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BMC pharmacology & toxicology 20130101
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Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia.
Haematologica 20121101
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A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261.
Gynecologic oncology 20121001
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Cancer research 20120815
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Blood 20120809
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Leukemia 20120601
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Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl+ hematological malignancies.
Cancer chemotherapy and pharmacology 20120601
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The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 20120501
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Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury.
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A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors.
Investigational new drugs 20120401
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Flavopiridol induces phosphorylation of AKT in a human glioblastoma cell line, in contrast to siRNA-mediated silencing of Cdk9: Implications for drug design and development.
Cell cycle (Georgetown, Tex.) 20120315
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CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.
International journal of cancer 20120301
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Hematologic improvement after flavopiridol treatment of pentostatin and rituximab refractory hairy cell leukemia.
Leukemia & lymphoma 20120301
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Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach.
Haematologica 20120301
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A mathematical model of cell cycle effects in gastric cancer chemotherapy.
Bulletin of mathematical biology 20120101
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GSK3β inhibition is involved in the neuroprotective effects of cyclin-dependent kinase inhibitors in neurons.
Pharmacological research 20120101
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Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis.
PloS one 20120101
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Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death.
PloS one 20120101
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Preclinical study of treatment response in HCT-116 cells and xenografts with (1) H-decoupled (31) P MRS.
NMR in biomedicine 20111101
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A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors.
Investigational new drugs 20111001
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Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia.
Leukemia & lymphoma 20111001
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The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract.
International journal of oncology 20111001
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Combining proteasome with cell cycle inhibitors: a dual attack potentially applicable to multiple hematopoietic malignancies.
Expert review of hematology 20111001
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Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol.
Leukemia 20110901
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Acute myeloid leukaemia: optimal management and recent developments.
Drugs 20110820
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Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.
Bioorganic & medicinal chemistry letters 20110701
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Leukemia cutis in association With Grover's disease.
The American Journal of dermatopathology 20110601
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Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition.
Pigment cell & melanoma research 20110601
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Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms.
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Blood 20110324
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Flavopiridol inhibits lipopolysaccharide-induced TNF-α production through inactivation of nuclear factor-κB and mitogen-activated protein kinases in the MyD88-dependent pathway.
Microbiology and immunology 20110301
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Homology modeling, molecular dynamic simulation and docking studies of cyclin dependent kinase 1.
Journal of molecular modeling 20110201
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Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9.
Arteriosclerosis, thrombosis, and vascular biology 20110201
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Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells.
Blood 20110113
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Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
Leukemia 20110101
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The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
BMC developmental biology 20110101
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CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.
Molecular endocrinology (Baltimore, Md.) 20101201
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Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.
Proteomics 20101201
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Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53.
Molecular cancer therapeutics 20101201
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Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
Cancer biology & therapy 20101101
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A phase I clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol.
Cancer chemotherapy and pharmacology 20101101
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Flavopiridol, the first cyclin-dependent kinase inhibitor: recent advances in combination chemotherapy.
Mini reviews in medicinal chemistry 20101001
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Zhonghua fu chan ke za zhi 20101001
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The Journal of biological chemistry 20100924
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Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.
Nature cell biology 20100901
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A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer.
American journal of clinical oncology 20100801
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Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome.
The Journal of clinical endocrinology and metabolism 20100801
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Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.
Molecular cancer therapeutics 20100801
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Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents.
Cancer chemotherapy and pharmacology 20100701
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Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia.
Leukemia research 20100701
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Journal of cellular physiology 20100701
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Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
Biochemical pharmacology 20100701
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Haematologica 20100701
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The Journal of pharmacology and experimental therapeutics 20100601
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Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178.
Molecular and biochemical parasitology 20100601
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Specificity in the interaction of natural products with their target proteins--a biochemical and structural insight.
Mini reviews in medicinal chemistry 20100601
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A combination of cisplatin-eluting gelatin microspheres and flavopiridol enhances anti-tumour effects in a rabbit VX2 liver tumour model.
The British journal of radiology 20100501
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Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.
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Fitoterapia 20100301
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PloS one 20100101
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BMC cancer 20100101
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Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease.
