1323403-33-3 | CC-220

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$24.00	$17.00
2mg	98%	in stock	$33.00	$23.00
5mg	98%	in stock	$69.00	$49.00
10mg	98%	in stock	$136.00	$95.00
25mg	98%	in stock	$275.00	$192.00
50mg	98%	in stock	$359.00	$252.00
100mg	98%	in stock	$470.00	$329.00
250mg	98%	in stock	$612.00	$428.00

Description

• Catalog Number: AX46913
• Chemical Name: CC-220
• CAS Number: 1323403-33-3
• Molecular Formula: C25H27N3O5
• Molecular Weight: 449.499
• MDL Number: MFCD31382133
• SMILES: O=C1CC[C@@H](C(=O)N1)N1Cc2c(C1=O)cccc2OCc1ccc(cc1)CN1CCOCC1

Computed Properties

• Complexity: 732
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 33
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 1.1

Literature

• A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.

  Journal of medicinal chemistry 20180125

• Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.

  Blood cancer journal 20151001

• Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population.

  PloS one 20140101