1355326-35-0 | Agi-5198

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$44.00	$31.00
25mg	98%	in stock	$93.00	$65.00
100mg	98%	in stock	$136.00	$95.00
250mg	98%	in stock	$258.00	$180.00

Description

• Catalog Number: AB70477
• Chemical Name: Agi-5198
• CAS Number: 1355326-35-0
• Molecular Formula: C27H31FN4O2
• Molecular Weight: 462.559
• MDL Number: MFCD24848688
• SMILES: Fc1cccc(c1)N(C(c1ccccc1C)C(=O)NC1CCCCC1)C(=O)Cn1ccnc1C

Computed Properties

• Complexity: 686
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 7
• Undefined Atom Stereocenter Count: 1
• XLogP3: 4.9

Literature

• Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines.

  Oncotarget 20150520

• Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule.

  The Journal of biological chemistry 20150109

• An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

  Science (New York, N.Y.) 20130503