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Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 20091201
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PLoS biology 20091101
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Molecular cell 20091009
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Blood reviews 20090901
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Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication.
Chembiochem : a European journal of chemical biology 20090817
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EMBO reports 20090801
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The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity.
Haematologica 20090701
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Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Blood 20090507
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Drug metabolism and disposition: the biological fate of chemicals 20090501
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Cell cycle (Georgetown, Tex.) 20090415
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The Journal of biological chemistry 20090410
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Blood 20090319
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Cancer chemotherapy and pharmacology 20090301
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Leukemia 20090301
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Mini reviews in medicinal chemistry 20090301
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International journal of pharmaceutics 20090105
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The International journal of biological markers 20090101
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A phase II study of flavopiridol (Alvocidib) in combination with docetaxel in refractory, metastatic pancreatic cancer.
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Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma.
Therapeutic drug monitoring 20081001
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Combinatorial antileukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide 2-(2,4-difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and flavopiridol.
Molecular pharmacology 20080901
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Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed.
International journal of radiation oncology, biology, physics 20080801
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Novel agents in chronic lymphocytic leukemia: efficacy and tolerability of new therapies.
Clinical lymphoma & myeloma 20080801
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The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
The EMBO journal 20080709
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Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule.
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Leukemia research 20080501
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Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.
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Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
Molecular pharmacology 20080501
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Clinical lung cancer 20080501
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Pediatric blood & cancer 20080401
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Cancer research 20080401
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Molecular cancer therapeutics 20071201
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Current opinion in oncology 20071101
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International journal of cancer 20070915
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Best practice & research. Clinical haematology 20070901
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Cancer chemotherapy and pharmacology 20070801
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Pharmacogenetics and genomics 20070801
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Blood 20070115
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Bioorganic & medicinal chemistry 20070115
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Retrovirology 20070101
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Bioorganic & medicinal chemistry 20061201
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Leukemia research 20061101
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The Prostate 20061001
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Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20060801
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Surgical oncology 20060801
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Life sciences 20060627
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Cancer research 20060601
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Nature 20060413
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Molecular pharmacology 20060101
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Cell cycle (Georgetown, Tex.) 20060101
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Expert opinion on investigational drugs 20060101
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Molecular cancer therapeutics 20060101
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Anticancer research 20060101
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AIDS (London, England) 20051202
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Leukemia research 20051101
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Blood 20051001
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Gynecologic oncology 20050801
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Cancer chemotherapy and pharmacology 20050701
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Neuro-oncology 20050701
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Investigational new drugs 20050601
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Breast cancer research and treatment 20050301
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Blood 20050201
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Anticancer research 20050101
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Journal of biological regulators and homeostatic agents 20050101
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Anticancer research 20050101
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Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
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E2F4 deficiency promotes drug-induced apoptosis.
Cancer biology & therapy 20041201
-
The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.
Molecular cancer therapeutics 20041201
-
Molecular models of cyclin-dependent kinase 1 complexed with inhibitors.
Biochemical and biophysical research communications 20041112
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Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation.
Leukemia 20041101
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Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
Molecular pharmacology 20041001
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Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma.
Investigational new drugs 20040801
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Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801
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Phase I trial of the cyclin-dependent kinase inhibitor flavopiridol in combination with docetaxel in patients with metastatic breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20040801
-
Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.
Blood 20040715
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Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse.
International journal of radiation oncology, biology, physics 20040715
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Transcriptional signature of flavopiridol-induced tumor cell death.
Molecular cancer therapeutics 20040701
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Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?
Molecular cancer therapeutics 20040701
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Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol.
Clinical cancer research : an official journal of the American Association for Cancer Research 20040615
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Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature.
Lung cancer (Amsterdam, Netherlands) 20040601
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Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.
European journal of biochemistry 20040601
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Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity.
Anti-cancer drugs 20040601
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Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
Cancer research 20040515
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Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor.
Cancer research 20040515
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Growth inhibition and induction of apoptosis by flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines.
Oncology reports 20040501
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Enhancement of radiation effects by combined docetaxel and flavopiridol treatment in lung cancer cells.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20040501
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Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.
Molecular cancer therapeutics 20040401
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Combining flavopiridol with various signal transduction inhibitors.
