neurons.

  European journal of pharmacology 20071121

• The protective effects of trimetazidine on testicular ischemia and reperfusion injury in rats.

  Pediatric surgery international 20071101

• Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial.

  Journal of cardiovascular pharmacology 20071101

• The effect of trimetazidine on left ventricular systolic function and physical tolerance in patients with ischaemic cardiomyopathy.

  Acta cardiologica 20071001

• Sensitive determination of trimetazidine in spiked human plasma by HPLC with fluorescence detection after pre-column derivatization with 9-fluorenylmethyl chloroformate.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

• Beneficial effects of trimetazidine treatment on exercise tolerance and B-type natriuretic peptide and troponin T plasma levels in patients with stable ischemic cardiomyopathy.

  American heart journal 20070901

• Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease.

  International journal of cardiology 20070809

• [Clinical study of trimetazidine for myocardial protection in acute myocardial infarction].

  Zhonghua nei ke za zhi 20070801

• Trimetazidine added to combined hemodynamic antianginal therapy in patients with type 2 diabetes: a randomized crossover trial.

  American heart journal 20070701

• Sensitive and rapid LC-ESI-MS method for the determination of trimetazidine in human plasma.

  Journal of pharmaceutical and biomedical analysis 20070628

• Trimetazidine in the prevention of contrast-induced nephropathy after coronary procedures.

  Heart (British Cardiac Society) 20070601

• Protective effect of an acute oral loading dose of trimetazidine on myocardial injury following percutaneous coronary intervention.

  Heart (British Cardiac Society) 20070601

• Trimetazidine to reverse ischemia in patients with class I or II angina: a randomized, double-blind, placebo-controlled dobutamine-atropine stress echocardiography study.

  Coronary artery disease 20070601

• Preventing contrast nephropathy in catheter laboratory.

  Heart (British Cardiac Society) 20070601

• Measurement and prevention of myocardial injury during percutaneous coronary intervention.

  Heart (British Cardiac Society) 20070601

• Trimetazidine improves endothelial dysfunction in chronic heart failure: an antioxidant effect.

  European heart journal 20070501

• The effects of chronic trimetazidine treatment on mechanical function and fatty acid oxidation in diabetic rat hearts.

  Canadian journal of physiology and pharmacology 20070501

• LC/ESI-MS method for the determination of trimetazidine in human plasma: application to a bioequivalence study on Chinese volunteers.

  Journal of pharmaceutical and biomedical analysis 20070411

• Trimetazidine improves post-ischemic recovery by preserving endothelial nitric oxide synthase expression in isolated working rat hearts.

  Nitric oxide : biology and chemistry 20070301

• Trimetazidine inhibits cardiomyocyte apoptosis in a rabbit model of ischemia-reperfusion.

  Translational research : the journal of laboratory and clinical medicine 20070301

• Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: a way of protecting rat steatotic livers.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20070301

• Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model.

  American journal of physiology. Renal physiology 20070301

• Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease.

  Clinical cardiology 20070201

• Quantification of trimetazidine in human plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to a bioequivalence study.

  Die Pharmazie 20070101

• [Comparative trial of efficacy of trimethasidine MB and 3-(2,2,2-trimethylhydrasine) propionate dihydrate in chronic heart failure].

  Terapevticheskii arkhiv 20070101

• Protective effects of trimetazidine on testicular ischemia-reperfusion injury in rats.

  Urologia internationalis 20070101

• [Derangements of contractility of left ventricular myocardium in patients subjected to coronary bypass surgery. Methods of their correction].

  Kardiologiia 20070101

• Trimetazidine administration minimizes myocardial damage and improves left ventricular function after percutaneous coronary intervention.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

• [Program for detection of patients with ineffective therapy with beta-adrenoblockers and comparative assessment of efficacy of addition of trimetazidine MB or isosorbide dinitrate in stable angina. Results of a Russian Study Parrallel].

  Kardiologiia 20070101

• Trimetazidine decreases Ca2+ response to thapsigargin in differentiated and undifferentiated human HL-60 cells.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20070101

• [Correction of episodes of transitory myocardial ischemia with trimetazidine in patients with ischemic heart disease combined with type 2 diabetes mellitus].

