1350514-68-9 | MK-5172

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$46.00	$33.00
2mg	98%	in stock	$67.00	$47.00
5mg	98%	in stock	$69.00	$48.00
10mg	98%	in stock	$119.00	$83.00
25mg	98%	in stock	$195.00	$136.00
50mg	98%	in stock	$248.00	$174.00
100mg	98%	in stock	$298.00	$209.00

Description

• Catalog Number: AE35735
• Chemical Name: MK-5172
• CAS Number: 1350514-68-9
• Molecular Formula: C38H50N6O9S
• Molecular Weight: 766.9034
• MDL Number: MFCD25976700
• SMILES: C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@@H](NC(=O)O[C@@H]1C[C@H]1CCCCCc1c(O2)nc2cc(OC)ccc2n1)C(C)(C)C)C(=O)NS(=O)(=O)C1CC1

Computed Properties

• Complexity: 1580
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 7
• Heavy Atom Count: 54
• Hydrogen Bond Acceptor Count: 11
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 8
• XLogP3: 4.7

Literature

• Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

  Drugs 20170701

• An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

  Canadian journal of gastroenterology & hepatology 20150101

• MK-5172 : a second-generation protease inhibitor for the treatment of hepatitis C virus infection.

  Expert opinion on investigational drugs 20140501

• MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.

  Antimicrobial agents and chemotherapy 20120801

• Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.

  ACS medicinal chemistry letters 20120412