Oncology reports 20040301
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Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol.
Molecular pharmacology 20040301
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Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 20040301
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Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
The Journal of biological chemistry 20040206
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Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment.
The Journal of pharmacology and experimental therapeutics 20040201
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Flavopiridol: where do we stand in chronic lymphocytic leukemia?
Leukemia 20040201
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Flavopiridol inhibits the growth of GL261 gliomas in vivo: implications for malignant glioma therapy.
Cell cycle (Georgetown, Tex.) 20040201
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A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20040201
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Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.
Molecular cell 20040116
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A novel approach to develop anti-HIV drugs: adapting non-nucleoside anticancer chemotherapeutics.
Antiviral research 20040101
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Cell-cycle targeted therapies.
The Lancet. Oncology 20040101
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Flavopiridol as a radio-sensitizer for esophageal cancer cell lines.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20040101
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Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53.
Advances in enzyme regulation 20040101
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In vitro cell growth pharmacodynamic studies: a new nonparametric approach to determining the relative importance of drug concentration and treatment time.
Cancer chemotherapy and pharmacology 20031201
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Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia.
Leukemia 20031201
-
The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031201
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The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: impact on therapy.
International journal of clinical pharmacology and therapeutics 20031201
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The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols.
Annals of the New York Academy of Sciences 20031201
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Inhibition of CDKs: a strategy for preventing kainic acid-induced apoptosis in neurons.
Annals of the New York Academy of Sciences 20031201
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Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
Molecular pharmacology 20031101
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Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity.
Cancer research 20031101
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Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2).
Life sciences 20031017
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Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.
Oncogene 20031016
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Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.
Neuropharmacology 20031001
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Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.
The Journal of pharmacology and experimental therapeutics 20031001
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Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.
The Annals of pharmacotherapy 20031001
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Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.
Clinical cancer research : an official journal of the American Association for Cancer Research 20031001
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Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030815
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Phase II study of flavopiridol in patients with advanced colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology 20030801
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Cyclin-dependent kinase inhibitors.
Current opinion in pharmacology 20030801
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A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors.
Journal of medicinal chemistry 20030717
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Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Cancer chemotherapy and pharmacology 20030701
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Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer.
Cancer research 20030701
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Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells.
Cancer research 20030615
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Commentary: effect of flavonoids on normal and leukemic cells.
Leukemia research 20030601
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Flavonoid effects on normal and leukemic cells.
Leukemia research 20030601
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The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines.
Melanoma research 20030601
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Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells.
Molecular cancer therapeutics 20030601
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Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501
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Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: activation of the mitochondria-dependent death-signaling pathway.
The Journal of thoracic and cardiovascular surgery 20030501
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The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
Cancer research 20030415
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Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol.
The Journal of antimicrobial chemotherapy 20030401
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Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030215
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Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines.
Cancer research 20030201
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Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms.
Anti-cancer drugs 20030201
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Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030201
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Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway.
Molecular cancer therapeutics 20030201
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Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.
Leukemia & lymphoma 20030201
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Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells.
Oral oncology 20030101
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Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.
Cancer research 20030101
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Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.
Cancer research 20030101
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Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.
Molecular cancer therapeutics 20030101
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Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.
Molecular cancer therapeutics 20030101
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Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research 20030101
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Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies.
Current medicinal chemistry. Anti-cancer agents 20030101
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Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.
Cell cycle (Georgetown, Tex.) 20030101
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Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor.
Cell cycle (Georgetown, Tex.) 20030101
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Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers.
Annals of oncology : official journal of the European Society for Medical Oncology 20030101
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c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases.
Cell cycle (Georgetown, Tex.) 20030101
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Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol.
Cancer chemotherapy and pharmacology 20021201
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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 20021101
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Zebrafish: a preclinical model for drug screening.
Assay and drug development technologies 20021101
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Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021001
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Cyclin-dependent kinases as new targets for the prevention and treatment of cancer.
Hematology/oncology clinics of North America 20021001
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A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma.
Biomedical chromatography : BMC 20020901
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Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 20020901
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Clinical trials referral resource. Flavopiridol.
Oncology (Williston Park, N.Y.) 20020901
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Hematologic malignancies: new developments and future treatments.