  Kardiologiia 20070101

• [The efficacy of complex therapy of ventricular arrhythmias with emoxipin and preductal in combination with antiarrhythmic agents].

  Klinicheskaia meditsina 20070101

• Metabolic modulation as a target for heart failure treatment: current perspective.

  Indian heart journal 20070101

• Menière's disease.

  BMJ clinical evidence 20070101

• Meta-analysis of antiplatelet therapy for IgA nephropathy.

  Clinical and experimental nephrology 20061201

• Effects of chronic trimetazidine treatment on myocardial preconditioning in anesthetized rats.

  Fundamental & clinical pharmacology 20061001

• Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure.

  Fundamental & clinical pharmacology 20061001

• A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure.

  Journal of the American College of Cardiology 20060905

• Metabolic approach in heart failure: rethinking how we translate from theory to clinical practice.

  Journal of the American College of Cardiology 20060905

• Clinical benefits of a metabolic approach with trimetazidine in revascularized patients with angina.

  The American journal of cardiology 20060904

• Metabolic therapy for patients with diabetes mellitus and coronary artery disease.

  The American journal of cardiology 20060904

• Role of trimetazidine in management of ischemic cardiomyopathy.

  The American journal of cardiology 20060904

• Clinical benefits of a metabolic approach in the cardiac rehabilitation of patients with coronary artery disease.

  The American journal of cardiology 20060904

• Modification of myocardial substrate use as a therapy for heart failure.

  Nature clinical practice. Cardiovascular medicine 20060901

• Trimetazidine reduces oxidative stress in cardiac surgery.

  Circulation journal : official journal of the Japanese Circulation Society 20060901

• Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.

  Seminars in cardiothoracic and vascular anesthesia 20060901

• Structure-activity studies on the protection of Trimetazidine derivatives modified with nitroxides and their precursors from myocardial ischemia-reperfusion injury.

  Bioorganic & medicinal chemistry 20060815

• Trimetazidine-induced enhancement of myocardial recovery during reperfusion: a comparative study in diabetic and non-diabetic rat hearts.

  Archives of medical research 20060801

• Metabolic approach to heart failure - evidence that trimetazidine improves symptoms, left ventricular function and possibly prognosis.

  International journal of clinical practice 20060801

• Reversible Parkinsonism linked to trimetazidine (continued).

  Prescrire international 20060801

• Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties.

  The Journal of pharmacology and experimental therapeutics 20060601

• Metabolic therapeutics in angina pectoris: history revisited with perhexiline.

  European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 20060601

• The anti-ischemic effect of trimetazidine in patients with postprandial myocardial ischemia is unrelated to meal composition.

  American heart journal 20060601

• [Treatment of stable angina pectoris with trimetazidine].

  Vnitrni lekarstvi 20060601

• [Modulation of myocardial metabolism with trimetazidine].

  Vnitrni lekarstvi 20060601

• [Trimetazidine in the treatment of stable angina pectoris TRIADA-(trimetazidine in stable angina twice daily)].

  Vnitrni lekarstvi 20060601

• Trimetazidine improved Ca2+ handling in isoprenaline-mediated myocardial injury of rats.

  Experimental physiology 20060501

• Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure.

  European heart journal 20060401

• The effects of trimetazidine on heart rate variability in patients with slow coronary artery flow.

  Journal of electrocardiology 20060401

• Rare cases of Ménière's disease in children.

  The Journal of laryngology and otology 20060401

• Effect of trimetazidine on the nucleotide profile in rat kidney with ischemia-reperfusion injury.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060301

• Suppression of angioplasty-related inflammation by pre-procedural treatment with trimetazidine.

  The Tohoku journal of experimental medicine 20060301

• Trimetazidine: is it a promising drug for use in steatotic grafts?

  World journal of gastroenterology 20060214

• Adverse effects of free fatty acid associated with increased oxidative stress in postischemic isolated rat hearts.

  Molecular and cellular biochemistry 20060201

• [Effect of trimitazidine on insulin resistance in patients with coronary heart disease].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060201

• [Effects of metabolic triad (25% polarizing solution, mildronat, preductal MR) in acute myocardial infarction].

  Georgian medical news 20060201

• Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy.