Seminars in oncology 20020801
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Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells.
Cancer research 20020715
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Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
Leukemia 20020701
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Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.
Molecular cancer therapeutics 20020701
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Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma.
International journal of cancer 20020610
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Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.
Molecular pharmacology 20020601
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Review of flavopiridol, a cyclin-dependent kinase inhibitor, as breast cancer therapy.
Seminars in oncology 20020601
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Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity.
The Journal of pharmacology and experimental therapeutics 20020501
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Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development.
The Annals of pharmacotherapy 20020501
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Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi.
Molecular and biochemical parasitology 20020501
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In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes.
Pharmaceutical research 20020501
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Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol.
Biochemical and biophysical research communications 20020426
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Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Journal of medicinal chemistry 20020425
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Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol.
Cancer research 20020415
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Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020415
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Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma.
Leukemia & lymphoma 20020401
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Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.
Cancer research 20020315
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Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol.
Leukemia research 20020301
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Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors.
The Journal of biological chemistry 20020215
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Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020201
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The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells.
Molecular cancer therapeutics 20020201
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The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.
The oncologist 20020101
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Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis.
Cancer biology & therapy 20020101
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[Report on 93rd AACR].
Bulletin du cancer 20020101
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CDK inhibitors: cell cycle arrest versus apoptosis.
Cell cycle (Georgetown, Tex.) 20020101
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Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel.
Cancer biology & therapy 20020101
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Role reversal for anticancer agents.
Cancer biology & therapy 20020101
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Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes.
Journal of the American Society of Nephrology : JASN 20011201
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Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 20011201
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Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.
Molecular pharmacology 20011101
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Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.
Neoplasia (New York, N.Y.) 20011101
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Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.
The Journal of biological chemistry 20010824
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Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit.
Clinical cancer research : an official journal of the American Association for Cancer Research 20010801
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Flavopiridol. National Cancer Institute.
Current opinion in investigational drugs (London, England : 2000) 20010801
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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway.
Cell death and differentiation 20010701
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Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia.
British journal of haematology 20010701
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A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 20010601
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Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.
Leukemia 20010601
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Mechanisms of action of flavopiridol.
Critical reviews in oncology/hematology 20010501
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Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases.
Hepatology (Baltimore, Md.) 20010501
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Effect of P-glycoprotein on flavopiridol sensitivity.
British journal of cancer 20010501
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The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.
Molecular and biochemical parasitology 20010406
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In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: involvement of UDP-glucuronosyltransferases 1A1 and 1A9.
Drug metabolism and disposition: the biological fate of chemicals 20010401
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Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010401
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[CDK inhibitors for therapy of cancer].
Nihon rinsho. Japanese journal of clinical medicine 20010401
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Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity.
Cancer research 20010315
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The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
Cancer research 20010315
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Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins.
Molecular and biochemical parasitology 20010301
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The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase.
Archives of biochemistry and biophysics 20010215
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Possible mechanisms of diarrheal side effects associated with the use of a novel chemotherapeutic agent, flavopiridol.
Clinical cancer research : an official journal of the American Association for Cancer Research 20010201
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Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas.
Seminars in cancer biology 20010201
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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
The Journal of biological chemistry 20010105
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Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 20010101
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Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
Leukemia 20010101
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Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.
Blood cells, molecules & diseases 20010101
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Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.
Genome biology 20010101
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Bcl-2 independence of flavopiridol-induced apoptosis. Mitochondrial depolarization in the absence of cytochrome c release.
The Journal of biological chemistry 20001013
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Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol.
International journal of oncology 20001001
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Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
Blood 20000715
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Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 19991001
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Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation In vivo after carotid injury in the rat.
Circulation 19990810
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Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 19990701
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Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.
Cancer research 19990601
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Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
Blood 19981115
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Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.
The Journal of clinical investigation 19981101
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Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 19981101
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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Science (New York, N.Y.) 19980724
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Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity In vivo against human leukemia and lymphoma xenografts.
Blood 19980401
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Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol.
Blood 19980115
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Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.
Cancer research 19960701
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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.
Biochemical and biophysical research communications 19940615
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Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity.
Biochemical pharmacology 19931117
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Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275.
Journal of the National Cancer Institute 19921118