  American journal of physiology. Endocrinology and metabolism 20060101

• Placebo or trimetazidine (99m)Tc tetrofosmin myocardial SPECT and low-dose dobutamine echocardiography in hibernating myocardium.

  Archives of medical research 20060101

• Trimetazidine increases [3H]glucose uptake in rat brain.

  Pharmacological reports : PR 20060101

• [Possibilities of myocardial cytoprotection in complex treatment of patients with chronic heart failure].

  Kardiologiia 20060101

• Protective effect of astragalosides on myocardial injury by isoproterenol in SD rats.

  The American journal of Chinese medicine 20060101

• [The effects of trimetazidine on left ventricular function and physical exercise tolerance in patients with ischemic cardiomyopathy].

  Klinicheskaia meditsina 20060101

• Trimetazidine inhibits mitochondrial permeability transition pore opening and prevents lethal ischemia-reperfusion injury.

  Journal of molecular and cellular cardiology 20051201

• Metabolic modulators for chronic cardiac ischemia.

  Journal of cardiovascular pharmacology and therapeutics 20051201

• Cardiac mitochondrial alterations induced by insulin deficiency and hyperinsulinaemia in rats: targeting membrane homeostasis with trimetazidine.

  Clinical and experimental pharmacology & physiology 20051201

• Metabolic therapy for ischemic heart disease: the rationale for inhibition of fatty acid oxidation.

  Heart failure reviews 20051201

• Metabolic therapy for heart disease: impact of trimetazidine.

  Heart failure reviews 20051201

• Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.

  Pharmacology 20051101

• Metabolic therapy for the diabetic patients with ischaemic heart disease.

  Coronary artery disease 20051101

• Meeting the challenge of chronic ischaemic heart disease with trimetazidine.

  Coronary artery disease 20051101

• Trimetazidine for stable angina.

  The Cochrane database of systematic reviews 20051019

• Evaluation of the effect of trimetazidine on Tc-99m methoxyisobutyl isonitrile gated scintigraphy in patients with coronary artery ectasia.

  Saudi medical journal 20051001

• Non-extractive procedure followed by LC/APCI MS/MS analysis of trimetazidine in plasma samples for assessing bioequivalence of immediate/modified release formulations.

  Biomedical chromatography : BMC 20050901

• [Observation on effect of compound danshen droplet-pill combined with trimetazidine in treating senile unstable angina pectoris].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050901

• [Therapeutic value of trimetazidine in patients with coronary heart disease and left ventricular dysfunction].

  Zhonghua xin xue guan bing za zhi 20050901

• Trimetazidine: a new cause for drug-induced parkinsonism?

  Movement disorders : official journal of the Movement Disorder Society 20050801

• [Trimetazidine, oxidative stress, and cell injury during myocardial reperfusion].

  Revista espanola de cardiologia 20050801

• [Ischemia-reperfusion injury during experimental heart transplantation. Evaluation of trimetazidine's cytoprotective effect].

  Revista espanola de cardiologia 20050801

• Trimetazidine normalizes postischemic function of hypertrophied rat hearts.

  The Journal of pharmacology and experimental therapeutics 20050701

• The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury.

  Journal of cardiovascular pharmacology 20050701

• Mitochondrial changes induced by trimetazidine in the myocardium.

  Medical science monitor : international medical journal of experimental and clinical research 20050601

• Reversible Parkinsonism linked to trimetazidine.

  Prescrire international 20050401

• Silent myocardial ischaemia: clinical relevance and treatment.

  Expert opinion on investigational drugs 20050401

• Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.

  FEBS letters 20050314

• Trimetazidine protects isolated rat hearts against ischemia-reperfusion injury in an experimental timing-dependent manner.

  Basic research in cardiology 20050301

• Trimetazidine reduces the degree of fibrosis in alkali burns of the esophagus.

  Journal of pediatric surgery 20050301

• Prevention of gentamicin induced ototoxicity by trimetazidine in animal model.

  International journal of pediatric otorhinolaryngology 20050201

• Myocardial metabolic manipulation: a new therapeutic approach in heart failure?

  Heart (British Cardiac Society) 20050201

• Long term cardioprotective action of trimetazidine and potential effect on the inflammatory process in patients with ischaemic dilated cardiomyopathy.

  Heart (British Cardiac Society) 20050201

• Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease.

  The American journal of cardiology 20050201

• [A prospective study on trimetazidine effectiveness and tolerability in diabetic patients in association to the previous treatment of their coronary disease. DIETRIC study].

  Revista clinica espanola 20050201

• Trimetazidine in Angina Combination Therapy--the TACT study: trimetazidine versus conventional treatment in patients with stable angina pectoris in a randomized, placebo-controlled, multicenter study.

  American journal of therapeutics 20050101

• [Limited application of prevention measures in patients with diabetes mellitus type 2 and coronary artery disease in Spain. DIETRIC study].

  Revista clinica espanola 20050101

• Effects of trimetazidine on myocardial perfusion and the contractile response of chronically dysfunctional myocardium in ischemic cardiomyopathy: a 24-month study.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

• [Anti-ischemic efficacy of combination of trimetazidine with enalapril in patients with stable effort angina and metabolic syndrome].

  Kardiologiia 20050101

• [Use of preductal in therapy of hemodynamic complications in patients with tuberculosis].

  Problemy tuberkuleza i boleznei legkikh 20050101

• Treatment of stable angina pectoris with trimetazidine modified release in Indian primary-care practice.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

• Modified-release formulation of trimetazidine for exceptional control of angina pectoris: fact or fiction.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

• Chronic angina: new medical options for treatment.

  Reviews in cardiovascular medicine 20050101

• [Trimetazidine effects on postinfarction remodeling of the left ventricle].

  Terapevticheskii arkhiv 20050101

• [Clinical efficacy of combined therapy with enalapril + trimetazidine in patients with hypertension comorbid with ischemic heart disease and metabolic disturbances].

  Terapevticheskii arkhiv 20050101

• Trimetazidine induces parkinsonism, gait disorders and tremor.

  Therapie 20050101

• Effects of trimetazidine on lipid peroxidation, antioxidant enzyme activities and plasma brain natriuretic peptide levels in patients with chronic cor pulmonale.

  The Journal of international medical research 20050101

• [Trimetazidine-a new aetiology for extrapyramidal disorders: A case of parkinsonism and akathisia].

  Therapie 20050101

• Effect of trimetazidine on renal ischemia/reperfusion injury in rats.

  Pharmacological research 20041201

• The potential benefits of trimetazidine in patients with diabetes and ischemic cardiomyopathy.

  American heart journal 20041201

• Comparison of the effects of trimetazidine and diltiazem on exercise performance in patients with coronary heart disease. The Turkish trimetazidine study (TTS).

  Acta cardiologica 20041201

• Inhibitory effect of trimetazidine on cardiac myocyte apoptosis in rabbit model of ischemia-reperfusion.

  Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20041201

• Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia.

  European journal of pharmacology 20041025

• Effects of trimetazidine on myocardial preconditioning in anesthetized rats.

  European journal of pharmacology 20041025

• Metabolic therapy for heart failure.

  European heart journal 20041001

• Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease.

  European heart journal 20041001

• [Trimetazidine-induced parkinsonism].

  Neurologia (Barcelona, Spain) 20040901

• Efficacy of trimetazidine in patients with recurrent angina: a subgroup analysis of the TRIMPOL II study.

  Current medical research and opinion 20040901

• Influence of colloid, preservation medium and trimetazidine on renal medulla injury.

  Biochimica et biophysica acta 20040804

• Ischemic heart disease: metabolic approaches to management.

  Clinical cardiology 20040801

• The acute administration of trimetazidine modified myocardial perfusion and left ventricular function in 31 patients with ischaemic ventricular dysfunction.

  The international journal of cardiovascular imaging 20040801

• Evidence for protective roles of polyethylene glycol plus high sodium solution and trimetazidine against consequences of renal medulla ischaemia during cold preservation and reperfusion in a pig kidney model.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040701

• Effects of trimetazidine on left ventricular function in patients with type 2 diabetes and heart failure.

  Journal of cardiovascular pharmacology 20040701

• The acute effect of trimetazidine on the high frequency fatigue in the isolated rat diaphragm muscle.

  Archives of pharmacal research 20040601

• Evidence for a mitochondrial impact of trimetazidine during cold ischemia and reperfusion.

  Pharmacology 20040501

• Clinical benefits of trimetazidine in patients with recurrent angina.

  Coronary artery disease 20040501

• Protective roles of polyethylene glycol and trimetazidine against cold ischemia and reperfusion injuries of pig kidney graft.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040401

• Metabolic manipulation in ischaemic heart disease, a novel approach to treatment.

  European heart journal 20040401

• [Ischemic heart disease and left ventricular dysfunction: the role of trimetazidine].

  Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

• [Trimetazidine and cardioprotection during ischemia-reperfusion].

  Italian heart journal : official journal of the Italian Federation of Cardiology 20040301

• Trimetazidine improves myocardial perfusion and left ventricular function in ischemic left ventricular dysfunction.

  Clinical nuclear medicine 20040201

• Anti-excitotoxic activity of trimetazidine in the retina.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040201

• Quantitative structure-activity relationship analysis of the substituent effects on the binding affinity of derivatives of trimetazidine.

  Arzneimittel-Forschung 20040101

• [Clinical and hemodynamic efficacy of selective beta-blocker bisoprolol and cytoprotector trimetazidine in the treatment of chronic cardiac failure in patients with ischemic heart disease].

  Terapevticheskii arkhiv 20040101

• Assessment of the sustained release properties of a new oral formulation of trimetazidine in pigs and dogs and confirmation in healthy human volunteers.

  European journal of drug metabolism and pharmacokinetics 20040101

• [Clinical Efficacy of Combination Therapy With Trimetazidine and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension and Ischemic Heart Disease Associated With Type II Diabetes].

  Kardiologiia 20040101

• [The protective effect of trimetazidine on the myocardium against reperfusion injury during thrombolytic therapy of acute infarction].

  Eksperimental'naia i klinicheskaia farmakologiia 20040101

• Nonsynergistic effects of trimetazidine and selenium combination therapy on renal ischemic-reperfusion injury in rats.

  Advances in therapy 20040101

• [Anti-ischemic effects of trimetazidine in patients with post-infarction heart failure].

  Klinicheskaia meditsina 20040101

• Determination of trimetazidine dihydrochloride in the presence of its acid-induced degradation products.

  Journal of AOAC International 20040101

• [Assessment of antianginal and antiischemic effect of trimetazidine and its effects on myocardial perfusion in patients with ischemic heart disease and stable angina.].

  Kardiologiia 20040101

• [Favorable effect of trimetazidine on clinical state and left ventricular function postinfarction period.].

  Kardiologiia 20040101

• [Potentialities of cytoprotection in the treatment of chronic heart failure in patients with coronary heart disease].

  Klinicheskaia meditsina 20040101

• [Usefulness of trimetazidine in ischemia-reperfusion lesion. Experimental study in myocardial stunning model].

  Archivos de cardiologia de Mexico 20040101

• Evaluation of various therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma.

  Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat 20040101

• Evidence for a protective role of trimetazidine during cold ischemia: targeting inflammation and nephron mass.

  Biochemical pharmacology 20031201

• Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20031201

• Trimetazidine in geriatric patients with stable angina pectoris: the tiger study.

  International journal of clinical practice 20031201

• Attenuation of renal ischemia-reperfusion injury by trimetazidine: evidence of an in vivo antioxidant effect.

  Methods and findings in experimental and clinical pharmacology 20031201

• [Regulation of myocardial metabolism: possibilities and application in cardiac surgery].

  Kardiologia polska 20031201

• Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy.

  American heart journal 20031101

• Carvedilol and trimetazidine attenuates ferric nitrilotriacetate-induced oxidative renal injury in rats.

  Toxicology 20030930

• The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

  Circulation research 20030808

• Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase.

  Circulation research 20030808

• Quantitative determination of some pharmaceutical piperazine derivatives through complexation with iron(III) chloride.

  Farmaco (Societa chimica italiana : 1989) 20030801

• Effect of trimetazidine on exercise performance in patients with coronary artery ectasia.

  Japanese heart journal 20030701

• Effects of trimetazidine on submaximal exercise test in patients with acute myocardial infarction.

  Cardiovascular drugs and therapy 20030701

• [Protective effect of trimetazidine on rabbit myocardium during ischemia- reperfusion].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20030601

• Pharmacokinetic profile of a modified release formulation of trimetazidine (TMZ MR 35 mg) in the elderly and patients with renal failure.

  Biopharmaceutics & drug disposition 20030501

• Trimetazidine reduces basal cytosolic Ca2+ concentration during hypoxia in single Xenopus skeletal myocytes.

  Experimental physiology 20030501

• Efficacy and tolerability of trimetazidine in stable angina: a meta-analysis of randomized, double-blind, controlled trials.

  Coronary artery disease 20030401

• Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine.

  Fundamental & clinical pharmacology 20030401

• Somatosensory evoked potential and histopathological investigations in ischaemia-induced brain damage: effects of trimetazidine in rats.

  The International journal of neuroscience 20030401

• Prevention of heart failure in rats by trimetazidine treatment: a consequence of accelerated phospholipid turnover?

  The Journal of pharmacology and experimental therapeutics 20030301

• Treatment of stable angina with low dose diltiazem in combination with the metabolic agent trimetazidine.

  International journal of cardiology 20030301

• Metabolic modulation and optimization of energy consumption in heart failure.

  The Medical clinics of North America 20030301

• Trimetazidine effect on phospholipid synthesis in ventricular myocytes: consequences in alpha-adrenergic signaling.

  Fundamental & clinical pharmacology 20030201

• Effects of trimetazidine on acetic acid-induced colitis in female Swiss rats.

  Journal of toxicology and environmental health. Part A 20030124

• Attenuation of glycerol-induced acute renal failure in rats by trimetazidine and deferoxamine.

  Pharmacology 20030101

• Myocardial cytoprotection by trimetazidine against anthracycline-induced cardiotoxicity in anticancer chemotherapy.

  Angiology 20030101

• [Effect of treatment with trimethazidine on characteristics of arrhythmia and indicators of heart rhythm in patients with chronic cardiac failure].

  Terapevticheskii arkhiv 20030101

• The effect of oxidative stress inhibition with trimetazidine on the peritoneal alterations induced by hypertonic peritoneal dialysis solution.

  Journal of nephrology 20030101

• The effect of trimetazidine on liver regeneration after partial hepatectomy under hepatic blood inflow occlusion.

  Hepato-gastroenterology 20030101

• [Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina].

  Kardiologiia 20030101

• [Efficacy and tolerability of trimetazidine in the treatment of stable effort angina (TRIUMPH Study in Russia)].

  Kardiologiia 20030101

• [Oxygen-dependent metabolism of neutrophils and monocytes in patients with unstable angina pectoris and its correction with preductal].

  Patologicheskaia fiziologiia i eksperimental'naia terapiia 20030101

• [Effect of trimetazidine and perindopril on myocardial function and metabolism in patients with low cardiac output during postinfarction period].

  Terapevticheskii arkhiv 20030101

• [Effect of acetyl-CoA C-acyltransferase inhibitor trimetazidine on parameters of global and local systolic and diastolic functions of left ventricular myocardium in patients with combined postinfarction ischemic syndrome].

  Kardiologiia 20030101

• [Clinical efficacy of myocardial cytoprotector trimetazidine in peri- and postmenopausal women with ischemic heart disease].

  Kardiologiia 20030101

• Cardioprotective effects of trimetazidine: a review.

  Current medical research and opinion 20030101

• Trimetazidine diminishes fasting glucose in rats with fasting hyperglycemia: a preliminary study.

  American journal of therapeutics 20030101

• Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris: a multicenter, double-blind, placebo-controlled study.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20030101

• Effects of trimetazidine and selenium on high-frequency fatigue in isolated rat diaphragm muscle.

  Advances in therapy 20030101

• [Effects of trimetazidine on serum oxygen free radicals in congestive heart failure].

  Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20021228

• Cardioprotective effect of trimetazidine during thrombolytic therapy in patients with acute myocardial infarction.

  Bulletin of experimental biology and medicine 20021201

• The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure.

  Herz 20021101

• [Coronary artery disease observed in general hospitals: ETTIC study. Comparison between trimetazidine and mononitrate isosorbide for patients receiving betablockers].

  Annales de cardiologie et d'angeiologie 20021101

• Bioavailability studies on guar gum-based three-layer matrix tablets of trimetazidine dihydrochloride in human volunteers.

  Journal of controlled release : official journal of the Controlled Release Society 20021004

• Effects of trimetazidine on tissue damage in kidney after hindlimb ischemia-reperfusion.

  Pharmacological research 20021001

• Trimetazidine: a second look. Still no efficacy in visual disorders.

  Prescrire international 20020801

• [The role of endogenous modulators of chemoreactivity in the regulation of coronary blood flow].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020701

• Three-layer guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride.

  Journal of controlled release : official journal of the Controlled Release Society 20020517

• Partial fatty acid oxidation inhibitors for stable angina.

  Expert opinion on investigational drugs 20020501

• Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity.

  Biochemical pharmacology 20020501

• Oxidative stress-mediated renal dysfunction by cyclosporine A in rats: attenuation by trimetazidine.

  Renal failure 20020501

• New concepts in organ preservation.

  Transplant immunology 20020501

• Cardioprotection of trimetazidine and anthracycline-induced acute cardiotoxic effects.

  Lancet (London, England) 20020330

• Last performance with VIAGRA: post-mortem identification of sildenafil and its metabolites in biological specimens including hair sample.

  Forensic science international 20020328

• Trimetazidine as a potential neuroprotectant in transient global ischemia in gerbils: a behavioral and histological study.

  Brain research 20020222

• Acute effects of heparin administration on the ischemic threshold of patients with coronary artery disease: evaluation of the protective role of the metabolic modulator trimetazidine.

  Journal of the American College of Cardiology 20020206

• Prolonged survival after experimental paraquat intoxication: role of alternative antioxidants.

  Veterinary and human toxicology 20020201

• Increase of adenosine plasma levels after oral trimetazidine: a pharmacological preconditioning?

  Pharmacological research 20020101

• [Enhancement of antioxidant status of the elderly patients with ischemic heart disease in response to amino acid composition of MP-33 in combined therapy with trimetazidine].

  Klinicheskaia meditsina 20020101

• [Oxygen dependent metabolism of neutrophils and monocytes in patients with unstable angina and its correction with preductal].

  Patologicheskaia fiziologiia i eksperimental'naia terapiia 20020101

• [Effect of atenolol and trimetazidine on dispersion of cardiac rhythm in patients with moderately expressed postinfarction left ventricular dysfunction].

  Terapevticheskii arkhiv 20020101

• Protective effect of trimetazidine in a model of ischemia-reperfusion in the rat retina.

  Ophthalmic research 20020101

• [Decrease in the sensitivity to the anti-ischemic effect of propranolol and prospects for correcting it in patients with stable angina pectoris].

  Terapevticheskii arkhiv 20020101

• Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty.

  Current medical research and opinion 20020101

• [Significance of trimetazidine for out of hospital physical rehabilitation after myocardial infarction].

  Kardiologiia 20020101

• [Use of trimetazidine in the combined therapy of myocardial infarction with left ventricular dysfunction].

  Kardiologiia 20020101

• [Trimetazidine in pectoris patients older than 65 years with stable angina].

  Kardiologiia 20020101

• [Trimetazidine in correction of chronic heart failure in patients with ischemic heart disease].

  Kardiologiia 20020101

• [Efficacy of trimetazidine in stable angina pectoris refractory to traditional treatment].

  Kardiologiia 20020101

• [The study and comparative evaluation of the actoprotective activity of ATF-LONG in experiment].

  Likars'ka sprava 20020101

• Antianginal effects of trimetazidine and left ventricular function improvement in patients with stable angina pectoris.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101

• Trimetazidine protects the energy status after ischemia and reduces reperfusion injury in a rat single lung transplant model.

  The Journal of thoracic and cardiovascular surgery 20011201

• Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand.

  European heart journal 20011201

• Can metabolic manipulation reverse myocardial dysfunction?

  European heart journal 20011201

• Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy.

  European heart journal 20011201

• Recipient treatment with trimetazidine improves graft function and protects energy status after lung transplantation.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20011001

• Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine.

  American journal of physiology. Heart and circulatory physiology 20010901

• Comments on EMIP-FR study's editorial.

  European heart journal 20010801

• The effect of trimetazidine on the survival of rat island skin flaps subjected to ischemia-reperfusion injury.

  Annals of plastic surgery 20010801

• Influence of trimetazidine on the synthesis of complex lipids in the heart and other target organs.

  Fundamental & clinical pharmacology 20010801

• Does trimetazidine exert cytoprotective activity on astrocytes subjected to hypoxia in vitro?

  Neurotoxicology 20010801

• Mitochondria as target for antiischemic drugs.

  Advanced drug delivery reviews 20010702

• QT dispersion--what does it mean?

  Cardiovascular drugs and therapy 20010701

• Metabolic management of coronary heart disease: adjunctive treatment with trimetazidine decreases QT dispersion in patients with a first acute myocardial infarction.

  Cardiovascular drugs and therapy 20010701

• Trimetazidine protects low-density lipoproteins from oxidation and cultured cells exposed to H(2)O(2) from DNA damage.

  Free radical biology & medicine 20010615

• About EMIP-FR and reperfusion damage in AMI: a comment to the comment.

  European heart journal 20010601

• The EMIP-FR Study: the evolution of scientific background as a non-controlled parameter.

  European heart journal 20010601

• Trimetazidine and reperfusion injury.

  European heart journal 20010601

• Trimetazidine in AMI.

  European heart journal 20010601

• Trimetazidine: stability indicating RPLC assay method.

  Journal of pharmaceutical and biomedical analysis 20010501

• Trimetazidine for stable angina pectoris.

  Expert opinion on pharmacotherapy 20010501

• Combination therapy in angina: a review of combined haemodynamic treatment and the role for combined haemodynamic and cardiac metabolic agents.

  International journal of clinical practice 20010501

• Stability indicating HPTLC determination of Trimetazidine as bulk drug and in pharmaceutical formulations.

  Journal of pharmaceutical and biomedical analysis 20010401

• The effects of trimetazidine on heart rate variability and signal-averaged electrocardiography in early period of acute myocardial infarction.

  International journal of cardiology 20010201

• A randomized double-blind trial of intravenous trimetazidine as adjunctive therapy to primary angioplasty for acute myocardial infarction.

  International journal of cardiology 20010201

• Dobutamine stress echocardiography and the effects of trimetazidine on left ventricular dysfunction in patients with coronary artery disease.

  Coronary artery disease 20010201

• Haemodynamic and metabolic agents in the treatment of stable angina: publication review.

  Coronary artery disease 20010201

• Anti-ischaemic efficacy and tolerability of trimetazidine administered to patients with angina pectoris: results of three studies.

  Coronary artery disease 20010201

• Metabolic energy metabolism in diabetes: therapeutic implications.

  Coronary artery disease 20010201

• Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?

  Coronary artery disease 20010201

• S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes.

  Fundamental & clinical pharmacology 20010201

• [Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography].

  Klinicheskaia meditsina 20010101

• Effect of trimetazidine on retinal ischemia/reperfusion injury in rats.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20010101

• [Aspects of diastolic function of the heart in vibration disease].

  Terapevticheskii arkhiv 20010101

• [Antioxidant effects of amtizol and trimetazidine in brain ischemia].

  Patologicheskaia fiziologiia i eksperimental'naia terapiia 20010101

• [Trimetazidine prevents ischemia-reperfusion injury in hepatic surgery under vascular clamping].

  Therapie 20010101

• [Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].

  Therapie 20010101

• [Therapeutic perspectives in the treatment of stable angina].

  Therapie 20010101

• The effect of trimetazidine on C-reactive protein, cytokines and adhesion molecules in the course of acute myocardial infarction.

  Acta medica (Hradec Kralove) 20010101

• Role of metabolically active drugs in the management of ischemic heart disease.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

• The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

  Circulation research 20000317

• Trimetazidine counteracts tacrolimus nephrotoxicity in a hypertensive liver transplant patient.

  Transplantation 19991027

• Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions.

  Drugs 19990701

• Cytoprotective effects of trimetazidine in carmustine cholestasis.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 19990701

• The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis.

  Pharmaceutical research 19990501

• Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease.

  The American journal of cardiology 19981001

• Effect of trimetazidine on early and delayed doxorubicin myocardial toxicity.

  Archives internationales de pharmacodynamie et de therapie 19890101